Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q479_LEIMA

TriTrypDb:

LmjF.33.1110 , LMJLV39_330018500 , LMJSD75_330018300

Length:

758

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q479

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q479

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	677	681	PF00656	0.778
CLV_NRD_NRD_1	162	164	PF00675	0.668
CLV_NRD_NRD_1	20	22	PF00675	0.605
CLV_NRD_NRD_1	518	520	PF00675	0.495
CLV_NRD_NRD_1	577	579	PF00675	0.557
CLV_NRD_NRD_1	696	698	PF00675	0.584
CLV_NRD_NRD_1	86	88	PF00675	0.624
CLV_PCSK_KEX2_1	162	164	PF00082	0.626
CLV_PCSK_KEX2_1	339	341	PF00082	0.760
CLV_PCSK_KEX2_1	461	463	PF00082	0.569
CLV_PCSK_KEX2_1	518	520	PF00082	0.574
CLV_PCSK_KEX2_1	577	579	PF00082	0.557
CLV_PCSK_KEX2_1	584	586	PF00082	0.553
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.760
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.569
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.627
CLV_PCSK_SKI1_1	224	228	PF00082	0.698
CLV_PCSK_SKI1_1	248	252	PF00082	0.678
CLV_PCSK_SKI1_1	268	272	PF00082	0.355
CLV_PCSK_SKI1_1	340	344	PF00082	0.759
CLV_PCSK_SKI1_1	487	491	PF00082	0.556
CLV_PCSK_SKI1_1	609	613	PF00082	0.523
DEG_APCC_DBOX_1	170	178	PF00400	0.551
DEG_Nend_UBRbox_4	1	3	PF02207	0.578
DEG_SPOP_SBC_1	149	153	PF00917	0.716
DEG_SPOP_SBC_1	721	725	PF00917	0.741
DOC_CKS1_1	133	138	PF01111	0.604
DOC_CKS1_1	711	716	PF01111	0.728
DOC_CYCLIN_RxL_1	481	494	PF00134	0.575
DOC_CYCLIN_RxL_1	499	510	PF00134	0.286
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.566
DOC_MAPK_gen_1	266	274	PF00069	0.647
DOC_MAPK_RevD_3	74	88	PF00069	0.668
DOC_PP4_FxxP_1	69	72	PF00568	0.662
DOC_USP7_MATH_1	110	114	PF00917	0.696
DOC_USP7_MATH_1	120	124	PF00917	0.572
DOC_USP7_MATH_1	137	141	PF00917	0.606
DOC_USP7_MATH_1	255	259	PF00917	0.673
DOC_USP7_MATH_1	341	345	PF00917	0.795
DOC_USP7_MATH_1	396	400	PF00917	0.741
DOC_USP7_MATH_1	60	64	PF00917	0.605
DOC_USP7_MATH_1	657	661	PF00917	0.620
DOC_USP7_MATH_1	702	706	PF00917	0.749
DOC_USP7_MATH_1	722	726	PF00917	0.567
DOC_USP7_MATH_1	741	745	PF00917	0.742
DOC_USP7_MATH_1	746	750	PF00917	0.711
DOC_USP7_MATH_1	79	83	PF00917	0.374
DOC_WW_Pin1_4	132	137	PF00397	0.743
DOC_WW_Pin1_4	199	204	PF00397	0.675
DOC_WW_Pin1_4	258	263	PF00397	0.567
DOC_WW_Pin1_4	354	359	PF00397	0.777
DOC_WW_Pin1_4	628	633	PF00397	0.692
DOC_WW_Pin1_4	710	715	PF00397	0.723
DOC_WW_Pin1_4	729	734	PF00397	0.772
LIG_14-3-3_CanoR_1	276	286	PF00244	0.513
LIG_14-3-3_CanoR_1	320	329	PF00244	0.724
LIG_14-3-3_CanoR_1	403	407	PF00244	0.668
LIG_14-3-3_CanoR_1	466	471	PF00244	0.675
LIG_14-3-3_CanoR_1	481	487	PF00244	0.420
LIG_14-3-3_CanoR_1	507	516	PF00244	0.484
LIG_14-3-3_CanoR_1	537	542	PF00244	0.488
LIG_14-3-3_CanoR_1	578	587	PF00244	0.574
LIG_14-3-3_CanoR_1	662	670	PF00244	0.711
LIG_14-3-3_CanoR_1	695	701	PF00244	0.776
LIG_14-3-3_CanoR_1	94	98	PF00244	0.617
LIG_14-3-3_CterR_2	754	758	PF00244	0.724
LIG_APCC_ABBA_1	470	475	PF00400	0.672
LIG_BIR_III_2	144	148	PF00653	0.759
LIG_Clathr_ClatBox_1	39	43	PF01394	0.581
LIG_deltaCOP1_diTrp_1	256	265	PF00928	0.679
LIG_eIF4E_1	34	40	PF01652	0.594
LIG_EVH1_1	69	73	PF00568	0.668
LIG_FHA_1	15	21	PF00498	0.594
LIG_FHA_1	196	202	PF00498	0.695
LIG_FHA_1	333	339	PF00498	0.829
LIG_FHA_1	347	353	PF00498	0.595
LIG_FHA_1	371	377	PF00498	0.767
LIG_FHA_1	467	473	PF00498	0.675
LIG_FHA_1	56	62	PF00498	0.587
LIG_FHA_1	561	567	PF00498	0.568
LIG_FHA_1	644	650	PF00498	0.777
LIG_FHA_2	110	116	PF00498	0.711
LIG_FHA_2	133	139	PF00498	0.784
LIG_FHA_2	355	361	PF00498	0.761
LIG_FHA_2	386	392	PF00498	0.711
LIG_FHA_2	403	409	PF00498	0.551
LIG_FHA_2	483	489	PF00498	0.593
LIG_FHA_2	506	512	PF00498	0.508
LIG_FHA_2	538	544	PF00498	0.522
LIG_FHA_2	616	622	PF00498	0.692
LIG_FHA_2	677	683	PF00498	0.764
LIG_FHA_2	730	736	PF00498	0.771
LIG_LIR_Apic_2	256	262	PF02991	0.596
LIG_LIR_Gen_1	236	247	PF02991	0.670
LIG_LIR_Gen_1	269	279	PF02991	0.608
LIG_LIR_Gen_1	498	506	PF02991	0.491
LIG_LIR_Gen_1	510	517	PF02991	0.288
LIG_LIR_Nem_3	236	242	PF02991	0.677
LIG_LIR_Nem_3	269	274	PF02991	0.535
LIG_LIR_Nem_3	288	292	PF02991	0.601
LIG_LIR_Nem_3	453	458	PF02991	0.589
LIG_LIR_Nem_3	485	489	PF02991	0.568
LIG_LIR_Nem_3	498	503	PF02991	0.458
LIG_LIR_Nem_3	510	516	PF02991	0.285
LIG_NRBOX	35	41	PF00104	0.641
LIG_PCNA_yPIPBox_3	584	593	PF02747	0.570
LIG_Pex14_1	285	289	PF04695	0.508
LIG_Pex14_2	486	490	PF04695	0.540
LIG_SH2_CRK	289	293	PF00017	0.591
LIG_SH2_CRK	500	504	PF00017	0.500
LIG_SH2_CRK	513	517	PF00017	0.485
LIG_SH2_NCK_1	50	54	PF00017	0.599
LIG_SH2_STAP1	30	34	PF00017	0.646
LIG_SH2_STAP1	500	504	PF00017	0.533
LIG_SH2_STAP1	513	517	PF00017	0.519
LIG_SH2_STAP1	541	545	PF00017	0.490
LIG_SH3_1	629	635	PF00018	0.682
LIG_SH3_3	197	203	PF00018	0.703
LIG_SH3_3	292	298	PF00018	0.556
LIG_SH3_3	335	341	PF00018	0.817
LIG_SH3_3	42	48	PF00018	0.685
LIG_SH3_3	629	635	PF00018	0.682
LIG_SH3_3	67	73	PF00018	0.537
LIG_Sin3_3	230	237	PF02671	0.749
LIG_SUMO_SIM_anti_2	169	176	PF11976	0.560
LIG_SUMO_SIM_anti_2	590	596	PF11976	0.623
LIG_SUMO_SIM_par_1	37	44	PF11976	0.596
LIG_SUMO_SIM_par_1	76	82	PF11976	0.559
LIG_TRAF2_1	405	408	PF00917	0.739
LIG_WRC_WIRS_1	483	488	PF05994	0.593
LIG_WRC_WIRS_1	747	752	PF05994	0.810
MOD_CK1_1	258	264	PF00069	0.627
MOD_CK1_1	275	281	PF00069	0.367
MOD_CK1_1	399	405	PF00069	0.687
MOD_CK1_1	498	504	PF00069	0.504
MOD_CK1_1	724	730	PF00069	0.749
MOD_CK1_1	749	755	PF00069	0.736
MOD_CK2_1	109	115	PF00069	0.762
MOD_CK2_1	124	130	PF00069	0.784
MOD_CK2_1	3	9	PF00069	0.497
MOD_CK2_1	318	324	PF00069	0.792
MOD_CK2_1	385	391	PF00069	0.768
MOD_CK2_1	402	408	PF00069	0.551
MOD_CK2_1	422	428	PF00069	0.485
MOD_CK2_1	48	54	PF00069	0.526
MOD_CK2_1	482	488	PF00069	0.638
MOD_CK2_1	505	511	PF00069	0.504
MOD_CK2_1	537	543	PF00069	0.489
MOD_CK2_1	600	606	PF00069	0.482
MOD_CK2_1	615	621	PF00069	0.548
MOD_CK2_1	676	682	PF00069	0.775
MOD_CK2_1	729	735	PF00069	0.771
MOD_GlcNHglycan	112	115	PF01048	0.651
MOD_GlcNHglycan	122	125	PF01048	0.533
MOD_GlcNHglycan	192	196	PF01048	0.633
MOD_GlcNHglycan	213	216	PF01048	0.723
MOD_GlcNHglycan	224	227	PF01048	0.591
MOD_GlcNHglycan	367	370	PF01048	0.779
MOD_GlcNHglycan	398	401	PF01048	0.753
MOD_GlcNHglycan	424	427	PF01048	0.737
MOD_GlcNHglycan	50	53	PF01048	0.532
MOD_GlcNHglycan	58	61	PF01048	0.505
MOD_GlcNHglycan	643	646	PF01048	0.664
MOD_GlcNHglycan	664	667	PF01048	0.748
MOD_GlcNHglycan	702	705	PF01048	0.737
MOD_GlcNHglycan	724	727	PF01048	0.784
MOD_GSK3_1	110	117	PF00069	0.656
MOD_GSK3_1	120	127	PF00069	0.681
MOD_GSK3_1	149	156	PF00069	0.691
MOD_GSK3_1	187	194	PF00069	0.584
MOD_GSK3_1	195	202	PF00069	0.640
MOD_GSK3_1	222	229	PF00069	0.685
MOD_GSK3_1	254	261	PF00069	0.590
MOD_GSK3_1	274	281	PF00069	0.319
MOD_GSK3_1	348	355	PF00069	0.709
MOD_GSK3_1	370	377	PF00069	0.769
MOD_GSK3_1	398	405	PF00069	0.677
MOD_GSK3_1	507	514	PF00069	0.611
MOD_GSK3_1	56	63	PF00069	0.543
MOD_GSK3_1	696	703	PF00069	0.744
MOD_GSK3_1	720	727	PF00069	0.798
MOD_GSK3_1	736	743	PF00069	0.492
MOD_GSK3_1	745	752	PF00069	0.760
MOD_GSK3_1	79	86	PF00069	0.589
MOD_NEK2_1	3	8	PF00069	0.517
MOD_NEK2_1	329	334	PF00069	0.813
MOD_NEK2_1	512	517	PF00069	0.556
MOD_NEK2_1	530	535	PF00069	0.351
MOD_NEK2_1	572	577	PF00069	0.573
MOD_NEK2_1	615	620	PF00069	0.656
MOD_NEK2_1	740	745	PF00069	0.763
MOD_NEK2_2	468	473	PF00069	0.667
MOD_NEK2_2	657	662	PF00069	0.588
MOD_PIKK_1	332	338	PF00454	0.762
MOD_PIKK_1	377	383	PF00454	0.818
MOD_PIKK_1	505	511	PF00454	0.504
MOD_PIKK_1	579	585	PF00454	0.504
MOD_PIKK_1	600	606	PF00454	0.497
MOD_PIKK_1	649	655	PF00454	0.688
MOD_PKA_2	275	281	PF00069	0.513
MOD_PKA_2	319	325	PF00069	0.720
MOD_PKA_2	402	408	PF00069	0.664
MOD_PKA_2	475	481	PF00069	0.613
MOD_PKA_2	696	702	PF00069	0.747
MOD_PKA_2	93	99	PF00069	0.615
MOD_Plk_1	114	120	PF00069	0.742
MOD_Plk_1	13	19	PF00069	0.632
MOD_Plk_1	191	197	PF00069	0.749
MOD_Plk_1	235	241	PF00069	0.738
MOD_Plk_1	255	261	PF00069	0.373
MOD_Plk_1	329	335	PF00069	0.812
MOD_Plk_1	377	383	PF00069	0.831
MOD_Plk_1	736	742	PF00069	0.797
MOD_Plk_2-3	348	354	PF00069	0.712
MOD_Plk_4	14	20	PF00069	0.567
MOD_Plk_4	177	183	PF00069	0.621
MOD_Plk_4	196	202	PF00069	0.535
MOD_Plk_4	468	474	PF00069	0.662
MOD_Plk_4	495	501	PF00069	0.536
MOD_Plk_4	512	518	PF00069	0.568
MOD_Plk_4	62	68	PF00069	0.579
MOD_Plk_4	79	85	PF00069	0.433
MOD_ProDKin_1	132	138	PF00069	0.743
MOD_ProDKin_1	199	205	PF00069	0.675
MOD_ProDKin_1	258	264	PF00069	0.562
MOD_ProDKin_1	354	360	PF00069	0.779
MOD_ProDKin_1	628	634	PF00069	0.688
MOD_ProDKin_1	710	716	PF00069	0.725
MOD_ProDKin_1	729	735	PF00069	0.771
MOD_SUMO_rev_2	453	463	PF00179	0.606
MOD_SUMO_rev_2	536	545	PF00179	0.489
TRG_AP2beta_CARGO_1	453	462	PF09066	0.677
TRG_DiLeu_BaEn_1	590	595	PF01217	0.623
TRG_DiLeu_BaEn_1	606	611	PF01217	0.502
TRG_DiLeu_BaEn_4	494	500	PF01217	0.538
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.559
TRG_DiLeu_BaLyEn_6	633	638	PF01217	0.721
TRG_DiLeu_LyEn_5	606	611	PF01217	0.583
TRG_ENDOCYTIC_2	289	292	PF00928	0.602
TRG_ENDOCYTIC_2	500	503	PF00928	0.505
TRG_ENDOCYTIC_2	513	516	PF00928	0.481
TRG_ER_diArg_1	161	163	PF00400	0.652
TRG_ER_diArg_1	265	268	PF00400	0.611
TRG_ER_diArg_1	517	519	PF00400	0.580
TRG_ER_diArg_1	667	670	PF00400	0.709
TRG_NLS_MonoExtC_3	385	391	PF00514	0.736
TRG_NLS_MonoExtN_4	383	390	PF00514	0.744
TRG_Pf-PMV_PEXEL_1	487	492	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S9	Leptomonas seymouri	57%	94%
A0A3Q8IDP5	Leishmania donovani	94%	100%
A4HLG5	Leishmania braziliensis	83%	100%
A4I8X6	Leishmania infantum	94%	100%
D0A4X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B3U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BPB5	Trypanosoma cruzi	36%	100%