Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4D1_LEIMA

TriTrypDb:

LmjF.33.0740 , LMJLV39_330014200 , LMJSD75_330014000

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4D1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.596
CLV_C14_Caspase3-7	56	60	PF00656	0.675
CLV_NRD_NRD_1	189	191	PF00675	0.698
CLV_PCSK_KEX2_1	187	189	PF00082	0.696
CLV_PCSK_KEX2_1	304	306	PF00082	0.630
CLV_PCSK_KEX2_1	340	342	PF00082	0.438
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.696
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.630
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.553
CLV_PCSK_SKI1_1	345	349	PF00082	0.556
DEG_APCC_DBOX_1	340	348	PF00400	0.527
DEG_SCF_FBW7_1	218	225	PF00400	0.619
DOC_CDC14_PxL_1	214	222	PF14671	0.670
DOC_CKS1_1	10	15	PF01111	0.535
DOC_CYCLIN_RxL_1	117	126	PF00134	0.530
DOC_CYCLIN_RxL_1	345	354	PF00134	0.538
DOC_PP1_RVXF_1	357	364	PF00149	0.536
DOC_PP2B_LxvP_1	122	125	PF13499	0.512
DOC_PP4_FxxP_1	10	13	PF00568	0.568
DOC_USP7_MATH_1	222	226	PF00917	0.683
DOC_USP7_MATH_1	229	233	PF00917	0.654
DOC_USP7_MATH_1	252	256	PF00917	0.608
DOC_USP7_MATH_1	257	261	PF00917	0.710
DOC_WW_Pin1_4	159	164	PF00397	0.468
DOC_WW_Pin1_4	218	223	PF00397	0.671
DOC_WW_Pin1_4	9	14	PF00397	0.533
LIG_14-3-3_CanoR_1	32	40	PF00244	0.637
LIG_14-3-3_CanoR_1	61	71	PF00244	0.638
LIG_Actin_WH2_2	147	162	PF00022	0.359
LIG_Actin_WH2_2	34	49	PF00022	0.484
LIG_APCC_ABBA_1	39	44	PF00400	0.617
LIG_BRCT_BRCA1_1	157	161	PF00533	0.413
LIG_eIF4E_1	279	285	PF01652	0.639
LIG_FHA_1	236	242	PF00498	0.682
LIG_FHA_1	315	321	PF00498	0.629
LIG_FHA_1	32	38	PF00498	0.629
LIG_FHA_1	99	105	PF00498	0.467
LIG_FHA_2	163	169	PF00498	0.387
LIG_FHA_2	20	26	PF00498	0.647
LIG_FHA_2	294	300	PF00498	0.422
LIG_FHA_2	73	79	PF00498	0.424
LIG_LIR_Apic_2	280	286	PF02991	0.633
LIG_LIR_Apic_2	65	71	PF02991	0.691
LIG_LIR_Apic_2	9	13	PF02991	0.570
LIG_LIR_Gen_1	314	323	PF02991	0.440
LIG_LIR_Gen_1	78	87	PF02991	0.347
LIG_LIR_Nem_3	314	319	PF02991	0.638
LIG_LIR_Nem_3	360	366	PF02991	0.435
LIG_LIR_Nem_3	78	82	PF02991	0.348
LIG_MYND_1	218	222	PF01753	0.656
LIG_MYND_1	282	286	PF01753	0.634
LIG_OCRL_FandH_1	28	40	PF00620	0.566
LIG_Pex14_1	68	72	PF04695	0.617
LIG_SH2_CRK	79	83	PF00017	0.375
LIG_SH2_STAP1	155	159	PF00017	0.486
LIG_SH2_STAP1	316	320	PF00017	0.602
LIG_SH2_STAP1	366	370	PF00017	0.542
LIG_SH2_STAP1	79	83	PF00017	0.350
LIG_SH2_STAT5	185	188	PF00017	0.698
LIG_SH2_STAT5	316	319	PF00017	0.617
LIG_SH2_STAT5	330	333	PF00017	0.615
LIG_SH2_STAT5	72	75	PF00017	0.464
LIG_SH3_1	203	209	PF00018	0.645
LIG_SH3_3	122	128	PF00018	0.507
LIG_SH3_3	203	209	PF00018	0.645
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.479
LIG_TRAF2_1	22	25	PF00917	0.574
LIG_TRAF2_1	242	245	PF00917	0.528
LIG_TRAF2_1	306	309	PF00917	0.621
LIG_UBA3_1	351	359	PF00899	0.546
LIG_WRC_WIRS_1	223	228	PF05994	0.626
LIG_WW_2	206	209	PF00397	0.630
MOD_CK1_1	236	242	PF00069	0.582
MOD_CK1_1	314	320	PF00069	0.680
MOD_CK1_1	54	60	PF00069	0.676
MOD_CK1_1	9	15	PF00069	0.590
MOD_CK2_1	19	25	PF00069	0.698
MOD_CK2_1	239	245	PF00069	0.595
MOD_CK2_1	293	299	PF00069	0.420
MOD_GlcNHglycan	129	132	PF01048	0.591
MOD_GlcNHglycan	139	142	PF01048	0.559
MOD_GlcNHglycan	180	183	PF01048	0.640
MOD_GlcNHglycan	231	234	PF01048	0.677
MOD_GlcNHglycan	241	244	PF01048	0.717
MOD_GlcNHglycan	53	56	PF01048	0.682
MOD_GlcNHglycan	64	67	PF01048	0.623
MOD_GSK3_1	155	162	PF00069	0.428
MOD_GSK3_1	218	225	PF00069	0.729
MOD_GSK3_1	229	236	PF00069	0.652
MOD_LATS_1	17	23	PF00433	0.516
MOD_N-GLC_1	277	282	PF02516	0.619
MOD_N-GLC_1	51	56	PF02516	0.677
MOD_N-GLC_1	97	102	PF02516	0.503
MOD_NEK2_1	136	141	PF00069	0.504
MOD_NEK2_1	234	239	PF00069	0.639
MOD_NEK2_1	277	282	PF00069	0.629
MOD_NEK2_1	31	36	PF00069	0.596
MOD_NEK2_1	6	11	PF00069	0.707
MOD_NEK2_1	97	102	PF00069	0.411
MOD_NEK2_2	155	160	PF00069	0.492
MOD_PIKK_1	103	109	PF00454	0.512
MOD_PIKK_1	12	18	PF00454	0.737
MOD_PKA_2	31	37	PF00069	0.661
MOD_PKA_2	311	317	PF00069	0.594
MOD_PKA_2	60	66	PF00069	0.736
MOD_Plk_1	92	98	PF00069	0.382
MOD_Plk_2-3	357	363	PF00069	0.369
MOD_Plk_4	92	98	PF00069	0.488
MOD_ProDKin_1	159	165	PF00069	0.477
MOD_ProDKin_1	218	224	PF00069	0.671
MOD_ProDKin_1	9	15	PF00069	0.532
MOD_SUMO_rev_2	287	296	PF00179	0.594
MOD_SUMO_rev_2	354	361	PF00179	0.536
TRG_DiLeu_BaEn_3	24	30	PF01217	0.564
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.561
TRG_ENDOCYTIC_2	316	319	PF00928	0.503
TRG_ENDOCYTIC_2	79	82	PF00928	0.357
TRG_ER_diArg_1	188	190	PF00400	0.710
TRG_NES_CRM1_1	342	354	PF08389	0.518
TRG_NLS_MonoCore_2	186	191	PF00514	0.705
TRG_NLS_MonoExtC_3	186	192	PF00514	0.676
TRG_NLS_MonoExtC_3	270	275	PF00514	0.628
TRG_NLS_MonoExtN_4	184	191	PF00514	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S6	Leptomonas seymouri	58%	99%
A0A3Q8IK00	Leishmania donovani	91%	100%
A0A422P2K1	Trypanosoma rangeli	33%	100%
A4HLB4	Leishmania braziliensis	79%	100%
A4I8U0	Leishmania infantum	91%	100%
E9B3Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AZW9	Trypanosoma cruzi	35%	100%