Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q483_LEIMA

TriTrypDb:

LmjF.33.1070 , LMJLV39_330018100 , LMJSD75_330017900

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q483

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q483

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.615
CLV_NRD_NRD_1	223	225	PF00675	0.601
CLV_PCSK_KEX2_1	217	219	PF00082	0.615
CLV_PCSK_SKI1_1	122	126	PF00082	0.672
CLV_PCSK_SKI1_1	25	29	PF00082	0.494
DOC_MAPK_gen_1	92	100	PF00069	0.546
DOC_PP1_RVXF_1	120	126	PF00149	0.378
DOC_PP1_RVXF_1	78	85	PF00149	0.628
DOC_PP4_FxxP_1	125	128	PF00568	0.394
LIG_14-3-3_CanoR_1	12	18	PF00244	0.697
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BRCT_BRCA1_1	68	72	PF00533	0.730
LIG_deltaCOP1_diTrp_1	52	59	PF00928	0.606
LIG_FHA_1	40	46	PF00498	0.558
LIG_FHA_2	14	20	PF00498	0.576
LIG_FHA_2	203	209	PF00498	0.344
LIG_FHA_2	33	39	PF00498	0.587
LIG_HCF-1_HBM_1	19	22	PF13415	0.588
LIG_IBAR_NPY_1	30	32	PF08397	0.577
LIG_IBAR_NPY_1	76	78	PF08397	0.656
LIG_LIR_Nem_3	116	121	PF02991	0.412
LIG_LIR_Nem_3	158	163	PF02991	0.534
LIG_PDZ_Class_2	238	243	PF00595	0.460
LIG_Pex14_1	55	59	PF04695	0.645
LIG_REV1ctd_RIR_1	70	76	PF16727	0.633
LIG_SH2_CRK	61	65	PF00017	0.682
LIG_SH2_NCK_1	209	213	PF00017	0.387
LIG_SH2_STAP1	209	213	PF00017	0.374
LIG_SH2_STAT5	209	212	PF00017	0.452
LIG_SH2_STAT5	23	26	PF00017	0.637
LIG_SH2_STAT5	32	35	PF00017	0.569
LIG_SH2_STAT5	44	47	PF00017	0.636
LIG_SH2_STAT5	81	84	PF00017	0.642
LIG_SH3_3	136	142	PF00018	0.450
LIG_SH3_4	141	148	PF00018	0.473
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.403
LIG_SUMO_SIM_par_1	109	116	PF11976	0.330
LIG_SUMO_SIM_par_1	96	102	PF11976	0.637
LIG_TRFH_1	22	26	PF08558	0.686
LIG_TRFH_1	61	65	PF08558	0.714
MOD_CK1_1	106	112	PF00069	0.466
MOD_CK1_1	2	8	PF00069	0.677
MOD_CK1_1	200	206	PF00069	0.396
MOD_CK1_1	230	236	PF00069	0.453
MOD_CK2_1	202	208	PF00069	0.324
MOD_CK2_1	85	91	PF00069	0.603
MOD_GlcNHglycan	210	213	PF01048	0.581
MOD_GlcNHglycan	234	237	PF01048	0.715
MOD_GlcNHglycan	68	71	PF01048	0.460
MOD_GlcNHglycan	8	11	PF01048	0.508
MOD_GSK3_1	113	120	PF00069	0.304
MOD_GSK3_1	2	9	PF00069	0.736
MOD_GSK3_1	227	234	PF00069	0.528
MOD_GSK3_1	99	106	PF00069	0.529
MOD_NEK2_1	113	118	PF00069	0.388
MOD_NEK2_1	202	207	PF00069	0.382
MOD_NEK2_1	85	90	PF00069	0.602
MOD_NEK2_2	128	133	PF00069	0.382
MOD_PIKK_1	197	203	PF00454	0.353
MOD_PIKK_1	228	234	PF00454	0.441
MOD_PIKK_1	32	38	PF00454	0.568
MOD_PKA_2	2	8	PF00069	0.651
MOD_Plk_1	128	134	PF00069	0.380
MOD_Plk_1	85	91	PF00069	0.603
MOD_Plk_2-3	86	92	PF00069	0.601
MOD_Plk_4	103	109	PF00069	0.337
MOD_Plk_4	13	19	PF00069	0.596
TRG_ENDOCYTIC_2	160	163	PF00928	0.467
TRG_ENDOCYTIC_2	61	64	PF00928	0.683
TRG_ER_diArg_1	216	218	PF00400	0.426
TRG_NES_CRM1_1	173	187	PF08389	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK0	Leptomonas seymouri	71%	100%
A0A0S4IVH5	Bodo saltans	53%	100%
A0A0S4IXX7	Bodo saltans	44%	92%
A0A1X0NYZ9	Trypanosomatidae	64%	100%
A0A3Q8IGT4	Leishmania donovani	95%	100%
A0A422MZK8	Trypanosoma rangeli	53%	100%
A4HGE2	Leishmania braziliensis	58%	100%
A4HLG1	Leishmania braziliensis	81%	100%
A4I3H5	Leishmania infantum	62%	100%
A4I8X2	Leishmania infantum	95%	100%
E9AZR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9B3U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
I1ZAQ0	Leishmania donovani	62%	100%
Q4Q8G9	Leishmania major	61%	100%
V5AL49	Trypanosoma cruzi	61%	95%