LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q4E8_LEIMA
TriTrypDb:
LmjF.33.0585 , LMJLV39_330012600 * , LMJSD75_330012400 *
Length:
677

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4E8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4E8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 134 138 PF00656 0.686
CLV_C14_Caspase3-7 173 177 PF00656 0.731
CLV_C14_Caspase3-7 194 198 PF00656 0.756
CLV_C14_Caspase3-7 525 529 PF00656 0.759
CLV_C14_Caspase3-7 531 535 PF00656 0.626
CLV_C14_Caspase3-7 540 544 PF00656 0.500
CLV_C14_Caspase3-7 668 672 PF00656 0.779
CLV_NRD_NRD_1 119 121 PF00675 0.631
CLV_NRD_NRD_1 364 366 PF00675 0.616
CLV_NRD_NRD_1 477 479 PF00675 0.633
CLV_NRD_NRD_1 480 482 PF00675 0.671
CLV_NRD_NRD_1 548 550 PF00675 0.755
CLV_NRD_NRD_1 594 596 PF00675 0.779
CLV_NRD_NRD_1 639 641 PF00675 0.721
CLV_PCSK_FUR_1 478 482 PF00082 0.735
CLV_PCSK_KEX2_1 119 121 PF00082 0.631
CLV_PCSK_KEX2_1 244 246 PF00082 0.615
CLV_PCSK_KEX2_1 364 366 PF00082 0.616
CLV_PCSK_KEX2_1 479 481 PF00082 0.643
CLV_PCSK_KEX2_1 550 552 PF00082 0.783
CLV_PCSK_KEX2_1 556 558 PF00082 0.669
CLV_PCSK_KEX2_1 593 595 PF00082 0.793
CLV_PCSK_KEX2_1 615 617 PF00082 0.637
CLV_PCSK_KEX2_1 639 641 PF00082 0.721
CLV_PCSK_PC1ET2_1 244 246 PF00082 0.615
CLV_PCSK_PC1ET2_1 479 481 PF00082 0.643
CLV_PCSK_PC1ET2_1 550 552 PF00082 0.783
CLV_PCSK_PC1ET2_1 556 558 PF00082 0.669
CLV_PCSK_PC1ET2_1 593 595 PF00082 0.793
CLV_PCSK_PC1ET2_1 615 617 PF00082 0.739
CLV_PCSK_SKI1_1 182 186 PF00082 0.618
CLV_PCSK_SKI1_1 218 222 PF00082 0.684
CLV_PCSK_SKI1_1 590 594 PF00082 0.767
CLV_PCSK_SKI1_1 639 643 PF00082 0.718
DEG_APCC_DBOX_1 181 189 PF00400 0.645
DEG_APCC_DBOX_1 639 647 PF00400 0.612
DEG_Nend_Nbox_1 1 3 PF02207 0.813
DEG_SCF_FBW7_2 512 519 PF00400 0.773
DEG_SPOP_SBC_1 606 610 PF00917 0.733
DOC_ANK_TNKS_1 326 333 PF00023 0.649
DOC_CKS1_1 646 651 PF01111 0.533
DOC_CKS1_1 8 13 PF01111 0.646
DOC_CYCLIN_yClb5_NLxxxL_5 486 492 PF00134 0.758
DOC_MAPK_gen_1 639 646 PF00069 0.609
DOC_MAPK_MEF2A_6 639 646 PF00069 0.609
DOC_PP2B_LxvP_1 221 224 PF13499 0.803
DOC_PP2B_LxvP_1 492 495 PF13499 0.764
DOC_PP4_FxxP_1 165 168 PF00568 0.674
DOC_USP7_MATH_1 140 144 PF00917 0.752
DOC_USP7_MATH_1 193 197 PF00917 0.656
DOC_USP7_MATH_1 209 213 PF00917 0.566
DOC_USP7_MATH_1 224 228 PF00917 0.663
DOC_USP7_MATH_1 239 243 PF00917 0.690
DOC_USP7_MATH_1 258 262 PF00917 0.586
DOC_USP7_MATH_1 276 280 PF00917 0.519
DOC_USP7_MATH_1 555 559 PF00917 0.832
DOC_USP7_MATH_1 599 603 PF00917 0.691
DOC_USP7_MATH_1 606 610 PF00917 0.685
DOC_USP7_MATH_1 670 674 PF00917 0.738
DOC_USP7_MATH_1 91 95 PF00917 0.743
DOC_USP7_UBL2_3 135 139 PF12436 0.583
DOC_WW_Pin1_4 118 123 PF00397 0.656
DOC_WW_Pin1_4 235 240 PF00397 0.732
DOC_WW_Pin1_4 256 261 PF00397 0.828
DOC_WW_Pin1_4 274 279 PF00397 0.518
DOC_WW_Pin1_4 497 502 PF00397 0.755
DOC_WW_Pin1_4 512 517 PF00397 0.774
DOC_WW_Pin1_4 607 612 PF00397 0.767
DOC_WW_Pin1_4 645 650 PF00397 0.678
DOC_WW_Pin1_4 656 661 PF00397 0.679
DOC_WW_Pin1_4 7 12 PF00397 0.766
LIG_14-3-3_CanoR_1 245 255 PF00244 0.611
LIG_14-3-3_CanoR_1 559 567 PF00244 0.736
LIG_14-3-3_CanoR_1 607 611 PF00244 0.801
LIG_14-3-3_CanoR_1 619 626 PF00244 0.580
LIG_Actin_WH2_2 625 641 PF00022 0.721
LIG_BIR_III_4 534 538 PF00653 0.750
LIG_Clathr_ClatBox_1 280 284 PF01394 0.828
LIG_deltaCOP1_diTrp_1 382 392 PF00928 0.821
LIG_FHA_1 111 117 PF00498 0.712
LIG_FHA_1 440 446 PF00498 0.841
LIG_FHA_1 45 51 PF00498 0.507
LIG_FHA_1 506 512 PF00498 0.847
LIG_FHA_1 612 618 PF00498 0.694
LIG_FHA_1 646 652 PF00498 0.657
LIG_FHA_2 411 417 PF00498 0.751
LIG_FHA_2 458 464 PF00498 0.768
LIG_FHA_2 513 519 PF00498 0.771
LIG_FHA_2 582 588 PF00498 0.716
LIG_FHA_2 599 605 PF00498 0.642
LIG_LIR_Apic_2 10 15 PF02991 0.636
LIG_LIR_Apic_2 164 168 PF02991 0.675
LIG_MYND_1 278 282 PF01753 0.823
LIG_PCNA_yPIPBox_3 615 629 PF02747 0.748
LIG_Pex14_2 161 165 PF04695 0.666
LIG_SH2_CRK 141 145 PF00017 0.762
LIG_SH2_NCK_1 105 109 PF00017 0.645
LIG_SH2_NCK_1 532 536 PF00017 0.791
LIG_SH2_SRC 105 108 PF00017 0.728
LIG_SH2_SRC 532 535 PF00017 0.752
LIG_SH2_STAP1 301 305 PF00017 0.759
LIG_SH2_STAP1 532 536 PF00017 0.713
LIG_SH2_STAT5 141 144 PF00017 0.766
LIG_SH2_STAT5 301 304 PF00017 0.684
LIG_SH3_3 217 223 PF00018 0.782
LIG_SH3_3 435 441 PF00018 0.751
LIG_SH3_3 643 649 PF00018 0.631
LIG_SH3_3 654 660 PF00018 0.734
LIG_SUMO_SIM_anti_2 99 107 PF11976 0.519
LIG_TRAF2_1 326 329 PF00917 0.703
LIG_TRAF2_1 409 412 PF00917 0.769
LIG_TRAF2_1 621 624 PF00917 0.724
LIG_TRFH_1 219 223 PF08558 0.723
MOD_CDC14_SPxK_1 121 124 PF00782 0.688
MOD_CDK_SPxK_1 118 124 PF00069 0.664
MOD_CK1_1 237 243 PF00069 0.832
MOD_CK1_1 247 253 PF00069 0.662
MOD_CK1_1 261 267 PF00069 0.569
MOD_CK1_1 349 355 PF00069 0.763
MOD_CK1_1 387 393 PF00069 0.836
MOD_CK1_1 493 499 PF00069 0.721
MOD_CK1_1 506 512 PF00069 0.812
MOD_CK1_1 524 530 PF00069 0.837
MOD_CK1_1 558 564 PF00069 0.825
MOD_CK1_1 85 91 PF00069 0.822
MOD_CK1_1 99 105 PF00069 0.538
MOD_CK2_1 301 307 PF00069 0.626
MOD_CK2_1 323 329 PF00069 0.744
MOD_CK2_1 393 399 PF00069 0.854
MOD_CK2_1 581 587 PF00069 0.796
MOD_CK2_1 598 604 PF00069 0.610
MOD_CK2_1 618 624 PF00069 0.417
MOD_Cter_Amidation 547 550 PF01082 0.755
MOD_GlcNHglycan 239 242 PF01048 0.727
MOD_GlcNHglycan 24 27 PF01048 0.609
MOD_GlcNHglycan 246 249 PF01048 0.654
MOD_GlcNHglycan 260 263 PF01048 0.639
MOD_GlcNHglycan 30 33 PF01048 0.657
MOD_GlcNHglycan 303 306 PF01048 0.749
MOD_GlcNHglycan 348 351 PF01048 0.787
MOD_GlcNHglycan 369 372 PF01048 0.749
MOD_GlcNHglycan 386 389 PF01048 0.532
MOD_GlcNHglycan 395 398 PF01048 0.663
MOD_GlcNHglycan 446 449 PF01048 0.671
MOD_GlcNHglycan 524 527 PF01048 0.835
MOD_GlcNHglycan 564 567 PF01048 0.820
MOD_GlcNHglycan 575 578 PF01048 0.671
MOD_GSK3_1 140 147 PF00069 0.688
MOD_GSK3_1 235 242 PF00069 0.825
MOD_GSK3_1 24 31 PF00069 0.750
MOD_GSK3_1 386 393 PF00069 0.835
MOD_GSK3_1 395 402 PF00069 0.705
MOD_GSK3_1 440 447 PF00069 0.700
MOD_GSK3_1 450 457 PF00069 0.746
MOD_GSK3_1 493 500 PF00069 0.746
MOD_GSK3_1 503 510 PF00069 0.847
MOD_GSK3_1 520 527 PF00069 0.800
MOD_GSK3_1 558 565 PF00069 0.738
MOD_GSK3_1 607 614 PF00069 0.714
MOD_GSK3_1 80 87 PF00069 0.817
MOD_GSK3_1 92 99 PF00069 0.600
MOD_N-GLC_1 234 239 PF02516 0.597
MOD_N-GLC_1 28 33 PF02516 0.656
MOD_N-GLC_1 512 517 PF02516 0.774
MOD_NEK2_1 21 26 PF00069 0.663
MOD_NEK2_1 311 316 PF00069 0.776
MOD_NEK2_1 375 380 PF00069 0.578
MOD_NEK2_1 507 512 PF00069 0.852
MOD_NEK2_1 51 56 PF00069 0.506
MOD_NEK2_1 522 527 PF00069 0.839
MOD_NEK2_1 562 567 PF00069 0.659
MOD_NEK2_1 75 80 PF00069 0.802
MOD_NEK2_2 473 478 PF00069 0.677
MOD_PIKK_1 239 245 PF00454 0.618
MOD_PIKK_1 618 624 PF00454 0.748
MOD_PIKK_1 75 81 PF00454 0.611
MOD_PK_1 222 228 PF00069 0.810
MOD_PKA_1 244 250 PF00069 0.610
MOD_PKA_2 170 176 PF00069 0.657
MOD_PKA_2 202 208 PF00069 0.597
MOD_PKA_2 244 250 PF00069 0.610
MOD_PKA_2 51 57 PF00069 0.593
MOD_PKA_2 558 564 PF00069 0.664
MOD_PKA_2 606 612 PF00069 0.797
MOD_PKA_2 618 624 PF00069 0.596
MOD_PKA_2 632 638 PF00069 0.521
MOD_PKB_1 333 341 PF00069 0.600
MOD_Plk_1 410 416 PF00069 0.595
MOD_Plk_2-3 665 671 PF00069 0.861
MOD_Plk_4 266 272 PF00069 0.822
MOD_Plk_4 276 282 PF00069 0.655
MOD_Plk_4 335 341 PF00069 0.572
MOD_Plk_4 46 52 PF00069 0.760
MOD_Plk_4 507 513 PF00069 0.837
MOD_Plk_4 99 105 PF00069 0.544
MOD_ProDKin_1 118 124 PF00069 0.664
MOD_ProDKin_1 235 241 PF00069 0.734
MOD_ProDKin_1 256 262 PF00069 0.828
MOD_ProDKin_1 274 280 PF00069 0.517
MOD_ProDKin_1 497 503 PF00069 0.756
MOD_ProDKin_1 512 518 PF00069 0.774
MOD_ProDKin_1 607 613 PF00069 0.764
MOD_ProDKin_1 645 651 PF00069 0.685
MOD_ProDKin_1 656 662 PF00069 0.682
MOD_ProDKin_1 7 13 PF00069 0.761
MOD_SUMO_for_1 409 412 PF00179 0.769
MOD_SUMO_rev_2 132 140 PF00179 0.748
MOD_SUMO_rev_2 659 668 PF00179 0.776
TRG_DiLeu_BaEn_1 307 312 PF01217 0.761
TRG_DiLeu_BaEn_3 623 629 PF01217 0.714
TRG_ENDOCYTIC_2 141 144 PF00928 0.766
TRG_ER_diArg_1 118 120 PF00400 0.748
TRG_ER_diArg_1 333 336 PF00400 0.640
TRG_ER_diArg_1 363 365 PF00400 0.607
TRG_ER_diArg_1 477 480 PF00400 0.620
TRG_ER_diArg_1 481 484 PF00400 0.659
TRG_ER_diArg_1 549 552 PF00400 0.643
TRG_ER_diArg_1 638 640 PF00400 0.722
TRG_NES_CRM1_1 623 636 PF08389 0.716
TRG_NLS_MonoCore_2 477 482 PF00514 0.691
TRG_NLS_MonoExtC_3 478 483 PF00514 0.815
TRG_NLS_MonoExtN_4 478 483 PF00514 0.815
TRG_NLS_MonoExtN_4 590 597 PF00514 0.769
TRG_Pf-PMV_PEXEL_1 73 77 PF00026 0.785

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ITV4 Leishmania donovani 89% 100%
A4HL97 Leishmania braziliensis 69% 100%
A4I8S3 Leishmania infantum 89% 100%
E9B3N9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS