Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q4D2_LEIMA

TriTrypDb:

LmjF.33.0730 , LMJLV39_330014100 , LMJSD75_330013900

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

Q4Q4D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4D2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006356	regulation of transcription by RNA polymerase I	7	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045943	positive regulation of transcription by RNA polymerase I	8	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.440
CLV_C14_Caspase3-7	492	496	PF00656	0.411
CLV_NRD_NRD_1	6	8	PF00675	0.410
CLV_PCSK_KEX2_1	36	38	PF00082	0.466
CLV_PCSK_KEX2_1	6	8	PF00082	0.410
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.466
CLV_PCSK_SKI1_1	137	141	PF00082	0.288
CLV_PCSK_SKI1_1	175	179	PF00082	0.302
CLV_PCSK_SKI1_1	411	415	PF00082	0.341
DEG_COP1_1	465	473	PF00400	0.305
DEG_COP1_1	65	74	PF00400	0.563
DEG_SCF_FBW7_1	113	118	PF00400	0.487
DEG_SPOP_SBC_1	108	112	PF00917	0.511
DOC_CKS1_1	176	181	PF01111	0.297
DOC_CYCLIN_RxL_1	133	143	PF00134	0.396
DOC_MAPK_gen_1	133	141	PF00069	0.470
DOC_PP4_FxxP_1	162	165	PF00568	0.287
DOC_USP7_MATH_1	108	112	PF00917	0.519
DOC_USP7_MATH_1	165	169	PF00917	0.373
DOC_USP7_MATH_1	294	298	PF00917	0.412
DOC_USP7_MATH_1	374	378	PF00917	0.479
DOC_USP7_MATH_1	379	383	PF00917	0.414
DOC_USP7_MATH_1	512	516	PF00917	0.461
DOC_USP7_MATH_1	62	66	PF00917	0.636
DOC_USP7_MATH_1	95	99	PF00917	0.579
DOC_WW_Pin1_4	109	114	PF00397	0.631
DOC_WW_Pin1_4	175	180	PF00397	0.298
DOC_WW_Pin1_4	207	212	PF00397	0.286
DOC_WW_Pin1_4	60	65	PF00397	0.586
LIG_14-3-3_CanoR_1	137	142	PF00244	0.403
LIG_14-3-3_CanoR_1	6	10	PF00244	0.415
LIG_Actin_WH2_2	63	81	PF00022	0.483
LIG_AP2alpha_2	356	358	PF02296	0.479
LIG_BRCT_BRCA1_1	37	41	PF00533	0.479
LIG_FHA_1	161	167	PF00498	0.334
LIG_FHA_1	172	178	PF00498	0.271
LIG_FHA_1	263	269	PF00498	0.397
LIG_FHA_1	290	296	PF00498	0.302
LIG_FHA_1	425	431	PF00498	0.355
LIG_FHA_1	443	449	PF00498	0.359
LIG_FHA_2	116	122	PF00498	0.449
LIG_LIR_Apic_2	161	165	PF02991	0.280
LIG_LIR_Gen_1	8	15	PF02991	0.415
LIG_LIR_Nem_3	8	13	PF02991	0.413
LIG_PDZ_Class_3	554	559	PF00595	0.428
LIG_SH2_CRK	10	14	PF00017	0.429
LIG_SH2_CRK	223	227	PF00017	0.290
LIG_SH2_NCK_1	342	346	PF00017	0.379
LIG_SH2_NCK_1	50	54	PF00017	0.501
LIG_SH2_SRC	463	466	PF00017	0.469
LIG_SH2_SRC	50	53	PF00017	0.485
LIG_SH2_STAP1	342	346	PF00017	0.379
LIG_SH2_STAP1	536	540	PF00017	0.430
LIG_SH2_STAT3	169	172	PF00017	0.294
LIG_SH2_STAT5	201	204	PF00017	0.420
LIG_SH2_STAT5	223	226	PF00017	0.335
LIG_SH3_2	347	352	PF14604	0.470
LIG_SH3_3	110	116	PF00018	0.490
LIG_SH3_3	173	179	PF00018	0.319
LIG_SH3_3	344	350	PF00018	0.667
LIG_SH3_3	539	545	PF00018	0.442
LIG_SH3_3	58	64	PF00018	0.524
LIG_SUMO_SIM_par_1	189	194	PF11976	0.255
LIG_TYR_ITIM	221	226	PF00017	0.291
LIG_TYR_ITSM	6	13	PF00017	0.411
LIG_UBA3_1	231	238	PF00899	0.307
LIG_UBA3_1	366	372	PF00899	0.346
LIG_WRC_WIRS_1	301	306	PF05994	0.364
MOD_CK1_1	109	115	PF00069	0.551
MOD_CK1_1	197	203	PF00069	0.280
MOD_CK1_1	297	303	PF00069	0.413
MOD_CK1_1	377	383	PF00069	0.629
MOD_CK1_1	404	410	PF00069	0.668
MOD_CK1_1	428	434	PF00069	0.499
MOD_CK1_1	43	49	PF00069	0.602
MOD_CK1_1	86	92	PF00069	0.537
MOD_CK2_1	43	49	PF00069	0.581
MOD_DYRK1A_RPxSP_1	175	179	PF00069	0.323
MOD_GlcNHglycan	184	187	PF01048	0.371
MOD_GlcNHglycan	216	219	PF01048	0.372
MOD_GlcNHglycan	285	288	PF01048	0.402
MOD_GlcNHglycan	313	316	PF01048	0.329
MOD_GlcNHglycan	379	382	PF01048	0.411
MOD_GlcNHglycan	390	393	PF01048	0.279
MOD_GlcNHglycan	426	430	PF01048	0.440
MOD_GlcNHglycan	45	48	PF01048	0.502
MOD_GlcNHglycan	503	506	PF01048	0.355
MOD_GlcNHglycan	514	517	PF01048	0.436
MOD_GlcNHglycan	72	75	PF01048	0.525
MOD_GlcNHglycan	79	82	PF01048	0.505
MOD_GlcNHglycan	85	88	PF01048	0.472
MOD_GSK3_1	107	114	PF00069	0.548
MOD_GSK3_1	14	21	PF00069	0.427
MOD_GSK3_1	140	147	PF00069	0.416
MOD_GSK3_1	171	178	PF00069	0.301
MOD_GSK3_1	258	265	PF00069	0.426
MOD_GSK3_1	283	290	PF00069	0.512
MOD_GSK3_1	401	408	PF00069	0.475
MOD_GSK3_1	424	431	PF00069	0.546
MOD_GSK3_1	436	443	PF00069	0.443
MOD_GSK3_1	53	60	PF00069	0.544
MOD_GSK3_1	62	69	PF00069	0.704
MOD_GSK3_1	95	102	PF00069	0.544
MOD_N-GLC_1	377	382	PF02516	0.385
MOD_N-GLC_1	83	88	PF02516	0.470
MOD_NEK2_1	2	7	PF00069	0.410
MOD_NEK2_1	268	273	PF00069	0.558
MOD_NEK2_1	289	294	PF00069	0.604
MOD_NEK2_1	40	45	PF00069	0.515
MOD_NEK2_1	425	430	PF00069	0.481
MOD_NEK2_1	442	447	PF00069	0.313
MOD_NEK2_1	66	71	PF00069	0.522
MOD_NEK2_1	77	82	PF00069	0.475
MOD_NEK2_2	53	58	PF00069	0.484
MOD_PIKK_1	258	264	PF00454	0.397
MOD_PIKK_1	29	35	PF00454	0.452
MOD_PK_1	275	281	PF00069	0.293
MOD_PKA_1	35	41	PF00069	0.474
MOD_PKA_2	182	188	PF00069	0.350
MOD_PKA_2	214	220	PF00069	0.403
MOD_PKA_2	450	456	PF00069	0.317
MOD_PKA_2	5	11	PF00069	0.419
MOD_PKB_1	135	143	PF00069	0.390
MOD_Plk_1	160	166	PF00069	0.476
MOD_Plk_1	197	203	PF00069	0.244
MOD_Plk_1	425	431	PF00069	0.474
MOD_Plk_1	53	59	PF00069	0.605
MOD_Plk_2-3	351	357	PF00069	0.571
MOD_Plk_4	102	108	PF00069	0.566
MOD_Plk_4	197	203	PF00069	0.258
MOD_Plk_4	437	443	PF00069	0.322
MOD_Plk_4	469	475	PF00069	0.317
MOD_Plk_4	66	72	PF00069	0.484
MOD_ProDKin_1	109	115	PF00069	0.630
MOD_ProDKin_1	175	181	PF00069	0.306
MOD_ProDKin_1	207	213	PF00069	0.281
MOD_ProDKin_1	60	66	PF00069	0.586
TRG_ENDOCYTIC_2	10	13	PF00928	0.421
TRG_ENDOCYTIC_2	223	226	PF00928	0.284
TRG_ER_diArg_1	37	40	PF00400	0.467
TRG_NLS_MonoCore_2	33	38	PF00514	0.460
TRG_NLS_MonoExtC_3	34	39	PF00514	0.464
TRG_NLS_MonoExtN_4	34	40	PF00514	0.465
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT4	Leptomonas seymouri	61%	100%
A0A1X0P1X3	Trypanosomatidae	40%	100%
A0A3Q8IGG9	Leishmania donovani	93%	100%
A0A422P2K2	Trypanosoma rangeli	45%	100%
A4HLB3	Leishmania braziliensis	80%	99%
A4I8T9	Leishmania infantum	93%	100%
D0A4T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B3Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DG89	Trypanosoma cruzi	44%	100%