Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4D0_LEIMA

TriTrypDb:

LmjF.33.0750 , LMJLV39_330014300 , LMJSD75_330014100

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4D0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.496
CLV_NRD_NRD_1	19	21	PF00675	0.382
CLV_NRD_NRD_1	197	199	PF00675	0.600
CLV_NRD_NRD_1	238	240	PF00675	0.703
CLV_NRD_NRD_1	680	682	PF00675	0.669
CLV_NRD_NRD_1	684	686	PF00675	0.691
CLV_NRD_NRD_1	706	708	PF00675	0.534
CLV_PCSK_FUR_1	233	237	PF00082	0.705
CLV_PCSK_FUR_1	681	685	PF00082	0.596
CLV_PCSK_KEX2_1	118	120	PF00082	0.496
CLV_PCSK_KEX2_1	19	21	PF00082	0.382
CLV_PCSK_KEX2_1	197	199	PF00082	0.680
CLV_PCSK_KEX2_1	233	235	PF00082	0.671
CLV_PCSK_KEX2_1	236	238	PF00082	0.672
CLV_PCSK_KEX2_1	676	678	PF00082	0.623
CLV_PCSK_KEX2_1	680	682	PF00082	0.672
CLV_PCSK_KEX2_1	683	685	PF00082	0.686
CLV_PCSK_KEX2_1	706	708	PF00082	0.534
CLV_PCSK_KEX2_1	758	760	PF00082	0.665
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.606
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.497
CLV_PCSK_PC7_1	193	199	PF00082	0.616
CLV_PCSK_PC7_1	233	239	PF00082	0.705
CLV_PCSK_PC7_1	680	686	PF00082	0.663
CLV_PCSK_SKI1_1	201	205	PF00082	0.640
CLV_PCSK_SKI1_1	377	381	PF00082	0.391
CLV_PCSK_SKI1_1	412	416	PF00082	0.508
CLV_PCSK_SKI1_1	605	609	PF00082	0.533
CLV_PCSK_SKI1_1	657	661	PF00082	0.455
CLV_PCSK_SKI1_1	759	763	PF00082	0.565
DEG_APCC_DBOX_1	376	384	PF00400	0.503
DEG_APCC_DBOX_1	411	419	PF00400	0.510
DEG_APCC_DBOX_1	604	612	PF00400	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.525
DEG_SCF_FBW7_1	64	71	PF00400	0.449
DEG_SPOP_SBC_1	563	567	PF00917	0.536
DOC_CKS1_1	714	719	PF01111	0.606
DOC_CYCLIN_RxL_1	374	382	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	417	420	PF00134	0.545
DOC_MAPK_DCC_7	308	316	PF00069	0.485
DOC_MAPK_gen_1	706	714	PF00069	0.647
DOC_MAPK_gen_1	758	766	PF00069	0.511
DOC_MAPK_MEF2A_6	10	17	PF00069	0.370
DOC_MAPK_MEF2A_6	274	281	PF00069	0.783
DOC_MAPK_MEF2A_6	478	487	PF00069	0.493
DOC_MAPK_MEF2A_6	758	766	PF00069	0.572
DOC_MAPK_MEF2A_6	86	95	PF00069	0.325
DOC_MAPK_NFAT4_5	759	767	PF00069	0.500
DOC_MAPK_NFAT4_5	86	94	PF00069	0.317
DOC_PP1_RVXF_1	359	366	PF00149	0.383
DOC_PP1_RVXF_1	476	483	PF00149	0.496
DOC_PP1_RVXF_1	61	67	PF00149	0.581
DOC_PP2B_LxvP_1	417	420	PF13499	0.545
DOC_USP7_MATH_1	167	171	PF00917	0.660
DOC_USP7_MATH_1	196	200	PF00917	0.600
DOC_USP7_MATH_1	212	216	PF00917	0.598
DOC_USP7_MATH_1	241	245	PF00917	0.741
DOC_USP7_MATH_1	257	261	PF00917	0.759
DOC_USP7_MATH_1	40	44	PF00917	0.691
DOC_USP7_MATH_1	45	49	PF00917	0.664
DOC_USP7_MATH_1	495	499	PF00917	0.682
DOC_USP7_MATH_1	505	509	PF00917	0.734
DOC_USP7_MATH_1	518	522	PF00917	0.733
DOC_USP7_MATH_1	531	535	PF00917	0.680
DOC_USP7_MATH_1	562	566	PF00917	0.455
DOC_USP7_MATH_1	593	597	PF00917	0.512
DOC_USP7_MATH_1	732	736	PF00917	0.694
DOC_USP7_MATH_1	754	758	PF00917	0.529
DOC_USP7_UBL2_3	515	519	PF12436	0.718
DOC_WW_Pin1_4	226	231	PF00397	0.734
DOC_WW_Pin1_4	29	34	PF00397	0.605
DOC_WW_Pin1_4	307	312	PF00397	0.535
DOC_WW_Pin1_4	326	331	PF00397	0.756
DOC_WW_Pin1_4	41	46	PF00397	0.603
DOC_WW_Pin1_4	589	594	PF00397	0.430
DOC_WW_Pin1_4	620	625	PF00397	0.498
DOC_WW_Pin1_4	64	69	PF00397	0.544
DOC_WW_Pin1_4	657	662	PF00397	0.418
DOC_WW_Pin1_4	695	700	PF00397	0.644
DOC_WW_Pin1_4	713	718	PF00397	0.510
LIG_14-3-3_CanoR_1	10	14	PF00244	0.524
LIG_14-3-3_CanoR_1	198	204	PF00244	0.730
LIG_14-3-3_CanoR_1	213	220	PF00244	0.661
LIG_14-3-3_CanoR_1	223	230	PF00244	0.638
LIG_14-3-3_CanoR_1	51	57	PF00244	0.656
LIG_14-3-3_CanoR_1	583	591	PF00244	0.418
LIG_14-3-3_CanoR_1	669	678	PF00244	0.568
LIG_Actin_WH2_2	540	557	PF00022	0.504
LIG_BIR_III_2	720	724	PF00653	0.628
LIG_BIR_III_4	473	477	PF00653	0.552
LIG_BIR_III_4	726	730	PF00653	0.620
LIG_BRCT_BRCA1_1	264	268	PF00533	0.725
LIG_BRCT_BRCA1_1	353	357	PF00533	0.437
LIG_FHA_1	10	16	PF00498	0.412
LIG_FHA_1	179	185	PF00498	0.698
LIG_FHA_1	486	492	PF00498	0.715
LIG_FHA_1	584	590	PF00498	0.426
LIG_FHA_1	620	626	PF00498	0.407
LIG_FHA_1	663	669	PF00498	0.676
LIG_FHA_2	170	176	PF00498	0.701
LIG_FHA_2	334	340	PF00498	0.586
LIG_FHA_2	577	583	PF00498	0.547
LIG_IBAR_NPY_1	599	601	PF08397	0.368
LIG_Integrin_RGD_1	685	687	PF01839	0.673
LIG_LIR_Apic_2	552	556	PF02991	0.547
LIG_LIR_Apic_2	626	632	PF02991	0.399
LIG_LIR_Gen_1	312	322	PF02991	0.529
LIG_LIR_Gen_1	386	395	PF02991	0.399
LIG_LIR_Gen_1	9	17	PF02991	0.450
LIG_LIR_Nem_3	312	318	PF02991	0.512
LIG_LIR_Nem_3	386	391	PF02991	0.421
LIG_LIR_Nem_3	9	14	PF02991	0.450
LIG_MAD2	616	624	PF02301	0.500
LIG_NRBOX	90	96	PF00104	0.481
LIG_PDZ_Class_2	767	772	PF00595	0.481
LIG_REV1ctd_RIR_1	767	772	PF16727	0.608
LIG_SH2_NCK_1	123	127	PF00017	0.539
LIG_SH2_NCK_1	591	595	PF00017	0.458
LIG_SH2_STAP1	426	430	PF00017	0.527
LIG_SH2_STAP1	585	589	PF00017	0.435
LIG_SH2_STAP1	83	87	PF00017	0.496
LIG_SH2_STAT3	456	459	PF00017	0.522
LIG_SH2_STAT5	23	26	PF00017	0.522
LIG_SH2_STAT5	344	347	PF00017	0.443
LIG_SH2_STAT5	375	378	PF00017	0.376
LIG_SH2_STAT5	456	459	PF00017	0.473
LIG_SH2_STAT5	585	588	PF00017	0.490
LIG_SH2_STAT5	629	632	PF00017	0.426
LIG_SH2_STAT5	752	755	PF00017	0.481
LIG_SH3_3	107	113	PF00018	0.635
LIG_SH3_3	114	120	PF00018	0.592
LIG_SH3_3	401	407	PF00018	0.449
LIG_SH3_3	413	419	PF00018	0.401
LIG_SH3_3	484	490	PF00018	0.545
LIG_SUMO_SIM_anti_2	390	396	PF11976	0.495
LIG_SUMO_SIM_anti_2	413	419	PF11976	0.438
LIG_SUMO_SIM_anti_2	622	629	PF11976	0.459
LIG_SUMO_SIM_par_1	11	16	PF11976	0.409
LIG_SUMO_SIM_par_1	277	282	PF11976	0.630
LIG_WRC_WIRS_1	535	540	PF05994	0.563
LIG_WRPW_2	402	405	PF00400	0.547
MOD_CDK_SPxxK_3	226	233	PF00069	0.566
MOD_CDK_SPxxK_3	657	664	PF00069	0.430
MOD_CK1_1	199	205	PF00069	0.756
MOD_CK1_1	226	232	PF00069	0.618
MOD_CK1_1	242	248	PF00069	0.756
MOD_CK1_1	252	258	PF00069	0.664
MOD_CK1_1	270	276	PF00069	0.761
MOD_CK1_1	329	335	PF00069	0.464
MOD_CK1_1	498	504	PF00069	0.645
MOD_CK1_1	534	540	PF00069	0.666
MOD_CK1_1	543	549	PF00069	0.644
MOD_CK1_1	662	668	PF00069	0.644
MOD_CK1_1	757	763	PF00069	0.492
MOD_CK2_1	151	157	PF00069	0.565
MOD_CK2_1	333	339	PF00069	0.575
MOD_CK2_1	732	738	PF00069	0.703
MOD_Cter_Amidation	17	20	PF01082	0.385
MOD_Cter_Amidation	231	234	PF01082	0.550
MOD_GlcNHglycan	148	151	PF01048	0.595
MOD_GlcNHglycan	198	201	PF01048	0.682
MOD_GlcNHglycan	214	217	PF01048	0.627
MOD_GlcNHglycan	230	233	PF01048	0.656
MOD_GlcNHglycan	241	244	PF01048	0.710
MOD_GlcNHglycan	254	257	PF01048	0.696
MOD_GlcNHglycan	259	262	PF01048	0.707
MOD_GlcNHglycan	33	36	PF01048	0.648
MOD_GlcNHglycan	331	334	PF01048	0.626
MOD_GlcNHglycan	426	429	PF01048	0.597
MOD_GlcNHglycan	468	471	PF01048	0.542
MOD_GlcNHglycan	497	500	PF01048	0.734
MOD_GlcNHglycan	52	55	PF01048	0.635
MOD_GlcNHglycan	58	61	PF01048	0.583
MOD_GlcNHglycan	690	693	PF01048	0.635
MOD_GlcNHglycan	733	737	PF01048	0.722
MOD_GSK3_1	139	146	PF00069	0.500
MOD_GSK3_1	222	229	PF00069	0.623
MOD_GSK3_1	252	259	PF00069	0.704
MOD_GSK3_1	329	336	PF00069	0.497
MOD_GSK3_1	40	47	PF00069	0.717
MOD_GSK3_1	52	59	PF00069	0.678
MOD_GSK3_1	533	540	PF00069	0.691
MOD_GSK3_1	589	596	PF00069	0.467
MOD_GSK3_1	64	71	PF00069	0.515
MOD_N-GLC_1	152	157	PF02516	0.541
MOD_N-GLC_1	620	625	PF02516	0.518
MOD_N-GLC_1	738	743	PF02516	0.597
MOD_NEK2_1	224	229	PF00069	0.784
MOD_NEK2_1	466	471	PF00069	0.475
MOD_NEK2_1	77	82	PF00069	0.421
MOD_NEK2_1	89	94	PF00069	0.347
MOD_PIKK_1	518	524	PF00454	0.532
MOD_PIKK_1	635	641	PF00454	0.562
MOD_PIKK_1	670	676	PF00454	0.604
MOD_PKA_1	676	682	PF00069	0.644
MOD_PKA_2	196	202	PF00069	0.660
MOD_PKA_2	212	218	PF00069	0.580
MOD_PKA_2	222	228	PF00069	0.626
MOD_PKA_2	495	501	PF00069	0.734
MOD_PKA_2	50	56	PF00069	0.669
MOD_PKA_2	576	582	PF00069	0.431
MOD_PKA_2	676	682	PF00069	0.665
MOD_PKA_2	9	15	PF00069	0.546
MOD_PKB_1	237	245	PF00069	0.658
MOD_Plk_1	178	184	PF00069	0.667
MOD_Plk_1	540	546	PF00069	0.588
MOD_Plk_1	650	656	PF00069	0.535
MOD_Plk_1	746	752	PF00069	0.456
MOD_Plk_4	199	205	PF00069	0.670
MOD_Plk_4	352	358	PF00069	0.366
MOD_Plk_4	389	395	PF00069	0.469
MOD_Plk_4	442	448	PF00069	0.428
MOD_Plk_4	52	58	PF00069	0.686
MOD_Plk_4	534	540	PF00069	0.565
MOD_Plk_4	89	95	PF00069	0.317
MOD_ProDKin_1	226	232	PF00069	0.736
MOD_ProDKin_1	29	35	PF00069	0.607
MOD_ProDKin_1	307	313	PF00069	0.535
MOD_ProDKin_1	326	332	PF00069	0.753
MOD_ProDKin_1	41	47	PF00069	0.602
MOD_ProDKin_1	589	595	PF00069	0.430
MOD_ProDKin_1	620	626	PF00069	0.498
MOD_ProDKin_1	64	70	PF00069	0.535
MOD_ProDKin_1	657	663	PF00069	0.421
MOD_ProDKin_1	695	701	PF00069	0.639
MOD_ProDKin_1	713	719	PF00069	0.511
MOD_SUMO_for_1	460	463	PF00179	0.508
MOD_SUMO_rev_2	514	521	PF00179	0.642
MOD_SUMO_rev_2	55	64	PF00179	0.580
TRG_DiLeu_BaEn_1	337	342	PF01217	0.512
TRG_DiLeu_BaEn_1	9	14	PF01217	0.349
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.334
TRG_ENDOCYTIC_2	344	347	PF00928	0.479
TRG_ENDOCYTIC_2	426	429	PF00928	0.443
TRG_ENDOCYTIC_2	647	650	PF00928	0.445
TRG_ER_diArg_1	109	112	PF00400	0.544
TRG_ER_diArg_1	117	119	PF00400	0.468
TRG_ER_diArg_1	233	236	PF00400	0.662
TRG_ER_diArg_1	237	239	PF00400	0.677
TRG_ER_diArg_1	680	682	PF00400	0.668
TRG_ER_diArg_1	683	685	PF00400	0.681
TRG_ER_diArg_1	705	707	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	548	552	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P467	Leptomonas seymouri	56%	90%
A0A0S4IVX1	Bodo saltans	27%	100%
A0A1X0P116	Trypanosomatidae	33%	100%
A0A3Q8IGR5	Leishmania donovani	93%	100%
A4HLB5	Leishmania braziliensis	76%	100%
A4I8U1	Leishmania infantum	93%	100%
D0A4T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B3Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BFB4	Trypanosoma cruzi	39%	100%