Dnaj chaperone-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dnaj chaperone-like protein

Species:

Leishmania major

UniProt:

Q4Q4A2_LEIMA

TriTrypDb:

LmjF.33.0900 , LMJLV39_330016100 , LMJSD75_330015900

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q4A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.351
CLV_NRD_NRD_1	225	227	PF00675	0.517
CLV_NRD_NRD_1	24	26	PF00675	0.455
CLV_NRD_NRD_1	541	543	PF00675	0.491
CLV_NRD_NRD_1	56	58	PF00675	0.453
CLV_PCSK_KEX2_1	12	14	PF00082	0.505
CLV_PCSK_KEX2_1	20	22	PF00082	0.446
CLV_PCSK_KEX2_1	225	227	PF00082	0.517
CLV_PCSK_KEX2_1	24	26	PF00082	0.440
CLV_PCSK_KEX2_1	541	543	PF00082	0.493
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.505
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.446
CLV_PCSK_SKI1_1	12	16	PF00082	0.581
CLV_PCSK_SKI1_1	225	229	PF00082	0.536
CLV_PCSK_SKI1_1	25	29	PF00082	0.449
CLV_PCSK_SKI1_1	294	298	PF00082	0.531
DEG_APCC_DBOX_1	293	301	PF00400	0.331
DOC_ANK_TNKS_1	540	547	PF00023	0.679
DOC_CDC14_PxL_1	138	146	PF14671	0.304
DOC_MAPK_gen_1	20	28	PF00069	0.269
DOC_MAPK_MEF2A_6	459	468	PF00069	0.325
DOC_MAPK_NFAT4_5	459	467	PF00069	0.325
DOC_PP1_RVXF_1	241	247	PF00149	0.308
DOC_USP7_MATH_1	340	344	PF00917	0.550
DOC_USP7_MATH_1	396	400	PF00917	0.515
DOC_WW_Pin1_4	12	17	PF00397	0.284
DOC_WW_Pin1_4	127	132	PF00397	0.501
DOC_WW_Pin1_4	151	156	PF00397	0.510
DOC_WW_Pin1_4	562	567	PF00397	0.690
LIG_14-3-3_CanoR_1	121	126	PF00244	0.546
LIG_14-3-3_CanoR_1	189	198	PF00244	0.553
LIG_BRCT_BRCA1_1	129	133	PF00533	0.469
LIG_Clathr_ClatBox_1	132	136	PF01394	0.347
LIG_FHA_1	172	178	PF00498	0.304
LIG_FHA_1	191	197	PF00498	0.541
LIG_FHA_1	286	292	PF00498	0.304
LIG_FHA_1	433	439	PF00498	0.302
LIG_FHA_1	550	556	PF00498	0.615
LIG_FHA_1	86	92	PF00498	0.360
LIG_FHA_2	46	52	PF00498	0.274
LIG_FHA_2	563	569	PF00498	0.701
LIG_GBD_Chelix_1	422	430	PF00786	0.336
LIG_IBAR_NPY_1	405	407	PF08397	0.442
LIG_LIR_Gen_1	122	133	PF02991	0.514
LIG_LIR_Gen_1	209	218	PF02991	0.304
LIG_LIR_Gen_1	274	284	PF02991	0.261
LIG_LIR_Gen_1	3	10	PF02991	0.269
LIG_LIR_Nem_3	122	128	PF02991	0.522
LIG_LIR_Nem_3	209	214	PF02991	0.304
LIG_LIR_Nem_3	272	278	PF02991	0.308
LIG_LIR_Nem_3	3	8	PF02991	0.269
LIG_LIR_Nem_3	413	417	PF02991	0.222
LIG_LIR_Nem_3	450	454	PF02991	0.469
LIG_LIR_Nem_3	48	53	PF02991	0.269
LIG_LIR_Nem_3	60	65	PF02991	0.268
LIG_NRBOX	163	169	PF00104	0.365
LIG_NRBOX	426	432	PF00104	0.325
LIG_Pex14_2	111	115	PF04695	0.477
LIG_Pex14_2	129	133	PF04695	0.395
LIG_SH2_CRK	23	27	PF00017	0.269
LIG_SH2_CRK	241	245	PF00017	0.316
LIG_SH2_CRK	451	455	PF00017	0.469
LIG_SH2_GRB2like	445	448	PF00017	0.568
LIG_SH2_NCK_1	241	245	PF00017	0.316
LIG_SH2_PTP2	125	128	PF00017	0.497
LIG_SH2_STAT3	407	410	PF00017	0.441
LIG_SH2_STAT5	125	128	PF00017	0.553
LIG_SH2_STAT5	195	198	PF00017	0.568
LIG_SH2_STAT5	206	209	PF00017	0.265
LIG_SH2_STAT5	241	244	PF00017	0.300
LIG_SH2_STAT5	275	278	PF00017	0.304
LIG_SH2_STAT5	298	301	PF00017	0.343
LIG_SH2_STAT5	303	306	PF00017	0.379
LIG_SH3_3	125	131	PF00018	0.505
LIG_SH3_3	136	142	PF00018	0.304
LIG_SH3_3	519	525	PF00018	0.706
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.325
LIG_SUMO_SIM_par_1	268	274	PF11976	0.422
LIG_SUMO_SIM_par_1	452	458	PF11976	0.308
LIG_SUMO_SIM_par_1	87	94	PF11976	0.348
LIG_TYR_ITIM	273	278	PF00017	0.325
LIG_UBA3_1	227	231	PF00899	0.386
LIG_Vh1_VBS_1	421	439	PF01044	0.230
LIG_WRC_WIRS_1	112	117	PF05994	0.325
LIG_WRC_WIRS_1	82	87	PF05994	0.542
MOD_CDK_SPK_2	562	567	PF00069	0.648
MOD_CDK_SPxxK_3	562	569	PF00069	0.627
MOD_CK1_1	154	160	PF00069	0.476
MOD_CK1_1	220	226	PF00069	0.441
MOD_CK1_1	302	308	PF00069	0.470
MOD_CK1_1	549	555	PF00069	0.632
MOD_CK2_1	45	51	PF00069	0.310
MOD_CK2_1	555	561	PF00069	0.629
MOD_CK2_1	562	568	PF00069	0.577
MOD_CMANNOS	198	201	PF00535	0.373
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.283
MOD_GlcNHglycan	398	401	PF01048	0.653
MOD_GlcNHglycan	505	509	PF01048	0.576
MOD_GlcNHglycan	548	551	PF01048	0.716
MOD_GlcNHglycan	557	560	PF01048	0.598
MOD_GSK3_1	216	223	PF00069	0.355
MOD_GSK3_1	298	305	PF00069	0.419
MOD_GSK3_1	340	347	PF00069	0.600
MOD_GSK3_1	443	450	PF00069	0.413
MOD_GSK3_1	551	558	PF00069	0.633
MOD_GSK3_1	570	577	PF00069	0.590
MOD_GSK3_1	81	88	PF00069	0.497
MOD_GSK3_1	91	98	PF00069	0.268
MOD_N-GLC_1	239	244	PF02516	0.389
MOD_N-GLC_1	359	364	PF02516	0.565
MOD_N-GLC_2	517	519	PF02516	0.536
MOD_NEK2_1	111	116	PF00069	0.284
MOD_NEK2_1	285	290	PF00069	0.369
MOD_NEK2_1	431	436	PF00069	0.287
MOD_NEK2_1	455	460	PF00069	0.437
MOD_NEK2_1	85	90	PF00069	0.490
MOD_NEK2_2	206	211	PF00069	0.325
MOD_PKA_2	344	350	PF00069	0.524
MOD_PKA_2	574	580	PF00069	0.684
MOD_Plk_1	239	245	PF00069	0.419
MOD_Plk_1	571	577	PF00069	0.685
MOD_Plk_4	111	117	PF00069	0.287
MOD_Plk_4	160	166	PF00069	0.369
MOD_Plk_4	171	177	PF00069	0.254
MOD_Plk_4	285	291	PF00069	0.304
MOD_Plk_4	299	305	PF00069	0.428
MOD_Plk_4	422	428	PF00069	0.353
MOD_ProDKin_1	12	18	PF00069	0.325
MOD_ProDKin_1	127	133	PF00069	0.349
MOD_ProDKin_1	151	157	PF00069	0.506
MOD_ProDKin_1	562	568	PF00069	0.611
MOD_SUMO_rev_2	224	233	PF00179	0.421
TRG_ENDOCYTIC_2	125	128	PF00928	0.362
TRG_ENDOCYTIC_2	23	26	PF00928	0.304
TRG_ENDOCYTIC_2	241	244	PF00928	0.367
TRG_ENDOCYTIC_2	275	278	PF00928	0.304
TRG_ENDOCYTIC_2	451	454	PF00928	0.304
TRG_ENDOCYTIC_2	5	8	PF00928	0.304
TRG_ENDOCYTIC_2	50	53	PF00928	0.304
TRG_ER_diArg_1	225	227	PF00400	0.374
TRG_ER_diArg_1	23	25	PF00400	0.284
TRG_ER_diArg_1	540	542	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P4	Leptomonas seymouri	51%	100%
A0A3S7X6M9	Leishmania donovani	91%	100%
A4HLE4	Leishmania braziliensis	66%	100%
A4I8V3	Leishmania infantum	91%	100%
E9B3S2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%