Related to both fungal ergosterol C-24 reductases and to a lesser extent, animal delta-14 lanosterol reductases (all preferentially ER-localized).. The highly changed Ser/Arg rich N-terminus might point to a mitochondrial transit signal (ergosterols are essential for Kinetoplastid mitochondria).. Localization: ER (by homology) / Mitochondrial (by feature)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 8 |
| NetGPI | no | yes: 0, no: 8 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 7 |
| GO:0110165 | cellular anatomical entity | 1 | 7 |
Related structures:
AlphaFold database: Q4Q4D7
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006066 | alcohol metabolic process | 3 | 2 |
| GO:0006629 | lipid metabolic process | 3 | 9 |
| GO:0006694 | steroid biosynthetic process | 5 | 9 |
| GO:0006696 | ergosterol biosynthetic process | 5 | 2 |
| GO:0008152 | metabolic process | 1 | 9 |
| GO:0008202 | steroid metabolic process | 4 | 9 |
| GO:0008204 | ergosterol metabolic process | 4 | 2 |
| GO:0008610 | lipid biosynthetic process | 4 | 9 |
| GO:0009058 | biosynthetic process | 2 | 9 |
| GO:0009987 | cellular process | 1 | 2 |
| GO:0016125 | sterol metabolic process | 4 | 9 |
| GO:0016126 | sterol biosynthetic process | 5 | 9 |
| GO:0016128 | phytosteroid metabolic process | 4 | 2 |
| GO:0016129 | phytosteroid biosynthetic process | 5 | 2 |
| GO:0044107 | obsolete cellular alcohol metabolic process | 3 | 2 |
| GO:0044108 | obsolete cellular alcohol biosynthetic process | 4 | 2 |
| GO:0044237 | cellular metabolic process | 2 | 2 |
| GO:0044238 | primary metabolic process | 2 | 9 |
| GO:0044249 | cellular biosynthetic process | 3 | 2 |
| GO:0044255 | cellular lipid metabolic process | 3 | 2 |
| GO:0044281 | small molecule metabolic process | 2 | 2 |
| GO:0044283 | small molecule biosynthetic process | 3 | 2 |
| GO:0046165 | alcohol biosynthetic process | 4 | 2 |
| GO:0071704 | organic substance metabolic process | 2 | 9 |
| GO:0097384 | cellular lipid biosynthetic process | 4 | 2 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 9 |
| GO:1901362 | organic cyclic compound biosynthetic process | 4 | 9 |
| GO:1901576 | organic substance biosynthetic process | 3 | 9 |
| GO:1901615 | organic hydroxy compound metabolic process | 3 | 9 |
| GO:1901617 | organic hydroxy compound biosynthetic process | 4 | 9 |
| GO:1902652 | secondary alcohol metabolic process | 4 | 2 |
| GO:1902653 | secondary alcohol biosynthetic process | 5 | 2 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000246 | delta24(24-1) sterol reductase activity | 5 | 7 |
| GO:0003824 | catalytic activity | 1 | 9 |
| GO:0016491 | oxidoreductase activity | 2 | 9 |
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | 3 | 9 |
| GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | 4 | 9 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 138 | 140 | PF00675 | 0.449 |
| CLV_NRD_NRD_1 | 369 | 371 | PF00675 | 0.225 |
| CLV_NRD_NRD_1 | 411 | 413 | PF00675 | 0.231 |
| CLV_PCSK_FUR_1 | 409 | 413 | PF00082 | 0.249 |
| CLV_PCSK_KEX2_1 | 138 | 140 | PF00082 | 0.449 |
| CLV_PCSK_KEX2_1 | 165 | 167 | PF00082 | 0.226 |
| CLV_PCSK_KEX2_1 | 411 | 413 | PF00082 | 0.249 |
| CLV_PCSK_PC1ET2_1 | 165 | 167 | PF00082 | 0.251 |
| CLV_PCSK_SKI1_1 | 295 | 299 | PF00082 | 0.399 |
| CLV_PCSK_SKI1_1 | 351 | 355 | PF00082 | 0.267 |
| CLV_PCSK_SKI1_1 | 54 | 58 | PF00082 | 0.476 |
| DEG_APCC_DBOX_1 | 294 | 302 | PF00400 | 0.328 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.456 |
| DOC_CYCLIN_RxL_1 | 91 | 101 | PF00134 | 0.492 |
| DOC_MAPK_gen_1 | 323 | 333 | PF00069 | 0.492 |
| DOC_MAPK_gen_1 | 370 | 378 | PF00069 | 0.506 |
| DOC_MAPK_gen_1 | 48 | 57 | PF00069 | 0.270 |
| DOC_MAPK_HePTP_8 | 184 | 196 | PF00069 | 0.449 |
| DOC_MAPK_MEF2A_6 | 187 | 196 | PF00069 | 0.442 |
| DOC_MAPK_MEF2A_6 | 201 | 209 | PF00069 | 0.212 |
| DOC_MAPK_MEF2A_6 | 371 | 380 | PF00069 | 0.410 |
| DOC_PP1_RVXF_1 | 52 | 58 | PF00149 | 0.241 |
| DOC_PP2B_LxvP_1 | 86 | 89 | PF13499 | 0.294 |
| DOC_PP2B_LxvP_1 | 96 | 99 | PF13499 | 0.398 |
| DOC_PP4_FxxP_1 | 186 | 189 | PF00568 | 0.410 |
| DOC_PP4_FxxP_1 | 8 | 11 | PF00568 | 0.482 |
| DOC_USP7_MATH_1 | 314 | 318 | PF00917 | 0.462 |
| DOC_USP7_MATH_1 | 97 | 101 | PF00917 | 0.425 |
| LIG_14-3-3_CanoR_1 | 105 | 109 | PF00244 | 0.492 |
| LIG_14-3-3_CanoR_1 | 201 | 205 | PF00244 | 0.260 |
| LIG_14-3-3_CanoR_1 | 351 | 361 | PF00244 | 0.429 |
| LIG_APCC_ABBA_1 | 194 | 199 | PF00400 | 0.425 |
| LIG_eIF4E_1 | 29 | 35 | PF01652 | 0.402 |
| LIG_FHA_1 | 18 | 24 | PF00498 | 0.343 |
| LIG_FHA_1 | 251 | 257 | PF00498 | 0.425 |
| LIG_FHA_1 | 268 | 274 | PF00498 | 0.260 |
| LIG_FHA_1 | 355 | 361 | PF00498 | 0.548 |
| LIG_FHA_1 | 373 | 379 | PF00498 | 0.349 |
| LIG_FHA_1 | 68 | 74 | PF00498 | 0.218 |
| LIG_LIR_Apic_2 | 7 | 11 | PF02991 | 0.484 |
| LIG_LIR_Gen_1 | 114 | 125 | PF02991 | 0.328 |
| LIG_LIR_Gen_1 | 203 | 212 | PF02991 | 0.260 |
| LIG_LIR_Gen_1 | 217 | 225 | PF02991 | 0.225 |
| LIG_LIR_Gen_1 | 255 | 266 | PF02991 | 0.431 |
| LIG_LIR_Gen_1 | 426 | 436 | PF02991 | 0.450 |
| LIG_LIR_Gen_1 | 70 | 79 | PF02991 | 0.378 |
| LIG_LIR_Gen_1 | 81 | 91 | PF02991 | 0.285 |
| LIG_LIR_Nem_3 | 114 | 120 | PF02991 | 0.382 |
| LIG_LIR_Nem_3 | 203 | 207 | PF02991 | 0.260 |
| LIG_LIR_Nem_3 | 217 | 222 | PF02991 | 0.225 |
| LIG_LIR_Nem_3 | 252 | 257 | PF02991 | 0.425 |
| LIG_LIR_Nem_3 | 363 | 368 | PF02991 | 0.425 |
| LIG_LIR_Nem_3 | 391 | 396 | PF02991 | 0.228 |
| LIG_LIR_Nem_3 | 426 | 431 | PF02991 | 0.430 |
| LIG_LIR_Nem_3 | 70 | 74 | PF02991 | 0.406 |
| LIG_LIR_Nem_3 | 81 | 86 | PF02991 | 0.316 |
| LIG_NRBOX | 74 | 80 | PF00104 | 0.354 |
| LIG_Pex14_1 | 254 | 258 | PF04695 | 0.425 |
| LIG_Pex14_1 | 263 | 267 | PF04695 | 0.260 |
| LIG_Pex14_2 | 174 | 178 | PF04695 | 0.548 |
| LIG_Pex14_2 | 393 | 397 | PF04695 | 0.260 |
| LIG_PTB_Apo_2 | 333 | 340 | PF02174 | 0.476 |
| LIG_SH2_CRK | 117 | 121 | PF00017 | 0.297 |
| LIG_SH2_CRK | 434 | 438 | PF00017 | 0.425 |
| LIG_SH2_GRB2like | 239 | 242 | PF00017 | 0.260 |
| LIG_SH2_GRB2like | 267 | 270 | PF00017 | 0.260 |
| LIG_SH2_PTP2 | 29 | 32 | PF00017 | 0.354 |
| LIG_SH2_PTP2 | 428 | 431 | PF00017 | 0.473 |
| LIG_SH2_SRC | 239 | 242 | PF00017 | 0.260 |
| LIG_SH2_STAP1 | 176 | 180 | PF00017 | 0.425 |
| LIG_SH2_STAP1 | 374 | 378 | PF00017 | 0.260 |
| LIG_SH2_STAT3 | 277 | 280 | PF00017 | 0.260 |
| LIG_SH2_STAT5 | 117 | 120 | PF00017 | 0.277 |
| LIG_SH2_STAT5 | 160 | 163 | PF00017 | 0.378 |
| LIG_SH2_STAT5 | 224 | 227 | PF00017 | 0.225 |
| LIG_SH2_STAT5 | 239 | 242 | PF00017 | 0.260 |
| LIG_SH2_STAT5 | 27 | 30 | PF00017 | 0.306 |
| LIG_SH2_STAT5 | 277 | 280 | PF00017 | 0.269 |
| LIG_SH2_STAT5 | 283 | 286 | PF00017 | 0.217 |
| LIG_SH2_STAT5 | 310 | 313 | PF00017 | 0.260 |
| LIG_SH2_STAT5 | 346 | 349 | PF00017 | 0.456 |
| LIG_SH2_STAT5 | 374 | 377 | PF00017 | 0.260 |
| LIG_SH2_STAT5 | 398 | 401 | PF00017 | 0.260 |
| LIG_SH2_STAT5 | 428 | 431 | PF00017 | 0.425 |
| LIG_SH2_STAT5 | 82 | 85 | PF00017 | 0.331 |
| LIG_SH2_STAT5 | 92 | 95 | PF00017 | 0.468 |
| LIG_SH3_3 | 337 | 343 | PF00018 | 0.425 |
| LIG_SH3_3 | 39 | 45 | PF00018 | 0.249 |
| LIG_SUMO_SIM_anti_2 | 203 | 209 | PF11976 | 0.260 |
| LIG_SUMO_SIM_anti_2 | 375 | 380 | PF11976 | 0.272 |
| LIG_SUMO_SIM_par_1 | 208 | 213 | PF11976 | 0.266 |
| LIG_TYR_ITIM | 126 | 131 | PF00017 | 0.294 |
| LIG_TYR_ITIM | 25 | 30 | PF00017 | 0.260 |
| LIG_TYR_ITIM | 432 | 437 | PF00017 | 0.425 |
| LIG_WRC_WIRS_1 | 390 | 395 | PF05994 | 0.225 |
| LIG_WRC_WIRS_1 | 56 | 61 | PF05994 | 0.273 |
| LIG_WRC_WIRS_1 | 68 | 73 | PF05994 | 0.191 |
| MOD_Cter_Amidation | 368 | 371 | PF01082 | 0.225 |
| MOD_GlcNHglycan | 181 | 184 | PF01048 | 0.239 |
| MOD_GlcNHglycan | 326 | 329 | PF01048 | 0.249 |
| MOD_GlcNHglycan | 354 | 357 | PF01048 | 0.360 |
| MOD_GlcNHglycan | 385 | 388 | PF01048 | 0.336 |
| MOD_N-GLC_2 | 269 | 271 | PF02516 | 0.260 |
| MOD_NEK2_1 | 179 | 184 | PF00069 | 0.447 |
| MOD_NEK2_1 | 18 | 23 | PF00069 | 0.291 |
| MOD_NEK2_1 | 208 | 213 | PF00069 | 0.294 |
| MOD_NEK2_1 | 324 | 329 | PF00069 | 0.437 |
| MOD_NEK2_1 | 35 | 40 | PF00069 | 0.225 |
| MOD_NEK2_1 | 383 | 388 | PF00069 | 0.275 |
| MOD_NEK2_2 | 278 | 283 | PF00069 | 0.354 |
| MOD_PIKK_1 | 314 | 320 | PF00454 | 0.425 |
| MOD_PKA_2 | 104 | 110 | PF00069 | 0.492 |
| MOD_PKA_2 | 168 | 174 | PF00069 | 0.425 |
| MOD_PKA_2 | 200 | 206 | PF00069 | 0.260 |
| MOD_Plk_4 | 146 | 152 | PF00069 | 0.243 |
| MOD_Plk_4 | 200 | 206 | PF00069 | 0.260 |
| MOD_Plk_4 | 278 | 284 | PF00069 | 0.268 |
| MOD_Plk_4 | 35 | 41 | PF00069 | 0.239 |
| MOD_Plk_4 | 389 | 395 | PF00069 | 0.260 |
| MOD_SUMO_for_1 | 47 | 50 | PF00179 | 0.223 |
| TRG_DiLeu_BaEn_1 | 427 | 432 | PF01217 | 0.473 |
| TRG_ENDOCYTIC_2 | 117 | 120 | PF00928 | 0.308 |
| TRG_ENDOCYTIC_2 | 128 | 131 | PF00928 | 0.260 |
| TRG_ENDOCYTIC_2 | 141 | 144 | PF00928 | 0.364 |
| TRG_ENDOCYTIC_2 | 176 | 179 | PF00928 | 0.425 |
| TRG_ENDOCYTIC_2 | 219 | 222 | PF00928 | 0.249 |
| TRG_ENDOCYTIC_2 | 258 | 261 | PF00928 | 0.425 |
| TRG_ENDOCYTIC_2 | 27 | 30 | PF00928 | 0.262 |
| TRG_ENDOCYTIC_2 | 398 | 401 | PF00928 | 0.260 |
| TRG_ENDOCYTIC_2 | 421 | 424 | PF00928 | 0.427 |
| TRG_ENDOCYTIC_2 | 428 | 431 | PF00928 | 0.427 |
| TRG_ENDOCYTIC_2 | 434 | 437 | PF00928 | 0.425 |
| TRG_ER_diArg_1 | 137 | 139 | PF00400 | 0.249 |
| TRG_NES_CRM1_1 | 50 | 62 | PF08389 | 0.177 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P3C6 | Leptomonas seymouri | 83% | 88% |
| A0A0N1PBH8 | Leptomonas seymouri | 29% | 100% |
| A0A0S4IS37 | Bodo saltans | 27% | 100% |
| A0A0S4KLN5 | Bodo saltans | 28% | 94% |
| A0A1D8PIC7 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 29% | 98% |
| A0A1D8PJ25 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 38% | 94% |
| A0A1X0NRH6 | Trypanosomatidae | 25% | 96% |
| A0A1X0P0Q6 | Trypanosomatidae | 68% | 89% |
| A0A3Q8IM20 | Leishmania donovani | 96% | 89% |
| A0A3R7KUI7 | Trypanosoma rangeli | 67% | 90% |
| A0A3R7N804 | Trypanosoma rangeli | 28% | 96% |
| A0A3S7X5R0 | Leishmania donovani | 26% | 100% |
| A4HKM3 | Leishmania braziliensis | 26% | 100% |
| A4HLA8 | Leishmania braziliensis | 85% | 88% |
| A4I855 | Leishmania infantum | 26% | 100% |
| A4I8T4 | Leishmania infantum | 96% | 89% |
| D0AAC2 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 25% | 96% |
| E9B312 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 100% |
| E9B3Q0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 93% | 89% |
| G4SW86 | Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) | 32% | 100% |
| I1RF79 | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) | 26% | 92% |
| I1RR90 | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) | 26% | 91% |
| I1RZZ3 | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) | 40% | 74% |
| O08984 | Rattus norvegicus | 32% | 71% |
| O13597 | Septoria lycopersici | 28% | 86% |
| O76062 | Homo sapiens | 32% | 100% |
| O88455 | Mus musculus | 26% | 94% |
| P23913 | Gallus gallus | 31% | 69% |
| P25340 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 37% | 93% |
| P32462 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 28% | 100% |
| P36209 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 37% | 97% |
| P38670 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 27% | 90% |
| P78575 | Ascobolus immersus | 28% | 100% |
| Q01447 | Fusarium vanettenii | 27% | 91% |
| Q09195 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 30% | 100% |
| Q14739 | Homo sapiens | 32% | 72% |
| Q3U9G9 | Mus musculus | 32% | 70% |
| Q4Q543 | Leishmania major | 26% | 100% |
| Q4WJ59 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 39% | 77% |
| Q4WJJ9 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 28% | 85% |
| Q4WKA5 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 26% | 89% |
| Q4WW43 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 41% | 94% |
| Q54PP1 | Dictyostelium discoideum | 31% | 95% |
| Q5E9J5 | Bos taurus | 26% | 93% |
| Q5R7H4 | Pongo abelii | 32% | 72% |
| Q5UQI4 | Acanthamoeba polyphaga mimivirus | 31% | 99% |
| Q6P4M0 | Xenopus tropicalis | 26% | 93% |
| Q71KT5 | Mus musculus | 32% | 100% |
| Q7SXF1 | Danio rerio | 26% | 92% |
| Q7ZXH1 | Xenopus laevis | 27% | 93% |
| Q8WMV1 | Bos taurus | 33% | 100% |
| Q9LDR4 | Arabidopsis thaliana | 28% | 100% |
| Q9LDU6 | Arabidopsis thaliana | 29% | 100% |
| Q9UBM7 | Homo sapiens | 26% | 93% |
| Q9Z2Z8 | Rattus norvegicus | 27% | 94% |
| V5BKN3 | Trypanosoma cruzi | 27% | 96% |