EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4E1_LEIMA

TriTrypDb:

LmjF.33.0640 , LMJLV39_330013200 , LMJSD75_330013000

Length:

117

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4E1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005509	calcium ion binding	5	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	19	23	PF00082	0.491
DEG_SPOP_SBC_1	20	24	PF00917	0.493
DOC_MAPK_DCC_7	37	47	PF00069	0.515
DOC_USP7_MATH_1	21	25	PF00917	0.583
LIG_14-3-3_CanoR_1	32	38	PF00244	0.547
LIG_FHA_1	1	7	PF00498	0.639
LIG_LIR_Gen_1	109	115	PF02991	0.356
LIG_LIR_Gen_1	91	100	PF02991	0.490
LIG_LIR_Nem_3	109	113	PF02991	0.488
LIG_SH2_STAT5	68	71	PF00017	0.474
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.505
LIG_TRAF2_1	86	89	PF00917	0.495
MOD_CK2_1	21	27	PF00069	0.491
MOD_CK2_1	83	89	PF00069	0.589
MOD_GlcNHglycan	23	26	PF01048	0.653
MOD_GlcNHglycan	33	36	PF01048	0.616
MOD_GSK3_1	19	26	PF00069	0.613
MOD_NEK2_1	2	7	PF00069	0.599
MOD_PKA_2	31	37	PF00069	0.529
MOD_Plk_1	50	56	PF00069	0.512
MOD_Plk_4	50	56	PF00069	0.471
TRG_DiLeu_BaEn_1	50	55	PF01217	0.511
TRG_DiLeu_BaEn_4	50	56	PF01217	0.512
TRG_ENDOCYTIC_2	107	110	PF00928	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IER1	Leishmania donovani	94%	100%
A4HLA4	Leishmania braziliensis	74%	100%
A4I8T0	Leishmania infantum	94%	100%