Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4A4_LEIMA

TriTrypDb:

LmjF.33.0880 , LMJLV39_330015900 , LMJSD75_330015700

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q4A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.652
CLV_NRD_NRD_1	215	217	PF00675	0.602
CLV_NRD_NRD_1	45	47	PF00675	0.591
CLV_NRD_NRD_1	79	81	PF00675	0.596
CLV_PCSK_FUR_1	92	96	PF00082	0.554
CLV_PCSK_KEX2_1	215	217	PF00082	0.602
CLV_PCSK_KEX2_1	257	259	PF00082	0.482
CLV_PCSK_KEX2_1	45	47	PF00082	0.594
CLV_PCSK_KEX2_1	79	81	PF00082	0.585
CLV_PCSK_KEX2_1	94	96	PF00082	0.508
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.388
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.547
CLV_PCSK_SKI1_1	197	201	PF00082	0.606
CLV_PCSK_SKI1_1	79	83	PF00082	0.551
DEG_APCC_DBOX_1	214	222	PF00400	0.427
DEG_SPOP_SBC_1	167	171	PF00917	0.421
DEG_SPOP_SBC_1	286	290	PF00917	0.654
DOC_CDC14_PxL_1	245	253	PF14671	0.325
DOC_CYCLIN_RxL_1	194	204	PF00134	0.342
DOC_CYCLIN_RxL_1	74	87	PF00134	0.381
DOC_MAPK_gen_1	121	131	PF00069	0.466
DOC_MAPK_gen_1	215	221	PF00069	0.400
DOC_MAPK_gen_1	76	84	PF00069	0.437
DOC_PP4_FxxP_1	119	122	PF00568	0.448
DOC_USP7_MATH_1	166	170	PF00917	0.448
DOC_USP7_MATH_1	287	291	PF00917	0.685
DOC_WW_Pin1_4	1	6	PF00397	0.728
DOC_WW_Pin1_4	104	109	PF00397	0.424
LIG_14-3-3_CanoR_1	258	262	PF00244	0.661
LIG_14-3-3_CanoR_1	316	326	PF00244	0.711
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_eIF4E_1	12	18	PF01652	0.484
LIG_eIF4E_1	331	337	PF01652	0.369
LIG_eIF4E_1	72	78	PF01652	0.342
LIG_FHA_1	2	8	PF00498	0.634
LIG_FHA_1	22	28	PF00498	0.369
LIG_FHA_1	66	72	PF00498	0.386
LIG_GBD_Chelix_1	328	336	PF00786	0.325
LIG_LIR_Apic_2	117	122	PF02991	0.445
LIG_LIR_Gen_1	228	239	PF02991	0.432
LIG_LIR_Gen_1	292	301	PF02991	0.653
LIG_LIR_Nem_3	228	234	PF02991	0.436
LIG_LIR_Nem_3	24	29	PF02991	0.356
LIG_LIR_Nem_3	292	297	PF02991	0.654
LIG_Pex14_2	115	119	PF04695	0.467
LIG_SH2_CRK	190	194	PF00017	0.305
LIG_SH2_GRB2like	12	15	PF00017	0.683
LIG_SH2_NCK_1	190	194	PF00017	0.305
LIG_SH2_SRC	247	250	PF00017	0.325
LIG_SH2_SRC	335	338	PF00017	0.369
LIG_SH2_SRC	72	75	PF00017	0.361
LIG_SH2_STAP1	29	33	PF00017	0.369
LIG_SH2_STAP1	98	102	PF00017	0.430
LIG_SH2_STAT5	12	15	PF00017	0.691
LIG_SH2_STAT5	151	154	PF00017	0.444
LIG_SH2_STAT5	198	201	PF00017	0.410
LIG_SH2_STAT5	231	234	PF00017	0.444
LIG_SH2_STAT5	247	250	PF00017	0.192
LIG_SH2_STAT5	331	334	PF00017	0.304
LIG_SH2_STAT5	335	338	PF00017	0.304
LIG_SH3_3	102	108	PF00018	0.417
LIG_SH3_3	233	239	PF00018	0.316
LIG_SH3_3	249	255	PF00018	0.193
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.357
LIG_TRAF2_2	309	314	PF00917	0.641
LIG_TYR_ITIM	188	193	PF00017	0.368
LIG_TYR_ITIM	229	234	PF00017	0.502
MOD_CK1_1	114	120	PF00069	0.549
MOD_CK1_1	154	160	PF00069	0.617
MOD_CK1_1	289	295	PF00069	0.561
MOD_CK2_1	264	270	PF00069	0.601
MOD_CK2_1	277	283	PF00069	0.516
MOD_CK2_1	46	52	PF00069	0.375
MOD_DYRK1A_RPxSP_1	104	108	PF00069	0.520
MOD_GlcNHglycan	100	103	PF01048	0.582
MOD_GlcNHglycan	158	161	PF01048	0.673
MOD_GlcNHglycan	182	185	PF01048	0.458
MOD_GlcNHglycan	203	206	PF01048	0.402
MOD_GlcNHglycan	289	292	PF01048	0.679
MOD_GlcNHglycan	294	297	PF01048	0.570
MOD_GlcNHglycan	299	302	PF01048	0.550
MOD_GlcNHglycan	48	51	PF01048	0.332
MOD_GSK3_1	151	158	PF00069	0.633
MOD_GSK3_1	221	228	PF00069	0.471
MOD_GSK3_1	257	264	PF00069	0.676
MOD_GSK3_1	285	292	PF00069	0.549
MOD_GSK3_1	295	302	PF00069	0.571
MOD_GSK3_1	318	325	PF00069	0.466
MOD_NEK2_1	152	157	PF00069	0.645
MOD_NEK2_1	180	185	PF00069	0.616
MOD_NEK2_1	225	230	PF00069	0.504
MOD_NEK2_1	261	266	PF00069	0.700
MOD_NEK2_2	192	197	PF00069	0.424
MOD_NEK2_2	29	34	PF00069	0.304
MOD_PKA_1	257	263	PF00069	0.556
MOD_PKA_2	120	126	PF00069	0.569
MOD_PKA_2	257	263	PF00069	0.556
MOD_Plk_1	225	231	PF00069	0.480
MOD_Plk_1	35	41	PF00069	0.535
MOD_Plk_1	72	78	PF00069	0.449
MOD_Plk_4	22	28	PF00069	0.363
MOD_Plk_4	257	263	PF00069	0.567
MOD_Plk_4	29	35	PF00069	0.427
MOD_Plk_4	322	328	PF00069	0.304
MOD_ProDKin_1	1	7	PF00069	0.658
MOD_ProDKin_1	104	110	PF00069	0.522
TRG_DiLeu_BaEn_1	73	78	PF01217	0.509
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.498
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.328
TRG_ENDOCYTIC_2	190	193	PF00928	0.359
TRG_ENDOCYTIC_2	231	234	PF00928	0.505
TRG_ENDOCYTIC_2	335	338	PF00928	0.322
TRG_ER_diArg_1	78	80	PF00400	0.471
TRG_ER_diArg_1	82	85	PF00400	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6H6	Leishmania donovani	84%	100%
A0A422P2P2	Trypanosoma rangeli	23%	100%
A4HLE2	Leishmania braziliensis	60%	100%
A4I8V1	Leishmania infantum	84%	100%
E9B3S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%