IPT/TIG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q476_LEIMA

TriTrypDb:

LmjF.33.1140 , LMJLV39_330018900 , LMJSD75_330018600

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	5
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q476

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q476

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.454
CLV_NRD_NRD_1	392	394	PF00675	0.495
CLV_NRD_NRD_1	421	423	PF00675	0.629
CLV_PCSK_SKI1_1	56	60	PF00082	0.644
DOC_ANK_TNKS_1	398	405	PF00023	0.699
DOC_MAPK_DCC_7	82	90	PF00069	0.402
DOC_MAPK_RevD_3	379	394	PF00069	0.421
DOC_PP4_MxPP_1	320	323	PF00568	0.418
DOC_SPAK_OSR1_1	200	204	PF12202	0.493
DOC_USP7_MATH_1	21	25	PF00917	0.434
DOC_USP7_MATH_1	238	242	PF00917	0.451
DOC_USP7_MATH_1	274	278	PF00917	0.518
DOC_USP7_MATH_1	302	306	PF00917	0.403
DOC_USP7_MATH_1	417	421	PF00917	0.735
DOC_USP7_MATH_1	76	80	PF00917	0.490
DOC_USP7_UBL2_3	204	208	PF12436	0.421
DOC_WW_Pin1_4	279	284	PF00397	0.409
DOC_WW_Pin1_4	298	303	PF00397	0.504
DOC_WW_Pin1_4	318	323	PF00397	0.280
LIG_Actin_WH2_2	377	395	PF00022	0.421
LIG_BRCT_BRCA1_1	144	148	PF00533	0.418
LIG_BRCT_BRCA1_1	154	158	PF00533	0.418
LIG_deltaCOP1_diTrp_1	134	142	PF00928	0.406
LIG_FHA_1	17	23	PF00498	0.532
LIG_FHA_1	172	178	PF00498	0.470
LIG_FHA_1	184	190	PF00498	0.348
LIG_FHA_1	208	214	PF00498	0.415
LIG_FHA_1	290	296	PF00498	0.493
LIG_FHA_1	87	93	PF00498	0.460
LIG_FHA_2	49	55	PF00498	0.491
LIG_FHA_2	57	63	PF00498	0.414
LIG_FHA_2	94	100	PF00498	0.422
LIG_HCF-1_HBM_1	261	264	PF13415	0.423
LIG_LIR_Gen_1	261	271	PF02991	0.430
LIG_LIR_Gen_1	363	374	PF02991	0.363
LIG_LIR_Nem_3	155	161	PF02991	0.408
LIG_LIR_Nem_3	261	267	PF02991	0.434
LIG_LIR_Nem_3	305	309	PF02991	0.373
LIG_LIR_Nem_3	363	369	PF02991	0.369
LIG_PCNA_APIM_2	198	204	PF02747	0.494
LIG_PCNA_yPIPBox_3	311	320	PF02747	0.503
LIG_Pex14_2	376	380	PF04695	0.495
LIG_SH2_CRK	154	158	PF00017	0.418
LIG_SH2_CRK	199	203	PF00017	0.414
LIG_SH2_PTP2	366	369	PF00017	0.421
LIG_SH2_STAP1	154	158	PF00017	0.418
LIG_SH2_STAT5	325	328	PF00017	0.375
LIG_SH2_STAT5	366	369	PF00017	0.495
LIG_SH3_3	220	226	PF00018	0.430
LIG_SUMO_SIM_anti_2	370	376	PF11976	0.421
LIG_SUMO_SIM_par_1	176	181	PF11976	0.422
LIG_SUMO_SIM_par_1	209	217	PF11976	0.421
LIG_SUMO_SIM_par_1	383	388	PF11976	0.347
LIG_SUMO_SIM_par_1	88	94	PF11976	0.470
LIG_TRAF2_1	52	55	PF00917	0.437
LIG_Vh1_VBS_1	371	389	PF01044	0.384
LIG_WW_1	322	325	PF00397	0.427
LIG_WW_2	225	228	PF00397	0.445
LIG_WW_3	321	325	PF00397	0.420
MOD_CAAXbox	429	432	PF01239	0.737
MOD_CDC14_SPxK_1	321	324	PF00782	0.514
MOD_CDK_SPxK_1	318	324	PF00069	0.518
MOD_CK1_1	113	119	PF00069	0.506
MOD_CK1_1	171	177	PF00069	0.532
MOD_CK1_1	183	189	PF00069	0.429
MOD_CK1_1	29	35	PF00069	0.397
MOD_CK1_1	348	354	PF00069	0.505
MOD_CK2_1	48	54	PF00069	0.487
MOD_CK2_1	93	99	PF00069	0.426
MOD_GlcNHglycan	122	125	PF01048	0.743
MOD_GlcNHglycan	144	147	PF01048	0.648
MOD_GlcNHglycan	240	243	PF01048	0.646
MOD_GlcNHglycan	252	255	PF01048	0.594
MOD_GlcNHglycan	276	279	PF01048	0.608
MOD_GlcNHglycan	332	335	PF01048	0.675
MOD_GlcNHglycan	362	365	PF01048	0.751
MOD_GlcNHglycan	79	82	PF01048	0.701
MOD_GSK3_1	113	120	PF00069	0.448
MOD_GSK3_1	126	133	PF00069	0.415
MOD_GSK3_1	140	147	PF00069	0.390
MOD_GSK3_1	176	183	PF00069	0.450
MOD_GSK3_1	203	210	PF00069	0.442
MOD_GSK3_1	248	255	PF00069	0.432
MOD_GSK3_1	298	305	PF00069	0.375
MOD_GSK3_1	342	349	PF00069	0.469
MOD_GSK3_1	35	42	PF00069	0.463
MOD_GSK3_1	67	74	PF00069	0.430
MOD_N-GLC_1	29	34	PF02516	0.636
MOD_NEK2_1	178	183	PF00069	0.451
MOD_NEK2_1	185	190	PF00069	0.398
MOD_NEK2_1	212	217	PF00069	0.443
MOD_NEK2_1	250	255	PF00069	0.386
MOD_NEK2_1	77	82	PF00069	0.407
MOD_PIKK_1	168	174	PF00454	0.426
MOD_PIKK_1	348	354	PF00454	0.476
MOD_PIKK_1	93	99	PF00454	0.448
MOD_Plk_1	29	35	PF00069	0.346
MOD_Plk_1	93	99	PF00069	0.384
MOD_Plk_4	152	158	PF00069	0.379
MOD_Plk_4	185	191	PF00069	0.485
MOD_Plk_4	207	213	PF00069	0.422
MOD_Plk_4	367	373	PF00069	0.497
MOD_Plk_4	385	391	PF00069	0.458
MOD_Plk_4	86	92	PF00069	0.409
MOD_Plk_4	99	105	PF00069	0.418
MOD_ProDKin_1	279	285	PF00069	0.411
MOD_ProDKin_1	298	304	PF00069	0.501
MOD_ProDKin_1	318	324	PF00069	0.281
MOD_SUMO_for_1	33	36	PF00179	0.452
MOD_SUMO_rev_2	420	425	PF00179	0.740
MOD_SUMO_rev_2	50	58	PF00179	0.438
TRG_ENDOCYTIC_2	154	157	PF00928	0.419
TRG_ENDOCYTIC_2	199	202	PF00928	0.416
TRG_ENDOCYTIC_2	264	267	PF00928	0.425
TRG_ENDOCYTIC_2	306	309	PF00928	0.407
TRG_ENDOCYTIC_2	366	369	PF00928	0.421
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8J7	Leptomonas seymouri	55%	89%
A0A3S7X6Q5	Leishmania donovani	91%	100%
A4HLG8	Leishmania braziliensis	75%	100%
A4HLG9	Leishmania braziliensis	72%	92%
A4I8X9	Leishmania infantum	91%	100%
E9B3U8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%