Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania major

UniProt:

Q4Q4D8_LEIMA

TriTrypDb:

LmjF.33.0670 , LMJLV39_330013500 , LMJSD75_330013300

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	9
GO:0005829	cytosol	2	2
GO:0008287	protein serine/threonine phosphatase complex	4	9
GO:0032991	protein-containing complex	1	9
GO:0110165	cellular anatomical entity	1	3
GO:1902494	catalytic complex	2	9
GO:1903293	phosphatase complex	3	9
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q4D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4D8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	9
GO:0019888	protein phosphatase regulator activity	4	9
GO:0030234	enzyme regulator activity	2	9
GO:0098772	molecular function regulator activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.762
CLV_C14_Caspase3-7	351	355	PF00656	0.527
CLV_C14_Caspase3-7	795	799	PF00656	0.402
CLV_NRD_NRD_1	229	231	PF00675	0.632
CLV_NRD_NRD_1	287	289	PF00675	0.666
CLV_NRD_NRD_1	424	426	PF00675	0.556
CLV_NRD_NRD_1	445	447	PF00675	0.585
CLV_NRD_NRD_1	724	726	PF00675	0.756
CLV_NRD_NRD_1	743	745	PF00675	0.295
CLV_NRD_NRD_1	818	820	PF00675	0.614
CLV_NRD_NRD_1	826	828	PF00675	0.635
CLV_PCSK_KEX2_1	228	230	PF00082	0.634
CLV_PCSK_KEX2_1	286	288	PF00082	0.661
CLV_PCSK_KEX2_1	424	426	PF00082	0.556
CLV_PCSK_KEX2_1	444	446	PF00082	0.575
CLV_PCSK_KEX2_1	724	726	PF00082	0.682
CLV_PCSK_KEX2_1	743	745	PF00082	0.295
CLV_PCSK_KEX2_1	818	820	PF00082	0.614
CLV_PCSK_KEX2_1	826	828	PF00082	0.635
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.692
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.661
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.665
CLV_PCSK_SKI1_1	32	36	PF00082	0.482
CLV_PCSK_SKI1_1	425	429	PF00082	0.581
CLV_PCSK_SKI1_1	744	748	PF00082	0.432
DEG_APCC_DBOX_1	423	431	PF00400	0.590
DEG_APCC_DBOX_1	67	75	PF00400	0.506
DEG_APCC_DBOX_1	751	759	PF00400	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.424
DEG_SPOP_SBC_1	277	281	PF00917	0.615
DEG_SPOP_SBC_1	360	364	PF00917	0.570
DOC_CDC14_PxL_1	95	103	PF14671	0.437
DOC_CKS1_1	49	54	PF01111	0.507
DOC_CKS1_1	720	725	PF01111	0.691
DOC_CYCLIN_RxL_1	422	429	PF00134	0.586
DOC_CYCLIN_yClb5_NLxxxL_5	98	107	PF00134	0.628
DOC_MAPK_gen_1	424	430	PF00069	0.560
DOC_MAPK_gen_1	519	529	PF00069	0.397
DOC_MAPK_gen_1	66	74	PF00069	0.511
DOC_MAPK_MEF2A_6	22	31	PF00069	0.414
DOC_MAPK_MEF2A_6	698	705	PF00069	0.346
DOC_MAPK_MEF2A_6	8	15	PF00069	0.430
DOC_PP2B_LxvP_1	168	171	PF13499	0.594
DOC_PP2B_LxvP_1	316	319	PF13499	0.579
DOC_PP2B_LxvP_1	35	38	PF13499	0.472
DOC_PP2B_LxvP_1	77	80	PF13499	0.447
DOC_PP4_FxxP_1	335	338	PF00568	0.465
DOC_PP4_FxxP_1	665	668	PF00568	0.502
DOC_SPAK_OSR1_1	39	43	PF12202	0.469
DOC_USP7_MATH_1	198	202	PF00917	0.633
DOC_USP7_MATH_1	248	252	PF00917	0.628
DOC_USP7_MATH_1	256	260	PF00917	0.555
DOC_USP7_MATH_1	290	294	PF00917	0.631
DOC_USP7_MATH_1	319	323	PF00917	0.642
DOC_USP7_MATH_1	341	345	PF00917	0.548
DOC_USP7_MATH_1	360	364	PF00917	0.483
DOC_USP7_MATH_1	373	377	PF00917	0.606
DOC_USP7_MATH_1	394	398	PF00917	0.376
DOC_USP7_MATH_1	452	456	PF00917	0.640
DOC_USP7_MATH_1	50	54	PF00917	0.518
DOC_USP7_MATH_1	603	607	PF00917	0.421
DOC_USP7_MATH_1	737	741	PF00917	0.585
DOC_USP7_MATH_1	848	852	PF00917	0.434
DOC_USP7_MATH_1	90	94	PF00917	0.483
DOC_USP7_UBL2_3	541	545	PF12436	0.566
DOC_WW_Pin1_4	125	130	PF00397	0.609
DOC_WW_Pin1_4	147	152	PF00397	0.548
DOC_WW_Pin1_4	166	171	PF00397	0.599
DOC_WW_Pin1_4	206	211	PF00397	0.633
DOC_WW_Pin1_4	269	274	PF00397	0.621
DOC_WW_Pin1_4	278	283	PF00397	0.692
DOC_WW_Pin1_4	288	293	PF00397	0.664
DOC_WW_Pin1_4	455	460	PF00397	0.713
DOC_WW_Pin1_4	48	53	PF00397	0.495
DOC_WW_Pin1_4	492	497	PF00397	0.373
DOC_WW_Pin1_4	611	616	PF00397	0.487
DOC_WW_Pin1_4	686	691	PF00397	0.385
DOC_WW_Pin1_4	719	724	PF00397	0.603
LIG_14-3-3_CanoR_1	110	115	PF00244	0.682
LIG_14-3-3_CanoR_1	117	124	PF00244	0.693
LIG_14-3-3_CanoR_1	130	140	PF00244	0.588
LIG_14-3-3_CanoR_1	153	159	PF00244	0.619
LIG_14-3-3_CanoR_1	22	28	PF00244	0.445
LIG_14-3-3_CanoR_1	276	282	PF00244	0.751
LIG_14-3-3_CanoR_1	349	359	PF00244	0.622
LIG_14-3-3_CanoR_1	39	49	PF00244	0.480
LIG_14-3-3_CanoR_1	424	428	PF00244	0.587
LIG_14-3-3_CanoR_1	445	449	PF00244	0.618
LIG_14-3-3_CanoR_1	461	469	PF00244	0.576
LIG_14-3-3_CanoR_1	555	560	PF00244	0.472
LIG_14-3-3_CanoR_1	652	656	PF00244	0.567
LIG_14-3-3_CanoR_1	8	14	PF00244	0.466
LIG_14-3-3_CanoR_1	818	823	PF00244	0.623
LIG_14-3-3_CanoR_1	831	838	PF00244	0.710
LIG_14-3-3_CanoR_1	841	845	PF00244	0.482
LIG_14-3-3_CanoR_1	847	853	PF00244	0.527
LIG_Actin_WH2_2	642	658	PF00022	0.451
LIG_BRCT_BRCA1_1	453	457	PF00533	0.772
LIG_BRCT_BRCA1_1	583	587	PF00533	0.382
LIG_EH_1	533	537	PF12763	0.524
LIG_eIF4E_1	759	765	PF01652	0.479
LIG_FHA_1	1	7	PF00498	0.423
LIG_FHA_1	12	18	PF00498	0.443
LIG_FHA_1	163	169	PF00498	0.751
LIG_FHA_1	19	25	PF00498	0.413
LIG_FHA_1	233	239	PF00498	0.547
LIG_FHA_1	321	327	PF00498	0.664
LIG_FHA_1	406	412	PF00498	0.465
LIG_FHA_1	461	467	PF00498	0.573
LIG_FHA_1	508	514	PF00498	0.455
LIG_FHA_1	542	548	PF00498	0.600
LIG_FHA_1	554	560	PF00498	0.448
LIG_FHA_1	592	598	PF00498	0.338
LIG_FHA_1	678	684	PF00498	0.459
LIG_FHA_1	787	793	PF00498	0.349
LIG_FHA_1	803	809	PF00498	0.413
LIG_FHA_2	234	240	PF00498	0.691
LIG_FHA_2	424	430	PF00498	0.589
LIG_FHA_2	587	593	PF00498	0.407
LIG_FHA_2	603	609	PF00498	0.422
LIG_FHA_2	793	799	PF00498	0.509
LIG_LIR_Gen_1	400	406	PF02991	0.383
LIG_LIR_Gen_1	633	640	PF02991	0.348
LIG_LIR_Gen_1	673	683	PF02991	0.512
LIG_LIR_Gen_1	699	708	PF02991	0.410
LIG_LIR_Gen_1	805	814	PF02991	0.505
LIG_LIR_Gen_1	846	855	PF02991	0.353
LIG_LIR_Gen_1	91	101	PF02991	0.428
LIG_LIR_LC3C_4	26	30	PF02991	0.457
LIG_LIR_Nem_3	400	404	PF02991	0.386
LIG_LIR_Nem_3	471	476	PF02991	0.586
LIG_LIR_Nem_3	633	638	PF02991	0.356
LIG_LIR_Nem_3	673	679	PF02991	0.536
LIG_LIR_Nem_3	699	703	PF02991	0.402
LIG_LIR_Nem_3	805	809	PF02991	0.560
LIG_LIR_Nem_3	870	874	PF02991	0.482
LIG_LYPXL_SIV_4	481	489	PF13949	0.482
LIG_PCNA_PIPBox_1	27	36	PF02747	0.436
LIG_Pex14_1	598	602	PF04695	0.459
LIG_Pex14_2	335	339	PF04695	0.458
LIG_Pex14_2	768	772	PF04695	0.325
LIG_PTB_Apo_2	782	789	PF02174	0.454
LIG_PTB_Phospho_1	782	788	PF10480	0.455
LIG_Rb_LxCxE_1	592	611	PF01857	0.399
LIG_RPA_C_Fungi	441	453	PF08784	0.466
LIG_SH2_CRK	871	875	PF00017	0.439
LIG_SH2_PTP2	482	485	PF00017	0.465
LIG_SH2_SRC	482	485	PF00017	0.484
LIG_SH2_SRC	616	619	PF00017	0.567
LIG_SH2_STAP1	473	477	PF00017	0.407
LIG_SH2_STAP1	583	587	PF00017	0.447
LIG_SH2_STAP1	788	792	PF00017	0.390
LIG_SH2_STAT3	476	479	PF00017	0.423
LIG_SH2_STAT3	583	586	PF00017	0.465
LIG_SH2_STAT5	223	226	PF00017	0.530
LIG_SH2_STAT5	333	336	PF00017	0.440
LIG_SH2_STAT5	391	394	PF00017	0.437
LIG_SH2_STAT5	476	479	PF00017	0.409
LIG_SH2_STAT5	482	485	PF00017	0.345
LIG_SH2_STAT5	512	515	PF00017	0.392
LIG_SH2_STAT5	694	697	PF00017	0.449
LIG_SH2_STAT5	788	791	PF00017	0.386
LIG_SH3_1	628	634	PF00018	0.412
LIG_SH3_1	717	723	PF00018	0.690
LIG_SH3_2	720	725	PF14604	0.700
LIG_SH3_3	466	472	PF00018	0.524
LIG_SH3_3	628	634	PF00018	0.412
LIG_SH3_3	717	723	PF00018	0.600
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.652
LIG_SUMO_SIM_anti_2	26	32	PF11976	0.457
LIG_SUMO_SIM_anti_2	322	328	PF11976	0.628
LIG_SUMO_SIM_anti_2	426	432	PF11976	0.557
LIG_SUMO_SIM_par_1	322	328	PF11976	0.584
LIG_TRAF2_1	113	116	PF00917	0.687
LIG_TRAF2_1	669	672	PF00917	0.546
LIG_TYR_ITIM	869	874	PF00017	0.380
LIG_WRC_WIRS_1	2	7	PF05994	0.449
LIG_WRC_WIRS_1	803	808	PF05994	0.485
LIG_WW_3	667	671	PF00397	0.496
MOD_CDC14_SPxK_1	150	153	PF00782	0.533
MOD_CDC14_SPxK_1	458	461	PF00782	0.577
MOD_CDK_SPK_2	125	130	PF00069	0.609
MOD_CDK_SPK_2	719	724	PF00069	0.696
MOD_CDK_SPxK_1	147	153	PF00069	0.545
MOD_CDK_SPxK_1	455	461	PF00069	0.707
MOD_CDK_SPxK_1	719	725	PF00069	0.698
MOD_CDK_SPxxK_3	269	276	PF00069	0.619
MOD_CDK_SPxxK_3	686	693	PF00069	0.362
MOD_CK1_1	157	163	PF00069	0.765
MOD_CK1_1	268	274	PF00069	0.761
MOD_CK1_1	293	299	PF00069	0.805
MOD_CK1_1	317	323	PF00069	0.609
MOD_CK1_1	325	331	PF00069	0.593
MOD_CK1_1	344	350	PF00069	0.478
MOD_CK1_1	393	399	PF00069	0.452
MOD_CK1_1	447	453	PF00069	0.622
MOD_CK1_1	455	461	PF00069	0.562
MOD_CK1_1	507	513	PF00069	0.489
MOD_CK1_1	553	559	PF00069	0.542
MOD_CK1_1	60	66	PF00069	0.525
MOD_CK1_1	606	612	PF00069	0.396
MOD_CK1_1	642	648	PF00069	0.447
MOD_CK1_1	677	683	PF00069	0.442
MOD_CK1_1	840	846	PF00069	0.471
MOD_CK1_1	93	99	PF00069	0.492
MOD_CK2_1	110	116	PF00069	0.681
MOD_CK2_1	176	182	PF00069	0.694
MOD_CK2_1	186	192	PF00069	0.707
MOD_CK2_1	525	531	PF00069	0.579
MOD_CK2_1	602	608	PF00069	0.426
MOD_CK2_1	611	617	PF00069	0.487
MOD_GlcNHglycan	156	159	PF01048	0.629
MOD_GlcNHglycan	215	218	PF01048	0.582
MOD_GlcNHglycan	258	261	PF01048	0.570
MOD_GlcNHglycan	292	295	PF01048	0.770
MOD_GlcNHglycan	301	304	PF01048	0.631
MOD_GlcNHglycan	316	319	PF01048	0.522
MOD_GlcNHglycan	343	346	PF01048	0.551
MOD_GlcNHglycan	364	367	PF01048	0.740
MOD_GlcNHglycan	375	378	PF01048	0.743
MOD_GlcNHglycan	392	395	PF01048	0.279
MOD_GlcNHglycan	42	45	PF01048	0.456
MOD_GlcNHglycan	433	436	PF01048	0.662
MOD_GlcNHglycan	450	453	PF01048	0.570
MOD_GlcNHglycan	506	509	PF01048	0.505
MOD_GlcNHglycan	531	534	PF01048	0.423
MOD_GlcNHglycan	641	644	PF01048	0.450
MOD_GlcNHglycan	690	693	PF01048	0.495
MOD_GlcNHglycan	712	715	PF01048	0.549
MOD_GlcNHglycan	795	798	PF01048	0.545
MOD_GlcNHglycan	822	825	PF01048	0.545
MOD_GlcNHglycan	852	855	PF01048	0.512
MOD_GSK3_1	105	112	PF00069	0.605
MOD_GSK3_1	149	156	PF00069	0.764
MOD_GSK3_1	162	169	PF00069	0.681
MOD_GSK3_1	172	179	PF00069	0.679
MOD_GSK3_1	265	272	PF00069	0.599
MOD_GSK3_1	307	314	PF00069	0.551
MOD_GSK3_1	341	348	PF00069	0.544
MOD_GSK3_1	355	362	PF00069	0.557
MOD_GSK3_1	375	382	PF00069	0.716
MOD_GSK3_1	386	393	PF00069	0.507
MOD_GSK3_1	40	47	PF00069	0.466
MOD_GSK3_1	444	451	PF00069	0.651
MOD_GSK3_1	457	464	PF00069	0.545
MOD_GSK3_1	488	495	PF00069	0.441
MOD_GSK3_1	504	511	PF00069	0.440
MOD_GSK3_1	525	532	PF00069	0.507
MOD_GSK3_1	550	557	PF00069	0.563
MOD_GSK3_1	57	64	PF00069	0.539
MOD_GSK3_1	602	609	PF00069	0.390
MOD_GSK3_1	638	645	PF00069	0.376
MOD_GSK3_1	754	761	PF00069	0.474
MOD_GSK3_1	798	805	PF00069	0.463
MOD_GSK3_1	808	815	PF00069	0.478
MOD_GSK3_1	84	91	PF00069	0.416
MOD_N-GLC_1	299	304	PF02516	0.585
MOD_N-GLC_1	677	682	PF02516	0.475
MOD_N-GLC_1	783	788	PF02516	0.459
MOD_NEK2_1	1	6	PF00069	0.453
MOD_NEK2_1	103	108	PF00069	0.600
MOD_NEK2_1	11	16	PF00069	0.452
MOD_NEK2_1	154	159	PF00069	0.616
MOD_NEK2_1	162	167	PF00069	0.697
MOD_NEK2_1	224	229	PF00069	0.553
MOD_NEK2_1	311	316	PF00069	0.590
MOD_NEK2_1	343	348	PF00069	0.622
MOD_NEK2_1	40	45	PF00069	0.523
MOD_NEK2_1	448	453	PF00069	0.671
MOD_NEK2_1	550	555	PF00069	0.528
MOD_NEK2_1	638	643	PF00069	0.392
MOD_NEK2_1	710	715	PF00069	0.597
MOD_NEK2_1	772	777	PF00069	0.437
MOD_NEK2_1	783	788	PF00069	0.331
MOD_NEK2_1	817	822	PF00069	0.510
MOD_NEK2_1	84	89	PF00069	0.724
MOD_NEK2_1	850	855	PF00069	0.562
MOD_NEK2_1	867	872	PF00069	0.371
MOD_NEK2_2	452	457	PF00069	0.569
MOD_PIKK_1	131	137	PF00454	0.650
MOD_PIKK_1	317	323	PF00454	0.597
MOD_PIKK_1	386	392	PF00454	0.554
MOD_PIKK_1	394	400	PF00454	0.475
MOD_PIKK_1	61	67	PF00454	0.491
MOD_PK_1	110	116	PF00069	0.666
MOD_PK_1	525	531	PF00069	0.491
MOD_PKA_1	444	450	PF00069	0.689
MOD_PKA_1	818	824	PF00069	0.606
MOD_PKA_2	109	115	PF00069	0.689
MOD_PKA_2	116	122	PF00069	0.653
MOD_PKA_2	152	158	PF00069	0.625
MOD_PKA_2	213	219	PF00069	0.689
MOD_PKA_2	348	354	PF00069	0.658
MOD_PKA_2	423	429	PF00069	0.559
MOD_PKA_2	444	450	PF00069	0.596
MOD_PKA_2	460	466	PF00069	0.511
MOD_PKA_2	529	535	PF00069	0.536
MOD_PKA_2	554	560	PF00069	0.478
MOD_PKA_2	620	626	PF00069	0.569
MOD_PKA_2	651	657	PF00069	0.562
MOD_PKA_2	67	73	PF00069	0.501
MOD_PKA_2	817	823	PF00069	0.561
MOD_PKA_2	830	836	PF00069	0.497
MOD_PKA_2	840	846	PF00069	0.483
MOD_Plk_1	176	182	PF00069	0.681
MOD_Plk_1	591	597	PF00069	0.325
MOD_Plk_1	603	609	PF00069	0.388
MOD_Plk_1	737	743	PF00069	0.503
MOD_Plk_1	783	789	PF00069	0.457
MOD_Plk_2-3	116	122	PF00069	0.670
MOD_Plk_4	1	7	PF00069	0.453
MOD_Plk_4	157	163	PF00069	0.608
MOD_Plk_4	23	29	PF00069	0.464
MOD_Plk_4	233	239	PF00069	0.560
MOD_Plk_4	44	50	PF00069	0.475
MOD_Plk_4	452	458	PF00069	0.625
MOD_Plk_4	508	514	PF00069	0.409
MOD_Plk_4	591	597	PF00069	0.445
MOD_Plk_4	67	73	PF00069	0.529
MOD_Plk_4	737	743	PF00069	0.503
MOD_Plk_4	754	760	PF00069	0.519
MOD_Plk_4	783	789	PF00069	0.398
MOD_Plk_4	840	846	PF00069	0.443
MOD_Plk_4	90	96	PF00069	0.473
MOD_ProDKin_1	125	131	PF00069	0.608
MOD_ProDKin_1	147	153	PF00069	0.549
MOD_ProDKin_1	166	172	PF00069	0.601
MOD_ProDKin_1	206	212	PF00069	0.634
MOD_ProDKin_1	269	275	PF00069	0.622
MOD_ProDKin_1	278	284	PF00069	0.692
MOD_ProDKin_1	288	294	PF00069	0.664
MOD_ProDKin_1	455	461	PF00069	0.712
MOD_ProDKin_1	48	54	PF00069	0.501
MOD_ProDKin_1	492	498	PF00069	0.367
MOD_ProDKin_1	611	617	PF00069	0.487
MOD_ProDKin_1	686	692	PF00069	0.390
MOD_ProDKin_1	719	725	PF00069	0.605
MOD_SUMO_for_1	809	812	PF00179	0.525
TRG_ENDOCYTIC_2	482	485	PF00928	0.399
TRG_ENDOCYTIC_2	524	527	PF00928	0.414
TRG_ENDOCYTIC_2	849	852	PF00928	0.377
TRG_ENDOCYTIC_2	871	874	PF00928	0.470
TRG_ER_diArg_1	414	417	PF00400	0.455
TRG_ER_diArg_1	423	425	PF00400	0.536
TRG_ER_diArg_1	66	69	PF00400	0.556
TRG_ER_diArg_1	723	725	PF00400	0.675
TRG_ER_diArg_1	742	744	PF00400	0.322
TRG_ER_diArg_1	817	819	PF00400	0.595
TRG_ER_FFAT_2	389	397	PF00635	0.467
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP1	Leptomonas seymouri	63%	100%
A0A3R7NES5	Trypanosoma rangeli	39%	100%
A0A3S7X6D7	Leishmania donovani	92%	100%
A4HLA7	Leishmania braziliensis	78%	100%
A4I8T3	Leishmania infantum	92%	95%
E9B3P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BFC1	Trypanosoma cruzi	38%	100%