Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4A8_LEIMA

TriTrypDb:

LmjF.33.0840 , LMJLV39_330015500 , LMJSD75_330015300

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.535
CLV_C14_Caspase3-7	61	65	PF00656	0.542
CLV_NRD_NRD_1	112	114	PF00675	0.718
CLV_NRD_NRD_1	23	25	PF00675	0.666
CLV_NRD_NRD_1	281	283	PF00675	0.604
CLV_NRD_NRD_1	314	316	PF00675	0.512
CLV_NRD_NRD_1	526	528	PF00675	0.578
CLV_NRD_NRD_1	599	601	PF00675	0.642
CLV_NRD_NRD_1	664	666	PF00675	0.525
CLV_NRD_NRD_1	704	706	PF00675	0.657
CLV_NRD_NRD_1	73	75	PF00675	0.622
CLV_PCSK_FUR_1	110	114	PF00082	0.680
CLV_PCSK_FUR_1	279	283	PF00082	0.579
CLV_PCSK_FUR_1	702	706	PF00082	0.645
CLV_PCSK_KEX2_1	112	114	PF00082	0.718
CLV_PCSK_KEX2_1	23	25	PF00082	0.666
CLV_PCSK_KEX2_1	279	281	PF00082	0.600
CLV_PCSK_KEX2_1	526	528	PF00082	0.505
CLV_PCSK_KEX2_1	599	601	PF00082	0.642
CLV_PCSK_KEX2_1	664	666	PF00082	0.526
CLV_PCSK_KEX2_1	704	706	PF00082	0.711
CLV_PCSK_KEX2_1	73	75	PF00082	0.622
CLV_PCSK_SKI1_1	315	319	PF00082	0.455
CLV_PCSK_SKI1_1	392	396	PF00082	0.507
CLV_PCSK_SKI1_1	45	49	PF00082	0.541
CLV_PCSK_SKI1_1	460	464	PF00082	0.373
CLV_PCSK_SKI1_1	600	604	PF00082	0.632
CLV_PCSK_SKI1_1	78	82	PF00082	0.706
CLV_PCSK_SKI1_1	8	12	PF00082	0.669
DEG_Nend_Nbox_1	1	3	PF02207	0.679
DEG_SCF_FBW7_1	552	557	PF00400	0.621
DEG_SCF_TRCP1_1	615	620	PF00400	0.533
DOC_AGCK_PIF_2	484	489	PF00069	0.516
DOC_CKS1_1	132	137	PF01111	0.632
DOC_CKS1_1	51	56	PF01111	0.621
DOC_CYCLIN_RxL_1	309	320	PF00134	0.569
DOC_CYCLIN_RxL_1	454	467	PF00134	0.483
DOC_CYCLIN_RxL_1	596	605	PF00134	0.580
DOC_MAPK_gen_1	236	246	PF00069	0.571
DOC_MAPK_gen_1	492	501	PF00069	0.405
DOC_MAPK_gen_1	680	688	PF00069	0.608
DOC_MAPK_MEF2A_6	495	503	PF00069	0.374
DOC_PP1_RVXF_1	6	12	PF00149	0.613
DOC_PP2B_LxvP_1	18	21	PF13499	0.502
DOC_PP2B_LxvP_1	297	300	PF13499	0.657
DOC_PP2B_LxvP_1	368	371	PF13499	0.489
DOC_PP2B_LxvP_1	86	89	PF13499	0.678
DOC_PP4_FxxP_1	11	14	PF00568	0.666
DOC_USP7_MATH_1	154	158	PF00917	0.594
DOC_USP7_MATH_1	207	211	PF00917	0.483
DOC_USP7_MATH_1	254	258	PF00917	0.699
DOC_USP7_MATH_1	379	383	PF00917	0.521
DOC_USP7_MATH_1	554	558	PF00917	0.707
DOC_USP7_MATH_1	89	93	PF00917	0.671
DOC_WW_Pin1_4	119	124	PF00397	0.676
DOC_WW_Pin1_4	131	136	PF00397	0.507
DOC_WW_Pin1_4	50	55	PF00397	0.752
DOC_WW_Pin1_4	550	555	PF00397	0.726
DOC_WW_Pin1_4	649	654	PF00397	0.659
LIG_14-3-3_CanoR_1	227	232	PF00244	0.546
LIG_14-3-3_CanoR_1	309	313	PF00244	0.539
LIG_14-3-3_CanoR_1	4	11	PF00244	0.618
LIG_14-3-3_CanoR_1	512	520	PF00244	0.519
LIG_14-3-3_CanoR_1	547	553	PF00244	0.640
LIG_14-3-3_CanoR_1	564	571	PF00244	0.478
LIG_BRCT_BRCA1_1	138	142	PF00533	0.577
LIG_CtBP_PxDLS_1	15	19	PF00389	0.483
LIG_eIF4E_1	312	318	PF01652	0.579
LIG_eIF4E_1	452	458	PF01652	0.305
LIG_eIF4E_1	497	503	PF01652	0.434
LIG_FHA_1	437	443	PF00498	0.495
LIG_FHA_1	509	515	PF00498	0.494
LIG_FHA_1	530	536	PF00498	0.517
LIG_FHA_1	553	559	PF00498	0.594
LIG_FHA_2	261	267	PF00498	0.781
LIG_FHA_2	268	274	PF00498	0.544
LIG_FHA_2	289	295	PF00498	0.666
LIG_FHA_2	328	334	PF00498	0.433
LIG_FHA_2	511	517	PF00498	0.607
LIG_FHA_2	551	557	PF00498	0.683
LIG_LIR_Gen_1	201	211	PF02991	0.513
LIG_LIR_Gen_1	500	509	PF02991	0.408
LIG_LIR_Nem_3	131	136	PF02991	0.688
LIG_LIR_Nem_3	201	206	PF02991	0.522
LIG_LIR_Nem_3	414	418	PF02991	0.613
LIG_LIR_Nem_3	500	506	PF02991	0.378
LIG_LYPXL_yS_3	452	455	PF13949	0.506
LIG_NRBOX	340	346	PF00104	0.412
LIG_PCNA_PIPBox_1	387	396	PF02747	0.362
LIG_PTB_Apo_2	211	218	PF02174	0.619
LIG_PTB_Phospho_1	211	217	PF10480	0.621
LIG_RPA_C_Fungi	660	672	PF08784	0.595
LIG_SH2_CRK	325	329	PF00017	0.469
LIG_SH2_STAP1	364	368	PF00017	0.472
LIG_SH2_STAP1	489	493	PF00017	0.511
LIG_SH2_STAT3	102	105	PF00017	0.715
LIG_SH2_STAT3	69	72	PF00017	0.513
LIG_SH2_STAT5	102	105	PF00017	0.634
LIG_SH2_STAT5	352	355	PF00017	0.457
LIG_SH2_STAT5	359	362	PF00017	0.411
LIG_SH2_STAT5	430	433	PF00017	0.325
LIG_SH3_1	447	453	PF00018	0.537
LIG_SH3_3	302	308	PF00018	0.619
LIG_SH3_3	397	403	PF00018	0.362
LIG_SH3_3	447	453	PF00018	0.414
LIG_SH3_3	462	468	PF00018	0.356
LIG_SH3_3	48	54	PF00018	0.754
LIG_SH3_3	79	85	PF00018	0.595
LIG_TRAF2_1	263	266	PF00917	0.770
LIG_TRAF2_1	270	273	PF00917	0.663
LIG_TRAF2_1	300	303	PF00917	0.648
LIG_TRAF2_1	580	583	PF00917	0.673
LIG_TYR_ITIM	323	328	PF00017	0.462
LIG_WRC_WIRS_1	412	417	PF05994	0.504
MOD_CDK_SPxxK_3	131	138	PF00069	0.597
MOD_CDK_SPxxK_3	649	656	PF00069	0.657
MOD_CK1_1	131	137	PF00069	0.649
MOD_CK1_1	36	42	PF00069	0.726
MOD_CK1_1	382	388	PF00069	0.461
MOD_CK1_1	426	432	PF00069	0.505
MOD_CK1_1	56	62	PF00069	0.610
MOD_CK1_1	649	655	PF00069	0.705
MOD_CK2_1	172	178	PF00069	0.553
MOD_CK2_1	260	266	PF00069	0.694
MOD_CK2_1	267	273	PF00069	0.701
MOD_CK2_1	288	294	PF00069	0.667
MOD_CK2_1	327	333	PF00069	0.440
MOD_CK2_1	510	516	PF00069	0.614
MOD_CK2_1	550	556	PF00069	0.668
MOD_GlcNHglycan	174	177	PF01048	0.672
MOD_GlcNHglycan	209	212	PF01048	0.574
MOD_GlcNHglycan	252	255	PF01048	0.709
MOD_GlcNHglycan	256	259	PF01048	0.705
MOD_GlcNHglycan	415	418	PF01048	0.431
MOD_GlcNHglycan	58	61	PF01048	0.612
MOD_GlcNHglycan	615	618	PF01048	0.732
MOD_GlcNHglycan	659	662	PF01048	0.667
MOD_GSK3_1	124	131	PF00069	0.680
MOD_GSK3_1	250	257	PF00069	0.666
MOD_GSK3_1	29	36	PF00069	0.789
MOD_GSK3_1	378	385	PF00069	0.481
MOD_GSK3_1	422	429	PF00069	0.549
MOD_GSK3_1	46	53	PF00069	0.682
MOD_GSK3_1	508	515	PF00069	0.565
MOD_GSK3_1	548	555	PF00069	0.713
MOD_GSK3_1	613	620	PF00069	0.638
MOD_GSK3_1	96	103	PF00069	0.652
MOD_N-GLC_1	536	541	PF02516	0.491
MOD_N-GLC_2	404	406	PF02516	0.371
MOD_NEK2_1	212	217	PF00069	0.586
MOD_NEK2_1	250	255	PF00069	0.629
MOD_NEK2_1	288	293	PF00069	0.672
MOD_NEK2_1	3	8	PF00069	0.588
MOD_NEK2_1	301	306	PF00069	0.623
MOD_NEK2_1	378	383	PF00069	0.536
MOD_NEK2_1	411	416	PF00069	0.498
MOD_NEK2_1	436	441	PF00069	0.363
MOD_NEK2_1	536	541	PF00069	0.652
MOD_NEK2_1	679	684	PF00069	0.585
MOD_PIKK_1	101	107	PF00454	0.559
MOD_PIKK_1	33	39	PF00454	0.657
MOD_PIKK_1	537	543	PF00454	0.522
MOD_PKA_2	154	160	PF00069	0.585
MOD_PKA_2	165	171	PF00069	0.538
MOD_PKA_2	3	9	PF00069	0.602
MOD_PKA_2	308	314	PF00069	0.539
MOD_PKA_2	491	497	PF00069	0.448
MOD_PKB_1	225	233	PF00069	0.540
MOD_PKB_1	527	535	PF00069	0.711
MOD_PKB_1	611	619	PF00069	0.648
MOD_Plk_1	124	130	PF00069	0.591
MOD_Plk_1	332	338	PF00069	0.439
MOD_Plk_2-3	333	339	PF00069	0.446
MOD_Plk_4	128	134	PF00069	0.705
MOD_Plk_4	212	218	PF00069	0.536
MOD_Plk_4	426	432	PF00069	0.409
MOD_Plk_4	437	443	PF00069	0.314
MOD_ProDKin_1	119	125	PF00069	0.679
MOD_ProDKin_1	131	137	PF00069	0.505
MOD_ProDKin_1	50	56	PF00069	0.752
MOD_ProDKin_1	550	556	PF00069	0.726
MOD_ProDKin_1	649	655	PF00069	0.659
TRG_DiLeu_BaEn_1	340	345	PF01217	0.412
TRG_DiLeu_BaLyEn_6	691	696	PF01217	0.730
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.527
TRG_ENDOCYTIC_2	143	146	PF00928	0.614
TRG_ENDOCYTIC_2	213	216	PF00928	0.503
TRG_ENDOCYTIC_2	325	328	PF00928	0.397
TRG_ENDOCYTIC_2	391	394	PF00928	0.485
TRG_ENDOCYTIC_2	430	433	PF00928	0.325
TRG_ENDOCYTIC_2	452	455	PF00928	0.506
TRG_ER_diArg_1	109	112	PF00400	0.708
TRG_ER_diArg_1	23	25	PF00400	0.694
TRG_ER_diArg_1	279	282	PF00400	0.601
TRG_ER_diArg_1	526	529	PF00400	0.567
TRG_ER_diArg_1	598	600	PF00400	0.651
TRG_ER_diArg_1	611	614	PF00400	0.774
TRG_ER_diArg_1	664	666	PF00400	0.526
TRG_ER_diArg_1	683	686	PF00400	0.593
TRG_ER_diArg_1	704	706	PF00400	0.733
TRG_ER_diArg_1	73	76	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	512	516	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E3	Leptomonas seymouri	60%	99%
A0A1X0P130	Trypanosomatidae	50%	100%
A0A3Q8IK12	Leishmania donovani	93%	100%
A0A422P2K6	Trypanosoma rangeli	51%	100%
A4HLD8	Leishmania braziliensis	81%	100%
A4I8U7	Leishmania infantum	93%	100%
D0A4U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B3R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AZV9	Trypanosoma cruzi	49%	100%