Peptidase_S9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q485_LEIMA

TriTrypDb:

LmjF.33.1050 , LMJLV39_330017900 , LMJSD75_330017700

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q485

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q485

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.721
CLV_NRD_NRD_1	233	235	PF00675	0.446
CLV_NRD_NRD_1	379	381	PF00675	0.572
CLV_NRD_NRD_1	74	76	PF00675	0.522
CLV_PCSK_FUR_1	377	381	PF00082	0.501
CLV_PCSK_KEX2_1	122	124	PF00082	0.721
CLV_PCSK_KEX2_1	233	235	PF00082	0.469
CLV_PCSK_KEX2_1	364	366	PF00082	0.496
CLV_PCSK_KEX2_1	379	381	PF00082	0.374
CLV_PCSK_KEX2_1	74	76	PF00082	0.565
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.559
CLV_PCSK_SKI1_1	194	198	PF00082	0.519
CLV_PCSK_SKI1_1	237	241	PF00082	0.526
CLV_PCSK_SKI1_1	276	280	PF00082	0.382
CLV_PCSK_SKI1_1	30	34	PF00082	0.471
CLV_PCSK_SKI1_1	77	81	PF00082	0.547
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.374
DOC_MAPK_gen_1	233	241	PF00069	0.440
DOC_MAPK_gen_1	263	272	PF00069	0.470
DOC_MAPK_gen_1	64	72	PF00069	0.558
DOC_MAPK_MEF2A_6	107	116	PF00069	0.653
DOC_MAPK_MEF2A_6	15	23	PF00069	0.536
DOC_MAPK_RevD_3	349	365	PF00069	0.469
DOC_USP7_MATH_1	117	121	PF00917	0.726
DOC_WW_Pin1_4	108	113	PF00397	0.722
DOC_WW_Pin1_4	166	171	PF00397	0.488
DOC_WW_Pin1_4	286	291	PF00397	0.529
DOC_WW_Pin1_4	8	13	PF00397	0.492
LIG_14-3-3_CanoR_1	107	112	PF00244	0.759
LIG_14-3-3_CanoR_1	276	286	PF00244	0.370
LIG_Actin_WH2_2	63	79	PF00022	0.555
LIG_Clathr_ClatBox_1	298	302	PF01394	0.364
LIG_FHA_1	227	233	PF00498	0.515
LIG_FHA_1	369	375	PF00498	0.406
LIG_FHA_1	400	406	PF00498	0.594
LIG_FHA_1	52	58	PF00498	0.578
LIG_FHA_2	108	114	PF00498	0.734
LIG_FHA_2	124	130	PF00498	0.656
LIG_FHA_2	241	247	PF00498	0.597
LIG_FHA_2	333	339	PF00498	0.483
LIG_FHA_2	35	41	PF00498	0.462
LIG_GBD_Chelix_1	72	80	PF00786	0.601
LIG_Integrin_RGD_1	127	129	PF01839	0.602
LIG_LIR_Gen_1	280	290	PF02991	0.386
LIG_LIR_Gen_1	302	312	PF02991	0.403
LIG_LIR_Nem_3	302	308	PF02991	0.398
LIG_LIR_Nem_3	419	425	PF02991	0.427
LIG_Pex14_2	325	329	PF04695	0.470
LIG_Rb_pABgroove_1	416	424	PF01858	0.401
LIG_SH2_CRK	181	185	PF00017	0.618
LIG_SH2_CRK	78	82	PF00017	0.351
LIG_SH2_NCK_1	211	215	PF00017	0.495
LIG_SH2_SRC	8	11	PF00017	0.520
LIG_SH2_STAT5	36	39	PF00017	0.456
LIG_SH2_STAT5	414	417	PF00017	0.397
LIG_SH2_STAT5	425	428	PF00017	0.428
LIG_SH2_STAT5	58	61	PF00017	0.594
LIG_SH3_3	18	24	PF00018	0.428
LIG_SH3_3	298	304	PF00018	0.428
LIG_SH3_3	50	56	PF00018	0.603
LIG_SUMO_SIM_anti_2	297	302	PF11976	0.384
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.506
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.441
LIG_SUMO_SIM_par_1	297	302	PF11976	0.388
LIG_SxIP_EBH_1	63	77	PF03271	0.387
LIG_TRAF2_1	289	292	PF00917	0.556
LIG_TRAF2_1	335	338	PF00917	0.527
LIG_TYR_ITIM	76	81	PF00017	0.358
LIG_WRC_WIRS_1	326	331	PF05994	0.457
LIG_WW_3	12	16	PF00397	0.558
MOD_CDK_SPxxK_3	8	15	PF00069	0.493
MOD_CK1_1	261	267	PF00069	0.643
MOD_CK1_1	28	34	PF00069	0.466
MOD_CK1_1	89	95	PF00069	0.716
MOD_CK2_1	240	246	PF00069	0.549
MOD_CK2_1	286	292	PF00069	0.468
MOD_CK2_1	332	338	PF00069	0.499
MOD_CK2_1	94	100	PF00069	0.693
MOD_GlcNHglycan	283	286	PF01048	0.457
MOD_GlcNHglycan	397	400	PF01048	0.485
MOD_GlcNHglycan	88	91	PF01048	0.574
MOD_GSK3_1	240	247	PF00069	0.555
MOD_GSK3_1	257	264	PF00069	0.620
MOD_GSK3_1	272	279	PF00069	0.323
MOD_GSK3_1	395	402	PF00069	0.537
MOD_GSK3_1	421	428	PF00069	0.475
MOD_LATS_1	238	244	PF00433	0.488
MOD_N-GLC_1	258	263	PF02516	0.663
MOD_N-GLC_1	46	51	PF02516	0.613
MOD_N-GLC_2	368	370	PF02516	0.503
MOD_NEK2_1	272	277	PF00069	0.365
MOD_NEK2_1	325	330	PF00069	0.480
MOD_NEK2_1	357	362	PF00069	0.392
MOD_NEK2_1	395	400	PF00069	0.415
MOD_NEK2_1	421	426	PF00069	0.448
MOD_NEK2_2	200	205	PF00069	0.546
MOD_NEK2_2	25	30	PF00069	0.527
MOD_NEK2_2	277	282	PF00069	0.394
MOD_PIKK_1	368	374	PF00454	0.452
MOD_PKA_2	332	338	PF00069	0.489
MOD_PKA_2	34	40	PF00069	0.458
MOD_PKA_2	65	71	PF00069	0.546
MOD_Plk_1	257	263	PF00069	0.698
MOD_Plk_1	312	318	PF00069	0.482
MOD_Plk_4	17	23	PF00069	0.510
MOD_Plk_4	294	300	PF00069	0.465
MOD_Plk_4	40	46	PF00069	0.538
MOD_ProDKin_1	108	114	PF00069	0.726
MOD_ProDKin_1	166	172	PF00069	0.488
MOD_ProDKin_1	286	292	PF00069	0.525
MOD_ProDKin_1	8	14	PF00069	0.489
MOD_SUMO_rev_2	289	296	PF00179	0.505
MOD_SUMO_rev_2	331	341	PF00179	0.471
MOD_SUMO_rev_2	343	349	PF00179	0.316
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.441
TRG_ENDOCYTIC_2	181	184	PF00928	0.632
TRG_ENDOCYTIC_2	283	286	PF00928	0.377
TRG_ENDOCYTIC_2	414	417	PF00928	0.397
TRG_ENDOCYTIC_2	78	81	PF00928	0.524
TRG_ER_diArg_1	122	125	PF00400	0.724
TRG_ER_diArg_1	152	155	PF00400	0.377
TRG_ER_diArg_1	175	178	PF00400	0.555
TRG_ER_diArg_1	232	234	PF00400	0.444
TRG_ER_diArg_1	377	380	PF00400	0.545
TRG_ER_diArg_1	74	77	PF00400	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5H7	Leptomonas seymouri	57%	94%
A0A1X0P162	Trypanosomatidae	49%	100%
A0A3Q8IGI7	Leishmania donovani	95%	100%
A0A422P2L6	Trypanosoma rangeli	45%	100%
A4HLF9	Leishmania braziliensis	76%	100%
A4I8X0	Leishmania infantum	95%	100%
D0A4W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B3T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%