Mediator of RNA polymerase II transcription subunit 13

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania major

UniProt:

Q4Q4E4_LEIMA

TriTrypDb:

LmjF.33.0610 , LMJLV39_330012900 , LMJSD75_330012700

Length:

193

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

Q4Q4E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	183	187	PF00082	0.379
CLV_PCSK_SKI1_1	21	25	PF00082	0.554
CLV_PCSK_SKI1_1	49	53	PF00082	0.573
DEG_APCC_DBOX_1	31	39	PF00400	0.550
DEG_SPOP_SBC_1	102	106	PF00917	0.478
DEG_SPOP_SBC_1	165	169	PF00917	0.475
DOC_CKS1_1	50	55	PF01111	0.562
DOC_MAPK_gen_1	30	38	PF00069	0.774
DOC_MAPK_MEF2A_6	32	40	PF00069	0.554
DOC_PP1_RVXF_1	181	187	PF00149	0.385
DOC_PP2B_PxIxI_1	80	86	PF00149	0.405
DOC_PP4_FxxP_1	78	81	PF00568	0.420
DOC_USP7_MATH_1	165	169	PF00917	0.568
DOC_USP7_MATH_1	17	21	PF00917	0.532
DOC_USP7_MATH_1	2	6	PF00917	0.527
DOC_USP7_MATH_1	51	55	PF00917	0.603
DOC_USP7_UBL2_3	45	49	PF12436	0.574
DOC_USP7_UBL2_3	55	59	PF12436	0.551
DOC_WW_Pin1_4	12	17	PF00397	0.510
DOC_WW_Pin1_4	44	49	PF00397	0.781
DOC_WW_Pin1_4	77	82	PF00397	0.428
LIG_14-3-3_CanoR_1	21	28	PF00244	0.585
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_BRCT_BRCA1_1	19	23	PF00533	0.698
LIG_deltaCOP1_diTrp_1	177	186	PF00928	0.375
LIG_FHA_1	106	112	PF00498	0.552
LIG_FHA_1	22	28	PF00498	0.596
LIG_LIR_Apic_2	77	81	PF02991	0.418
LIG_LIR_Gen_1	155	165	PF02991	0.445
LIG_LIR_Gen_1	20	31	PF02991	0.526
LIG_LIR_Gen_1	54	64	PF02991	0.587
LIG_LIR_Nem_3	155	161	PF02991	0.438
LIG_LIR_Nem_3	20	26	PF02991	0.650
LIG_LIR_Nem_3	54	60	PF02991	0.596
LIG_NRBOX	143	149	PF00104	0.408
LIG_PTB_Apo_2	72	79	PF02174	0.406
LIG_REV1ctd_RIR_1	183	192	PF16727	0.424
LIG_SH2_PTP2	57	60	PF00017	0.590
LIG_SH2_STAT5	120	123	PF00017	0.468
LIG_SH2_STAT5	18	21	PF00017	0.712
LIG_SH2_STAT5	57	60	PF00017	0.590
LIG_SH3_3	118	124	PF00018	0.420
LIG_SH3_3	25	31	PF00018	0.531
LIG_SH3_3	57	63	PF00018	0.679
LIG_SH3_5	53	57	PF00018	0.559
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.413
LIG_SUMO_SIM_par_1	144	150	PF11976	0.406
LIG_SUMO_SIM_par_1	33	39	PF11976	0.748
LIG_TRAF2_1	151	154	PF00917	0.411
LIG_TRAF2_1	88	91	PF00917	0.452
MOD_CDK_SPK_2	44	49	PF00069	0.726
MOD_CDK_SPxK_1	49	55	PF00069	0.568
MOD_CK1_1	104	110	PF00069	0.518
MOD_CK1_1	12	18	PF00069	0.512
MOD_CK1_1	163	169	PF00069	0.526
MOD_CK1_1	77	83	PF00069	0.369
MOD_CK2_1	2	8	PF00069	0.610
MOD_CK2_1	89	95	PF00069	0.471
MOD_GSK3_1	101	108	PF00069	0.486
MOD_GSK3_1	135	142	PF00069	0.386
MOD_GSK3_1	156	163	PF00069	0.620
MOD_GSK3_1	17	24	PF00069	0.533
MOD_GSK3_1	26	33	PF00069	0.545
MOD_GSK3_1	62	69	PF00069	0.621
MOD_N-GLC_1	74	79	PF02516	0.406
MOD_NEK2_1	160	165	PF00069	0.465
MOD_NEK2_1	184	189	PF00069	0.412
MOD_NEK2_1	9	14	PF00069	0.496
MOD_NEK2_2	2	7	PF00069	0.518
MOD_PIKK_1	160	166	PF00454	0.461
MOD_Plk_1	74	80	PF00069	0.410
MOD_Plk_1	90	96	PF00069	0.348
MOD_ProDKin_1	12	18	PF00069	0.512
MOD_ProDKin_1	44	50	PF00069	0.781
MOD_ProDKin_1	77	83	PF00069	0.423
MOD_SUMO_for_1	116	119	PF00179	0.461
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.465
TRG_ENDOCYTIC_2	182	185	PF00928	0.391
TRG_ENDOCYTIC_2	57	60	PF00928	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6I1	Leishmania donovani	88%	100%