YEATS_family_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

YEATS family, putative

Species:

Leishmania major

UniProt:

Q4Q482_LEIMA

TriTrypDb:

LmjF.33.1080 , LMJLV39_330018200 , LMJSD75_330018000

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000123	histone acetyltransferase complex	4	2
GO:0005654	nucleoplasm	2	2
GO:0031248	protein acetyltransferase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0035267	NuA4 histone acetyltransferase complex	7	2
GO:0043189	H4/H2A histone acetyltransferase complex	6	2
GO:0110165	cellular anatomical entity	1	10
GO:0140535	intracellular protein-containing complex	2	2
GO:1902493	acetyltransferase complex	4	2
GO:1902494	catalytic complex	2	2
GO:1902562	H4 histone acetyltransferase complex	5	2
GO:1990234	transferase complex	3	2
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

Q4Q482

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q482

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	2
GO:0006338	chromatin remodeling	5	2
GO:0006355	regulation of DNA-templated transcription	6	10
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0006473	protein acetylation	6	2
GO:0006475	internal protein amino acid acetylation	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009889	regulation of biosynthetic process	4	10
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	10
GO:0010556	regulation of macromolecule biosynthetic process	5	10
GO:0016043	cellular component organization	3	2
GO:0016570	histone modification	5	2
GO:0016573	histone acetylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0018393	internal peptidyl-lysine acetylation	8	2
GO:0018394	peptidyl-lysine acetylation	7	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	10
GO:0019222	regulation of metabolic process	3	10
GO:0019538	protein metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031326	regulation of cellular biosynthetic process	5	10
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051252	regulation of RNA metabolic process	5	10
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0080090	regulation of primary metabolic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1903506	regulation of nucleic acid-templated transcription	7	10
GO:2001141	regulation of RNA biosynthetic process	6	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.807
CLV_NRD_NRD_1	166	168	PF00675	0.290
CLV_NRD_NRD_1	170	172	PF00675	0.290
CLV_NRD_NRD_1	211	213	PF00675	0.655
CLV_NRD_NRD_1	266	268	PF00675	0.783
CLV_NRD_NRD_1	55	57	PF00675	0.758
CLV_NRD_NRD_1	67	69	PF00675	0.630
CLV_PCSK_FUR_1	164	168	PF00082	0.308
CLV_PCSK_KEX2_1	166	168	PF00082	0.291
CLV_PCSK_KEX2_1	170	172	PF00082	0.291
CLV_PCSK_KEX2_1	211	213	PF00082	0.580
CLV_PCSK_KEX2_1	266	268	PF00082	0.728
CLV_PCSK_KEX2_1	402	404	PF00082	0.520
CLV_PCSK_KEX2_1	54	56	PF00082	0.763
CLV_PCSK_KEX2_1	67	69	PF00082	0.632
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.564
CLV_PCSK_PC7_1	166	172	PF00082	0.351
CLV_PCSK_SKI1_1	166	170	PF00082	0.329
CLV_PCSK_SKI1_1	211	215	PF00082	0.673
CLV_PCSK_SKI1_1	306	310	PF00082	0.529
CLV_PCSK_SKI1_1	321	325	PF00082	0.551
CLV_PCSK_SKI1_1	437	441	PF00082	0.599
DEG_SCF_FBW7_1	346	351	PF00400	0.572
DOC_CKS1_1	119	124	PF01111	0.813
DOC_CKS1_1	138	143	PF01111	0.347
DOC_CKS1_1	328	333	PF01111	0.571
DOC_CKS1_1	363	368	PF01111	0.616
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.576
DOC_MAPK_gen_1	303	311	PF00069	0.458
DOC_MAPK_JIP1_4	249	255	PF00069	0.743
DOC_PP1_RVXF_1	150	157	PF00149	0.511
DOC_PP2B_LxvP_1	14	17	PF13499	0.344
DOC_PP2B_LxvP_1	196	199	PF13499	0.561
DOC_PP2B_LxvP_1	214	217	PF13499	0.694
DOC_PP4_FxxP_1	156	159	PF00568	0.490
DOC_PP4_FxxP_1	162	165	PF00568	0.490
DOC_USP7_MATH_1	123	127	PF00917	0.830
DOC_USP7_MATH_1	19	23	PF00917	0.468
DOC_USP7_MATH_1	219	223	PF00917	0.688
DOC_USP7_MATH_1	336	340	PF00917	0.715
DOC_USP7_MATH_1	352	356	PF00917	0.716
DOC_USP7_MATH_1	387	391	PF00917	0.534
DOC_USP7_MATH_1	50	54	PF00917	0.770
DOC_USP7_UBL2_3	440	444	PF12436	0.629
DOC_WW_Pin1_4	118	123	PF00397	0.782
DOC_WW_Pin1_4	137	142	PF00397	0.407
DOC_WW_Pin1_4	223	228	PF00397	0.723
DOC_WW_Pin1_4	31	36	PF00397	0.684
DOC_WW_Pin1_4	327	332	PF00397	0.548
DOC_WW_Pin1_4	337	342	PF00397	0.597
DOC_WW_Pin1_4	344	349	PF00397	0.827
DOC_WW_Pin1_4	362	367	PF00397	0.588
DOC_WW_Pin1_4	46	51	PF00397	0.713
LIG_14-3-3_CanoR_1	211	217	PF00244	0.719
LIG_14-3-3_CanoR_1	386	392	PF00244	0.587
LIG_14-3-3_CanoR_1	55	63	PF00244	0.702
LIG_14-3-3_CanoR_1	67	76	PF00244	0.392
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_BIR_III_4	28	32	PF00653	0.540
LIG_BRCT_BRCA1_1	371	375	PF00533	0.511
LIG_CSL_BTD_1	237	240	PF09270	0.698
LIG_eIF4E_1	247	253	PF01652	0.740
LIG_FHA_1	229	235	PF00498	0.676
LIG_FHA_1	289	295	PF00498	0.470
LIG_FHA_1	352	358	PF00498	0.753
LIG_FHA_1	422	428	PF00498	0.558
LIG_FHA_2	178	184	PF00498	0.490
LIG_FHA_2	332	338	PF00498	0.716
LIG_FHA_2	345	351	PF00498	0.737
LIG_FHA_2	427	433	PF00498	0.578
LIG_LIR_Apic_2	161	165	PF02991	0.509
LIG_LIR_Apic_2	245	250	PF02991	0.688
LIG_LIR_Apic_2	325	331	PF02991	0.515
LIG_LIR_Apic_2	370	374	PF02991	0.552
LIG_LIR_Gen_1	145	156	PF02991	0.344
LIG_LIR_Gen_1	372	383	PF02991	0.472
LIG_LIR_Nem_3	145	151	PF02991	0.386
LIG_LIR_Nem_3	372	378	PF02991	0.483
LIG_LIR_Nem_3	86	92	PF02991	0.514
LIG_MYND_3	314	318	PF01753	0.588
LIG_Pex14_1	371	375	PF04695	0.401
LIG_Pex14_2	367	371	PF04695	0.554
LIG_SH2_CRK	148	152	PF00017	0.444
LIG_SH2_CRK	247	251	PF00017	0.735
LIG_SH2_CRK	328	332	PF00017	0.559
LIG_SH2_CRK	74	78	PF00017	0.421
LIG_SH2_NCK_1	328	332	PF00017	0.559
LIG_SH2_SRC	18	21	PF00017	0.493
LIG_SH2_STAT3	382	385	PF00017	0.569
LIG_SH2_STAT5	74	77	PF00017	0.417
LIG_SH3_3	113	119	PF00018	0.801
LIG_SH3_3	135	141	PF00018	0.671
LIG_SH3_3	20	26	PF00018	0.408
LIG_SH3_3	224	230	PF00018	0.710
LIG_SH3_3	234	240	PF00018	0.702
LIG_SH3_3	256	262	PF00018	0.671
LIG_SH3_3	422	428	PF00018	0.616
LIG_SUMO_SIM_anti_2	280	287	PF11976	0.616
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.450
LIG_SUMO_SIM_anti_2	388	395	PF11976	0.595
LIG_SUMO_SIM_par_1	251	257	PF11976	0.652
LIG_SUMO_SIM_par_1	280	287	PF11976	0.531
LIG_SUMO_SIM_par_1	307	312	PF11976	0.432
LIG_SUMO_SIM_par_1	423	429	PF11976	0.589
LIG_TRAF2_1	415	418	PF00917	0.552
LIG_TYR_ITIM	146	151	PF00017	0.525
LIG_WW_1	217	220	PF00397	0.676
MOD_CDC14_SPxK_1	34	37	PF00782	0.792
MOD_CDC14_SPxK_1	51	54	PF00782	0.694
MOD_CDK_SPxK_1	31	37	PF00069	0.771
MOD_CDK_SPxK_1	48	54	PF00069	0.690
MOD_CDK_SPxxK_3	337	344	PF00069	0.586
MOD_CDK_SPxxK_3	48	55	PF00069	0.691
MOD_CK1_1	142	148	PF00069	0.469
MOD_CK1_1	2	8	PF00069	0.671
MOD_CK1_1	33	39	PF00069	0.658
MOD_CK1_1	362	368	PF00069	0.587
MOD_CK1_1	59	65	PF00069	0.588
MOD_CK2_1	177	183	PF00069	0.528
MOD_CK2_1	412	418	PF00069	0.546
MOD_CK2_1	426	432	PF00069	0.346
MOD_DYRK1A_RPxSP_1	344	348	PF00069	0.697
MOD_GlcNHglycan	1	4	PF01048	0.736
MOD_GlcNHglycan	125	128	PF01048	0.742
MOD_GlcNHglycan	134	137	PF01048	0.622
MOD_GlcNHglycan	221	224	PF01048	0.777
MOD_GlcNHglycan	59	62	PF01048	0.720
MOD_GSK3_1	100	107	PF00069	0.628
MOD_GSK3_1	121	128	PF00069	0.820
MOD_GSK3_1	219	226	PF00069	0.741
MOD_GSK3_1	326	333	PF00069	0.668
MOD_GSK3_1	342	349	PF00069	0.764
MOD_GSK3_1	358	365	PF00069	0.737
MOD_GSK3_1	408	415	PF00069	0.597
MOD_GSK3_1	46	53	PF00069	0.758
MOD_GSK3_1	57	64	PF00069	0.759
MOD_NEK2_1	147	152	PF00069	0.480
MOD_NEK2_1	242	247	PF00069	0.589
MOD_NEK2_1	30	35	PF00069	0.722
MOD_NEK2_1	309	314	PF00069	0.473
MOD_NEK2_1	324	329	PF00069	0.559
MOD_NEK2_1	367	372	PF00069	0.585
MOD_PIKK_1	2	8	PF00454	0.694
MOD_PIKK_1	426	432	PF00454	0.585
MOD_PKA_1	67	73	PF00069	0.574
MOD_PKA_2	385	391	PF00069	0.543
MOD_PKA_2	67	73	PF00069	0.475
MOD_PKB_1	54	62	PF00069	0.705
MOD_Plk_1	177	183	PF00069	0.490
MOD_Plk_1	324	330	PF00069	0.525
MOD_Plk_1	358	364	PF00069	0.661
MOD_Plk_1	412	418	PF00069	0.556
MOD_Plk_2-3	177	183	PF00069	0.561
MOD_Plk_4	142	148	PF00069	0.556
MOD_Plk_4	199	205	PF00069	0.561
MOD_Plk_4	359	365	PF00069	0.653
MOD_Plk_4	421	427	PF00069	0.541
MOD_ProDKin_1	118	124	PF00069	0.780
MOD_ProDKin_1	137	143	PF00069	0.389
MOD_ProDKin_1	223	229	PF00069	0.722
MOD_ProDKin_1	31	37	PF00069	0.690
MOD_ProDKin_1	327	333	PF00069	0.560
MOD_ProDKin_1	337	343	PF00069	0.597
MOD_ProDKin_1	344	350	PF00069	0.827
MOD_ProDKin_1	362	368	PF00069	0.581
MOD_ProDKin_1	46	52	PF00069	0.713
MOD_SUMO_for_1	401	404	PF00179	0.532
TRG_DiLeu_BaEn_1	359	364	PF01217	0.660
TRG_DiLeu_BaEn_4	417	423	PF01217	0.544
TRG_ENDOCYTIC_2	148	151	PF00928	0.376
TRG_ENDOCYTIC_2	74	77	PF00928	0.398
TRG_ENDOCYTIC_2	89	92	PF00928	0.425
TRG_ER_diArg_1	163	166	PF00400	0.495
TRG_ER_diArg_1	169	171	PF00400	0.485
TRG_ER_diArg_1	211	213	PF00400	0.696
TRG_ER_diArg_1	54	56	PF00400	0.796
TRG_ER_diArg_1	66	68	PF00400	0.623
TRG_NES_CRM1_1	15	28	PF08389	0.567
TRG_NES_CRM1_1	417	430	PF08389	0.617
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S1	Leptomonas seymouri	46%	93%
A0A3R7LCY2	Trypanosoma rangeli	28%	96%
A0A3S7X6P8	Leishmania donovani	94%	100%
A4HLG2	Leishmania braziliensis	80%	81%
A4I8X3	Leishmania infantum	94%	100%
D0A4W8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
E9B3U2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DG54	Trypanosoma cruzi	29%	82%