P66_CC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q478_LEIMA

TriTrypDb:

LmjF.33.1120 , LMJLV39_330018600 , LMJSD75_330018400

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q478

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q478

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.615
CLV_NRD_NRD_1	217	219	PF00675	0.706
CLV_NRD_NRD_1	294	296	PF00675	0.637
CLV_NRD_NRD_1	89	91	PF00675	0.363
CLV_PCSK_KEX2_1	154	156	PF00082	0.529
CLV_PCSK_KEX2_1	217	219	PF00082	0.693
CLV_PCSK_KEX2_1	294	296	PF00082	0.637
CLV_PCSK_KEX2_1	89	91	PF00082	0.363
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.555
CLV_PCSK_SKI1_1	247	251	PF00082	0.668
CLV_PCSK_SKI1_1	319	323	PF00082	0.570
CLV_PCSK_SKI1_1	84	88	PF00082	0.538
CLV_PCSK_SKI1_1	96	100	PF00082	0.534
DEG_APCC_DBOX_1	111	119	PF00400	0.461
DEG_APCC_DBOX_1	318	326	PF00400	0.522
DEG_SPOP_SBC_1	225	229	PF00917	0.568
DEG_SPOP_SBC_1	62	66	PF00917	0.576
DOC_CKS1_1	1	6	PF01111	0.644
DOC_USP7_MATH_1	12	16	PF00917	0.701
DOC_USP7_MATH_1	190	194	PF00917	0.771
DOC_USP7_MATH_1	200	204	PF00917	0.701
DOC_USP7_MATH_1	28	32	PF00917	0.668
DOC_USP7_MATH_1	45	49	PF00917	0.644
DOC_WW_Pin1_4	13	18	PF00397	0.772
DOC_WW_Pin1_4	192	197	PF00397	0.733
DOC_WW_Pin1_4	47	52	PF00397	0.766
DOC_WW_Pin1_4	68	73	PF00397	0.680
LIG_14-3-3_CanoR_1	101	109	PF00244	0.561
LIG_14-3-3_CanoR_1	165	173	PF00244	0.413
LIG_14-3-3_CanoR_1	24	33	PF00244	0.677
LIG_14-3-3_CanoR_1	294	298	PF00244	0.599
LIG_BIR_II_1	1	5	PF00653	0.727
LIG_BRCT_BRCA1_1	82	86	PF00533	0.542
LIG_CaM_IQ_9	88	103	PF13499	0.491
LIG_FHA_2	165	171	PF00498	0.431
LIG_RPA_C_Fungi	85	97	PF08784	0.360
LIG_SH2_CRK	253	257	PF00017	0.620
LIG_SH2_STAT5	265	268	PF00017	0.681
LIG_SH3_3	37	43	PF00018	0.605
LIG_SH3_3	48	54	PF00018	0.769
LIG_SH3_3	66	72	PF00018	0.627
LIG_SUMO_SIM_par_1	127	134	PF11976	0.566
LIG_TRAF2_1	149	152	PF00917	0.593
LIG_TYR_ITIM	251	256	PF00017	0.642
LIG_UBA3_1	115	121	PF00899	0.547
LIG_UBA3_1	321	326	PF00899	0.531
LIG_WW_3	214	218	PF00397	0.536
MOD_CDK_SPxxK_3	192	199	PF00069	0.556
MOD_CK1_1	238	244	PF00069	0.560
MOD_CK1_1	269	275	PF00069	0.701
MOD_CK1_1	8	14	PF00069	0.691
MOD_CK2_1	121	127	PF00069	0.499
MOD_CK2_1	164	170	PF00069	0.407
MOD_CK2_1	185	191	PF00069	0.617
MOD_GlcNHglycan	144	147	PF01048	0.475
MOD_GlcNHglycan	176	179	PF01048	0.632
MOD_GlcNHglycan	187	190	PF01048	0.615
MOD_GlcNHglycan	207	210	PF01048	0.666
MOD_GlcNHglycan	228	231	PF01048	0.587
MOD_GlcNHglycan	26	29	PF01048	0.538
MOD_GlcNHglycan	271	274	PF01048	0.690
MOD_GlcNHglycan	66	69	PF01048	0.721
MOD_GlcNHglycan	8	11	PF01048	0.773
MOD_GSK3_1	180	187	PF00069	0.700
MOD_GSK3_1	201	208	PF00069	0.685
MOD_GSK3_1	220	227	PF00069	0.568
MOD_GSK3_1	234	241	PF00069	0.554
MOD_GSK3_1	24	31	PF00069	0.641
MOD_GSK3_1	64	71	PF00069	0.656
MOD_GSK3_1	8	15	PF00069	0.765
MOD_N-GLC_1	225	230	PF02516	0.614
MOD_N-GLC_1	6	11	PF02516	0.675
MOD_PIKK_1	121	127	PF00454	0.468
MOD_PKA_2	100	106	PF00069	0.619
MOD_PKA_2	142	148	PF00069	0.428
MOD_PKA_2	164	170	PF00069	0.407
MOD_PKA_2	269	275	PF00069	0.682
MOD_PKA_2	293	299	PF00069	0.632
MOD_Plk_1	190	196	PF00069	0.549
MOD_Plk_1	238	244	PF00069	0.600
MOD_Plk_4	220	226	PF00069	0.661
MOD_ProDKin_1	13	19	PF00069	0.771
MOD_ProDKin_1	192	198	PF00069	0.734
MOD_ProDKin_1	47	53	PF00069	0.781
MOD_ProDKin_1	68	74	PF00069	0.675
MOD_SUMO_rev_2	302	311	PF00179	0.491
TRG_DiLeu_BaEn_1	111	116	PF01217	0.569
TRG_DiLeu_BaEn_1	317	322	PF01217	0.500
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.532
TRG_ENDOCYTIC_2	253	256	PF00928	0.614
TRG_ER_diArg_1	216	218	PF00400	0.595
TRG_ER_diArg_1	293	295	PF00400	0.638
TRG_ER_diArg_1	88	90	PF00400	0.366
TRG_NES_CRM1_1	127	142	PF08389	0.539
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE12	Leptomonas seymouri	56%	100%
A0A1X0P0W7	Trypanosomatidae	38%	100%
A0A3S7X6M7	Leishmania donovani	91%	100%
A4HLG6	Leishmania braziliensis	63%	100%
A4I8X7	Leishmania infantum	92%	100%
D0A4X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B3U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%