Geranylgeranyl transferase type-2 subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein prenyltransferase alpha subunit repeat, putative

Species:

Leishmania major

UniProt:

Q4Q488_LEIMA

TriTrypDb:

LmjF.33.1030 , LMJLV39_330017600 , LMJSD75_330017400

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005968	Rab-protein geranylgeranyltransferase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

Q4Q488

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q488

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0018342	protein prenylation	4	12
GO:0018344	protein geranylgeranylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0097354	prenylation	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004659	prenyltransferase activity	4	12
GO:0004661	protein geranylgeranyltransferase activity	4	12
GO:0004663	Rab geranylgeranyltransferase activity	5	12
GO:0008318	protein prenyltransferase activity	3	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.563
CLV_C14_Caspase3-7	352	356	PF00656	0.393
CLV_NRD_NRD_1	104	106	PF00675	0.443
CLV_NRD_NRD_1	174	176	PF00675	0.451
CLV_NRD_NRD_1	198	200	PF00675	0.242
CLV_NRD_NRD_1	344	346	PF00675	0.504
CLV_NRD_NRD_1	424	426	PF00675	0.467
CLV_NRD_NRD_1	456	458	PF00675	0.468
CLV_NRD_NRD_1	473	475	PF00675	0.515
CLV_NRD_NRD_1	68	70	PF00675	0.353
CLV_PCSK_KEX2_1	103	105	PF00082	0.472
CLV_PCSK_KEX2_1	198	200	PF00082	0.242
CLV_PCSK_KEX2_1	258	260	PF00082	0.219
CLV_PCSK_KEX2_1	344	346	PF00082	0.500
CLV_PCSK_KEX2_1	424	426	PF00082	0.457
CLV_PCSK_KEX2_1	455	457	PF00082	0.482
CLV_PCSK_KEX2_1	473	475	PF00082	0.543
CLV_PCSK_KEX2_1	68	70	PF00082	0.353
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.190
CLV_PCSK_SKI1_1	117	121	PF00082	0.303
CLV_PCSK_SKI1_1	199	203	PF00082	0.258
CLV_PCSK_SKI1_1	305	309	PF00082	0.411
CLV_PCSK_SKI1_1	32	36	PF00082	0.481
CLV_PCSK_SKI1_1	425	429	PF00082	0.503
CLV_PCSK_SKI1_1	69	73	PF00082	0.341
CLV_PCSK_SKI1_1	9	13	PF00082	0.606
DEG_APCC_DBOX_1	68	76	PF00400	0.363
DEG_SPOP_SBC_1	231	235	PF00917	0.655
DEG_SPOP_SBC_1	290	294	PF00917	0.447
DEG_SPOP_SBC_1	89	93	PF00917	0.584
DOC_PP2B_LxvP_1	56	59	PF13499	0.486
DOC_PP4_FxxP_1	241	244	PF00568	0.419
DOC_PP4_FxxP_1	334	337	PF00568	0.469
DOC_USP7_MATH_1	221	225	PF00917	0.642
DOC_USP7_MATH_1	231	235	PF00917	0.693
DOC_USP7_MATH_1	273	277	PF00917	0.513
DOC_USP7_MATH_1	74	78	PF00917	0.535
DOC_USP7_MATH_1	89	93	PF00917	0.619
DOC_USP7_UBL2_3	113	117	PF12436	0.500
DOC_USP7_UBL2_3	5	9	PF12436	0.667
DOC_WW_Pin1_4	10	15	PF00397	0.623
DOC_WW_Pin1_4	217	222	PF00397	0.664
DOC_WW_Pin1_4	233	238	PF00397	0.683
DOC_WW_Pin1_4	240	245	PF00397	0.460
LIG_14-3-3_CanoR_1	207	214	PF00244	0.479
LIG_14-3-3_CanoR_1	376	385	PF00244	0.571
LIG_14-3-3_CanoR_1	418	424	PF00244	0.502
LIG_14-3-3_CanoR_1	425	431	PF00244	0.416
LIG_Actin_WH2_1	305	322	PF00022	0.315
LIG_APCC_ABBAyCdc20_2	320	326	PF00400	0.526
LIG_APCC_ABBAyCdc20_2	473	479	PF00400	0.502
LIG_BRCT_BRCA1_1	237	241	PF00533	0.550
LIG_BRCT_BRCA1_1	330	334	PF00533	0.448
LIG_Clathr_ClatBox_1	184	188	PF01394	0.463
LIG_FHA_1	164	170	PF00498	0.501
LIG_FHA_1	245	251	PF00498	0.329
LIG_FHA_1	252	258	PF00498	0.428
LIG_FHA_1	49	55	PF00498	0.474
LIG_FHA_2	141	147	PF00498	0.446
LIG_FHA_2	291	297	PF00498	0.668
LIG_FHA_2	377	383	PF00498	0.562
LIG_LIR_Apic_2	238	244	PF02991	0.484
LIG_LIR_Apic_2	331	337	PF02991	0.389
LIG_LIR_Gen_1	164	174	PF02991	0.491
LIG_LIR_Nem_3	164	170	PF02991	0.502
LIG_LIR_Nem_3	60	65	PF02991	0.360
LIG_MLH1_MIPbox_1	238	242	PF16413	0.486
LIG_NRBOX	169	175	PF00104	0.479
LIG_OCRL_FandH_1	128	140	PF00620	0.538
LIG_OCRL_FandH_1	458	470	PF00620	0.481
LIG_PCNA_yPIPBox_3	17	31	PF02747	0.551
LIG_PCNA_yPIPBox_3	280	291	PF02747	0.375
LIG_Pex14_2	334	338	PF04695	0.469
LIG_SH2_CRK	31	35	PF00017	0.391
LIG_SH2_CRK	67	71	PF00017	0.398
LIG_SH2_STAP1	477	481	PF00017	0.473
LIG_SH2_STAT5	252	255	PF00017	0.522
LIG_SH2_STAT5	324	327	PF00017	0.383
LIG_SH2_STAT5	347	350	PF00017	0.456
LIG_SH2_STAT5	388	391	PF00017	0.370
LIG_SH2_STAT5	461	464	PF00017	0.456
LIG_SH2_STAT5	62	65	PF00017	0.370
LIG_SH3_3	211	217	PF00018	0.360
LIG_SH3_3	8	14	PF00018	0.643
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.529
LIG_SUMO_SIM_par_1	54	60	PF11976	0.472
LIG_TRAF2_1	20	23	PF00917	0.446
LIG_TRAF2_1	243	246	PF00917	0.552
LIG_TRAF2_1	358	361	PF00917	0.402
LIG_UBA3_1	135	144	PF00899	0.527
LIG_UBA3_1	169	176	PF00899	0.483
MOD_CDK_SPxxK_3	10	17	PF00069	0.611
MOD_CK1_1	232	238	PF00069	0.615
MOD_CK1_1	262	268	PF00069	0.441
MOD_CK1_1	401	407	PF00069	0.539
MOD_CK1_1	419	425	PF00069	0.544
MOD_CK1_1	84	90	PF00069	0.709
MOD_CK2_1	140	146	PF00069	0.455
MOD_CK2_1	240	246	PF00069	0.438
MOD_CK2_1	273	279	PF00069	0.460
MOD_CK2_1	376	382	PF00069	0.553
MOD_CK2_1	84	90	PF00069	0.680
MOD_GlcNHglycan	223	226	PF01048	0.612
MOD_GlcNHglycan	238	241	PF01048	0.582
MOD_GlcNHglycan	264	267	PF01048	0.252
MOD_GlcNHglycan	275	278	PF01048	0.350
MOD_GlcNHglycan	329	333	PF01048	0.308
MOD_GlcNHglycan	411	414	PF01048	0.668
MOD_GlcNHglycan	419	422	PF01048	0.476
MOD_GlcNHglycan	439	442	PF01048	0.601
MOD_GlcNHglycan	83	87	PF01048	0.700
MOD_GSK3_1	159	166	PF00069	0.620
MOD_GSK3_1	217	224	PF00069	0.606
MOD_GSK3_1	226	233	PF00069	0.671
MOD_GSK3_1	236	243	PF00069	0.526
MOD_GSK3_1	30	37	PF00069	0.423
MOD_GSK3_1	401	408	PF00069	0.572
MOD_GSK3_1	433	440	PF00069	0.526
MOD_GSK3_1	44	51	PF00069	0.390
MOD_GSK3_1	84	91	PF00069	0.707
MOD_N-GLC_1	159	164	PF02516	0.608
MOD_N-GLC_1	259	264	PF02516	0.261
MOD_N-GLC_1	43	48	PF02516	0.502
MOD_NEK2_1	169	174	PF00069	0.376
MOD_NEK2_1	206	211	PF00069	0.480
MOD_NEK2_1	250	255	PF00069	0.457
MOD_NEK2_1	30	35	PF00069	0.452
MOD_NEK2_1	359	364	PF00069	0.478
MOD_NEK2_1	437	442	PF00069	0.404
MOD_PIKK_1	206	212	PF00454	0.420
MOD_PIKK_1	226	232	PF00454	0.622
MOD_PIKK_1	398	404	PF00454	0.554
MOD_PKA_2	206	212	PF00069	0.544
MOD_PKA_2	375	381	PF00069	0.358
MOD_PKA_2	417	423	PF00069	0.515
MOD_Plk_1	262	268	PF00069	0.447
MOD_Plk_1	328	334	PF00069	0.364
MOD_Plk_1	359	365	PF00069	0.501
MOD_Plk_1	43	49	PF00069	0.431
MOD_Plk_4	169	175	PF00069	0.465
MOD_Plk_4	30	36	PF00069	0.414
MOD_Plk_4	359	365	PF00069	0.457
MOD_Plk_4	433	439	PF00069	0.532
MOD_Plk_4	60	66	PF00069	0.364
MOD_ProDKin_1	10	16	PF00069	0.615
MOD_ProDKin_1	217	223	PF00069	0.669
MOD_ProDKin_1	233	239	PF00069	0.676
MOD_ProDKin_1	240	246	PF00069	0.453
MOD_SUMO_rev_2	13	19	PF00179	0.530
TRG_DiLeu_BaEn_2	313	319	PF01217	0.459
TRG_DiLeu_BaEn_4	245	251	PF01217	0.451
TRG_ENDOCYTIC_2	126	129	PF00928	0.442
TRG_ENDOCYTIC_2	167	170	PF00928	0.524
TRG_ENDOCYTIC_2	31	34	PF00928	0.400
TRG_ENDOCYTIC_2	335	338	PF00928	0.339
TRG_ENDOCYTIC_2	388	391	PF00928	0.387
TRG_ENDOCYTIC_2	477	480	PF00928	0.356
TRG_ENDOCYTIC_2	67	70	PF00928	0.303
TRG_ER_diArg_1	102	105	PF00400	0.397
TRG_ER_diArg_1	197	199	PF00400	0.442
TRG_ER_diArg_1	343	345	PF00400	0.490
TRG_ER_diArg_1	423	425	PF00400	0.306
TRG_ER_diArg_1	455	457	PF00400	0.470
TRG_ER_diArg_1	472	474	PF00400	0.553
TRG_ER_diArg_1	67	69	PF00400	0.353
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	68	73	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6W4	Leptomonas seymouri	51%	100%
A0A0S4JI96	Bodo saltans	28%	100%
A0A1X0P0V1	Trypanosomatidae	27%	88%
A0A3S7X6L4	Leishmania donovani	89%	100%
A0A422P2I9	Trypanosoma rangeli	32%	97%
A4HLF6	Leishmania braziliensis	74%	100%
A4I8W7	Leishmania infantum	89%	100%
A5A779	Sus scrofa	25%	86%
D0A4W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B3T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O93829	Candida albicans	24%	100%
Q08602	Rattus norvegicus	25%	86%
Q5EA80	Bos taurus	24%	86%
Q5NVK5	Pongo abelii	27%	86%
Q92696	Homo sapiens	27%	86%
Q9JHK4	Mus musculus	26%	86%
V5BJU9	Trypanosoma cruzi	35%	100%