PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania major

UniProt:

Q4Q489_LEIMA

TriTrypDb:

LmjF.33.1020 , LMJLV39_330017500 , LMJSD75_330017300

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q489

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q489

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.624
CLV_C14_Caspase3-7	299	303	PF00656	0.664
CLV_C14_Caspase3-7	415	419	PF00656	0.626
CLV_C14_Caspase3-7	899	903	PF00656	0.632
CLV_NRD_NRD_1	145	147	PF00675	0.713
CLV_NRD_NRD_1	310	312	PF00675	0.668
CLV_NRD_NRD_1	57	59	PF00675	0.723
CLV_NRD_NRD_1	604	606	PF00675	0.506
CLV_NRD_NRD_1	854	856	PF00675	0.412
CLV_NRD_NRD_1	99	101	PF00675	0.718
CLV_PCSK_FUR_1	97	101	PF00082	0.668
CLV_PCSK_KEX2_1	145	147	PF00082	0.715
CLV_PCSK_KEX2_1	310	312	PF00082	0.718
CLV_PCSK_KEX2_1	57	59	PF00082	0.723
CLV_PCSK_KEX2_1	604	606	PF00082	0.506
CLV_PCSK_KEX2_1	97	99	PF00082	0.718
CLV_PCSK_PC1ET2_1	604	606	PF00082	0.506
CLV_PCSK_PC7_1	94	100	PF00082	0.666
CLV_PCSK_SKI1_1	264	268	PF00082	0.662
CLV_PCSK_SKI1_1	802	806	PF00082	0.412
CLV_PCSK_SKI1_1	819	823	PF00082	0.231
CLV_PCSK_SKI1_1	844	848	PF00082	0.412
CLV_PCSK_SKI1_1	855	859	PF00082	0.295
DEG_SPOP_SBC_1	121	125	PF00917	0.621
DEG_SPOP_SBC_1	181	185	PF00917	0.562
DEG_SPOP_SBC_1	25	29	PF00917	0.688
DEG_SPOP_SBC_1	41	45	PF00917	0.578
DEG_SPOP_SBC_1	572	576	PF00917	0.644
DOC_CKS1_1	455	460	PF01111	0.507
DOC_CYCLIN_RxL_1	851	860	PF00134	0.412
DOC_MAPK_DCC_7	800	809	PF00069	0.337
DOC_MAPK_gen_1	164	174	PF00069	0.671
DOC_MAPK_gen_1	578	589	PF00069	0.485
DOC_MAPK_gen_1	800	809	PF00069	0.337
DOC_MAPK_gen_1	832	839	PF00069	0.412
DOC_MAPK_gen_1	841	850	PF00069	0.316
DOC_MAPK_gen_1	859	867	PF00069	0.220
DOC_MAPK_MEF2A_6	593	601	PF00069	0.456
DOC_MAPK_MEF2A_6	65	74	PF00069	0.650
DOC_MAPK_MEF2A_6	832	839	PF00069	0.412
DOC_MAPK_MEF2A_6	841	850	PF00069	0.316
DOC_MAPK_NFAT4_5	832	840	PF00069	0.412
DOC_SPAK_OSR1_1	588	592	PF12202	0.552
DOC_USP7_MATH_1	121	125	PF00917	0.621
DOC_USP7_MATH_1	213	217	PF00917	0.665
DOC_USP7_MATH_1	25	29	PF00917	0.704
DOC_USP7_MATH_1	39	43	PF00917	0.584
DOC_USP7_MATH_1	429	433	PF00917	0.688
DOC_USP7_MATH_1	467	471	PF00917	0.616
DOC_USP7_MATH_1	479	483	PF00917	0.560
DOC_USP7_MATH_1	507	511	PF00917	0.564
DOC_USP7_MATH_1	540	544	PF00917	0.574
DOC_USP7_MATH_1	572	576	PF00917	0.712
DOC_USP7_MATH_1	622	626	PF00917	0.538
DOC_USP7_MATH_1	769	773	PF00917	0.369
DOC_USP7_MATH_1	887	891	PF00917	0.644
DOC_USP7_UBL2_3	578	582	PF12436	0.680
DOC_WW_Pin1_4	124	129	PF00397	0.700
DOC_WW_Pin1_4	14	19	PF00397	0.667
DOC_WW_Pin1_4	157	162	PF00397	0.573
DOC_WW_Pin1_4	228	233	PF00397	0.694
DOC_WW_Pin1_4	294	299	PF00397	0.650
DOC_WW_Pin1_4	314	319	PF00397	0.588
DOC_WW_Pin1_4	379	384	PF00397	0.561
DOC_WW_Pin1_4	419	424	PF00397	0.520
DOC_WW_Pin1_4	454	459	PF00397	0.518
DOC_WW_Pin1_4	501	506	PF00397	0.680
DOC_WW_Pin1_4	563	568	PF00397	0.568
DOC_WW_Pin1_4	802	807	PF00397	0.412
LIG_14-3-3_CanoR_1	171	181	PF00244	0.715
LIG_14-3-3_CanoR_1	310	314	PF00244	0.632
LIG_14-3-3_CanoR_1	40	46	PF00244	0.680
LIG_14-3-3_CanoR_1	571	581	PF00244	0.678
LIG_14-3-3_CanoR_1	58	64	PF00244	0.550
LIG_14-3-3_CanoR_1	65	73	PF00244	0.656
LIG_14-3-3_CanoR_1	97	105	PF00244	0.712
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_BIR_III_2	178	182	PF00653	0.620
LIG_BIR_III_3	1	5	PF00653	0.509
LIG_BIR_III_4	902	906	PF00653	0.548
LIG_BRCT_BRCA1_1	421	425	PF00533	0.596
LIG_BRCT_BRCA1_1	881	885	PF00533	0.599
LIG_CtBP_PxDLS_1	253	257	PF00389	0.648
LIG_EVH1_1	455	459	PF00568	0.603
LIG_FHA_1	249	255	PF00498	0.593
LIG_FHA_1	485	491	PF00498	0.641
LIG_FHA_1	834	840	PF00498	0.412
LIG_FHA_1	904	910	PF00498	0.594
LIG_FHA_2	127	133	PF00498	0.697
LIG_FHA_2	188	194	PF00498	0.705
LIG_FHA_2	422	428	PF00498	0.638
LIG_FHA_2	715	721	PF00498	0.520
LIG_FHA_2	820	826	PF00498	0.412
LIG_FHA_2	897	903	PF00498	0.680
LIG_HCF-1_HBM_1	287	290	PF13415	0.564
LIG_HP1_1	70	74	PF01393	0.651
LIG_IBAR_NPY_1	69	71	PF08397	0.687
LIG_Integrin_RGD_1	34	36	PF01839	0.637
LIG_Integrin_RGD_1	900	902	PF01839	0.633
LIG_LIR_Apic_2	328	334	PF02991	0.790
LIG_LIR_Gen_1	287	298	PF02991	0.583
LIG_LIR_Gen_1	422	433	PF02991	0.675
LIG_LIR_Gen_1	470	479	PF02991	0.654
LIG_LIR_Gen_1	881	891	PF02991	0.617
LIG_LIR_Nem_3	287	293	PF02991	0.589
LIG_LIR_Nem_3	375	381	PF02991	0.583
LIG_LIR_Nem_3	422	428	PF02991	0.675
LIG_LIR_Nem_3	470	474	PF02991	0.645
LIG_LIR_Nem_3	709	713	PF02991	0.485
LIG_LIR_Nem_3	881	886	PF02991	0.595
LIG_LYPXL_yS_3	378	381	PF13949	0.685
LIG_PCNA_yPIPBox_3	658	668	PF02747	0.489
LIG_PDZ_Class_3	905	910	PF00595	0.670
LIG_SH2_CRK	388	392	PF00017	0.686
LIG_SH2_CRK	401	405	PF00017	0.525
LIG_SH2_CRK	452	456	PF00017	0.675
LIG_SH2_CRK	463	467	PF00017	0.567
LIG_SH2_GRB2like	105	108	PF00017	0.700
LIG_SH2_NCK_1	388	392	PF00017	0.686
LIG_SH2_NCK_1	401	405	PF00017	0.525
LIG_SH2_PTP2	290	293	PF00017	0.590
LIG_SH2_PTP2	71	74	PF00017	0.708
LIG_SH2_SRC	290	293	PF00017	0.590
LIG_SH2_SRC	331	334	PF00017	0.719
LIG_SH2_SRC	368	371	PF00017	0.696
LIG_SH2_SRC	401	404	PF00017	0.635
LIG_SH2_SRC	736	739	PF00017	0.344
LIG_SH2_STAP1	492	496	PF00017	0.541
LIG_SH2_STAP1	612	616	PF00017	0.449
LIG_SH2_STAT3	147	150	PF00017	0.571
LIG_SH2_STAT3	351	354	PF00017	0.694
LIG_SH2_STAT3	358	361	PF00017	0.637
LIG_SH2_STAT3	387	390	PF00017	0.710
LIG_SH2_STAT3	9	12	PF00017	0.565
LIG_SH2_STAT5	290	293	PF00017	0.590
LIG_SH2_STAT5	319	322	PF00017	0.636
LIG_SH2_STAT5	368	371	PF00017	0.696
LIG_SH2_STAT5	388	391	PF00017	0.494
LIG_SH2_STAT5	454	457	PF00017	0.667
LIG_SH2_STAT5	492	495	PF00017	0.541
LIG_SH2_STAT5	703	706	PF00017	0.481
LIG_SH2_STAT5	71	74	PF00017	0.708
LIG_SH2_STAT5	838	841	PF00017	0.412
LIG_SH3_1	400	406	PF00018	0.633
LIG_SH3_3	155	161	PF00018	0.709
LIG_SH3_3	315	321	PF00018	0.638
LIG_SH3_3	400	406	PF00018	0.683
LIG_SH3_3	453	459	PF00018	0.611
LIG_SH3_3	533	539	PF00018	0.671
LIG_SH3_3	564	570	PF00018	0.607
LIG_SH3_3	76	82	PF00018	0.656
LIG_SH3_3	836	842	PF00018	0.412
LIG_SH3_3	881	887	PF00018	0.600
LIG_SH3_4	740	747	PF00018	0.485
LIG_SUMO_SIM_anti_2	820	825	PF11976	0.412
LIG_SUMO_SIM_par_1	805	811	PF11976	0.382
LIG_SUMO_SIM_par_1	813	818	PF11976	0.357
LIG_TRAF2_1	617	620	PF00917	0.536
LIG_TRAF2_1	808	811	PF00917	0.412
LIG_TRAF2_1	82	85	PF00917	0.678
LIG_WRC_WIRS_1	468	473	PF05994	0.646
LIG_WRC_WIRS_1	858	863	PF05994	0.412
MOD_CDK_SPxxK_3	14	21	PF00069	0.608
MOD_CDK_SPxxK_3	157	164	PF00069	0.577
MOD_CK1_1	101	107	PF00069	0.708
MOD_CK1_1	120	126	PF00069	0.516
MOD_CK1_1	160	166	PF00069	0.583
MOD_CK1_1	216	222	PF00069	0.747
MOD_CK1_1	260	266	PF00069	0.730
MOD_CK1_1	268	274	PF00069	0.653
MOD_CK1_1	296	302	PF00069	0.653
MOD_CK1_1	42	48	PF00069	0.620
MOD_CK1_1	444	450	PF00069	0.548
MOD_CK1_1	53	59	PF00069	0.603
MOD_CK1_1	541	547	PF00069	0.656
MOD_CK1_1	559	565	PF00069	0.585
MOD_CK1_1	574	580	PF00069	0.549
MOD_CK1_1	64	70	PF00069	0.586
MOD_CK1_1	706	712	PF00069	0.498
MOD_CK1_1	840	846	PF00069	0.412
MOD_CK2_1	189	195	PF00069	0.653
MOD_CK2_1	268	274	PF00069	0.718
MOD_CK2_1	309	315	PF00069	0.686
MOD_CK2_1	421	427	PF00069	0.630
MOD_CK2_1	714	720	PF00069	0.447
MOD_CK2_1	805	811	PF00069	0.412
MOD_CK2_1	84	90	PF00069	0.704
MOD_GlcNHglycan	119	122	PF01048	0.623
MOD_GlcNHglycan	140	143	PF01048	0.692
MOD_GlcNHglycan	18	21	PF01048	0.707
MOD_GlcNHglycan	211	214	PF01048	0.691
MOD_GlcNHglycan	235	238	PF01048	0.729
MOD_GlcNHglycan	267	270	PF01048	0.723
MOD_GlcNHglycan	414	417	PF01048	0.629
MOD_GlcNHglycan	443	446	PF01048	0.603
MOD_GlcNHglycan	482	485	PF01048	0.676
MOD_GlcNHglycan	509	512	PF01048	0.621
MOD_GlcNHglycan	558	561	PF01048	0.652
MOD_GlcNHglycan	787	791	PF01048	0.392
MOD_GlcNHglycan	85	89	PF01048	0.652
MOD_GSK3_1	117	124	PF00069	0.536
MOD_GSK3_1	170	177	PF00069	0.700
MOD_GSK3_1	181	188	PF00069	0.688
MOD_GSK3_1	207	214	PF00069	0.707
MOD_GSK3_1	226	233	PF00069	0.687
MOD_GSK3_1	248	255	PF00069	0.559
MOD_GSK3_1	256	263	PF00069	0.610
MOD_GSK3_1	264	271	PF00069	0.766
MOD_GSK3_1	275	282	PF00069	0.602
MOD_GSK3_1	293	300	PF00069	0.588
MOD_GSK3_1	40	47	PF00069	0.663
MOD_GSK3_1	450	457	PF00069	0.553
MOD_GSK3_1	480	487	PF00069	0.651
MOD_GSK3_1	513	520	PF00069	0.676
MOD_GSK3_1	52	59	PF00069	0.626
MOD_GSK3_1	540	547	PF00069	0.696
MOD_GSK3_1	554	561	PF00069	0.574
MOD_GSK3_1	765	772	PF00069	0.373
MOD_GSK3_1	815	822	PF00069	0.412
MOD_GSK3_1	833	840	PF00069	0.220
MOD_GSK3_1	99	106	PF00069	0.644
MOD_N-GLC_1	106	111	PF02516	0.568
MOD_N-GLC_1	217	222	PF02516	0.723
MOD_N-GLC_1	242	247	PF02516	0.727
MOD_N-GLC_1	260	265	PF02516	0.679
MOD_N-GLC_1	484	489	PF02516	0.596
MOD_N-GLC_1	802	807	PF02516	0.412
MOD_N-GLC_1	90	95	PF02516	0.648
MOD_NEK2_1	133	138	PF00069	0.647
MOD_NEK2_1	172	177	PF00069	0.741
MOD_NEK2_1	217	222	PF00069	0.706
MOD_NEK2_1	256	261	PF00069	0.672
MOD_NEK2_1	265	270	PF00069	0.660
MOD_NEK2_1	63	68	PF00069	0.680
MOD_NEK2_1	837	842	PF00069	0.412
MOD_NEK2_1	857	862	PF00069	0.199
MOD_NEK2_1	89	94	PF00069	0.639
MOD_NEK2_2	703	708	PF00069	0.489
MOD_PIKK_1	107	113	PF00454	0.688
MOD_PIKK_1	146	152	PF00454	0.712
MOD_PIKK_1	280	286	PF00454	0.709
MOD_PIKK_1	386	392	PF00454	0.573
MOD_PIKK_1	490	496	PF00454	0.569
MOD_PIKK_1	517	523	PF00454	0.722
MOD_PIKK_1	554	560	PF00454	0.677
MOD_PK_1	642	648	PF00069	0.370
MOD_PKA_1	98	104	PF00069	0.717
MOD_PKA_2	170	176	PF00069	0.671
MOD_PKA_2	309	315	PF00069	0.636
MOD_PKA_2	39	45	PF00069	0.683
MOD_PKA_2	479	485	PF00069	0.676
MOD_PKA_2	56	62	PF00069	0.568
MOD_PKA_2	64	70	PF00069	0.616
MOD_PKA_2	840	846	PF00069	0.412
MOD_PKA_2	98	104	PF00069	0.717
MOD_PKB_1	205	213	PF00069	0.561
MOD_PKB_1	97	105	PF00069	0.715
MOD_Plk_1	242	248	PF00069	0.626
MOD_Plk_1	260	266	PF00069	0.681
MOD_Plk_1	819	825	PF00069	0.412
MOD_Plk_1	84	90	PF00069	0.675
MOD_Plk_4	219	225	PF00069	0.548
MOD_Plk_4	325	331	PF00069	0.643
MOD_Plk_4	444	450	PF00069	0.603
MOD_Plk_4	819	825	PF00069	0.412
MOD_Plk_4	879	885	PF00069	0.592
MOD_ProDKin_1	124	130	PF00069	0.696
MOD_ProDKin_1	14	20	PF00069	0.667
MOD_ProDKin_1	157	163	PF00069	0.575
MOD_ProDKin_1	228	234	PF00069	0.690
MOD_ProDKin_1	294	300	PF00069	0.652
MOD_ProDKin_1	314	320	PF00069	0.588
MOD_ProDKin_1	379	385	PF00069	0.561
MOD_ProDKin_1	419	425	PF00069	0.524
MOD_ProDKin_1	454	460	PF00069	0.520
MOD_ProDKin_1	501	507	PF00069	0.684
MOD_ProDKin_1	563	569	PF00069	0.565
MOD_ProDKin_1	802	808	PF00069	0.412
TRG_DiLeu_BaEn_2	880	886	PF01217	0.593
TRG_DiLeu_BaEn_4	810	816	PF01217	0.412
TRG_ENDOCYTIC_2	290	293	PF00928	0.590
TRG_ENDOCYTIC_2	378	381	PF00928	0.685
TRG_ENDOCYTIC_2	388	391	PF00928	0.600
TRG_ENDOCYTIC_2	430	433	PF00928	0.667
TRG_ENDOCYTIC_2	452	455	PF00928	0.681
TRG_ENDOCYTIC_2	463	466	PF00928	0.569
TRG_ENDOCYTIC_2	71	74	PF00928	0.708
TRG_ENDOCYTIC_2	888	891	PF00928	0.497
TRG_ER_diArg_1	144	146	PF00400	0.705
TRG_ER_diArg_1	205	208	PF00400	0.767
TRG_ER_diArg_1	57	60	PF00400	0.672
TRG_ER_diArg_1	659	662	PF00400	0.530
TRG_ER_diArg_1	861	864	PF00400	0.412
TRG_ER_diArg_1	96	99	PF00400	0.714
TRG_NES_CRM1_1	636	647	PF08389	0.495
TRG_NES_CRM1_1	813	827	PF08389	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IM55	Leishmania donovani	88%	100%
A4HLF5	Leishmania braziliensis	65%	97%
A4I8W6	Leishmania infantum	87%	95%
E9B3T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%