LeishMANIAdb
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Putative CYC2-like cyclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative CYC2-like cyclin
Gene product:
G1 cyclin CycE4, putative
Species:
Leishmania major
UniProt:
Q4Q4C8_LEIMA
TriTrypDb:
LmjF.33.0770 * , LMJLV39_330014800 * , LMJSD75_330014600 *
Length:
882

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4Q4C8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4C8

Function

Biological processes
Term Name Level Count
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6 6
GO:0001932 regulation of protein phosphorylation 7 6
GO:0019220 regulation of phosphate metabolic process 6 6
GO:0019222 regulation of metabolic process 3 6
GO:0031323 regulation of cellular metabolic process 4 6
GO:0031399 regulation of protein modification process 6 6
GO:0042325 regulation of phosphorylation 7 6
GO:0043549 regulation of kinase activity 5 6
GO:0045859 regulation of protein kinase activity 6 6
GO:0050789 regulation of biological process 2 6
GO:0050790 regulation of catalytic activity 3 6
GO:0050794 regulation of cellular process 3 6
GO:0051171 regulation of nitrogen compound metabolic process 4 6
GO:0051174 regulation of phosphorus metabolic process 5 6
GO:0051246 regulation of protein metabolic process 5 6
GO:0051338 regulation of transferase activity 4 6
GO:0051726 regulation of cell cycle 4 6
GO:0060255 regulation of macromolecule metabolic process 4 6
GO:0065007 biological regulation 1 6
GO:0065009 regulation of molecular function 2 6
GO:0071900 regulation of protein serine/threonine kinase activity 7 6
GO:0080090 regulation of primary metabolic process 4 6
GO:1904029 regulation of cyclin-dependent protein kinase activity 5 6
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0005515 protein binding 2 6
GO:0019899 enzyme binding 3 6
GO:0019900 kinase binding 4 6
GO:0019901 protein kinase binding 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 449 453 PF00656 0.700
CLV_C14_Caspase3-7 835 839 PF00656 0.520
CLV_NRD_NRD_1 304 306 PF00675 0.563
CLV_NRD_NRD_1 474 476 PF00675 0.709
CLV_NRD_NRD_1 496 498 PF00675 0.655
CLV_NRD_NRD_1 579 581 PF00675 0.706
CLV_NRD_NRD_1 60 62 PF00675 0.559
CLV_NRD_NRD_1 610 612 PF00675 0.643
CLV_NRD_NRD_1 692 694 PF00675 0.697
CLV_NRD_NRD_1 710 712 PF00675 0.581
CLV_NRD_NRD_1 755 757 PF00675 0.776
CLV_PCSK_KEX2_1 304 306 PF00082 0.563
CLV_PCSK_KEX2_1 474 476 PF00082 0.709
CLV_PCSK_KEX2_1 495 497 PF00082 0.650
CLV_PCSK_KEX2_1 579 581 PF00082 0.712
CLV_PCSK_KEX2_1 60 62 PF00082 0.559
CLV_PCSK_KEX2_1 609 611 PF00082 0.725
CLV_PCSK_KEX2_1 692 694 PF00082 0.766
CLV_PCSK_KEX2_1 755 757 PF00082 0.776
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.650
CLV_PCSK_PC1ET2_1 609 611 PF00082 0.725
CLV_PCSK_SKI1_1 474 478 PF00082 0.577
CLV_PCSK_SKI1_1 496 500 PF00082 0.661
CLV_PCSK_SKI1_1 540 544 PF00082 0.755
CLV_PCSK_SKI1_1 622 626 PF00082 0.646
DEG_APCC_DBOX_1 270 278 PF00400 0.439
DEG_APCC_DBOX_1 632 640 PF00400 0.711
DEG_SCF_FBW7_1 307 313 PF00400 0.592
DEG_SPOP_SBC_1 777 781 PF00917 0.661
DOC_CKS1_1 307 312 PF01111 0.587
DOC_CKS1_1 747 752 PF01111 0.699
DOC_CYCLIN_RxL_1 490 500 PF00134 0.656
DOC_MAPK_DCC_7 474 483 PF00069 0.636
DOC_MAPK_HePTP_8 471 483 PF00069 0.657
DOC_MAPK_MEF2A_6 199 206 PF00069 0.490
DOC_MAPK_MEF2A_6 474 483 PF00069 0.636
DOC_PP2B_LxvP_1 153 156 PF13499 0.673
DOC_PP2B_LxvP_1 425 428 PF13499 0.667
DOC_PP2B_LxvP_1 489 492 PF13499 0.782
DOC_PP2B_LxvP_1 528 531 PF13499 0.769
DOC_PP2B_LxvP_1 651 654 PF13499 0.768
DOC_PP4_FxxP_1 123 126 PF00568 0.784
DOC_PP4_FxxP_1 477 480 PF00568 0.630
DOC_PP4_FxxP_1 92 95 PF00568 0.604
DOC_USP7_MATH_1 144 148 PF00917 0.537
DOC_USP7_MATH_1 259 263 PF00917 0.439
DOC_USP7_MATH_1 29 33 PF00917 0.718
DOC_USP7_MATH_1 331 335 PF00917 0.742
DOC_USP7_MATH_1 403 407 PF00917 0.670
DOC_USP7_MATH_1 437 441 PF00917 0.713
DOC_USP7_MATH_1 467 471 PF00917 0.539
DOC_USP7_MATH_1 602 606 PF00917 0.723
DOC_USP7_MATH_1 665 669 PF00917 0.613
DOC_USP7_MATH_1 678 682 PF00917 0.685
DOC_USP7_MATH_1 684 688 PF00917 0.730
DOC_USP7_MATH_1 722 726 PF00917 0.712
DOC_USP7_MATH_1 769 773 PF00917 0.699
DOC_USP7_MATH_1 777 781 PF00917 0.636
DOC_USP7_MATH_1 95 99 PF00917 0.726
DOC_WW_Pin1_4 113 118 PF00397 0.559
DOC_WW_Pin1_4 148 153 PF00397 0.750
DOC_WW_Pin1_4 248 253 PF00397 0.236
DOC_WW_Pin1_4 306 311 PF00397 0.585
DOC_WW_Pin1_4 319 324 PF00397 0.542
DOC_WW_Pin1_4 327 332 PF00397 0.613
DOC_WW_Pin1_4 356 361 PF00397 0.763
DOC_WW_Pin1_4 507 512 PF00397 0.720
DOC_WW_Pin1_4 520 525 PF00397 0.597
DOC_WW_Pin1_4 595 600 PF00397 0.645
DOC_WW_Pin1_4 733 738 PF00397 0.640
DOC_WW_Pin1_4 746 751 PF00397 0.679
DOC_WW_Pin1_4 754 759 PF00397 0.692
DOC_WW_Pin1_4 760 765 PF00397 0.616
DOC_WW_Pin1_4 875 880 PF00397 0.712
DOC_WW_Pin1_4 91 96 PF00397 0.623
LIG_14-3-3_CanoR_1 13 19 PF00244 0.647
LIG_14-3-3_CanoR_1 148 152 PF00244 0.688
LIG_14-3-3_CanoR_1 233 241 PF00244 0.439
LIG_14-3-3_CanoR_1 391 401 PF00244 0.543
LIG_14-3-3_CanoR_1 4 10 PF00244 0.676
LIG_14-3-3_CanoR_1 438 447 PF00244 0.719
LIG_14-3-3_CanoR_1 466 472 PF00244 0.609
LIG_14-3-3_CanoR_1 496 502 PF00244 0.716
LIG_14-3-3_CanoR_1 579 586 PF00244 0.675
LIG_14-3-3_CanoR_1 667 673 PF00244 0.669
LIG_14-3-3_CanoR_1 676 684 PF00244 0.703
LIG_14-3-3_CanoR_1 726 735 PF00244 0.632
LIG_14-3-3_CanoR_1 872 882 PF00244 0.721
LIG_14-3-3_CanoR_1 96 103 PF00244 0.734
LIG_Actin_WH2_2 272 289 PF00022 0.439
LIG_BRCT_BRCA1_1 119 123 PF00533 0.662
LIG_BRCT_BRCA1_1 537 541 PF00533 0.691
LIG_BRCT_BRCA1_2 537 543 PF00533 0.694
LIG_Clathr_ClatBox_1 279 283 PF01394 0.439
LIG_Clathr_ClatBox_1 295 299 PF01394 0.313
LIG_deltaCOP1_diTrp_1 292 297 PF00928 0.508
LIG_EVH1_1 700 704 PF00568 0.758
LIG_FHA_1 234 240 PF00498 0.505
LIG_FHA_1 298 304 PF00498 0.494
LIG_FHA_1 311 317 PF00498 0.477
LIG_FHA_1 320 326 PF00498 0.564
LIG_FHA_1 348 354 PF00498 0.632
LIG_FHA_1 357 363 PF00498 0.671
LIG_FHA_1 424 430 PF00498 0.712
LIG_FHA_1 626 632 PF00498 0.659
LIG_FHA_1 668 674 PF00498 0.706
LIG_FHA_1 747 753 PF00498 0.552
LIG_FHA_1 777 783 PF00498 0.681
LIG_FHA_2 268 274 PF00498 0.439
LIG_FXI_DFP_1 279 283 PF00024 0.439
LIG_IRF3_LxIS_1 14 21 PF10401 0.531
LIG_LIR_Apic_2 120 126 PF02991 0.657
LIG_LIR_Apic_2 89 95 PF02991 0.600
LIG_LIR_Gen_1 221 229 PF02991 0.439
LIG_LIR_Gen_1 273 284 PF02991 0.439
LIG_LIR_Gen_1 376 387 PF02991 0.522
LIG_LIR_Gen_1 41 51 PF02991 0.519
LIG_LIR_Gen_1 452 463 PF02991 0.751
LIG_LIR_Nem_3 221 226 PF02991 0.439
LIG_LIR_Nem_3 273 279 PF02991 0.439
LIG_LIR_Nem_3 281 285 PF02991 0.259
LIG_LIR_Nem_3 376 382 PF02991 0.538
LIG_LIR_Nem_3 41 46 PF02991 0.540
LIG_LIR_Nem_3 452 458 PF02991 0.782
LIG_LIR_Nem_3 699 703 PF02991 0.764
LIG_LIR_Nem_3 816 822 PF02991 0.665
LIG_LIR_Nem_3 824 830 PF02991 0.566
LIG_LIR_Nem_3 838 844 PF02991 0.586
LIG_Pex14_2 703 707 PF04695 0.554
LIG_PTAP_UEV_1 736 741 PF05743 0.569
LIG_REV1ctd_RIR_1 539 547 PF16727 0.755
LIG_SH2_CRK 7 11 PF00017 0.651
LIG_SH2_NCK_1 7 11 PF00017 0.651
LIG_SH2_SRC 246 249 PF00017 0.439
LIG_SH2_SRC 800 803 PF00017 0.768
LIG_SH2_STAP1 47 51 PF00017 0.494
LIG_SH2_STAP1 778 782 PF00017 0.746
LIG_SH2_STAP1 841 845 PF00017 0.712
LIG_SH2_STAT5 211 214 PF00017 0.439
LIG_SH2_STAT5 278 281 PF00017 0.439
LIG_SH2_STAT5 314 317 PF00017 0.620
LIG_SH2_STAT5 778 781 PF00017 0.688
LIG_SH2_STAT5 814 817 PF00017 0.604
LIG_SH2_STAT5 822 825 PF00017 0.586
LIG_SH2_STAT5 827 830 PF00017 0.625
LIG_SH2_STAT5 867 870 PF00017 0.714
LIG_SH3_1 744 750 PF00018 0.635
LIG_SH3_2 524 529 PF14604 0.634
LIG_SH3_2 737 742 PF14604 0.607
LIG_SH3_3 115 121 PF00018 0.674
LIG_SH3_3 149 155 PF00018 0.729
LIG_SH3_3 441 447 PF00018 0.616
LIG_SH3_3 476 482 PF00018 0.616
LIG_SH3_3 485 491 PF00018 0.594
LIG_SH3_3 505 511 PF00018 0.485
LIG_SH3_3 521 527 PF00018 0.600
LIG_SH3_3 635 641 PF00018 0.798
LIG_SH3_3 698 704 PF00018 0.762
LIG_SH3_3 734 740 PF00018 0.752
LIG_SH3_3 744 750 PF00018 0.630
LIG_TRAF2_1 168 171 PF00917 0.642
LIG_TRAF2_1 50 53 PF00917 0.536
LIG_WW_2 479 482 PF00397 0.582
LIG_WW_3 435 439 PF00397 0.707
LIG_WW_3 689 693 PF00397 0.773
MOD_CDC14_SPxK_1 526 529 PF00782 0.770
MOD_CDK_SPK_2 117 122 PF00069 0.654
MOD_CDK_SPK_2 248 253 PF00069 0.236
MOD_CDK_SPK_2 327 332 PF00069 0.620
MOD_CDK_SPK_2 91 96 PF00069 0.623
MOD_CDK_SPxK_1 523 529 PF00069 0.762
MOD_CDK_SPxxK_3 754 761 PF00069 0.710
MOD_CK1_1 113 119 PF00069 0.560
MOD_CK1_1 147 153 PF00069 0.641
MOD_CK1_1 267 273 PF00069 0.450
MOD_CK1_1 319 325 PF00069 0.643
MOD_CK1_1 334 340 PF00069 0.564
MOD_CK1_1 377 383 PF00069 0.700
MOD_CK1_1 439 445 PF00069 0.737
MOD_CK1_1 456 462 PF00069 0.714
MOD_CK1_1 510 516 PF00069 0.739
MOD_CK1_1 523 529 PF00069 0.669
MOD_CK1_1 544 550 PF00069 0.758
MOD_CK1_1 578 584 PF00069 0.707
MOD_CK1_1 669 675 PF00069 0.759
MOD_CK1_1 696 702 PF00069 0.629
MOD_CK1_1 725 731 PF00069 0.615
MOD_CK1_1 772 778 PF00069 0.741
MOD_CK1_1 88 94 PF00069 0.587
MOD_CK2_1 267 273 PF00069 0.439
MOD_CK2_1 286 292 PF00069 0.513
MOD_CK2_1 803 809 PF00069 0.754
MOD_CMANNOS 294 297 PF00535 0.496
MOD_GlcNHglycan 165 168 PF01048 0.700
MOD_GlcNHglycan 261 264 PF01048 0.439
MOD_GlcNHglycan 31 34 PF01048 0.739
MOD_GlcNHglycan 317 321 PF01048 0.668
MOD_GlcNHglycan 379 382 PF01048 0.663
MOD_GlcNHglycan 405 408 PF01048 0.637
MOD_GlcNHglycan 439 442 PF01048 0.786
MOD_GlcNHglycan 455 458 PF01048 0.677
MOD_GlcNHglycan 556 559 PF01048 0.773
MOD_GlcNHglycan 590 593 PF01048 0.730
MOD_GlcNHglycan 641 644 PF01048 0.768
MOD_GlcNHglycan 673 676 PF01048 0.728
MOD_GlcNHglycan 686 689 PF01048 0.610
MOD_GlcNHglycan 695 698 PF01048 0.693
MOD_GlcNHglycan 771 774 PF01048 0.680
MOD_GlcNHglycan 97 100 PF01048 0.702
MOD_GSK3_1 106 113 PF00069 0.598
MOD_GSK3_1 14 21 PF00069 0.659
MOD_GSK3_1 144 151 PF00069 0.616
MOD_GSK3_1 159 166 PF00069 0.581
MOD_GSK3_1 218 225 PF00069 0.439
MOD_GSK3_1 25 32 PF00069 0.534
MOD_GSK3_1 306 313 PF00069 0.592
MOD_GSK3_1 315 322 PF00069 0.591
MOD_GSK3_1 327 334 PF00069 0.650
MOD_GSK3_1 356 363 PF00069 0.682
MOD_GSK3_1 370 377 PF00069 0.554
MOD_GSK3_1 392 399 PF00069 0.680
MOD_GSK3_1 403 410 PF00069 0.660
MOD_GSK3_1 436 443 PF00069 0.569
MOD_GSK3_1 5 12 PF00069 0.717
MOD_GSK3_1 584 591 PF00069 0.736
MOD_GSK3_1 665 672 PF00069 0.744
MOD_GSK3_1 722 729 PF00069 0.760
MOD_GSK3_1 768 775 PF00069 0.706
MOD_GSK3_1 84 91 PF00069 0.632
MOD_LATS_1 134 140 PF00433 0.712
MOD_LATS_1 409 415 PF00433 0.503
MOD_N-GLC_2 255 257 PF02516 0.439
MOD_NEK2_1 18 23 PF00069 0.537
MOD_NEK2_1 224 229 PF00069 0.439
MOD_NEK2_1 234 239 PF00069 0.319
MOD_NEK2_1 258 263 PF00069 0.439
MOD_NEK2_1 316 321 PF00069 0.651
MOD_NEK2_1 451 456 PF00069 0.703
MOD_NEK2_1 541 546 PF00069 0.757
MOD_NEK2_1 625 630 PF00069 0.651
MOD_NEK2_1 666 671 PF00069 0.604
MOD_NEK2_1 85 90 PF00069 0.624
MOD_PIKK_1 541 547 PF00454 0.720
MOD_PIKK_1 660 666 PF00454 0.772
MOD_PIKK_1 69 75 PF00454 0.642
MOD_PIKK_1 772 778 PF00454 0.744
MOD_PK_1 497 503 PF00069 0.721
MOD_PK_1 529 535 PF00069 0.758
MOD_PKA_2 147 153 PF00069 0.687
MOD_PKA_2 213 219 PF00069 0.442
MOD_PKA_2 232 238 PF00069 0.490
MOD_PKA_2 25 31 PF00069 0.564
MOD_PKA_2 259 265 PF00069 0.365
MOD_PKA_2 437 443 PF00069 0.660
MOD_PKA_2 465 471 PF00069 0.597
MOD_PKA_2 578 584 PF00069 0.702
MOD_PKA_2 666 672 PF00069 0.722
MOD_PKA_2 678 684 PF00069 0.628
MOD_PKA_2 69 75 PF00069 0.617
MOD_PKA_2 691 697 PF00069 0.696
MOD_PKA_2 725 731 PF00069 0.720
MOD_PKA_2 95 101 PF00069 0.726
MOD_Plk_1 267 273 PF00069 0.494
MOD_Plk_1 370 376 PF00069 0.611
MOD_Plk_1 430 436 PF00069 0.552
MOD_Plk_1 646 652 PF00069 0.781
MOD_Plk_2-3 36 42 PF00069 0.607
MOD_Plk_4 159 165 PF00069 0.557
MOD_Plk_4 176 182 PF00069 0.508
MOD_Plk_4 185 191 PF00069 0.301
MOD_Plk_4 310 316 PF00069 0.603
MOD_Plk_4 374 380 PF00069 0.631
MOD_Plk_4 440 446 PF00069 0.720
MOD_Plk_4 627 633 PF00069 0.667
MOD_ProDKin_1 113 119 PF00069 0.560
MOD_ProDKin_1 148 154 PF00069 0.745
MOD_ProDKin_1 248 254 PF00069 0.236
MOD_ProDKin_1 306 312 PF00069 0.588
MOD_ProDKin_1 319 325 PF00069 0.543
MOD_ProDKin_1 327 333 PF00069 0.609
MOD_ProDKin_1 356 362 PF00069 0.768
MOD_ProDKin_1 507 513 PF00069 0.718
MOD_ProDKin_1 520 526 PF00069 0.599
MOD_ProDKin_1 595 601 PF00069 0.644
MOD_ProDKin_1 733 739 PF00069 0.641
MOD_ProDKin_1 746 752 PF00069 0.681
MOD_ProDKin_1 754 760 PF00069 0.682
MOD_ProDKin_1 875 881 PF00069 0.716
MOD_ProDKin_1 91 97 PF00069 0.638
MOD_SUMO_rev_2 705 713 PF00179 0.666
TRG_DiLeu_BaEn_4 646 652 PF01217 0.781
TRG_ENDOCYTIC_2 700 703 PF00928 0.761
TRG_ER_diArg_1 303 305 PF00400 0.552
TRG_ER_diArg_1 496 498 PF00400 0.708
TRG_ER_diArg_1 59 61 PF00400 0.562
TRG_ER_diArg_1 610 612 PF00400 0.643
TRG_ER_diArg_1 691 693 PF00400 0.690
TRG_ER_diArg_1 870 873 PF00400 0.719
TRG_NES_CRM1_1 275 290 PF08389 0.439
TRG_NES_CRM1_1 293 306 PF08389 0.521
TRG_NLS_MonoExtN_4 492 499 PF00514 0.658
TRG_Pf-PMV_PEXEL_1 136 141 PF00026 0.714

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IDM6 Leishmania donovani 88% 100%
A4HLB8 Leishmania braziliensis 70% 100%
A4I8U4 Leishmania infantum 88% 100%
E9B3R0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS