TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4D5_LEIMA

TriTrypDb:

LmjF.33.0700 , LMJLV39_330013800 , LMJSD75_330013600

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4D5

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0030544	Hsp70 protein binding	4	2
GO:0031072	heat shock protein binding	3	5
GO:0051879	Hsp90 protein binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.557
CLV_NRD_NRD_1	162	164	PF00675	0.481
CLV_NRD_NRD_1	190	192	PF00675	0.530
CLV_NRD_NRD_1	227	229	PF00675	0.612
CLV_NRD_NRD_1	32	34	PF00675	0.536
CLV_NRD_NRD_1	83	85	PF00675	0.459
CLV_PCSK_KEX2_1	102	104	PF00082	0.557
CLV_PCSK_KEX2_1	190	192	PF00082	0.530
CLV_PCSK_KEX2_1	227	229	PF00082	0.525
CLV_PCSK_KEX2_1	32	34	PF00082	0.536
CLV_PCSK_SKI1_1	168	172	PF00082	0.425
CLV_PCSK_SKI1_1	242	246	PF00082	0.414
DEG_Nend_Nbox_1	1	3	PF02207	0.590
DEG_SPOP_SBC_1	243	247	PF00917	0.525
DOC_CDC14_PxL_1	277	285	PF14671	0.360
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.351
DOC_MAPK_gen_1	177	183	PF00069	0.442
DOC_MAPK_gen_1	321	331	PF00069	0.398
DOC_MAPK_MEF2A_6	177	185	PF00069	0.394
DOC_MAPK_MEF2A_6	324	332	PF00069	0.452
DOC_MAPK_NFAT4_5	178	186	PF00069	0.411
DOC_PP2B_LxvP_1	278	281	PF13499	0.354
DOC_USP7_MATH_1	10	14	PF00917	0.539
DOC_USP7_MATH_1	133	137	PF00917	0.348
DOC_USP7_MATH_1	152	156	PF00917	0.256
DOC_USP7_MATH_1	229	233	PF00917	0.509
DOC_USP7_MATH_1	235	239	PF00917	0.441
DOC_USP7_MATH_1	243	247	PF00917	0.367
DOC_USP7_MATH_1	66	70	PF00917	0.465
LIG_14-3-3_CanoR_1	228	237	PF00244	0.550
LIG_14-3-3_CanoR_1	242	251	PF00244	0.355
LIG_APCC_ABBA_1	283	288	PF00400	0.371
LIG_APCC_ABBA_1	353	358	PF00400	0.449
LIG_deltaCOP1_diTrp_1	347	356	PF00928	0.432
LIG_deltaCOP1_diTrp_1	41	49	PF00928	0.505
LIG_eIF4E_1	361	367	PF01652	0.377
LIG_FHA_1	113	119	PF00498	0.390
LIG_FHA_1	208	214	PF00498	0.564
LIG_FHA_1	374	380	PF00498	0.419
LIG_FHA_2	52	58	PF00498	0.502
LIG_LIR_Apic_2	358	364	PF02991	0.378
LIG_LIR_Gen_1	204	213	PF02991	0.418
LIG_LIR_Gen_1	41	50	PF02991	0.501
LIG_LIR_Gen_1	69	80	PF02991	0.485
LIG_LIR_Nem_3	340	346	PF02991	0.391
LIG_LIR_Nem_3	347	353	PF02991	0.393
LIG_LIR_Nem_3	69	75	PF02991	0.481
LIG_MYND_1	364	368	PF01753	0.378
LIG_Rb_pABgroove_1	280	288	PF01858	0.325
LIG_REV1ctd_RIR_1	329	337	PF16727	0.447
LIG_RPA_C_Fungi	130	142	PF08784	0.368
LIG_SH2_CRK	265	269	PF00017	0.533
LIG_SH2_CRK	322	326	PF00017	0.334
LIG_SH2_GRB2like	132	135	PF00017	0.366
LIG_SH2_NCK_1	361	365	PF00017	0.487
LIG_SH2_NCK_1	72	76	PF00017	0.497
LIG_SH2_SRC	72	75	PF00017	0.532
LIG_SH2_STAP1	114	118	PF00017	0.483
LIG_SH2_STAT5	114	117	PF00017	0.363
LIG_SH2_STAT5	271	274	PF00017	0.482
LIG_SH3_3	189	195	PF00018	0.591
LIG_TRAF2_1	13	16	PF00917	0.573
LIG_TRAF2_1	220	223	PF00917	0.633
LIG_TRAF2_1	98	101	PF00917	0.590
LIG_TYR_ITIM	341	346	PF00017	0.335
LIG_TYR_ITIM	70	75	PF00017	0.505
LIG_UBA3_1	366	375	PF00899	0.383
MOD_CK2_1	10	16	PF00069	0.497
MOD_CK2_1	110	116	PF00069	0.487
MOD_CK2_1	250	256	PF00069	0.463
MOD_Cter_Amidation	188	191	PF01082	0.526
MOD_GlcNHglycan	246	249	PF01048	0.457
MOD_GSK3_1	122	129	PF00069	0.568
MOD_N-GLC_1	133	138	PF02516	0.364
MOD_N-GLC_1	51	56	PF02516	0.491
MOD_NEK2_1	127	132	PF00069	0.445
MOD_PIKK_1	229	235	PF00454	0.601
MOD_Plk_1	133	139	PF00069	0.357
MOD_Plk_1	346	352	PF00069	0.380
MOD_Plk_1	357	363	PF00069	0.395
MOD_Plk_2-3	51	57	PF00069	0.463
MOD_Plk_4	127	133	PF00069	0.446
MOD_Plk_4	66	72	PF00069	0.579
TRG_DiLeu_BaEn_1	362	367	PF01217	0.523
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.451
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.484
TRG_ENDOCYTIC_2	322	325	PF00928	0.371
TRG_ENDOCYTIC_2	343	346	PF00928	0.342
TRG_ENDOCYTIC_2	72	75	PF00928	0.508
TRG_ER_diArg_1	190	192	PF00400	0.508
TRG_ER_diArg_1	319	322	PF00400	0.422
TRG_NES_CRM1_1	323	336	PF08389	0.461
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R4	Leptomonas seymouri	79%	100%
A0A1X0P0Q3	Trypanosomatidae	60%	100%
A0A3S7X6F2	Leishmania donovani	96%	100%
A0A422P2K3	Trypanosoma rangeli	59%	100%
A1Z6M6	Drosophila melanogaster	28%	98%
A4HLB0	Leishmania braziliensis	85%	100%
A4I8T6	Leishmania infantum	95%	100%
D0A4T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	90%
E9B3Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O13754	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O95801	Homo sapiens	27%	100%
P33313	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q54M20	Dictyostelium discoideum	24%	98%
Q5EA11	Bos taurus	30%	100%
Q8R3H9	Mus musculus	27%	100%