Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q4A7_LEIMA

TriTrypDb:

LmjF.33.0850 , LMJLV39_330015600 , LMJSD75_330015400

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.780
CLV_C14_Caspase3-7	353	357	PF00656	0.637
CLV_C14_Caspase3-7	533	537	PF00656	0.756
CLV_NRD_NRD_1	108	110	PF00675	0.769
CLV_NRD_NRD_1	119	121	PF00675	0.657
CLV_NRD_NRD_1	270	272	PF00675	0.544
CLV_NRD_NRD_1	49	51	PF00675	0.507
CLV_NRD_NRD_1	734	736	PF00675	0.676
CLV_NRD_NRD_1	743	745	PF00675	0.785
CLV_NRD_NRD_1	792	794	PF00675	0.626
CLV_PCSK_KEX2_1	108	110	PF00082	0.719
CLV_PCSK_KEX2_1	119	121	PF00082	0.609
CLV_PCSK_KEX2_1	270	272	PF00082	0.539
CLV_PCSK_KEX2_1	49	51	PF00082	0.507
CLV_PCSK_KEX2_1	743	745	PF00082	0.811
CLV_PCSK_KEX2_1	792	794	PF00082	0.626
CLV_PCSK_SKI1_1	393	397	PF00082	0.695
CLV_PCSK_SKI1_1	769	773	PF00082	0.715
CLV_PCSK_SKI1_1	780	784	PF00082	0.569
CLV_PCSK_SKI1_1	796	800	PF00082	0.494
DEG_APCC_DBOX_1	768	776	PF00400	0.716
DEG_MDM2_SWIB_1	593	600	PF02201	0.459
DEG_SCF_FBW7_1	248	255	PF00400	0.549
DEG_SCF_FBW7_1	857	863	PF00400	0.781
DEG_SCF_SKP2-CKS1_1	514	521	PF00560	0.575
DEG_SPOP_SBC_1	506	510	PF00917	0.706
DEG_SPOP_SBC_1	540	544	PF00917	0.688
DOC_CDC14_PxL_1	101	109	PF14671	0.732
DOC_CKS1_1	249	254	PF01111	0.500
DOC_CKS1_1	784	789	PF01111	0.758
DOC_CKS1_1	857	862	PF01111	0.688
DOC_CYCLIN_yCln2_LP_2	655	661	PF00134	0.737
DOC_CYCLIN_yCln2_LP_2	784	790	PF00134	0.713
DOC_MAPK_gen_1	267	277	PF00069	0.510
DOC_MAPK_gen_1	371	380	PF00069	0.760
DOC_MAPK_HePTP_8	163	175	PF00069	0.523
DOC_MAPK_MEF2A_6	166	175	PF00069	0.528
DOC_MAPK_MEF2A_6	94	101	PF00069	0.539
DOC_PP1_RVXF_1	199	206	PF00149	0.510
DOC_PP2B_LxvP_1	175	178	PF13499	0.478
DOC_PP2B_LxvP_1	448	451	PF13499	0.760
DOC_PP2B_LxvP_1	655	658	PF13499	0.731
DOC_PP2B_LxvP_1	855	858	PF13499	0.705
DOC_PP4_FxxP_1	125	128	PF00568	0.727
DOC_PP4_FxxP_1	205	208	PF00568	0.504
DOC_PP4_FxxP_1	681	684	PF00568	0.657
DOC_USP7_MATH_1	121	125	PF00917	0.737
DOC_USP7_MATH_1	20	24	PF00917	0.652
DOC_USP7_MATH_1	218	222	PF00917	0.689
DOC_USP7_MATH_1	347	351	PF00917	0.733
DOC_USP7_MATH_1	397	401	PF00917	0.704
DOC_USP7_MATH_1	57	61	PF00917	0.616
DOC_USP7_MATH_1	662	666	PF00917	0.718
DOC_USP7_MATH_1	756	760	PF00917	0.715
DOC_WW_Pin1_4	113	118	PF00397	0.579
DOC_WW_Pin1_4	248	253	PF00397	0.494
DOC_WW_Pin1_4	330	335	PF00397	0.774
DOC_WW_Pin1_4	393	398	PF00397	0.698
DOC_WW_Pin1_4	419	424	PF00397	0.714
DOC_WW_Pin1_4	437	442	PF00397	0.606
DOC_WW_Pin1_4	502	507	PF00397	0.752
DOC_WW_Pin1_4	515	520	PF00397	0.551
DOC_WW_Pin1_4	562	567	PF00397	0.790
DOC_WW_Pin1_4	752	757	PF00397	0.683
DOC_WW_Pin1_4	78	83	PF00397	0.722
DOC_WW_Pin1_4	783	788	PF00397	0.766
DOC_WW_Pin1_4	835	840	PF00397	0.657
DOC_WW_Pin1_4	846	851	PF00397	0.697
DOC_WW_Pin1_4	856	861	PF00397	0.676
LIG_14-3-3_CanoR_1	108	118	PF00244	0.691
LIG_14-3-3_CanoR_1	120	126	PF00244	0.663
LIG_14-3-3_CanoR_1	180	188	PF00244	0.464
LIG_14-3-3_CanoR_1	201	206	PF00244	0.510
LIG_14-3-3_CanoR_1	473	481	PF00244	0.723
LIG_14-3-3_CanoR_1	5	12	PF00244	0.670
LIG_14-3-3_CanoR_1	559	566	PF00244	0.686
LIG_14-3-3_CanoR_1	584	588	PF00244	0.782
LIG_Actin_WH2_2	660	678	PF00022	0.718
LIG_APCC_ABBA_1	93	98	PF00400	0.523
LIG_BIR_III_2	449	453	PF00653	0.723
LIG_BIR_III_4	42	46	PF00653	0.508
LIG_BRCT_BRCA1_1	183	187	PF00533	0.455
LIG_BRCT_BRCA1_1	201	205	PF00533	0.513
LIG_BRCT_BRCA1_1	794	798	PF00533	0.729
LIG_CSL_BTD_1	698	701	PF09270	0.615
LIG_deltaCOP1_diTrp_1	198	205	PF00928	0.609
LIG_deltaCOP1_diTrp_1	409	415	PF00928	0.584
LIG_FHA_1	177	183	PF00498	0.476
LIG_FHA_1	208	214	PF00498	0.660
LIG_FHA_1	857	863	PF00498	0.679
LIG_FHA_2	351	357	PF00498	0.818
LIG_FHA_2	394	400	PF00498	0.703
LIG_FHA_2	489	495	PF00498	0.748
LIG_FHA_2	541	547	PF00498	0.665
LIG_LIR_Apic_2	124	128	PF02991	0.731
LIG_LIR_Apic_2	202	208	PF02991	0.501
LIG_LIR_Apic_2	611	617	PF02991	0.601
LIG_LIR_Gen_1	240	249	PF02991	0.542
LIG_LIR_Gen_1	48	58	PF02991	0.581
LIG_LIR_Gen_1	594	604	PF02991	0.564
LIG_LIR_Nem_3	198	203	PF02991	0.513
LIG_LIR_Nem_3	240	246	PF02991	0.549
LIG_LIR_Nem_3	251	256	PF02991	0.529
LIG_LIR_Nem_3	48	54	PF02991	0.682
LIG_LIR_Nem_3	589	593	PF02991	0.668
LIG_LIR_Nem_3	594	600	PF02991	0.562
LIG_LIR_Nem_3	868	874	PF02991	0.641
LIG_NRBOX	190	196	PF00104	0.472
LIG_NRBOX	526	532	PF00104	0.790
LIG_Pex14_1	627	631	PF04695	0.615
LIG_Pex14_2	593	597	PF04695	0.601
LIG_SH2_CRK	660	664	PF00017	0.726
LIG_SH2_SRC	51	54	PF00017	0.598
LIG_SH2_STAP1	214	218	PF00017	0.750
LIG_SH2_STAP1	281	285	PF00017	0.565
LIG_SH2_STAP1	51	55	PF00017	0.562
LIG_SH2_STAT3	61	64	PF00017	0.600
LIG_SH2_STAT3	632	635	PF00017	0.554
LIG_SH2_STAT5	315	318	PF00017	0.790
LIG_SH2_STAT5	557	560	PF00017	0.740
LIG_SH2_STAT5	61	64	PF00017	0.576
LIG_SH3_1	331	337	PF00018	0.717
LIG_SH3_3	222	228	PF00018	0.679
LIG_SH3_3	26	32	PF00018	0.652
LIG_SH3_3	331	337	PF00018	0.738
LIG_SH3_3	51	57	PF00018	0.696
LIG_SH3_3	79	85	PF00018	0.720
LIG_SH3_3	854	860	PF00018	0.697
LIG_SH3_3	9	15	PF00018	0.530
LIG_SUMO_SIM_anti_2	295	303	PF11976	0.673
LIG_TRAF2_1	307	310	PF00917	0.774
LIG_TRAF2_1	325	328	PF00917	0.516
LIG_TRAF2_1	491	494	PF00917	0.739
LIG_TRAF2_1	689	692	PF00917	0.653
LIG_TRAF2_1	829	832	PF00917	0.738
LIG_TRAF2_1	863	866	PF00917	0.669
LIG_TRAF2_2	337	342	PF00917	0.731
LIG_TRFH_1	783	787	PF08558	0.668
LIG_WRC_WIRS_1	291	296	PF05994	0.557
LIG_WW_3	116	120	PF00397	0.620
LIG_WW_3	470	474	PF00397	0.566
MOD_CDC14_SPxK_1	116	119	PF00782	0.579
MOD_CDK_SPxK_1	113	119	PF00069	0.580
MOD_CDK_SPxK_1	515	521	PF00069	0.572
MOD_CDK_SPxxK_3	113	120	PF00069	0.581
MOD_CDK_SPxxK_3	562	569	PF00069	0.746
MOD_CDK_SPxxK_3	846	853	PF00069	0.574
MOD_CK1_1	199	205	PF00069	0.536
MOD_CK1_1	229	235	PF00069	0.697
MOD_CK1_1	350	356	PF00069	0.690
MOD_CK1_1	437	443	PF00069	0.679
MOD_CK1_1	500	506	PF00069	0.831
MOD_CK1_1	562	568	PF00069	0.793
MOD_CK1_1	66	72	PF00069	0.706
MOD_CK1_1	78	84	PF00069	0.629
MOD_CK1_1	838	844	PF00069	0.584
MOD_CK2_1	322	328	PF00069	0.798
MOD_CK2_1	393	399	PF00069	0.701
MOD_CK2_1	488	494	PF00069	0.743
MOD_CK2_1	507	513	PF00069	0.670
MOD_CK2_1	686	692	PF00069	0.729
MOD_CK2_1	744	750	PF00069	0.802
MOD_CK2_1	860	866	PF00069	0.684
MOD_CMANNOS	412	415	PF00535	0.559
MOD_DYRK1A_RPxSP_1	393	397	PF00069	0.695
MOD_DYRK1A_RPxSP_1	835	839	PF00069	0.653
MOD_GlcNHglycan	144	147	PF01048	0.542
MOD_GlcNHglycan	216	219	PF01048	0.785
MOD_GlcNHglycan	22	25	PF01048	0.523
MOD_GlcNHglycan	228	231	PF01048	0.788
MOD_GlcNHglycan	324	327	PF01048	0.739
MOD_GlcNHglycan	349	352	PF01048	0.624
MOD_GlcNHglycan	392	396	PF01048	0.781
MOD_GlcNHglycan	423	426	PF01048	0.742
MOD_GlcNHglycan	437	440	PF01048	0.608
MOD_GlcNHglycan	499	502	PF01048	0.831
MOD_GlcNHglycan	509	512	PF01048	0.670
MOD_GlcNHglycan	593	596	PF01048	0.626
MOD_GlcNHglycan	65	68	PF01048	0.723
MOD_GlcNHglycan	664	667	PF01048	0.708
MOD_GlcNHglycan	7	10	PF01048	0.682
MOD_GlcNHglycan	77	80	PF01048	0.627
MOD_GSK3_1	108	115	PF00069	0.729
MOD_GSK3_1	16	23	PF00069	0.785
MOD_GSK3_1	214	221	PF00069	0.770
MOD_GSK3_1	248	255	PF00069	0.588
MOD_GSK3_1	290	297	PF00069	0.534
MOD_GSK3_1	318	325	PF00069	0.713
MOD_GSK3_1	346	353	PF00069	0.779
MOD_GSK3_1	393	400	PF00069	0.685
MOD_GSK3_1	415	422	PF00069	0.634
MOD_GSK3_1	430	437	PF00069	0.698
MOD_GSK3_1	493	500	PF00069	0.746
MOD_GSK3_1	502	509	PF00069	0.709
MOD_GSK3_1	535	542	PF00069	0.706
MOD_GSK3_1	555	562	PF00069	0.680
MOD_GSK3_1	591	598	PF00069	0.577
MOD_GSK3_1	608	615	PF00069	0.522
MOD_GSK3_1	691	698	PF00069	0.669
MOD_GSK3_1	752	759	PF00069	0.683
MOD_GSK3_1	856	863	PF00069	0.713
MOD_N-GLC_1	418	423	PF02516	0.686
MOD_N-GLC_1	815	820	PF02516	0.591
MOD_N-GLC_1	822	827	PF02516	0.615
MOD_NEK2_1	142	147	PF00069	0.522
MOD_NEK2_1	181	186	PF00069	0.463
MOD_NEK2_1	262	267	PF00069	0.561
MOD_NEK2_1	27	32	PF00069	0.549
MOD_NEK2_1	294	299	PF00069	0.522
MOD_NEK2_1	434	439	PF00069	0.709
MOD_NEK2_1	507	512	PF00069	0.609
MOD_NEK2_1	612	617	PF00069	0.636
MOD_NEK2_1	7	12	PF00069	0.744
MOD_NEK2_1	708	713	PF00069	0.623
MOD_NEK2_1	815	820	PF00069	0.645
MOD_NEK2_1	867	872	PF00069	0.644
MOD_PIKK_1	181	187	PF00454	0.460
MOD_PIKK_1	472	478	PF00454	0.751
MOD_PIKK_1	631	637	PF00454	0.748
MOD_PIKK_1	7	13	PF00454	0.749
MOD_PK_1	744	750	PF00069	0.802
MOD_PKA_1	108	114	PF00069	0.776
MOD_PKA_1	792	798	PF00069	0.617
MOD_PKA_2	108	114	PF00069	0.730
MOD_PKA_2	121	127	PF00069	0.731
MOD_PKA_2	196	202	PF00069	0.426
MOD_PKA_2	472	478	PF00069	0.700
MOD_PKA_2	555	561	PF00069	0.760
MOD_PKA_2	583	589	PF00069	0.781
MOD_PKA_2	792	798	PF00069	0.617
MOD_PKB_1	389	397	PF00069	0.815
MOD_Plk_1	294	300	PF00069	0.524
MOD_Plk_1	442	448	PF00069	0.812
MOD_Plk_1	459	465	PF00069	0.585
MOD_Plk_1	722	728	PF00069	0.643
MOD_Plk_1	815	821	PF00069	0.646
MOD_Plk_1	822	828	PF00069	0.562
MOD_Plk_1	830	836	PF00069	0.488
MOD_Plk_1	867	873	PF00069	0.669
MOD_Plk_1	97	103	PF00069	0.566
MOD_Plk_4	121	127	PF00069	0.770
MOD_Plk_4	294	300	PF00069	0.543
MOD_Plk_4	430	436	PF00069	0.591
MOD_Plk_4	459	465	PF00069	0.711
MOD_Plk_4	57	63	PF00069	0.597
MOD_Plk_4	608	614	PF00069	0.599
MOD_Plk_4	695	701	PF00069	0.619
MOD_ProDKin_1	113	119	PF00069	0.580
MOD_ProDKin_1	248	254	PF00069	0.498
MOD_ProDKin_1	330	336	PF00069	0.771
MOD_ProDKin_1	393	399	PF00069	0.701
MOD_ProDKin_1	419	425	PF00069	0.714
MOD_ProDKin_1	437	443	PF00069	0.606
MOD_ProDKin_1	502	508	PF00069	0.753
MOD_ProDKin_1	515	521	PF00069	0.550
MOD_ProDKin_1	562	568	PF00069	0.790
MOD_ProDKin_1	752	758	PF00069	0.684
MOD_ProDKin_1	78	84	PF00069	0.715
MOD_ProDKin_1	783	789	PF00069	0.762
MOD_ProDKin_1	835	841	PF00069	0.660
MOD_ProDKin_1	846	852	PF00069	0.697
MOD_ProDKin_1	856	862	PF00069	0.671
MOD_SUMO_for_1	520	523	PF00179	0.798
MOD_SUMO_rev_2	791	798	PF00179	0.616
TRG_DiLeu_BaEn_1	526	531	PF01217	0.678
TRG_DiLeu_BaEn_1	670	675	PF01217	0.600
TRG_DiLeu_BaEn_1	723	728	PF01217	0.716
TRG_DiLeu_BaEn_4	682	688	PF01217	0.713
TRG_DiLeu_BaEn_4	691	697	PF01217	0.653
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.513
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.479
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.676
TRG_DiLeu_BaLyEn_6	850	855	PF01217	0.693
TRG_DiLeu_LyEn_5	526	531	PF01217	0.751
TRG_DiLeu_LyEn_5	670	675	PF01217	0.600
TRG_DiLeu_LyEn_5	682	687	PF01217	0.672
TRG_DiLeu_LyEn_5	723	728	PF01217	0.716
TRG_ENDOCYTIC_2	51	54	PF00928	0.655
TRG_ENDOCYTIC_2	660	663	PF00928	0.730
TRG_ER_diArg_1	107	109	PF00400	0.715
TRG_ER_diArg_1	118	120	PF00400	0.683
TRG_ER_diArg_1	269	271	PF00400	0.530
TRG_ER_diArg_1	477	480	PF00400	0.676
TRG_ER_diArg_1	49	51	PF00400	0.507
TRG_ER_diArg_1	724	727	PF00400	0.614
TRG_ER_diArg_1	773	776	PF00400	0.640
TRG_NES_CRM1_1	186	198	PF08389	0.575
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.662
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.790
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH80	Leptomonas seymouri	40%	88%
A0A3S7X6H4	Leishmania donovani	87%	96%
A4HLD9	Leishmania braziliensis	66%	96%
A4I8U8	Leishmania infantum	87%	96%
E9B3R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	94%