Skp1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SKP1-like protein

Species:

Leishmania major

UniProt:

Q4Q493_LEIMA

TriTrypDb:

LmjF.33.0980 , LMJLV39_330017100 , LMJSD75_330016900

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q493

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q493

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006511	ubiquitin-dependent protein catabolic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	7
GO:0019941	modification-dependent protein catabolic process	6	7
GO:0030163	protein catabolic process	4	2
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	7
GO:0043632	modification-dependent macromolecule catabolic process	5	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0051603	proteolysis involved in protein catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	7
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0016567	protein ubiquitination	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0097602	cullin family protein binding	3	2
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.284
CLV_PCSK_SKI1_1	106	110	PF00082	0.330
CLV_PCSK_SKI1_1	137	141	PF00082	0.454
CLV_PCSK_SKI1_1	75	79	PF00082	0.457
DEG_MDM2_SWIB_1	92	100	PF02201	0.308
DOC_MAPK_JIP1_4	75	81	PF00069	0.389
DOC_WW_Pin1_4	10	15	PF00397	0.504
LIG_14-3-3_CanoR_1	45	50	PF00244	0.422
LIG_14-3-3_CanoR_1	52	57	PF00244	0.498
LIG_14-3-3_CanoR_1	75	80	PF00244	0.605
LIG_BIR_II_1	1	5	PF00653	0.456
LIG_BRCT_BRCA1_1	47	51	PF00533	0.363
LIG_FHA_1	34	40	PF00498	0.330
LIG_FHA_1	68	74	PF00498	0.381
LIG_FHA_1	76	82	PF00498	0.354
LIG_FHA_1	99	105	PF00498	0.249
LIG_FHA_2	24	30	PF00498	0.473
LIG_LIR_Gen_1	95	104	PF02991	0.313
LIG_LIR_Nem_3	29	35	PF02991	0.490
LIG_LIR_Nem_3	60	66	PF02991	0.490
LIG_LIR_Nem_3	95	99	PF02991	0.354
LIG_MYND_1	21	25	PF01753	0.465
LIG_Pex14_2	92	96	PF04695	0.305
LIG_SH2_SRC	84	87	PF00017	0.299
LIG_SH2_STAP1	113	117	PF00017	0.330
LIG_SH2_STAT5	127	130	PF00017	0.393
LIG_SH2_STAT5	34	37	PF00017	0.442
LIG_SH2_STAT5	66	69	PF00017	0.589
LIG_SH2_STAT5	84	87	PF00017	0.451
LIG_SH3_3	11	17	PF00018	0.637
LIG_SH3_3	18	24	PF00018	0.519
LIG_SH3_3	25	31	PF00018	0.450
LIG_TYR_ITIM	111	116	PF00017	0.341
LIG_UBA3_1	116	123	PF00899	0.371
LIG_WRC_WIRS_1	53	58	PF05994	0.382
MOD_CDC14_SPxK_1	13	16	PF00782	0.500
MOD_CDK_SPxK_1	10	16	PF00069	0.512
MOD_CK1_1	15	21	PF00069	0.694
MOD_CK1_1	55	61	PF00069	0.526
MOD_CK2_1	23	29	PF00069	0.489
MOD_GlcNHglycan	120	123	PF01048	0.295
MOD_GSK3_1	15	22	PF00069	0.597
MOD_GSK3_1	51	58	PF00069	0.496
MOD_NEK2_1	51	56	PF00069	0.586
MOD_NEK2_1	7	12	PF00069	0.463
MOD_PKA_2	51	57	PF00069	0.498
MOD_PKB_1	50	58	PF00069	0.365
MOD_Plk_4	106	112	PF00069	0.335
MOD_Plk_4	123	129	PF00069	0.259
MOD_ProDKin_1	10	16	PF00069	0.505
MOD_SUMO_for_1	154	157	PF00179	0.509
TRG_DiLeu_BaEn_4	114	120	PF01217	0.324
TRG_ENDOCYTIC_2	113	116	PF00928	0.329
TRG_NES_CRM1_1	132	145	PF08389	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J0Y1	Bodo saltans	41%	93%
A0A1X0P0U8	Trypanosomatidae	51%	67%
A4HLF3	Leishmania braziliensis	88%	85%
D0A4V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	72%
E9B3T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	85%