Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4E2_LEIMA

TriTrypDb:

LmjF.33.0630 , LMJLV39_330013100 , LMJSD75_330012900

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4E2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.660
CLV_C14_Caspase3-7	440	444	PF00656	0.564
CLV_NRD_NRD_1	178	180	PF00675	0.524
CLV_NRD_NRD_1	205	207	PF00675	0.635
CLV_NRD_NRD_1	229	231	PF00675	0.608
CLV_NRD_NRD_1	289	291	PF00675	0.566
CLV_PCSK_FUR_1	176	180	PF00082	0.514
CLV_PCSK_FUR_1	362	366	PF00082	0.530
CLV_PCSK_KEX2_1	176	178	PF00082	0.512
CLV_PCSK_KEX2_1	205	207	PF00082	0.640
CLV_PCSK_KEX2_1	229	231	PF00082	0.608
CLV_PCSK_KEX2_1	288	290	PF00082	0.564
CLV_PCSK_KEX2_1	364	366	PF00082	0.534
CLV_PCSK_KEX2_1	46	48	PF00082	0.638
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.534
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.596
CLV_PCSK_PC7_1	285	291	PF00082	0.458
CLV_PCSK_SKI1_1	179	183	PF00082	0.583
CLV_PCSK_SKI1_1	230	234	PF00082	0.561
CLV_PCSK_SKI1_1	25	29	PF00082	0.601
CLV_PCSK_SKI1_1	294	298	PF00082	0.601
CLV_PCSK_SKI1_1	327	331	PF00082	0.502
CLV_PCSK_SKI1_1	408	412	PF00082	0.422
CLV_PCSK_SKI1_1	47	51	PF00082	0.655
DEG_APCC_DBOX_1	178	186	PF00400	0.550
DEG_APCC_DBOX_1	403	411	PF00400	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.523
DOC_CKS1_1	358	363	PF01111	0.594
DOC_CYCLIN_RxL_1	176	184	PF00134	0.425
DOC_CYCLIN_RxL_1	288	299	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.559
DOC_MAPK_gen_1	205	213	PF00069	0.670
DOC_MAPK_gen_1	288	298	PF00069	0.516
DOC_MAPK_gen_1	479	489	PF00069	0.440
DOC_MAPK_MEF2A_6	479	487	PF00069	0.543
DOC_PP2B_LxvP_1	211	214	PF13499	0.666
DOC_USP7_MATH_1	345	349	PF00917	0.532
DOC_USP7_MATH_1	382	386	PF00917	0.616
DOC_USP7_MATH_1	425	429	PF00917	0.663
DOC_USP7_MATH_1	441	445	PF00917	0.350
DOC_USP7_MATH_1	478	482	PF00917	0.466
DOC_USP7_MATH_1	85	89	PF00917	0.550
DOC_USP7_UBL2_3	482	486	PF12436	0.455
DOC_WW_Pin1_4	308	313	PF00397	0.753
DOC_WW_Pin1_4	331	336	PF00397	0.600
DOC_WW_Pin1_4	357	362	PF00397	0.596
DOC_WW_Pin1_4	463	468	PF00397	0.461
DOC_WW_Pin1_4	472	477	PF00397	0.432
DOC_WW_Pin1_4	91	96	PF00397	0.768
LIG_14-3-3_CanoR_1	206	212	PF00244	0.624
LIG_14-3-3_CanoR_1	288	298	PF00244	0.623
LIG_APCC_ABBA_1	336	341	PF00400	0.545
LIG_BIR_III_4	118	122	PF00653	0.649
LIG_BRCT_BRCA1_1	275	279	PF00533	0.459
LIG_FHA_1	1	7	PF00498	0.474
LIG_FHA_1	164	170	PF00498	0.499
LIG_FHA_1	208	214	PF00498	0.712
LIG_FHA_1	293	299	PF00498	0.543
LIG_FHA_1	358	364	PF00498	0.533
LIG_FHA_1	450	456	PF00498	0.427
LIG_FHA_1	478	484	PF00498	0.461
LIG_FHA_1	57	63	PF00498	0.622
LIG_FHA_2	124	130	PF00498	0.557
LIG_FHA_2	240	246	PF00498	0.437
LIG_FHA_2	28	34	PF00498	0.589
LIG_FHA_2	438	444	PF00498	0.583
LIG_FHA_2	6	12	PF00498	0.515
LIG_LIR_Gen_1	446	456	PF02991	0.432
LIG_LIR_Nem_3	103	108	PF02991	0.715
LIG_LIR_Nem_3	139	145	PF02991	0.385
LIG_LIR_Nem_3	220	226	PF02991	0.601
LIG_LIR_Nem_3	245	249	PF02991	0.464
LIG_LIR_Nem_3	268	274	PF02991	0.414
LIG_LIR_Nem_3	446	451	PF02991	0.438
LIG_LYPXL_S_1	156	160	PF13949	0.559
LIG_LYPXL_yS_3	105	108	PF13949	0.693
LIG_LYPXL_yS_3	157	160	PF13949	0.543
LIG_PDZ_Class_2	485	490	PF00595	0.588
LIG_PTAP_UEV_1	306	311	PF05743	0.544
LIG_SH2_CRK	473	477	PF00017	0.559
LIG_SH2_STAT5	251	254	PF00017	0.354
LIG_SH2_STAT5	274	277	PF00017	0.438
LIG_SH2_STAT5	456	459	PF00017	0.462
LIG_SH3_1	177	183	PF00018	0.424
LIG_SH3_3	177	183	PF00018	0.582
LIG_SH3_3	304	310	PF00018	0.687
LIG_SH3_3	329	335	PF00018	0.553
LIG_SH3_3	368	374	PF00018	0.529
LIG_SUMO_SIM_par_1	294	299	PF11976	0.551
LIG_TYR_ITSM	101	108	PF00017	0.614
MOD_CDK_SPK_2	308	313	PF00069	0.581
MOD_CDK_SPK_2	357	362	PF00069	0.522
MOD_CDK_SPK_2	91	96	PF00069	0.667
MOD_CDK_SPxxK_3	357	364	PF00069	0.597
MOD_CDK_SPxxK_3	463	470	PF00069	0.467
MOD_CDK_SPxxK_3	472	479	PF00069	0.419
MOD_CK1_1	107	113	PF00069	0.690
MOD_CK1_1	148	154	PF00069	0.549
MOD_CK1_1	308	314	PF00069	0.710
MOD_CK1_1	449	455	PF00069	0.398
MOD_CK1_1	97	103	PF00069	0.715
MOD_CK2_1	239	245	PF00069	0.492
MOD_CK2_1	27	33	PF00069	0.579
MOD_CK2_1	85	91	PF00069	0.780
MOD_Cter_Amidation	44	47	PF01082	0.479
MOD_GlcNHglycan	113	116	PF01048	0.715
MOD_GlcNHglycan	306	310	PF01048	0.650
MOD_GlcNHglycan	391	394	PF01048	0.641
MOD_GlcNHglycan	420	423	PF01048	0.609
MOD_GlcNHglycan	427	430	PF01048	0.585
MOD_GlcNHglycan	87	90	PF01048	0.659
MOD_GSK3_1	100	107	PF00069	0.739
MOD_GSK3_1	316	323	PF00069	0.710
MOD_GSK3_1	327	334	PF00069	0.515
MOD_GSK3_1	425	432	PF00069	0.627
MOD_GSK3_1	437	444	PF00069	0.477
MOD_GSK3_1	91	98	PF00069	0.716
MOD_N-GLC_1	21	26	PF02516	0.401
MOD_N-GLC_1	85	90	PF02516	0.736
MOD_NEK2_1	186	191	PF00069	0.494
MOD_NEK2_1	21	26	PF00069	0.479
MOD_NEK2_1	27	32	PF00069	0.516
MOD_NEK2_1	325	330	PF00069	0.592
MOD_NEK2_1	389	394	PF00069	0.474
MOD_NEK2_1	77	82	PF00069	0.517
MOD_PIKK_1	108	114	PF00454	0.755
MOD_PIKK_1	47	53	PF00454	0.486
MOD_PK_1	32	38	PF00069	0.557
MOD_PKA_1	289	295	PF00069	0.617
MOD_PKA_2	289	295	PF00069	0.466
MOD_PKA_2	382	388	PF00069	0.564
MOD_PKA_2	441	447	PF00069	0.482
MOD_PKA_2	478	484	PF00069	0.497
MOD_PKA_2	95	101	PF00069	0.767
MOD_Plk_1	32	38	PF00069	0.692
MOD_Plk_4	104	110	PF00069	0.728
MOD_Plk_4	164	170	PF00069	0.474
MOD_Plk_4	207	213	PF00069	0.670
MOD_Plk_4	218	224	PF00069	0.649
MOD_ProDKin_1	308	314	PF00069	0.753
MOD_ProDKin_1	331	337	PF00069	0.593
MOD_ProDKin_1	357	363	PF00069	0.596
MOD_ProDKin_1	463	469	PF00069	0.463
MOD_ProDKin_1	472	478	PF00069	0.429
MOD_ProDKin_1	91	97	PF00069	0.766
TRG_DiLeu_BaEn_2	22	28	PF01217	0.627
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.577
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.581
TRG_ENDOCYTIC_2	105	108	PF00928	0.711
TRG_ENDOCYTIC_2	157	160	PF00928	0.493
TRG_ENDOCYTIC_2	251	254	PF00928	0.538
TRG_ER_diArg_1	176	179	PF00400	0.517
TRG_ER_diArg_1	287	290	PF00400	0.540
TRG_NES_CRM1_1	405	420	PF08389	0.523
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL5	Leptomonas seymouri	37%	100%
A0A1X0P1W2	Trypanosomatidae	24%	100%
A0A3Q8IHD2	Leishmania donovani	90%	100%
A0A3R7K4P6	Trypanosoma rangeli	25%	100%
A4HLA3	Leishmania braziliensis	73%	100%
A4I8S9	Leishmania infantum	90%	100%
E9B3P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BJY6	Trypanosoma cruzi	26%	100%