Coiled-coil domain-containing protein 40

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coiled-coil domain-containing protein 40 homolog

Species:

Leishmania major

UniProt:

Q4Q4E7_LEIMA

TriTrypDb:

LmjF.33.0590 , LMJLV39_330012700 , LMJSD75_330012500

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4E7

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	12
GO:0001578	microtubule bundle formation	4	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	12
GO:0007017	microtubule-based process	2	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0035082	axoneme assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.522
CLV_C14_Caspase3-7	294	298	PF00656	0.383
CLV_NRD_NRD_1	157	159	PF00675	0.434
CLV_NRD_NRD_1	246	248	PF00675	0.393
CLV_NRD_NRD_1	251	253	PF00675	0.394
CLV_NRD_NRD_1	31	33	PF00675	0.528
CLV_NRD_NRD_1	334	336	PF00675	0.609
CLV_NRD_NRD_1	37	39	PF00675	0.473
CLV_NRD_NRD_1	391	393	PF00675	0.505
CLV_NRD_NRD_1	456	458	PF00675	0.430
CLV_NRD_NRD_1	462	464	PF00675	0.445
CLV_NRD_NRD_1	611	613	PF00675	0.245
CLV_NRD_NRD_1	615	617	PF00675	0.239
CLV_NRD_NRD_1	652	654	PF00675	0.381
CLV_NRD_NRD_1	754	756	PF00675	0.588
CLV_NRD_NRD_1	847	849	PF00675	0.428
CLV_PCSK_KEX2_1	157	159	PF00082	0.476
CLV_PCSK_KEX2_1	186	188	PF00082	0.445
CLV_PCSK_KEX2_1	210	212	PF00082	0.549
CLV_PCSK_KEX2_1	246	248	PF00082	0.393
CLV_PCSK_KEX2_1	31	33	PF00082	0.565
CLV_PCSK_KEX2_1	455	457	PF00082	0.439
CLV_PCSK_KEX2_1	582	584	PF00082	0.277
CLV_PCSK_KEX2_1	611	613	PF00082	0.242
CLV_PCSK_KEX2_1	617	619	PF00082	0.242
CLV_PCSK_KEX2_1	749	751	PF00082	0.471
CLV_PCSK_KEX2_1	754	756	PF00082	0.473
CLV_PCSK_KEX2_1	809	811	PF00082	0.482
CLV_PCSK_KEX2_1	847	849	PF00082	0.411
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.445
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.549
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.278
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.246
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.471
CLV_PCSK_PC1ET2_1	809	811	PF00082	0.508
CLV_PCSK_PC7_1	206	212	PF00082	0.549
CLV_PCSK_PC7_1	750	756	PF00082	0.472
CLV_PCSK_SKI1_1	358	362	PF00082	0.572
CLV_PCSK_SKI1_1	385	389	PF00082	0.515
CLV_PCSK_SKI1_1	392	396	PF00082	0.446
CLV_PCSK_SKI1_1	679	683	PF00082	0.598
CLV_PCSK_SKI1_1	741	745	PF00082	0.518
CLV_PCSK_SKI1_1	758	762	PF00082	0.406
DEG_APCC_DBOX_1	237	245	PF00400	0.513
DEG_APCC_DBOX_1	37	45	PF00400	0.497
DEG_APCC_KENBOX_2	736	740	PF00400	0.596
DEG_Nend_UBRbox_1	1	4	PF02207	0.577
DOC_MAPK_gen_1	174	182	PF00069	0.510
DOC_MAPK_gen_1	60	69	PF00069	0.486
DOC_MAPK_gen_1	616	623	PF00069	0.372
DOC_MAPK_gen_1	676	683	PF00069	0.454
DOC_MAPK_gen_1	713	721	PF00069	0.570
DOC_MAPK_gen_1	847	853	PF00069	0.402
DOC_MAPK_MEF2A_6	176	184	PF00069	0.511
DOC_MAPK_MEF2A_6	573	581	PF00069	0.257
DOC_PP1_RVXF_1	644	651	PF00149	0.382
DOC_PP1_RVXF_1	677	684	PF00149	0.602
DOC_USP7_MATH_1	110	114	PF00917	0.540
DOC_USP7_MATH_1	291	295	PF00917	0.548
DOC_USP7_MATH_1	4	8	PF00917	0.676
DOC_USP7_MATH_1	505	509	PF00917	0.419
DOC_USP7_MATH_1	594	598	PF00917	0.263
DOC_USP7_MATH_1	9	13	PF00917	0.636
DOC_USP7_UBL2_3	341	345	PF12436	0.637
DOC_USP7_UBL2_3	354	358	PF12436	0.477
DOC_USP7_UBL2_3	381	385	PF12436	0.526
LIG_14-3-3_CanoR_1	238	242	PF00244	0.496
LIG_14-3-3_CanoR_1	252	258	PF00244	0.419
LIG_14-3-3_CanoR_1	520	528	PF00244	0.388
LIG_14-3-3_CanoR_1	583	588	PF00244	0.465
LIG_14-3-3_CanoR_1	631	641	PF00244	0.422
LIG_APCC_ABBA_1	740	745	PF00400	0.472
LIG_APCC_ABBAyCdc20_2	646	652	PF00400	0.386
LIG_BRCT_BRCA1_1	857	861	PF00533	0.559
LIG_Clathr_ClatBox_1	139	143	PF01394	0.528
LIG_Clathr_ClatBox_1	265	269	PF01394	0.519
LIG_DLG_GKlike_1	176	184	PF00625	0.408
LIG_FHA_1	134	140	PF00498	0.414
LIG_FHA_1	521	527	PF00498	0.272
LIG_FHA_1	824	830	PF00498	0.472
LIG_FHA_2	161	167	PF00498	0.431
LIG_FHA_2	213	219	PF00498	0.470
LIG_FHA_2	404	410	PF00498	0.553
LIG_FHA_2	430	436	PF00498	0.382
LIG_FHA_2	49	55	PF00498	0.551
LIG_FHA_2	507	513	PF00498	0.304
LIG_FHA_2	680	686	PF00498	0.527
LIG_FHA_2	775	781	PF00498	0.466
LIG_LIR_Gen_1	318	329	PF02991	0.436
LIG_LIR_Gen_1	517	526	PF02991	0.242
LIG_LIR_Nem_3	318	324	PF02991	0.424
LIG_LIR_Nem_3	517	521	PF02991	0.355
LIG_LIR_Nem_3	826	830	PF02991	0.433
LIG_LIR_Nem_3	858	864	PF02991	0.444
LIG_MYND_1	862	866	PF01753	0.586
LIG_PCNA_yPIPBox_3	280	293	PF02747	0.539
LIG_PDZ_Class_1	870	875	PF00595	0.478
LIG_Rb_LxCxE_1	666	685	PF01857	0.521
LIG_SH2_CRK	827	831	PF00017	0.452
LIG_SH2_GRB2like	128	131	PF00017	0.411
LIG_SH2_STAP1	475	479	PF00017	0.528
LIG_SH2_STAT3	70	73	PF00017	0.424
LIG_SH2_STAT5	125	128	PF00017	0.465
LIG_SH3_3	22	28	PF00018	0.526
LIG_SUMO_SIM_anti_2	264	269	PF11976	0.522
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.388
LIG_SUMO_SIM_par_1	264	269	PF11976	0.522
LIG_SUMO_SIM_par_1	299	304	PF11976	0.466
LIG_TRAF2_1	103	106	PF00917	0.604
LIG_TRAF2_1	331	334	PF00917	0.596
LIG_TRAF2_1	387	390	PF00917	0.495
LIG_UBA3_1	180	186	PF00899	0.402
LIG_UBA3_1	370	376	PF00899	0.480
LIG_UBA3_1	556	564	PF00899	0.276
LIG_UBA3_1	698	704	PF00899	0.510
LIG_UBA3_1	742	749	PF00899	0.469
MOD_CK1_1	14	20	PF00069	0.563
MOD_CK1_1	327	333	PF00069	0.559
MOD_CK1_1	375	381	PF00069	0.545
MOD_CK2_1	106	112	PF00069	0.623
MOD_CK2_1	165	171	PF00069	0.422
MOD_CK2_1	218	224	PF00069	0.400
MOD_CK2_1	279	285	PF00069	0.572
MOD_CK2_1	327	333	PF00069	0.428
MOD_CK2_1	347	353	PF00069	0.419
MOD_CK2_1	403	409	PF00069	0.545
MOD_CK2_1	48	54	PF00069	0.583
MOD_CK2_1	506	512	PF00069	0.467
MOD_CK2_1	679	685	PF00069	0.523
MOD_CK2_1	760	766	PF00069	0.476
MOD_CK2_1	774	780	PF00069	0.376
MOD_Cter_Amidation	845	848	PF01082	0.544
MOD_GlcNHglycan	108	111	PF01048	0.558
MOD_GlcNHglycan	112	115	PF01048	0.553
MOD_GlcNHglycan	194	197	PF01048	0.489
MOD_GlcNHglycan	443	446	PF01048	0.448
MOD_GlcNHglycan	54	58	PF01048	0.507
MOD_GlcNHglycan	596	599	PF01048	0.263
MOD_GlcNHglycan	855	860	PF01048	0.520
MOD_GSK3_1	106	113	PF00069	0.515
MOD_GSK3_1	176	183	PF00069	0.559
MOD_GSK3_1	287	294	PF00069	0.453
MOD_GSK3_1	324	331	PF00069	0.503
MOD_GSK3_1	372	379	PF00069	0.568
MOD_GSK3_1	425	432	PF00069	0.430
MOD_GSK3_1	75	82	PF00069	0.479
MOD_N-GLC_1	192	197	PF02516	0.514
MOD_N-GLC_1	4	9	PF02516	0.600
MOD_N-GLC_1	425	430	PF02516	0.420
MOD_N-GLC_1	558	563	PF02516	0.367
MOD_N-GLC_1	571	576	PF02516	0.276
MOD_NEK2_1	135	140	PF00069	0.395
MOD_NEK2_1	180	185	PF00069	0.511
MOD_NEK2_1	324	329	PF00069	0.508
MOD_NEK2_1	429	434	PF00069	0.416
MOD_NEK2_1	493	498	PF00069	0.429
MOD_NEK2_1	630	635	PF00069	0.390
MOD_PIKK_1	279	285	PF00454	0.557
MOD_PIKK_1	403	409	PF00454	0.474
MOD_PIKK_1	42	48	PF00454	0.508
MOD_PIKK_1	547	553	PF00454	0.176
MOD_PIKK_1	586	592	PF00454	0.258
MOD_PIKK_1	686	692	PF00454	0.608
MOD_PIKK_1	774	780	PF00454	0.510
MOD_PKA_2	212	218	PF00069	0.508
MOD_PKA_2	237	243	PF00069	0.493
MOD_PKA_2	251	257	PF00069	0.419
MOD_PKA_2	279	285	PF00069	0.419
MOD_PKA_2	61	67	PF00069	0.567
MOD_PKA_2	630	636	PF00069	0.426
MOD_PKA_2	658	664	PF00069	0.549
MOD_PKA_2	686	692	PF00069	0.496
MOD_PKB_1	414	422	PF00069	0.425
MOD_Plk_1	192	198	PF00069	0.449
MOD_Plk_1	324	330	PF00069	0.509
MOD_Plk_1	376	382	PF00069	0.573
MOD_Plk_1	4	10	PF00069	0.737
MOD_Plk_1	425	431	PF00069	0.419
MOD_Plk_1	493	499	PF00069	0.425
MOD_Plk_1	679	685	PF00069	0.523
MOD_Plk_2-3	218	224	PF00069	0.476
MOD_Plk_2-3	780	786	PF00069	0.407
MOD_Plk_4	135	141	PF00069	0.414
MOD_Plk_4	176	182	PF00069	0.406
MOD_Plk_4	237	243	PF00069	0.380
MOD_Plk_4	544	550	PF00069	0.242
MOD_Plk_4	583	589	PF00069	0.388
MOD_SUMO_for_1	140	143	PF00179	0.439
MOD_SUMO_for_1	149	152	PF00179	0.373
MOD_SUMO_for_1	312	315	PF00179	0.512
MOD_SUMO_for_1	380	383	PF00179	0.543
MOD_SUMO_for_1	677	680	PF00179	0.600
MOD_SUMO_for_1	798	801	PF00179	0.506
MOD_SUMO_rev_2	207	212	PF00179	0.480
MOD_SUMO_rev_2	224	233	PF00179	0.309
MOD_SUMO_rev_2	330	338	PF00179	0.468
MOD_SUMO_rev_2	377	387	PF00179	0.520
MOD_SUMO_rev_2	396	406	PF00179	0.307
MOD_SUMO_rev_2	574	584	PF00179	0.298
MOD_SUMO_rev_2	619	627	PF00179	0.380
MOD_SUMO_rev_2	647	655	PF00179	0.359
MOD_SUMO_rev_2	689	698	PF00179	0.533
MOD_SUMO_rev_2	801	811	PF00179	0.476
TRG_DiLeu_BaEn_1	229	234	PF01217	0.395
TRG_DiLeu_BaEn_1	367	372	PF01217	0.655
TRG_DiLeu_BaEn_1	694	699	PF01217	0.484
TRG_DiLeu_BaEn_3	700	706	PF01217	0.519
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.257
TRG_DiLeu_BaLyEn_6	825	830	PF01217	0.453
TRG_ENDOCYTIC_2	321	324	PF00928	0.441
TRG_ENDOCYTIC_2	475	478	PF00928	0.500
TRG_ENDOCYTIC_2	827	830	PF00928	0.522
TRG_ER_diArg_1	101	104	PF00400	0.563
TRG_ER_diArg_1	31	33	PF00400	0.617
TRG_ER_diArg_1	414	417	PF00400	0.417
TRG_ER_diArg_1	454	457	PF00400	0.463
TRG_ER_diArg_1	610	612	PF00400	0.257
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	611	615	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I582	Leptomonas seymouri	82%	100%
A0A0S4JM03	Bodo saltans	50%	99%
A0A1X0P1D5	Trypanosomatidae	59%	100%
A0A3R7RFG2	Trypanosoma rangeli	59%	100%
A0A3S7X6D9	Leishmania donovani	98%	100%
A4HL98	Leishmania braziliensis	91%	100%
A4I8S4	Leishmania infantum	98%	100%
D0A4R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9B3P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4G0X9	Homo sapiens	25%	77%
Q56A40	Danio rerio	24%	93%
Q8BI79	Mus musculus	25%	73%
V5BJZ2	Trypanosoma cruzi	58%	100%