Nkap_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras-induced vulval development antagonist, putative

Species:

Leishmania major

UniProt:

Q4Q4E9_LEIMA

TriTrypDb:

LmjF.33.0580 , LMJLV39_330012500 , LMJSD75_330012300

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4E9

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	9
GO:0005488	binding	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.650
CLV_C14_Caspase3-7	148	152	PF00656	0.695
CLV_NRD_NRD_1	141	143	PF00675	0.819
CLV_NRD_NRD_1	192	194	PF00675	0.821
CLV_NRD_NRD_1	206	208	PF00675	0.815
CLV_NRD_NRD_1	302	304	PF00675	0.357
CLV_NRD_NRD_1	32	34	PF00675	0.547
CLV_NRD_NRD_1	354	356	PF00675	0.412
CLV_NRD_NRD_1	38	40	PF00675	0.628
CLV_PCSK_FUR_1	30	34	PF00082	0.671
CLV_PCSK_KEX2_1	192	194	PF00082	0.832
CLV_PCSK_KEX2_1	208	210	PF00082	0.811
CLV_PCSK_KEX2_1	298	300	PF00082	0.357
CLV_PCSK_KEX2_1	30	32	PF00082	0.539
CLV_PCSK_KEX2_1	302	304	PF00082	0.357
CLV_PCSK_KEX2_1	37	39	PF00082	0.601
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.811
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.357
CLV_PCSK_PC7_1	33	39	PF00082	0.617
CLV_Separin_Metazoa	139	143	PF03568	0.813
DEG_Nend_UBRbox_2	1	3	PF02207	0.671
DOC_MAPK_MEF2A_6	361	370	PF00069	0.486
DOC_PP1_RVXF_1	206	213	PF00149	0.756
DOC_USP7_MATH_1	101	105	PF00917	0.698
DOC_USP7_MATH_1	115	119	PF00917	0.680
DOC_USP7_MATH_1	134	138	PF00917	0.784
DOC_USP7_MATH_1	259	263	PF00917	0.709
DOC_USP7_MATH_1	87	91	PF00917	0.657
DOC_USP7_UBL2_3	166	170	PF12436	0.650
DOC_WW_Pin1_4	124	129	PF00397	0.788
LIG_14-3-3_CanoR_1	59	67	PF00244	0.504
LIG_CaM_IQ_9	347	363	PF13499	0.438
LIG_FHA_1	120	126	PF00498	0.556
LIG_FHA_1	148	154	PF00498	0.757
LIG_FHA_1	159	165	PF00498	0.619
LIG_FHA_1	242	248	PF00498	0.751
LIG_FHA_1	46	52	PF00498	0.572
LIG_FHA_2	287	293	PF00498	0.670
LIG_FHA_2	307	313	PF00498	0.438
LIG_FHA_2	91	97	PF00498	0.627
LIG_LIR_Nem_3	24	29	PF02991	0.619
LIG_Pex14_1	22	26	PF04695	0.612
LIG_Pex14_2	293	297	PF04695	0.357
LIG_SH2_STAT3	14	17	PF00017	0.611
LIG_SH2_STAT5	321	324	PF00017	0.357
LIG_SH2_STAT5	334	337	PF00017	0.357
LIG_SH2_STAT5	76	79	PF00017	0.526
LIG_SH3_1	193	199	PF00018	0.617
LIG_SH3_3	127	133	PF00018	0.754
LIG_SH3_3	154	160	PF00018	0.669
LIG_SH3_3	193	199	PF00018	0.742
LIG_Sin3_3	182	189	PF02671	0.569
LIG_TRAF2_1	309	312	PF00917	0.492
LIG_TRAF2_1	8	11	PF00917	0.600
LIG_WW_3	139	143	PF00397	0.813
MOD_CK1_1	253	259	PF00069	0.655
MOD_CK1_1	286	292	PF00069	0.527
MOD_CK1_1	328	334	PF00069	0.438
MOD_CK1_1	52	58	PF00069	0.660
MOD_CK1_1	90	96	PF00069	0.743
MOD_CK2_1	142	148	PF00069	0.795
MOD_CK2_1	286	292	PF00069	0.562
MOD_CK2_1	306	312	PF00069	0.454
MOD_CK2_1	43	49	PF00069	0.760
MOD_CK2_1	5	11	PF00069	0.637
MOD_CK2_1	57	63	PF00069	0.595
MOD_Cter_Amidation	205	208	PF01082	0.819
MOD_GlcNHglycan	102	106	PF01048	0.615
MOD_GlcNHglycan	117	120	PF01048	0.638
MOD_GlcNHglycan	136	139	PF01048	0.756
MOD_GlcNHglycan	161	164	PF01048	0.567
MOD_GlcNHglycan	202	205	PF01048	0.691
MOD_GlcNHglycan	261	264	PF01048	0.787
MOD_GlcNHglycan	323	326	PF01048	0.356
MOD_GlcNHglycan	49	54	PF01048	0.659
MOD_GlcNHglycan	77	80	PF01048	0.532
MOD_GlcNHglycan	89	92	PF01048	0.608
MOD_GSK3_1	101	108	PF00069	0.690
MOD_GSK3_1	115	122	PF00069	0.655
MOD_GSK3_1	124	131	PF00069	0.511
MOD_GSK3_1	147	154	PF00069	0.676
MOD_GSK3_1	250	257	PF00069	0.586
MOD_GSK3_1	321	328	PF00069	0.438
MOD_GSK3_1	373	380	PF00069	0.446
MOD_GSK3_1	45	52	PF00069	0.707
MOD_GSK3_1	55	62	PF00069	0.580
MOD_NEK2_1	21	26	PF00069	0.616
MOD_NEK2_1	323	328	PF00069	0.357
MOD_NEK2_1	373	378	PF00069	0.422
MOD_NEK2_1	81	86	PF00069	0.577
MOD_PIKK_1	198	204	PF00454	0.788
MOD_PIKK_1	250	256	PF00454	0.576
MOD_PIKK_1	283	289	PF00454	0.533
MOD_PIKK_1	292	298	PF00454	0.357
MOD_PIKK_1	57	63	PF00454	0.723
MOD_PKA_1	142	148	PF00069	0.741
MOD_Plk_1	239	245	PF00069	0.798
MOD_Plk_2-3	43	49	PF00069	0.675
MOD_ProDKin_1	124	130	PF00069	0.790
TRG_DiLeu_BaEn_2	368	374	PF01217	0.415
TRG_ER_diArg_1	207	210	PF00400	0.814
TRG_ER_diArg_1	29	32	PF00400	0.539
TRG_ER_diArg_1	301	303	PF00400	0.348
TRG_ER_diArg_1	37	39	PF00400	0.590
TRG_ER_diLys_1	377	380	PF00400	0.608
TRG_NLS_Bipartite_1	192	211	PF00514	0.815
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC1	Leptomonas seymouri	51%	91%
A0A3S7X6H7	Leishmania donovani	91%	100%
A0A422N868	Trypanosoma rangeli	34%	100%
A4HL96	Leishmania braziliensis	76%	100%
A4I8S2	Leishmania infantum	91%	100%
E9B3N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BFD1	Trypanosoma cruzi	32%	100%