LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q4C9_LEIMA
TriTrypDb:
LmjF.33.0760 * , LMJLV39_330014400 * , LMJSD75_330014200 *
Length:
373

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4C9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4C9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 246 250 PF00656 0.678
CLV_C14_Caspase3-7 87 91 PF00656 0.632
CLV_NRD_NRD_1 105 107 PF00675 0.490
CLV_NRD_NRD_1 120 122 PF00675 0.626
CLV_NRD_NRD_1 345 347 PF00675 0.502
CLV_NRD_NRD_1 358 360 PF00675 0.489
CLV_NRD_NRD_1 40 42 PF00675 0.495
CLV_NRD_NRD_1 49 51 PF00675 0.524
CLV_PCSK_KEX2_1 105 107 PF00082 0.553
CLV_PCSK_KEX2_1 115 117 PF00082 0.488
CLV_PCSK_KEX2_1 345 347 PF00082 0.502
CLV_PCSK_KEX2_1 358 360 PF00082 0.489
CLV_PCSK_KEX2_1 39 41 PF00082 0.499
CLV_PCSK_KEX2_1 49 51 PF00082 0.526
CLV_PCSK_PC1ET2_1 115 117 PF00082 0.591
CLV_PCSK_SKI1_1 111 115 PF00082 0.489
CLV_PCSK_SKI1_1 149 153 PF00082 0.469
CLV_PCSK_SKI1_1 224 228 PF00082 0.498
CLV_PCSK_SKI1_1 340 344 PF00082 0.602
DOC_CDC14_PxL_1 225 233 PF14671 0.626
DOC_CYCLIN_yCln2_LP_2 62 68 PF00134 0.577
DOC_MAPK_MEF2A_6 136 144 PF00069 0.488
DOC_PP2B_LxvP_1 272 275 PF13499 0.668
DOC_PP2B_LxvP_1 298 301 PF13499 0.746
DOC_PP2B_LxvP_1 62 65 PF13499 0.657
DOC_USP7_MATH_1 16 20 PF00917 0.583
DOC_USP7_MATH_1 168 172 PF00917 0.619
DOC_USP7_MATH_1 211 215 PF00917 0.695
DOC_USP7_MATH_1 264 268 PF00917 0.545
DOC_USP7_MATH_1 31 35 PF00917 0.494
DOC_USP7_MATH_1 68 72 PF00917 0.614
DOC_USP7_MATH_1 74 78 PF00917 0.626
DOC_USP7_MATH_2 158 164 PF00917 0.624
DOC_USP7_UBL2_3 111 115 PF12436 0.579
DOC_WW_Pin1_4 207 212 PF00397 0.646
DOC_WW_Pin1_4 254 259 PF00397 0.751
DOC_WW_Pin1_4 289 294 PF00397 0.648
DOC_WW_Pin1_4 82 87 PF00397 0.706
LIG_14-3-3_CanoR_1 200 206 PF00244 0.589
LIG_14-3-3_CanoR_1 363 369 PF00244 0.520
LIG_FHA_1 255 261 PF00498 0.695
LIG_FHA_1 303 309 PF00498 0.670
LIG_FHA_1 349 355 PF00498 0.534
LIG_FHA_2 274 280 PF00498 0.550
LIG_FHA_2 301 307 PF00498 0.642
LIG_FHA_2 85 91 PF00498 0.637
LIG_LIR_Gen_1 220 230 PF02991 0.543
LIG_LIR_Nem_3 145 151 PF02991 0.560
LIG_LIR_Nem_3 220 225 PF02991 0.559
LIG_LIR_Nem_3 367 372 PF02991 0.578
LIG_SH2_CRK 148 152 PF00017 0.544
LIG_SH2_STAP1 222 226 PF00017 0.528
LIG_SH2_STAP1 29 33 PF00017 0.591
LIG_SH2_STAT3 14 17 PF00017 0.655
LIG_SH2_STAT3 192 195 PF00017 0.498
LIG_SH2_STAT5 192 195 PF00017 0.498
LIG_SH3_3 3 9 PF00018 0.607
LIG_TRAF2_1 123 126 PF00917 0.630
LIG_UBA3_1 113 122 PF00899 0.467
MOD_CDK_SPK_2 254 259 PF00069 0.541
MOD_CK1_1 19 25 PF00069 0.599
MOD_CK1_1 207 213 PF00069 0.654
MOD_CK1_1 85 91 PF00069 0.611
MOD_CK2_1 180 186 PF00069 0.581
MOD_CK2_1 273 279 PF00069 0.552
MOD_CK2_1 300 306 PF00069 0.644
MOD_CK2_1 31 37 PF00069 0.514
MOD_Cter_Amidation 343 346 PF01082 0.492
MOD_GlcNHglycan 124 130 PF01048 0.677
MOD_GlcNHglycan 14 17 PF01048 0.658
MOD_GlcNHglycan 162 165 PF01048 0.655
MOD_GlcNHglycan 201 204 PF01048 0.562
MOD_GlcNHglycan 21 24 PF01048 0.585
MOD_GlcNHglycan 213 216 PF01048 0.577
MOD_GlcNHglycan 236 239 PF01048 0.664
MOD_GlcNHglycan 262 265 PF01048 0.679
MOD_GlcNHglycan 287 290 PF01048 0.596
MOD_GlcNHglycan 326 329 PF01048 0.476
MOD_GlcNHglycan 33 36 PF01048 0.516
MOD_GlcNHglycan 72 75 PF01048 0.657
MOD_GlcNHglycan 77 80 PF01048 0.605
MOD_GlcNHglycan 82 85 PF01048 0.555
MOD_GlcNHglycan 87 90 PF01048 0.507
MOD_GSK3_1 156 163 PF00069 0.551
MOD_GSK3_1 195 202 PF00069 0.530
MOD_GSK3_1 207 214 PF00069 0.637
MOD_GSK3_1 260 267 PF00069 0.642
MOD_GSK3_1 285 292 PF00069 0.608
MOD_GSK3_1 364 371 PF00069 0.500
MOD_GSK3_1 70 77 PF00069 0.612
MOD_GSK3_1 8 15 PF00069 0.659
MOD_GSK3_1 80 87 PF00069 0.636
MOD_N-GLC_1 234 239 PF02516 0.680
MOD_NEK2_1 196 201 PF00069 0.515
MOD_NEK2_1 243 248 PF00069 0.664
MOD_NEK2_1 284 289 PF00069 0.537
MOD_NEK2_1 336 341 PF00069 0.492
MOD_NEK2_1 368 373 PF00069 0.529
MOD_NEK2_1 94 99 PF00069 0.522
MOD_NEK2_2 100 105 PF00069 0.413
MOD_PKA_2 199 205 PF00069 0.547
MOD_Plk_1 109 115 PF00069 0.523
MOD_Plk_1 68 74 PF00069 0.565
MOD_Plk_2-3 180 186 PF00069 0.552
MOD_Plk_4 109 115 PF00069 0.523
MOD_Plk_4 349 355 PF00069 0.635
MOD_Plk_4 364 370 PF00069 0.406
MOD_ProDKin_1 207 213 PF00069 0.646
MOD_ProDKin_1 254 260 PF00069 0.751
MOD_ProDKin_1 289 295 PF00069 0.648
MOD_ProDKin_1 82 88 PF00069 0.704
TRG_DiLeu_BaEn_1 279 284 PF01217 0.549
TRG_DiLeu_BaEn_2 138 144 PF01217 0.489
TRG_DiLeu_BaLyEn_6 226 231 PF01217 0.650
TRG_ENDOCYTIC_2 148 151 PF00928 0.462
TRG_ENDOCYTIC_2 222 225 PF00928 0.557
TRG_ER_diArg_1 104 106 PF00400 0.543
TRG_ER_diArg_1 39 41 PF00400 0.478
TRG_ER_diArg_1 49 51 PF00400 0.504
TRG_Pf-PMV_PEXEL_1 131 135 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0S4 Leptomonas seymouri 42% 93%
A0A3S7X6J7 Leishmania donovani 83% 100%
A4HLB6 Leishmania braziliensis 64% 94%
A4I8U2 Leishmania infantum 83% 100%
E9B3Q8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS