POT_family_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

POT family, putative

Species:

Leishmania major

UniProt:

Q4Q4D4_LEIMA

TriTrypDb:

LmjF.33.0710 , LMJLV39_330013900 , LMJSD75_330013700

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q4D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4D4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0022857	transmembrane transporter activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.628
CLV_C14_Caspase3-7	166	170	PF00656	0.685
CLV_NRD_NRD_1	181	183	PF00675	0.361
CLV_NRD_NRD_1	535	537	PF00675	0.431
CLV_PCSK_KEX2_1	181	183	PF00082	0.361
CLV_PCSK_SKI1_1	114	118	PF00082	0.502
CLV_PCSK_SKI1_1	232	236	PF00082	0.243
DEG_APCC_DBOX_1	147	155	PF00400	0.558
DEG_MDM2_SWIB_1	472	480	PF02201	0.311
DEG_Nend_UBRbox_4	1	3	PF02207	0.612
DEG_SPOP_SBC_1	393	397	PF00917	0.431
DOC_AGCK_PIF_1	30	35	PF00069	0.358
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.268
DOC_CYCLIN_yCln2_LP_2	543	549	PF00134	0.266
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.223
DOC_MAPK_gen_1	421	431	PF00069	0.502
DOC_MAPK_gen_1	572	580	PF00069	0.502
DOC_MAPK_gen_1	72	80	PF00069	0.469
DOC_MAPK_MEF2A_6	424	431	PF00069	0.298
DOC_MAPK_MEF2A_6	72	80	PF00069	0.474
DOC_MAPK_NFAT4_5	424	432	PF00069	0.298
DOC_PP2B_LxvP_1	450	453	PF13499	0.259
DOC_PP2B_LxvP_1	454	457	PF13499	0.259
DOC_PP2B_LxvP_1	5	8	PF13499	0.566
DOC_PP2B_LxvP_1	543	546	PF13499	0.266
DOC_PP4_FxxP_1	255	258	PF00568	0.298
DOC_PP4_FxxP_1	556	559	PF00568	0.347
DOC_USP7_MATH_1	165	169	PF00917	0.714
DOC_USP7_MATH_1	221	225	PF00917	0.393
DOC_USP7_MATH_1	380	384	PF00917	0.517
DOC_USP7_MATH_1	393	397	PF00917	0.435
DOC_USP7_MATH_1	407	411	PF00917	0.395
DOC_WW_Pin1_4	593	598	PF00397	0.248
DOC_WW_Pin1_4	95	100	PF00397	0.473
LIG_14-3-3_CanoR_1	181	187	PF00244	0.606
LIG_14-3-3_CanoR_1	317	321	PF00244	0.589
LIG_14-3-3_CanoR_1	341	347	PF00244	0.559
LIG_14-3-3_CanoR_1	417	421	PF00244	0.594
LIG_14-3-3_CanoR_1	536	545	PF00244	0.231
LIG_14-3-3_CanoR_1	77	86	PF00244	0.443
LIG_Actin_WH2_2	25	43	PF00022	0.250
LIG_Actin_WH2_2	316	333	PF00022	0.530
LIG_BIR_III_4	405	409	PF00653	0.492
LIG_BRCT_BRCA1_1	235	239	PF00533	0.437
LIG_BRCT_BRCA1_1	618	622	PF00533	0.335
LIG_Clathr_ClatBox_1	14	18	PF01394	0.465
LIG_eIF4E_1	279	285	PF01652	0.259
LIG_eIF4E_1	86	92	PF01652	0.342
LIG_FHA_1	133	139	PF00498	0.475
LIG_FHA_1	178	184	PF00498	0.633
LIG_FHA_1	220	226	PF00498	0.450
LIG_FHA_1	310	316	PF00498	0.433
LIG_FHA_1	35	41	PF00498	0.346
LIG_FHA_1	363	369	PF00498	0.454
LIG_FHA_1	417	423	PF00498	0.485
LIG_FHA_1	466	472	PF00498	0.354
LIG_FHA_1	85	91	PF00498	0.302
LIG_FHA_1	96	102	PF00498	0.362
LIG_FHA_2	154	160	PF00498	0.637
LIG_FHA_2	558	564	PF00498	0.437
LIG_LIR_Apic_2	477	482	PF02991	0.494
LIG_LIR_Apic_2	554	559	PF02991	0.331
LIG_LIR_Gen_1	312	321	PF02991	0.393
LIG_LIR_Gen_1	34	40	PF02991	0.283
LIG_LIR_Gen_1	352	361	PF02991	0.555
LIG_LIR_Gen_1	459	469	PF02991	0.236
LIG_LIR_Gen_1	539	549	PF02991	0.281
LIG_LIR_Gen_1	9	20	PF02991	0.493
LIG_LIR_Nem_3	21	26	PF02991	0.453
LIG_LIR_Nem_3	277	283	PF02991	0.273
LIG_LIR_Nem_3	312	316	PF02991	0.393
LIG_LIR_Nem_3	34	38	PF02991	0.281
LIG_LIR_Nem_3	349	353	PF02991	0.453
LIG_LIR_Nem_3	459	464	PF02991	0.236
LIG_LIR_Nem_3	506	512	PF02991	0.298
LIG_LIR_Nem_3	588	593	PF02991	0.346
LIG_LIR_Nem_3	619	625	PF02991	0.266
LIG_LIR_Nem_3	9	15	PF02991	0.500
LIG_Pex14_2	19	23	PF04695	0.422
LIG_Pex14_2	472	476	PF04695	0.406
LIG_Pex14_2	552	556	PF04695	0.320
LIG_PTB_Apo_2	49	56	PF02174	0.266
LIG_PTB_Phospho_1	49	55	PF10480	0.266
LIG_SH2_CRK	281	285	PF00017	0.350
LIG_SH2_CRK	35	39	PF00017	0.298
LIG_SH2_CRK	353	357	PF00017	0.418
LIG_SH2_CRK	487	491	PF00017	0.431
LIG_SH2_NCK_1	26	30	PF00017	0.358
LIG_SH2_NCK_1	567	571	PF00017	0.393
LIG_SH2_PTP2	55	58	PF00017	0.358
LIG_SH2_STAP1	208	212	PF00017	0.619
LIG_SH2_STAP1	241	245	PF00017	0.358
LIG_SH2_STAP1	26	30	PF00017	0.358
LIG_SH2_STAP1	281	285	PF00017	0.347
LIG_SH2_STAP1	86	90	PF00017	0.294
LIG_SH2_STAT3	547	550	PF00017	0.266
LIG_SH2_STAT5	102	105	PF00017	0.356
LIG_SH2_STAT5	35	38	PF00017	0.266
LIG_SH2_STAT5	504	507	PF00017	0.206
LIG_SH2_STAT5	529	532	PF00017	0.256
LIG_SH2_STAT5	547	550	PF00017	0.196
LIG_SH2_STAT5	55	58	PF00017	0.162
LIG_SH2_STAT5	623	626	PF00017	0.322
LIG_SH2_STAT5	86	89	PF00017	0.358
LIG_SH3_3	591	597	PF00018	0.313
LIG_SH3_3	70	76	PF00018	0.542
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.358
LIG_SUMO_SIM_par_1	36	42	PF11976	0.379
LIG_TRFH_1	55	59	PF08558	0.266
LIG_TRFH_1	593	597	PF08558	0.276
LIG_TYR_ITIM	351	356	PF00017	0.418
LIG_WRC_WIRS_1	280	285	PF05994	0.347
LIG_WRC_WIRS_1	608	613	PF05994	0.311
MOD_CDK_SPxxK_3	593	600	PF00069	0.248
MOD_CK1_1	31	37	PF00069	0.358
MOD_CK1_1	360	366	PF00069	0.467
MOD_CK1_1	383	389	PF00069	0.570
MOD_CK1_1	394	400	PF00069	0.542
MOD_CK1_1	585	591	PF00069	0.266
MOD_CK1_1	610	616	PF00069	0.276
MOD_CK2_1	221	227	PF00069	0.513
MOD_CK2_1	557	563	PF00069	0.437
MOD_CMANNOS	476	479	PF00535	0.294
MOD_GlcNHglycan	124	127	PF01048	0.266
MOD_GlcNHglycan	332	335	PF01048	0.320
MOD_GlcNHglycan	368	371	PF01048	0.263
MOD_GlcNHglycan	385	388	PF01048	0.371
MOD_GlcNHglycan	490	493	PF01048	0.268
MOD_GlcNHglycan	538	541	PF01048	0.477
MOD_GlcNHglycan	553	556	PF01048	0.205
MOD_GlcNHglycan	585	588	PF01048	0.271
MOD_GlcNHglycan	65	68	PF01048	0.310
MOD_GlcNHglycan	95	98	PF01048	0.397
MOD_GSK3_1	208	215	PF00069	0.713
MOD_GSK3_1	269	276	PF00069	0.283
MOD_GSK3_1	362	369	PF00069	0.450
MOD_GSK3_1	391	398	PF00069	0.536
MOD_NEK2_1	122	127	PF00069	0.232
MOD_NEK2_1	212	217	PF00069	0.626
MOD_NEK2_1	330	335	PF00069	0.489
MOD_NEK2_1	39	44	PF00069	0.325
MOD_NEK2_1	503	508	PF00069	0.266
MOD_NEK2_1	513	518	PF00069	0.266
MOD_NEK2_1	573	578	PF00069	0.486
MOD_NEK2_1	607	612	PF00069	0.283
MOD_NEK2_1	616	621	PF00069	0.235
MOD_NEK2_1	63	68	PF00069	0.364
MOD_NEK2_1	93	98	PF00069	0.285
MOD_NEK2_2	127	132	PF00069	0.358
MOD_NEK2_2	208	213	PF00069	0.633
MOD_NEK2_2	221	226	PF00069	0.393
MOD_NEK2_2	416	421	PF00069	0.502
MOD_PIKK_1	380	386	PF00454	0.501
MOD_PK_1	357	363	PF00069	0.443
MOD_PKA_1	536	542	PF00069	0.231
MOD_PKA_2	316	322	PF00069	0.557
MOD_PKA_2	330	336	PF00069	0.455
MOD_PKA_2	416	422	PF00069	0.502
MOD_PKB_1	486	494	PF00069	0.431
MOD_Plk_1	208	214	PF00069	0.736
MOD_Plk_4	153	159	PF00069	0.633
MOD_Plk_4	208	214	PF00069	0.632
MOD_Plk_4	221	227	PF00069	0.456
MOD_Plk_4	279	285	PF00069	0.265
MOD_Plk_4	309	315	PF00069	0.426
MOD_Plk_4	316	322	PF00069	0.469
MOD_Plk_4	34	40	PF00069	0.290
MOD_Plk_4	407	413	PF00069	0.462
MOD_Plk_4	465	471	PF00069	0.292
MOD_Plk_4	503	509	PF00069	0.307
MOD_Plk_4	557	563	PF00069	0.437
MOD_Plk_4	573	579	PF00069	0.437
MOD_Plk_4	616	622	PF00069	0.266
MOD_Plk_4	7	13	PF00069	0.636
MOD_Plk_4	86	92	PF00069	0.367
MOD_ProDKin_1	593	599	PF00069	0.248
MOD_ProDKin_1	95	101	PF00069	0.473
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.266
TRG_ENDOCYTIC_2	102	105	PF00928	0.291
TRG_ENDOCYTIC_2	128	131	PF00928	0.266
TRG_ENDOCYTIC_2	25	28	PF00928	0.323
TRG_ENDOCYTIC_2	280	283	PF00928	0.317
TRG_ENDOCYTIC_2	298	301	PF00928	0.266
TRG_ENDOCYTIC_2	35	38	PF00928	0.266
TRG_ENDOCYTIC_2	353	356	PF00928	0.418
TRG_ENDOCYTIC_2	432	435	PF00928	0.266
TRG_ENDOCYTIC_2	504	507	PF00928	0.206
TRG_ENDOCYTIC_2	55	58	PF00928	0.162
TRG_ER_diArg_1	181	183	PF00400	0.561
TRG_ER_diArg_1	75	78	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C4	Leptomonas seymouri	58%	96%
A0A1X0P0R8	Trypanosomatidae	39%	95%
A0A3S7X6J4	Leishmania donovani	91%	100%
A4HLB1	Leishmania braziliensis	74%	100%
A4I8T7	Leishmania infantum	91%	100%
E9B3Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BPE7	Trypanosoma cruzi	38%	100%