Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4A5_LEIMA

TriTrypDb:

LmjF.33.0870 , LMJLV39_330015800 , LMJSD75_330015600

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4A5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.505
CLV_C14_Caspase3-7	365	369	PF00656	0.618
CLV_C14_Caspase3-7	69	73	PF00656	0.677
CLV_MEL_PAP_1	259	265	PF00089	0.525
CLV_NRD_NRD_1	19	21	PF00675	0.444
CLV_NRD_NRD_1	281	283	PF00675	0.529
CLV_NRD_NRD_1	331	333	PF00675	0.693
CLV_NRD_NRD_1	40	42	PF00675	0.447
CLV_NRD_NRD_1	433	435	PF00675	0.402
CLV_NRD_NRD_1	474	476	PF00675	0.390
CLV_PCSK_KEX2_1	119	121	PF00082	0.649
CLV_PCSK_KEX2_1	261	263	PF00082	0.553
CLV_PCSK_KEX2_1	281	283	PF00082	0.585
CLV_PCSK_KEX2_1	325	327	PF00082	0.649
CLV_PCSK_KEX2_1	39	41	PF00082	0.446
CLV_PCSK_KEX2_1	474	476	PF00082	0.390
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.649
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.532
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.603
CLV_PCSK_SKI1_1	206	210	PF00082	0.405
CLV_PCSK_SKI1_1	21	25	PF00082	0.369
CLV_PCSK_SKI1_1	255	259	PF00082	0.553
CLV_PCSK_SKI1_1	310	314	PF00082	0.557
CLV_PCSK_SKI1_1	333	337	PF00082	0.604
CLV_PCSK_SKI1_1	345	349	PF00082	0.598
CLV_PCSK_SKI1_1	47	51	PF00082	0.504
CLV_PCSK_SKI1_1	59	63	PF00082	0.519
CLV_PCSK_SKI1_1	9	13	PF00082	0.637
DEG_APCC_DBOX_1	205	213	PF00400	0.401
DOC_CKS1_1	97	102	PF01111	0.679
DOC_CYCLIN_RxL_1	203	210	PF00134	0.416
DOC_CYCLIN_RxL_1	474	485	PF00134	0.462
DOC_MAPK_MEF2A_6	198	205	PF00069	0.326
DOC_MAPK_MEF2A_6	226	234	PF00069	0.467
DOC_PP1_RVXF_1	477	484	PF00149	0.492
DOC_PP2B_LxvP_1	220	223	PF13499	0.390
DOC_PP4_FxxP_1	336	339	PF00568	0.611
DOC_USP7_MATH_1	105	109	PF00917	0.542
DOC_USP7_MATH_1	11	15	PF00917	0.629
DOC_USP7_MATH_1	150	154	PF00917	0.615
DOC_USP7_MATH_1	179	183	PF00917	0.658
DOC_USP7_MATH_1	286	290	PF00917	0.483
DOC_USP7_MATH_1	398	402	PF00917	0.600
DOC_USP7_MATH_1	405	409	PF00917	0.621
DOC_USP7_MATH_1	86	90	PF00917	0.611
DOC_USP7_UBL2_3	321	325	PF12436	0.627
DOC_USP7_UBL2_3	56	60	PF12436	0.690
DOC_WW_Pin1_4	125	130	PF00397	0.734
DOC_WW_Pin1_4	403	408	PF00397	0.546
DOC_WW_Pin1_4	59	64	PF00397	0.518
DOC_WW_Pin1_4	79	84	PF00397	0.643
DOC_WW_Pin1_4	93	98	PF00397	0.550
LIG_Actin_WH2_2	266	283	PF00022	0.461
LIG_APCC_ABBA_1	232	237	PF00400	0.501
LIG_APCC_ABBAyCdc20_2	479	485	PF00400	0.391
LIG_EH_1	2	6	PF12763	0.530
LIG_FHA_1	167	173	PF00498	0.713
LIG_FHA_1	445	451	PF00498	0.369
LIG_FHA_2	153	159	PF00498	0.697
LIG_FHA_2	213	219	PF00498	0.521
LIG_FHA_2	265	271	PF00498	0.620
LIG_FHA_2	312	318	PF00498	0.536
LIG_FHA_2	368	374	PF00498	0.621
LIG_FHA_2	409	415	PF00498	0.511
LIG_LIR_Apic_2	389	395	PF02991	0.556
LIG_LIR_Apic_2	424	430	PF02991	0.473
LIG_LIR_Nem_3	357	363	PF02991	0.681
LIG_MYND_3	429	433	PF01753	0.405
LIG_Rb_pABgroove_1	437	445	PF01858	0.489
LIG_SH2_CRK	245	249	PF00017	0.369
LIG_SH2_CRK	392	396	PF00017	0.654
LIG_SH2_CRK	443	447	PF00017	0.489
LIG_SH2_GRB2like	484	487	PF00017	0.390
LIG_SH2_NCK_1	443	447	PF00017	0.489
LIG_SH2_SRC	384	387	PF00017	0.569
LIG_SH2_SRC	443	446	PF00017	0.549
LIG_SH2_SRC	484	487	PF00017	0.390
LIG_SH2_STAP1	101	105	PF00017	0.568
LIG_SH2_STAP1	245	249	PF00017	0.369
LIG_SH2_STAT5	252	255	PF00017	0.402
LIG_SH2_STAT5	360	363	PF00017	0.616
LIG_SH3_3	182	188	PF00018	0.550
LIG_SH3_3	374	380	PF00018	0.685
LIG_SH3_3	80	86	PF00018	0.587
LIG_SH3_3	94	100	PF00018	0.607
LIG_SH3_5	380	384	PF00018	0.578
LIG_SUMO_SIM_anti_2	447	452	PF11976	0.378
LIG_TRAF2_1	108	111	PF00917	0.719
LIG_TRAF2_1	189	192	PF00917	0.506
LIG_TRAF2_1	35	38	PF00917	0.545
MOD_CK1_1	164	170	PF00069	0.649
MOD_CK1_1	264	270	PF00069	0.537
MOD_CK1_1	285	291	PF00069	0.506
MOD_CK1_1	311	317	PF00069	0.564
MOD_CK1_1	401	407	PF00069	0.705
MOD_CK1_1	408	414	PF00069	0.636
MOD_CK1_1	91	97	PF00069	0.629
MOD_CK2_1	105	111	PF00069	0.700
MOD_CK2_1	152	158	PF00069	0.697
MOD_CK2_1	193	199	PF00069	0.526
MOD_CK2_1	264	270	PF00069	0.627
MOD_CK2_1	32	38	PF00069	0.548
MOD_CK2_1	408	414	PF00069	0.531
MOD_CK2_1	464	470	PF00069	0.515
MOD_Cter_Amidation	259	262	PF01082	0.508
MOD_GlcNHglycan	158	161	PF01048	0.551
MOD_GlcNHglycan	181	184	PF01048	0.607
MOD_GlcNHglycan	284	287	PF01048	0.595
MOD_GlcNHglycan	288	291	PF01048	0.572
MOD_GlcNHglycan	310	313	PF01048	0.625
MOD_GlcNHglycan	336	339	PF01048	0.614
MOD_GlcNHglycan	414	418	PF01048	0.730
MOD_GlcNHglycan	90	93	PF01048	0.716
MOD_GSK3_1	101	108	PF00069	0.728
MOD_GSK3_1	152	159	PF00069	0.641
MOD_GSK3_1	179	186	PF00069	0.633
MOD_GSK3_1	282	289	PF00069	0.510
MOD_GSK3_1	304	311	PF00069	0.754
MOD_GSK3_1	397	404	PF00069	0.638
MOD_GSK3_1	74	81	PF00069	0.705
MOD_GSK3_1	84	91	PF00069	0.566
MOD_N-GLC_1	341	346	PF02516	0.548
MOD_N-GLC_1	401	406	PF02516	0.635
MOD_NEK2_1	251	256	PF00069	0.424
MOD_NEK2_1	340	345	PF00069	0.550
MOD_NEK2_1	397	402	PF00069	0.543
MOD_PIKK_1	150	156	PF00454	0.648
MOD_PIKK_1	161	167	PF00454	0.624
MOD_PIKK_1	22	28	PF00454	0.521
MOD_PIKK_1	453	459	PF00454	0.410
MOD_PK_1	435	441	PF00069	0.377
MOD_PKA_1	261	267	PF00069	0.542
MOD_PKA_1	453	459	PF00069	0.410
MOD_PKA_2	261	267	PF00069	0.550
MOD_PKA_2	398	404	PF00069	0.662
MOD_Plk_1	112	118	PF00069	0.687
MOD_Plk_1	193	199	PF00069	0.528
MOD_Plk_1	275	281	PF00069	0.575
MOD_Plk_1	367	373	PF00069	0.728
MOD_Plk_1	423	429	PF00069	0.500
MOD_Plk_4	243	249	PF00069	0.494
MOD_Plk_4	264	270	PF00069	0.667
MOD_Plk_4	275	281	PF00069	0.448
MOD_Plk_4	435	441	PF00069	0.389
MOD_ProDKin_1	125	131	PF00069	0.735
MOD_ProDKin_1	403	409	PF00069	0.548
MOD_ProDKin_1	59	65	PF00069	0.519
MOD_ProDKin_1	79	85	PF00069	0.644
MOD_ProDKin_1	93	99	PF00069	0.552
MOD_SUMO_for_1	324	327	PF00179	0.663
MOD_SUMO_for_1	361	364	PF00179	0.585
MOD_SUMO_rev_2	428	437	PF00179	0.371
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.516
TRG_ENDOCYTIC_2	245	248	PF00928	0.372
TRG_ENDOCYTIC_2	443	446	PF00928	0.549
TRG_ER_diArg_1	280	282	PF00400	0.525
TRG_ER_diArg_1	39	41	PF00400	0.542
TRG_ER_diArg_1	473	475	PF00400	0.392
TRG_NLS_Bipartite_1	40	62	PF00514	0.604
TRG_NLS_MonoExtC_3	118	124	PF00514	0.743
TRG_NLS_MonoExtN_4	56	62	PF00514	0.687
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA2	Leptomonas seymouri	43%	100%
A0A3Q8ITX1	Leishmania donovani	93%	100%
A4HLE1	Leishmania braziliensis	74%	100%
A4I8V0	Leishmania infantum	93%	100%
E9B3R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%