LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q4A6_LEIMA
TriTrypDb:
LmjF.33.0860 , LMJLV39_330015700 , LMJSD75_330015500 *
Length:
451

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 5, no: 12
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q4A6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4A6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 235 237 PF00675 0.337
CLV_NRD_NRD_1 26 28 PF00675 0.367
CLV_NRD_NRD_1 49 51 PF00675 0.635
CLV_NRD_NRD_1 90 92 PF00675 0.344
CLV_PCSK_FUR_1 24 28 PF00082 0.344
CLV_PCSK_KEX2_1 235 237 PF00082 0.333
CLV_PCSK_KEX2_1 26 28 PF00082 0.367
CLV_PCSK_KEX2_1 424 426 PF00082 0.639
CLV_PCSK_PC1ET2_1 424 426 PF00082 0.670
CLV_PCSK_SKI1_1 185 189 PF00082 0.295
CLV_PCSK_SKI1_1 235 239 PF00082 0.296
CLV_PCSK_SKI1_1 413 417 PF00082 0.568
CLV_PCSK_SKI1_1 94 98 PF00082 0.350
DEG_SPOP_SBC_1 129 133 PF00917 0.540
DOC_CYCLIN_RxL_1 56 64 PF00134 0.309
DOC_CYCLIN_yCln2_LP_2 311 317 PF00134 0.550
DOC_MAPK_gen_1 24 34 PF00069 0.425
DOC_MAPK_gen_1 350 358 PF00069 0.462
DOC_MAPK_MEF2A_6 223 231 PF00069 0.550
DOC_MAPK_MEF2A_6 24 32 PF00069 0.399
DOC_MAPK_MEF2A_6 351 360 PF00069 0.470
DOC_MAPK_NFAT4_5 27 35 PF00069 0.467
DOC_PP1_RVXF_1 192 198 PF00149 0.550
DOC_PP2B_LxvP_1 117 120 PF13499 0.550
DOC_PP2B_LxvP_1 311 314 PF13499 0.512
DOC_USP7_MATH_1 128 132 PF00917 0.529
DOC_USP7_MATH_1 136 140 PF00917 0.492
DOC_USP7_MATH_1 145 149 PF00917 0.604
DOC_USP7_MATH_1 172 176 PF00917 0.550
DOC_USP7_MATH_1 251 255 PF00917 0.531
DOC_USP7_MATH_1 354 358 PF00917 0.271
DOC_USP7_MATH_1 419 423 PF00917 0.412
DOC_USP7_MATH_1 436 440 PF00917 0.438
DOC_USP7_UBL2_3 420 424 PF12436 0.348
DOC_WW_Pin1_4 138 143 PF00397 0.446
DOC_WW_Pin1_4 147 152 PF00397 0.425
DOC_WW_Pin1_4 237 242 PF00397 0.468
DOC_WW_Pin1_4 249 254 PF00397 0.541
LIG_14-3-3_CanoR_1 12 18 PF00244 0.544
LIG_14-3-3_CanoR_1 27 33 PF00244 0.418
LIG_14-3-3_CanoR_1 50 60 PF00244 0.460
LIG_14-3-3_CanoR_1 94 99 PF00244 0.516
LIG_Actin_WH2_2 220 237 PF00022 0.550
LIG_Actin_WH2_2 261 276 PF00022 0.399
LIG_Actin_WH2_2 35 52 PF00022 0.434
LIG_APCC_ABBA_1 279 284 PF00400 0.539
LIG_APCC_ABBA_1 393 398 PF00400 0.457
LIG_APCC_ABBAyCdc20_2 156 162 PF00400 0.440
LIG_APCC_ABBAyCdc20_2 386 392 PF00400 0.409
LIG_BRCT_BRCA1_1 356 360 PF00533 0.271
LIG_BRCT_BRCA1_1 422 426 PF00533 0.340
LIG_deltaCOP1_diTrp_1 302 310 PF00928 0.506
LIG_FHA_1 124 130 PF00498 0.598
LIG_FHA_1 182 188 PF00498 0.500
LIG_FHA_1 270 276 PF00498 0.550
LIG_FHA_1 29 35 PF00498 0.471
LIG_FHA_2 335 341 PF00498 0.550
LIG_FHA_2 83 89 PF00498 0.525
LIG_GBD_Chelix_1 362 370 PF00786 0.281
LIG_LIR_Apic_2 202 207 PF02991 0.550
LIG_LIR_Gen_1 101 106 PF02991 0.487
LIG_LIR_Gen_1 111 120 PF02991 0.487
LIG_LIR_Gen_1 170 181 PF02991 0.508
LIG_LIR_Gen_1 254 264 PF02991 0.440
LIG_LIR_Gen_1 309 318 PF02991 0.550
LIG_LIR_Gen_1 357 368 PF02991 0.399
LIG_LIR_Nem_3 101 105 PF02991 0.487
LIG_LIR_Nem_3 111 117 PF02991 0.487
LIG_LIR_Nem_3 170 176 PF02991 0.508
LIG_LIR_Nem_3 302 307 PF02991 0.496
LIG_LIR_Nem_3 309 313 PF02991 0.496
LIG_LIR_Nem_3 357 363 PF02991 0.399
LIG_LIR_Nem_3 375 381 PF02991 0.374
LIG_LIR_Nem_3 384 388 PF02991 0.358
LIG_NRBOX 365 371 PF00104 0.425
LIG_SH2_STAT5 388 391 PF00017 0.390
LIG_SH2_STAT5 84 87 PF00017 0.494
LIG_SH3_3 152 158 PF00018 0.519
LIG_SH3_3 162 168 PF00018 0.478
LIG_SH3_3 186 192 PF00018 0.512
LIG_SH3_3 310 316 PF00018 0.544
LIG_SH3_3 323 329 PF00018 0.550
LIG_SH3_3 33 39 PF00018 0.242
LIG_SH3_CIN85_PxpxPR_1 151 156 PF14604 0.440
LIG_SUMO_SIM_anti_2 183 191 PF11976 0.489
LIG_SUMO_SIM_par_1 183 191 PF11976 0.489
LIG_SUMO_SIM_par_1 367 373 PF11976 0.481
LIG_SUMO_SIM_par_1 59 64 PF11976 0.372
LIG_SxIP_EBH_1 59 72 PF03271 0.312
LIG_UBA3_1 443 451 PF00899 0.382
LIG_Vh1_VBS_1 2 20 PF01044 0.537
LIG_WRC_WIRS_1 371 376 PF05994 0.500
LIG_WW_3 56 60 PF00397 0.412
MOD_CDK_SPK_2 151 156 PF00069 0.454
MOD_CK1_1 252 258 PF00069 0.547
MOD_CK1_1 336 342 PF00069 0.522
MOD_CK1_1 372 378 PF00069 0.413
MOD_CK1_1 408 414 PF00069 0.482
MOD_CK2_1 370 376 PF00069 0.535
MOD_GlcNHglycan 132 135 PF01048 0.332
MOD_GlcNHglycan 151 154 PF01048 0.345
MOD_GlcNHglycan 214 217 PF01048 0.240
MOD_GlcNHglycan 275 278 PF01048 0.306
MOD_GlcNHglycan 351 354 PF01048 0.412
MOD_GlcNHglycan 406 410 PF01048 0.697
MOD_GlcNHglycan 440 443 PF01048 0.622
MOD_GlcNHglycan 53 56 PF01048 0.578
MOD_GSK3_1 143 150 PF00069 0.607
MOD_GSK3_1 264 271 PF00069 0.566
MOD_GSK3_1 82 89 PF00069 0.506
MOD_N-GLC_1 219 224 PF02516 0.268
MOD_N-GLC_1 334 339 PF02516 0.355
MOD_NEK2_1 160 165 PF00069 0.581
MOD_NEK2_1 268 273 PF00069 0.422
MOD_NEK2_1 28 33 PF00069 0.441
MOD_NEK2_1 349 354 PF00069 0.589
MOD_NEK2_1 369 374 PF00069 0.353
MOD_NEK2_1 61 66 PF00069 0.363
MOD_NEK2_1 86 91 PF00069 0.495
MOD_PKA_1 420 426 PF00069 0.428
MOD_PKA_2 13 19 PF00069 0.540
MOD_PKA_2 181 187 PF00069 0.550
MOD_PKA_2 273 279 PF00069 0.610
MOD_Plk_1 108 114 PF00069 0.557
MOD_Plk_1 405 411 PF00069 0.427
MOD_Plk_1 86 92 PF00069 0.528
MOD_Plk_4 13 19 PF00069 0.533
MOD_Plk_4 160 166 PF00069 0.501
MOD_Plk_4 172 178 PF00069 0.462
MOD_Plk_4 354 360 PF00069 0.373
MOD_Plk_4 61 67 PF00069 0.363
MOD_ProDKin_1 138 144 PF00069 0.446
MOD_ProDKin_1 147 153 PF00069 0.425
MOD_ProDKin_1 237 243 PF00069 0.468
MOD_ProDKin_1 249 255 PF00069 0.541
MOD_SUMO_rev_2 372 381 PF00179 0.566
TRG_DiLeu_BaEn_4 190 196 PF01217 0.550
TRG_DiLeu_BaLyEn_6 291 296 PF01217 0.456
TRG_DiLeu_BaLyEn_6 56 61 PF01217 0.278
TRG_DiLeu_BaLyEn_6 91 96 PF01217 0.482
TRG_ENDOCYTIC_2 378 381 PF00928 0.408
TRG_ER_diArg_1 11 14 PF00400 0.546
TRG_ER_diArg_1 23 26 PF00400 0.544
TRG_ER_diArg_1 234 236 PF00400 0.537
TRG_ER_diArg_1 248 251 PF00400 0.468
TRG_ER_diArg_1 298 301 PF00400 0.440

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P304 Leptomonas seymouri 56% 100%
A0A0N0P958 Leptomonas seymouri 26% 100%
A0A0S4JG88 Bodo saltans 31% 100%
A0A1X0P126 Trypanosomatidae 33% 100%
A0A3Q8IGS5 Leishmania donovani 93% 100%
A0A3S7X466 Leishmania donovani 26% 100%
A4HJ26 Leishmania braziliensis 26% 100%
A4HLE0 Leishmania braziliensis 80% 100%
A4I6E8 Leishmania infantum 26% 100%
A4I8U9 Leishmania infantum 93% 100%
D0A4U6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E8NHM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B1J8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B3R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q6L5 Leishmania major 26% 95%
V5BPD5 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS