LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q477_LEIMA
TriTrypDb:
LmjF.33.1130 , LMJLV39_330018700 * , LMJSD75_330018500 *
Length:
680

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 10, no: 0
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q477
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q477

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.740
CLV_NRD_NRD_1 558 560 PF00675 0.497
CLV_NRD_NRD_1 583 585 PF00675 0.516
CLV_PCSK_FUR_1 567 571 PF00082 0.498
CLV_PCSK_KEX2_1 2 4 PF00082 0.744
CLV_PCSK_KEX2_1 558 560 PF00082 0.467
CLV_PCSK_KEX2_1 569 571 PF00082 0.484
CLV_PCSK_KEX2_1 583 585 PF00082 0.523
CLV_PCSK_PC1ET2_1 569 571 PF00082 0.518
CLV_PCSK_SKI1_1 171 175 PF00082 0.616
CLV_PCSK_SKI1_1 569 573 PF00082 0.485
CLV_PCSK_SKI1_1 88 92 PF00082 0.661
CLV_Separin_Metazoa 593 597 PF03568 0.721
DEG_Nend_UBRbox_1 1 4 PF02207 0.637
DEG_SCF_FBW7_1 602 609 PF00400 0.709
DEG_SCF_FBW7_2 587 593 PF00400 0.718
DEG_SPOP_SBC_1 445 449 PF00917 0.361
DOC_CKS1_1 587 592 PF01111 0.753
DOC_CYCLIN_yCln2_LP_2 659 665 PF00134 0.621
DOC_MAPK_MEF2A_6 134 142 PF00069 0.350
DOC_MAPK_MEF2A_6 340 349 PF00069 0.422
DOC_PP1_RVXF_1 205 212 PF00149 0.347
DOC_PP1_RVXF_1 468 475 PF00149 0.407
DOC_PP4_FxxP_1 213 216 PF00568 0.358
DOC_USP7_MATH_1 163 167 PF00917 0.372
DOC_USP7_MATH_1 221 225 PF00917 0.430
DOC_USP7_MATH_1 25 29 PF00917 0.545
DOC_USP7_MATH_1 268 272 PF00917 0.403
DOC_USP7_MATH_1 462 466 PF00917 0.452
DOC_USP7_MATH_1 468 472 PF00917 0.379
DOC_USP7_MATH_1 519 523 PF00917 0.441
DOC_USP7_MATH_1 663 667 PF00917 0.757
DOC_USP7_UBL2_3 569 573 PF12436 0.647
DOC_WW_Pin1_4 338 343 PF00397 0.501
DOC_WW_Pin1_4 393 398 PF00397 0.343
DOC_WW_Pin1_4 481 486 PF00397 0.455
DOC_WW_Pin1_4 586 591 PF00397 0.751
DOC_WW_Pin1_4 595 600 PF00397 0.673
DOC_WW_Pin1_4 602 607 PF00397 0.782
DOC_WW_Pin1_4 608 613 PF00397 0.779
DOC_WW_Pin1_4 653 658 PF00397 0.803
LIG_14-3-3_CanoR_1 2 8 PF00244 0.619
LIG_14-3-3_CanoR_1 366 376 PF00244 0.445
LIG_14-3-3_CanoR_1 653 657 PF00244 0.752
LIG_Actin_WH2_2 498 516 PF00022 0.325
LIG_APCC_ABBA_1 492 497 PF00400 0.386
LIG_APCC_ABBAyCdc20_2 171 177 PF00400 0.323
LIG_BIR_III_4 122 126 PF00653 0.418
LIG_BRCT_BRCA1_1 395 399 PF00533 0.295
LIG_BRCT_BRCA1_1 470 474 PF00533 0.399
LIG_FHA_1 137 143 PF00498 0.482
LIG_FHA_1 145 151 PF00498 0.350
LIG_FHA_1 201 207 PF00498 0.418
LIG_FHA_1 223 229 PF00498 0.393
LIG_FHA_1 260 266 PF00498 0.400
LIG_FHA_1 315 321 PF00498 0.394
LIG_FHA_1 331 337 PF00498 0.395
LIG_FHA_1 400 406 PF00498 0.439
LIG_FHA_1 478 484 PF00498 0.381
LIG_FHA_1 531 537 PF00498 0.504
LIG_FHA_1 590 596 PF00498 0.749
LIG_FHA_1 81 87 PF00498 0.423
LIG_FHA_1 96 102 PF00498 0.300
LIG_FHA_2 106 112 PF00498 0.408
LIG_FHA_2 154 160 PF00498 0.333
LIG_FHA_2 445 451 PF00498 0.427
LIG_FHA_2 494 500 PF00498 0.379
LIG_LIR_Apic_2 212 216 PF02991 0.398
LIG_LIR_Apic_2 36 42 PF02991 0.355
LIG_LIR_Gen_1 427 437 PF02991 0.340
LIG_LIR_Gen_1 487 495 PF02991 0.378
LIG_LIR_Gen_1 631 642 PF02991 0.707
LIG_LIR_Nem_3 427 433 PF02991 0.319
LIG_LIR_Nem_3 471 476 PF02991 0.365
LIG_LIR_Nem_3 487 492 PF02991 0.397
LIG_LIR_Nem_3 493 498 PF02991 0.440
LIG_LIR_Nem_3 631 637 PF02991 0.703
LIG_LIR_Nem_3 71 76 PF02991 0.435
LIG_MLH1_MIPbox_1 395 399 PF16413 0.295
LIG_MYND_1 250 254 PF01753 0.358
LIG_MYND_1 657 661 PF01753 0.648
LIG_NRBOX 12 18 PF00104 0.583
LIG_Pex3_1 13 24 PF04882 0.547
LIG_PTAP_UEV_1 216 221 PF05743 0.374
LIG_PTB_Apo_2 196 203 PF02174 0.338
LIG_PTB_Apo_2 454 461 PF02174 0.365
LIG_PTB_Phospho_1 454 460 PF10480 0.367
LIG_SH2_CRK 39 43 PF00017 0.474
LIG_SH2_CRK 476 480 PF00017 0.371
LIG_SH2_CRK 545 549 PF00017 0.448
LIG_SH2_CRK 61 65 PF00017 0.479
LIG_SH2_NCK_1 495 499 PF00017 0.511
LIG_SH2_NCK_1 634 638 PF00017 0.747
LIG_SH2_PTP2 346 349 PF00017 0.336
LIG_SH2_PTP2 489 492 PF00017 0.378
LIG_SH2_SRC 175 178 PF00017 0.310
LIG_SH2_SRC 489 492 PF00017 0.347
LIG_SH2_STAP1 22 26 PF00017 0.455
LIG_SH2_STAP1 361 365 PF00017 0.411
LIG_SH2_STAT5 117 120 PF00017 0.379
LIG_SH2_STAT5 346 349 PF00017 0.355
LIG_SH2_STAT5 39 42 PF00017 0.501
LIG_SH2_STAT5 398 401 PF00017 0.357
LIG_SH2_STAT5 460 463 PF00017 0.469
LIG_SH2_STAT5 489 492 PF00017 0.368
LIG_SH2_STAT5 495 498 PF00017 0.435
LIG_SH3_3 214 220 PF00018 0.459
LIG_SH3_3 339 345 PF00018 0.368
LIG_SH3_3 584 590 PF00018 0.747
LIG_SH3_3 655 661 PF00018 0.794
LIG_SH3_5 485 489 PF00018 0.364
LIG_SUMO_SIM_anti_2 139 144 PF11976 0.334
LIG_SUMO_SIM_anti_2 666 674 PF11976 0.669
LIG_SUMO_SIM_par_1 138 144 PF11976 0.380
LIG_SUMO_SIM_par_1 17 23 PF11976 0.458
LIG_SUMO_SIM_par_1 224 231 PF11976 0.428
LIG_TRAF2_1 156 159 PF00917 0.319
LIG_TYR_ITIM 543 548 PF00017 0.403
LIG_WRC_WIRS_1 21 26 PF05994 0.597
LIG_WRC_WIRS_1 210 215 PF05994 0.420
LIG_WRC_WIRS_1 223 228 PF05994 0.356
MOD_CDC14_SPxK_1 341 344 PF00782 0.372
MOD_CDK_SPxK_1 338 344 PF00069 0.364
MOD_CK1_1 105 111 PF00069 0.313
MOD_CK1_1 136 142 PF00069 0.402
MOD_CK1_1 144 150 PF00069 0.409
MOD_CK1_1 179 185 PF00069 0.371
MOD_CK1_1 192 198 PF00069 0.382
MOD_CK1_1 224 230 PF00069 0.364
MOD_CK1_1 231 237 PF00069 0.443
MOD_CK1_1 260 266 PF00069 0.354
MOD_CK1_1 314 320 PF00069 0.564
MOD_CK1_1 356 362 PF00069 0.484
MOD_CK1_1 380 386 PF00069 0.517
MOD_CK1_1 423 429 PF00069 0.400
MOD_CK1_1 438 444 PF00069 0.413
MOD_CK1_1 453 459 PF00069 0.330
MOD_CK1_1 493 499 PF00069 0.463
MOD_CK1_1 629 635 PF00069 0.695
MOD_CK1_1 652 658 PF00069 0.828
MOD_CK1_1 80 86 PF00069 0.407
MOD_CK1_1 95 101 PF00069 0.351
MOD_CK2_1 153 159 PF00069 0.305
MOD_CK2_1 356 362 PF00069 0.439
MOD_CK2_1 446 452 PF00069 0.369
MOD_CK2_1 493 499 PF00069 0.377
MOD_DYRK1A_RPxSP_1 653 657 PF00069 0.732
MOD_GlcNHglycan 127 130 PF01048 0.653
MOD_GlcNHglycan 13 16 PF01048 0.631
MOD_GlcNHglycan 135 138 PF01048 0.603
MOD_GlcNHglycan 176 181 PF01048 0.655
MOD_GlcNHglycan 185 188 PF01048 0.659
MOD_GlcNHglycan 193 197 PF01048 0.551
MOD_GlcNHglycan 203 206 PF01048 0.452
MOD_GlcNHglycan 27 30 PF01048 0.640
MOD_GlcNHglycan 280 283 PF01048 0.649
MOD_GlcNHglycan 379 382 PF01048 0.694
MOD_GlcNHglycan 422 425 PF01048 0.560
MOD_GlcNHglycan 437 440 PF01048 0.580
MOD_GlcNHglycan 502 505 PF01048 0.637
MOD_GlcNHglycan 523 526 PF01048 0.767
MOD_GlcNHglycan 599 602 PF01048 0.532
MOD_GlcNHglycan 631 634 PF01048 0.605
MOD_GlcNHglycan 7 10 PF01048 0.666
MOD_GlcNHglycan 88 91 PF01048 0.630
MOD_GSK3_1 100 107 PF00069 0.310
MOD_GSK3_1 141 148 PF00069 0.416
MOD_GSK3_1 153 160 PF00069 0.375
MOD_GSK3_1 175 182 PF00069 0.425
MOD_GSK3_1 211 218 PF00069 0.330
MOD_GSK3_1 222 229 PF00069 0.330
MOD_GSK3_1 268 275 PF00069 0.463
MOD_GSK3_1 285 292 PF00069 0.480
MOD_GSK3_1 328 335 PF00069 0.417
MOD_GSK3_1 380 387 PF00069 0.506
MOD_GSK3_1 416 423 PF00069 0.397
MOD_GSK3_1 435 442 PF00069 0.329
MOD_GSK3_1 446 453 PF00069 0.411
MOD_GSK3_1 477 484 PF00069 0.478
MOD_GSK3_1 521 528 PF00069 0.535
MOD_GSK3_1 602 609 PF00069 0.764
MOD_GSK3_1 629 636 PF00069 0.753
MOD_GSK3_1 649 656 PF00069 0.777
MOD_GSK3_1 76 83 PF00069 0.411
MOD_GSK3_1 92 99 PF00069 0.342
MOD_N-GLC_1 289 294 PF02516 0.637
MOD_N-GLC_1 424 429 PF02516 0.529
MOD_N-GLC_1 456 461 PF02516 0.575
MOD_N-GLC_1 629 634 PF02516 0.558
MOD_N-GLC_1 80 85 PF02516 0.575
MOD_N-GLC_1 96 101 PF02516 0.472
MOD_NEK2_1 102 107 PF00069 0.312
MOD_NEK2_1 164 169 PF00069 0.308
MOD_NEK2_1 200 205 PF00069 0.375
MOD_NEK2_1 209 214 PF00069 0.288
MOD_NEK2_1 222 227 PF00069 0.361
MOD_NEK2_1 228 233 PF00069 0.315
MOD_NEK2_1 259 264 PF00069 0.439
MOD_NEK2_1 289 294 PF00069 0.391
MOD_NEK2_1 334 339 PF00069 0.367
MOD_NEK2_1 399 404 PF00069 0.328
MOD_NEK2_1 409 414 PF00069 0.374
MOD_NEK2_1 544 549 PF00069 0.445
MOD_NEK2_1 671 676 PF00069 0.696
MOD_NEK2_1 76 81 PF00069 0.454
MOD_NEK2_2 439 444 PF00069 0.291
MOD_PIKK_1 33 39 PF00454 0.465
MOD_PIKK_1 353 359 PF00454 0.427
MOD_PIKK_1 526 532 PF00454 0.431
MOD_PIKK_1 606 612 PF00454 0.643
MOD_PK_1 451 457 PF00069 0.420
MOD_PK_1 562 568 PF00069 0.575
MOD_PKA_2 133 139 PF00069 0.373
MOD_PKA_2 164 170 PF00069 0.312
MOD_PKA_2 33 39 PF00069 0.356
MOD_PKA_2 416 422 PF00069 0.375
MOD_PKA_2 450 456 PF00069 0.416
MOD_PKA_2 557 563 PF00069 0.704
MOD_PKA_2 652 658 PF00069 0.751
MOD_PKA_2 77 83 PF00069 0.481
MOD_PKA_2 92 98 PF00069 0.449
MOD_PKB_1 3 11 PF00069 0.445
MOD_Plk_1 289 295 PF00069 0.435
MOD_Plk_1 298 304 PF00069 0.413
MOD_Plk_1 424 430 PF00069 0.384
MOD_Plk_1 439 445 PF00069 0.363
MOD_Plk_1 451 457 PF00069 0.369
MOD_Plk_1 490 496 PF00069 0.414
MOD_Plk_1 498 504 PF00069 0.353
MOD_Plk_1 80 86 PF00069 0.397
MOD_Plk_1 95 101 PF00069 0.291
MOD_Plk_4 138 144 PF00069 0.311
MOD_Plk_4 179 185 PF00069 0.372
MOD_Plk_4 356 362 PF00069 0.454
MOD_Plk_4 416 422 PF00069 0.399
MOD_Plk_4 439 445 PF00069 0.418
MOD_Plk_4 456 462 PF00069 0.427
MOD_Plk_4 490 496 PF00069 0.383
MOD_Plk_4 544 550 PF00069 0.382
MOD_Plk_4 96 102 PF00069 0.343
MOD_ProDKin_1 338 344 PF00069 0.501
MOD_ProDKin_1 393 399 PF00069 0.346
MOD_ProDKin_1 481 487 PF00069 0.453
MOD_ProDKin_1 586 592 PF00069 0.752
MOD_ProDKin_1 595 601 PF00069 0.673
MOD_ProDKin_1 602 608 PF00069 0.783
MOD_ProDKin_1 653 659 PF00069 0.802
MOD_SUMO_rev_2 351 356 PF00179 0.448
TRG_DiLeu_BaEn_1 46 51 PF01217 0.357
TRG_DiLeu_BaLyEn_6 8 13 PF01217 0.531
TRG_ENDOCYTIC_2 346 349 PF00928 0.466
TRG_ENDOCYTIC_2 489 492 PF00928 0.432
TRG_ENDOCYTIC_2 495 498 PF00928 0.463
TRG_ENDOCYTIC_2 545 548 PF00928 0.455
TRG_ENDOCYTIC_2 634 637 PF00928 0.709
TRG_ER_diArg_1 1 3 PF00400 0.693
TRG_ER_diArg_1 294 297 PF00400 0.424
TRG_ER_diArg_1 364 367 PF00400 0.420
TRG_ER_diArg_1 557 559 PF00400 0.677
TRG_Pf-PMV_PEXEL_1 570 574 PF00026 0.492

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILM2 Leptomonas seymouri 50% 100%
A0A0S4J6Q6 Bodo saltans 30% 100%
A0A1X0P168 Trypanosomatidae 34% 100%
A0A3Q8IHQ4 Leishmania donovani 88% 100%
A0A3R7N2S1 Trypanosoma rangeli 32% 100%
A4HLG7 Leishmania braziliensis 64% 100%
A4I8X8 Leishmania infantum 88% 100%
E9B3U7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
V5BJT9 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS