Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4E5_LEIMA

TriTrypDb:

LmjF.33.0605

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.530
CLV_NRD_NRD_1	215	217	PF00675	0.417
CLV_NRD_NRD_1	29	31	PF00675	0.572
CLV_NRD_NRD_1	324	326	PF00675	0.505
CLV_PCSK_KEX2_1	193	195	PF00082	0.640
CLV_PCSK_KEX2_1	215	217	PF00082	0.448
CLV_PCSK_KEX2_1	29	31	PF00082	0.572
CLV_PCSK_KEX2_1	62	64	PF00082	0.615
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.550
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.447
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.615
CLV_PCSK_SKI1_1	254	258	PF00082	0.359
CLV_PCSK_SKI1_1	29	33	PF00082	0.496
CLV_PCSK_SKI1_1	389	393	PF00082	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DOC_CYCLIN_RxL_1	140	150	PF00134	0.506
DOC_CYCLIN_RxL_1	26	37	PF00134	0.511
DOC_CYCLIN_RxL_1	91	102	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.509
DOC_MAPK_gen_1	193	202	PF00069	0.509
DOC_PP1_RVXF_1	418	425	PF00149	0.527
DOC_PP2B_LxvP_1	340	343	PF13499	0.511
DOC_PP4_FxxP_1	51	54	PF00568	0.394
DOC_USP7_MATH_1	189	193	PF00917	0.405
DOC_USP7_MATH_1	353	357	PF00917	0.661
DOC_USP7_MATH_1	398	402	PF00917	0.526
DOC_USP7_UBL2_3	193	197	PF12436	0.577
DOC_WW_Pin1_4	246	251	PF00397	0.503
DOC_WW_Pin1_4	34	39	PF00397	0.610
LIG_14-3-3_CanoR_1	141	146	PF00244	0.596
LIG_14-3-3_CanoR_1	176	180	PF00244	0.550
LIG_14-3-3_CanoR_1	310	315	PF00244	0.355
LIG_14-3-3_CanoR_1	373	379	PF00244	0.437
LIG_14-3-3_CanoR_1	389	394	PF00244	0.479
LIG_14-3-3_CanoR_1	412	422	PF00244	0.440
LIG_Actin_WH2_2	114	129	PF00022	0.438
LIG_BIR_III_2	137	141	PF00653	0.477
LIG_EH1_1	220	228	PF00400	0.487
LIG_eIF4E_1	221	227	PF01652	0.482
LIG_FHA_1	123	129	PF00498	0.479
LIG_FHA_1	148	154	PF00498	0.664
LIG_FHA_1	56	62	PF00498	0.561
LIG_FHA_1	74	80	PF00498	0.302
LIG_FHA_2	302	308	PF00498	0.559
LIG_FHA_2	367	373	PF00498	0.402
LIG_GBD_Chelix_1	104	112	PF00786	0.524
LIG_LIR_Gen_1	130	139	PF02991	0.579
LIG_LIR_Nem_3	130	134	PF02991	0.586
LIG_LIR_Nem_3	177	182	PF02991	0.503
LIG_Pex14_1	64	68	PF04695	0.430
LIG_PTB_Apo_2	164	171	PF02174	0.669
LIG_REV1ctd_RIR_1	422	427	PF16727	0.323
LIG_SH2_CRK	233	237	PF00017	0.418
LIG_SH2_STAP1	219	223	PF00017	0.455
LIG_SH2_STAP1	338	342	PF00017	0.504
LIG_SH2_STAT5	179	182	PF00017	0.518
LIG_Sin3_3	75	82	PF02671	0.412
LIG_SUMO_SIM_par_1	148	155	PF11976	0.485
LIG_SUMO_SIM_par_1	37	42	PF11976	0.548
LIG_TRAF2_1	172	175	PF00917	0.488
LIG_UBA3_1	95	100	PF00899	0.505
LIG_WRC_WIRS_1	276	281	PF05994	0.486
MOD_CK1_1	264	270	PF00069	0.483
MOD_CK1_1	299	305	PF00069	0.532
MOD_CK1_1	347	353	PF00069	0.611
MOD_CK1_1	355	361	PF00069	0.692
MOD_CK1_1	414	420	PF00069	0.483
MOD_CK1_1	52	58	PF00069	0.620
MOD_CK1_1	9	15	PF00069	0.661
MOD_CK2_1	151	157	PF00069	0.676
MOD_CK2_1	237	243	PF00069	0.453
MOD_CK2_1	34	40	PF00069	0.437
MOD_CK2_1	379	385	PF00069	0.561
MOD_CK2_1	398	404	PF00069	0.455
MOD_GlcNHglycan	101	104	PF01048	0.490
MOD_GlcNHglycan	183	186	PF01048	0.469
MOD_GlcNHglycan	331	334	PF01048	0.550
MOD_GSK3_1	141	148	PF00069	0.634
MOD_GSK3_1	248	255	PF00069	0.353
MOD_GSK3_1	260	267	PF00069	0.355
MOD_GSK3_1	275	282	PF00069	0.422
MOD_GSK3_1	347	354	PF00069	0.525
MOD_GSK3_1	360	367	PF00069	0.553
MOD_GSK3_1	414	421	PF00069	0.619
MOD_GSK3_1	6	13	PF00069	0.570
MOD_N-GLC_1	158	163	PF02516	0.586
MOD_N-GLC_1	264	269	PF02516	0.257
MOD_N-GLC_1	317	322	PF02516	0.283
MOD_NEK2_1	10	15	PF00069	0.540
MOD_NEK2_1	145	150	PF00069	0.691
MOD_NEK2_1	151	156	PF00069	0.614
MOD_NEK2_1	252	257	PF00069	0.367
MOD_NEK2_1	275	280	PF00069	0.445
MOD_NEK2_1	288	293	PF00069	0.416
MOD_NEK2_1	3	8	PF00069	0.593
MOD_NEK2_1	345	350	PF00069	0.544
MOD_NEK2_1	351	356	PF00069	0.610
MOD_NEK2_1	364	369	PF00069	0.574
MOD_NEK2_1	374	379	PF00069	0.479
MOD_NEK2_1	411	416	PF00069	0.547
MOD_NEK2_1	49	54	PF00069	0.583
MOD_NEK2_2	122	127	PF00069	0.486
MOD_PIKK_1	237	243	PF00454	0.330
MOD_PIKK_1	41	47	PF00454	0.536
MOD_PIKK_1	49	55	PF00454	0.563
MOD_PK_1	310	316	PF00069	0.406
MOD_PK_1	63	69	PF00069	0.572
MOD_PKA_2	175	181	PF00069	0.514
MOD_PKA_2	411	417	PF00069	0.460
MOD_Plk_1	174	180	PF00069	0.552
MOD_Plk_1	264	270	PF00069	0.472
MOD_Plk_1	299	305	PF00069	0.508
MOD_Plk_1	317	323	PF00069	0.249
MOD_Plk_4	147	153	PF00069	0.660
MOD_Plk_4	248	254	PF00069	0.452
MOD_Plk_4	310	316	PF00069	0.401
MOD_Plk_4	317	323	PF00069	0.370
MOD_Plk_4	360	366	PF00069	0.596
MOD_Plk_4	374	380	PF00069	0.308
MOD_Plk_4	389	395	PF00069	0.474
MOD_Plk_4	414	420	PF00069	0.473
MOD_Plk_4	63	69	PF00069	0.527
MOD_ProDKin_1	246	252	PF00069	0.496
MOD_ProDKin_1	34	40	PF00069	0.611
MOD_SUMO_rev_2	192	199	PF00179	0.549
MOD_SUMO_rev_2	337	343	PF00179	0.498
TRG_DiLeu_BaEn_1	317	322	PF01217	0.533
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.445
TRG_ENDOCYTIC_2	179	182	PF00928	0.514
TRG_ENDOCYTIC_2	233	236	PF00928	0.463
TRG_ER_diArg_1	28	30	PF00400	0.559
TRG_NLS_MonoExtC_3	214	220	PF00514	0.319
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R7	Leptomonas seymouri	53%	99%
A0A1X0P0P1	Trypanosomatidae	30%	98%
A0A3Q8IHM8	Leishmania donovani	91%	100%
A0A3S5IQQ0	Trypanosoma rangeli	26%	100%
A4HLA0	Leishmania braziliensis	77%	98%
A4I8S6	Leishmania infantum	91%	100%
D0A4S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
E9B3P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BFC5	Trypanosoma cruzi	25%	98%