Putative pumilio protein 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein 6, putative

Species:

Leishmania major

UniProt:

Q4Q475_LEIMA

TriTrypDb:

LmjF.33.1150 , LMJLV39_330019000 , LMJSD75_330018700

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q475

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q475

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.441
CLV_C14_Caspase3-7	698	702	PF00656	0.597
CLV_C14_Caspase3-7	713	717	PF00656	0.364
CLV_NRD_NRD_1	154	156	PF00675	0.675
CLV_NRD_NRD_1	337	339	PF00675	0.685
CLV_NRD_NRD_1	790	792	PF00675	0.487
CLV_NRD_NRD_1	94	96	PF00675	0.483
CLV_PCSK_KEX2_1	337	339	PF00082	0.685
CLV_PCSK_KEX2_1	676	678	PF00082	0.453
CLV_PCSK_KEX2_1	790	792	PF00082	0.487
CLV_PCSK_KEX2_1	94	96	PF00082	0.483
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.453
CLV_PCSK_PC7_1	333	339	PF00082	0.699
CLV_PCSK_SKI1_1	677	681	PF00082	0.463
CLV_PCSK_SKI1_1	705	709	PF00082	0.582
CLV_PCSK_SKI1_1	712	716	PF00082	0.440
CLV_PCSK_SKI1_1	770	774	PF00082	0.441
CLV_PCSK_SKI1_1	792	796	PF00082	0.508
DEG_Nend_Nbox_1	1	3	PF02207	0.634
DEG_SPOP_SBC_1	804	808	PF00917	0.655
DOC_ANK_TNKS_1	20	27	PF00023	0.682
DOC_ANK_TNKS_1	696	703	PF00023	0.638
DOC_CKS1_1	129	134	PF01111	0.661
DOC_CKS1_1	209	214	PF01111	0.588
DOC_MAPK_DCC_7	112	122	PF00069	0.666
DOC_MAPK_gen_1	712	721	PF00069	0.568
DOC_MAPK_gen_1	787	795	PF00069	0.506
DOC_MAPK_MEF2A_6	467	475	PF00069	0.374
DOC_PP1_RVXF_1	397	404	PF00149	0.374
DOC_PP2B_LxvP_1	223	226	PF13499	0.673
DOC_PP4_FxxP_1	445	448	PF00568	0.367
DOC_PP4_FxxP_1	66	69	PF00568	0.678
DOC_USP7_MATH_1	116	120	PF00917	0.736
DOC_USP7_MATH_1	138	142	PF00917	0.796
DOC_USP7_MATH_1	210	214	PF00917	0.725
DOC_USP7_MATH_1	224	228	PF00917	0.571
DOC_USP7_MATH_1	69	73	PF00917	0.746
DOC_USP7_MATH_1	695	699	PF00917	0.687
DOC_USP7_MATH_2	132	138	PF00917	0.644
DOC_USP7_UBL2_3	156	160	PF12436	0.675
DOC_USP7_UBL2_3	463	467	PF12436	0.374
DOC_USP7_UBL2_3	611	615	PF12436	0.309
DOC_WW_Pin1_4	128	133	PF00397	0.659
DOC_WW_Pin1_4	190	195	PF00397	0.564
DOC_WW_Pin1_4	202	207	PF00397	0.577
DOC_WW_Pin1_4	208	213	PF00397	0.564
DOC_WW_Pin1_4	430	435	PF00397	0.412
DOC_WW_Pin1_4	444	449	PF00397	0.288
DOC_WW_Pin1_4	467	472	PF00397	0.374
DOC_WW_Pin1_4	57	62	PF00397	0.686
DOC_WW_Pin1_4	645	650	PF00397	0.402
DOC_WW_Pin1_4	72	77	PF00397	0.642
LIG_14-3-3_CanoR_1	776	781	PF00244	0.496
LIG_14-3-3_CanoR_1	94	102	PF00244	0.475
LIG_BRCT_BRCA1_1	194	198	PF00533	0.611
LIG_BRCT_BRCA1_1	378	382	PF00533	0.641
LIG_CSL_BTD_1	692	695	PF09270	0.612
LIG_CtBP_PxDLS_1	448	452	PF00389	0.333
LIG_eIF4E_1	459	465	PF01652	0.309
LIG_FAT_LD_1	509	517	PF03623	0.243
LIG_FHA_1	266	272	PF00498	0.762
LIG_FHA_1	468	474	PF00498	0.374
LIG_FHA_1	680	686	PF00498	0.679
LIG_FHA_2	125	131	PF00498	0.657
LIG_FHA_2	272	278	PF00498	0.648
LIG_FHA_2	701	707	PF00498	0.661
LIG_FHA_2	73	79	PF00498	0.458
LIG_IBAR_NPY_1	179	181	PF08397	0.601
LIG_IBAR_NPY_1	300	302	PF08397	0.622
LIG_LIR_Apic_2	443	448	PF02991	0.362
LIG_LIR_Apic_2	64	69	PF02991	0.682
LIG_LIR_Apic_2	769	774	PF02991	0.421
LIG_LIR_Apic_2	777	783	PF02991	0.398
LIG_LIR_Gen_1	124	132	PF02991	0.644
LIG_LIR_Gen_1	438	449	PF02991	0.333
LIG_LIR_Gen_1	580	590	PF02991	0.309
LIG_LIR_Gen_1	617	628	PF02991	0.384
LIG_LIR_Gen_1	759	768	PF02991	0.309
LIG_LIR_Gen_1	78	83	PF02991	0.476
LIG_LIR_Nem_3	130	136	PF02991	0.705
LIG_LIR_Nem_3	196	202	PF02991	0.617
LIG_LIR_Nem_3	268	272	PF02991	0.657
LIG_LIR_Nem_3	438	444	PF02991	0.309
LIG_LIR_Nem_3	453	459	PF02991	0.309
LIG_LIR_Nem_3	580	586	PF02991	0.346
LIG_LIR_Nem_3	596	601	PF02991	0.427
LIG_LIR_Nem_3	617	623	PF02991	0.384
LIG_LIR_Nem_3	64	70	PF02991	0.633
LIG_LIR_Nem_3	741	747	PF02991	0.483
LIG_LIR_Nem_3	759	764	PF02991	0.206
LIG_LIR_Nem_3	78	82	PF02991	0.429
LIG_LIR_Nem_3	98	103	PF02991	0.345
LIG_LYPXL_S_1	66	70	PF13949	0.628
LIG_LYPXL_yS_3	67	70	PF13949	0.623
LIG_MYND_3	117	121	PF01753	0.623
LIG_NRBOX	460	466	PF00104	0.309
LIG_NRBOX	508	514	PF00104	0.243
LIG_NRP_CendR_1	849	850	PF00754	0.615
LIG_PCNA_yPIPBox_3	458	467	PF02747	0.309
LIG_PCNA_yPIPBox_3	595	607	PF02747	0.315
LIG_Pex14_2	441	445	PF04695	0.309
LIG_SH2_CRK	317	321	PF00017	0.670
LIG_SH2_CRK	50	54	PF00017	0.678
LIG_SH2_CRK	620	624	PF00017	0.420
LIG_SH2_CRK	780	784	PF00017	0.417
LIG_SH2_GRB2like	50	53	PF00017	0.557
LIG_SH2_GRB2like	744	747	PF00017	0.426
LIG_SH2_NCK_1	317	321	PF00017	0.670
LIG_SH2_NCK_1	50	54	PF00017	0.643
LIG_SH2_PTP2	771	774	PF00017	0.540
LIG_SH2_SRC	218	221	PF00017	0.597
LIG_SH2_STAP1	411	415	PF00017	0.369
LIG_SH2_STAP1	50	54	PF00017	0.568
LIG_SH2_STAP1	744	748	PF00017	0.426
LIG_SH2_STAT3	2	5	PF00017	0.645
LIG_SH2_STAT3	260	263	PF00017	0.604
LIG_SH2_STAT3	459	462	PF00017	0.309
LIG_SH2_STAT3	601	604	PF00017	0.309
LIG_SH2_STAT3	747	750	PF00017	0.309
LIG_SH2_STAT5	261	264	PF00017	0.597
LIG_SH2_STAT5	459	462	PF00017	0.309
LIG_SH2_STAT5	601	604	PF00017	0.309
LIG_SH2_STAT5	629	632	PF00017	0.410
LIG_SH2_STAT5	747	750	PF00017	0.309
LIG_SH2_STAT5	771	774	PF00017	0.398
LIG_SH2_STAT5	778	781	PF00017	0.428
LIG_SH3_3	105	111	PF00018	0.659
LIG_SH3_3	791	797	PF00018	0.454
LIG_SUMO_SIM_anti_2	435	441	PF11976	0.378
LIG_SUMO_SIM_anti_2	446	454	PF11976	0.256
LIG_SUMO_SIM_anti_2	668	674	PF11976	0.467
LIG_SUMO_SIM_par_1	446	454	PF11976	0.333
LIG_SUMO_SIM_par_1	483	488	PF11976	0.336
LIG_TRAF2_1	576	579	PF00917	0.309
LIG_UBA3_1	512	517	PF00899	0.369
LIG_UBA3_1	582	588	PF00899	0.369
LIG_WRC_WIRS_1	266	271	PF05994	0.663
MOD_CDK_SPxxK_3	645	652	PF00069	0.426
MOD_CK1_1	184	190	PF00069	0.658
MOD_CK1_1	193	199	PF00069	0.499
MOD_CK1_1	254	260	PF00069	0.683
MOD_CK1_1	3	9	PF00069	0.605
MOD_CK1_1	31	37	PF00069	0.748
MOD_CK1_1	328	334	PF00069	0.635
MOD_CK1_1	370	376	PF00069	0.635
MOD_CK1_1	433	439	PF00069	0.374
MOD_CK1_1	549	555	PF00069	0.413
MOD_CK1_1	72	78	PF00069	0.509
MOD_CK1_1	808	814	PF00069	0.744
MOD_CK2_1	124	130	PF00069	0.662
MOD_CK2_1	444	450	PF00069	0.447
MOD_CK2_1	611	617	PF00069	0.330
MOD_CK2_1	700	706	PF00069	0.671
MOD_CK2_1	830	836	PF00069	0.717
MOD_Cter_Amidation	153	156	PF01082	0.679
MOD_GlcNHglycan	13	16	PF01048	0.625
MOD_GlcNHglycan	134	139	PF01048	0.646
MOD_GlcNHglycan	150	153	PF01048	0.824
MOD_GlcNHglycan	227	230	PF01048	0.630
MOD_GlcNHglycan	30	33	PF01048	0.651
MOD_GlcNHglycan	343	346	PF01048	0.684
MOD_GlcNHglycan	372	375	PF01048	0.712
MOD_GlcNHglycan	42	45	PF01048	0.762
MOD_GlcNHglycan	426	429	PF01048	0.353
MOD_GlcNHglycan	548	551	PF01048	0.412
MOD_GlcNHglycan	677	680	PF01048	0.512
MOD_GSK3_1	124	131	PF00069	0.767
MOD_GSK3_1	134	141	PF00069	0.653
MOD_GSK3_1	186	193	PF00069	0.735
MOD_GSK3_1	283	290	PF00069	0.706
MOD_GSK3_1	315	322	PF00069	0.740
MOD_GSK3_1	372	379	PF00069	0.662
MOD_GSK3_1	424	431	PF00069	0.374
MOD_GSK3_1	467	474	PF00069	0.417
MOD_GSK3_1	57	64	PF00069	0.646
MOD_GSK3_1	611	618	PF00069	0.466
MOD_GSK3_1	675	682	PF00069	0.531
MOD_GSK3_1	68	75	PF00069	0.408
MOD_GSK3_1	689	696	PF00069	0.698
MOD_GSK3_1	804	811	PF00069	0.740
MOD_N-GLC_1	341	346	PF02516	0.676
MOD_NEK2_1	315	320	PF00069	0.672
MOD_NEK2_1	424	429	PF00069	0.374
MOD_NEK2_1	546	551	PF00069	0.388
MOD_NEK2_1	628	633	PF00069	0.454
MOD_NEK2_1	675	680	PF00069	0.514
MOD_NEK2_1	82	87	PF00069	0.584
MOD_NEK2_2	700	705	PF00069	0.622
MOD_PIKK_1	169	175	PF00454	0.668
MOD_PIKK_1	193	199	PF00454	0.547
MOD_PIKK_1	254	260	PF00454	0.648
MOD_PIKK_1	283	289	PF00454	0.776
MOD_PIKK_1	315	321	PF00454	0.671
MOD_PIKK_1	93	99	PF00454	0.530
MOD_PK_1	615	621	PF00069	0.427
MOD_PKA_2	230	236	PF00069	0.639
MOD_PKA_2	245	251	PF00069	0.709
MOD_PKA_2	328	334	PF00069	0.635
MOD_PKA_2	786	792	PF00069	0.514
MOD_PKA_2	93	99	PF00069	0.469
MOD_Plk_1	134	140	PF00069	0.700
MOD_Plk_1	3	9	PF00069	0.563
MOD_Plk_1	485	491	PF00069	0.426
MOD_Plk_1	578	584	PF00069	0.426
MOD_Plk_4	181	187	PF00069	0.665
MOD_Plk_4	578	584	PF00069	0.439
MOD_Plk_4	615	621	PF00069	0.427
MOD_Plk_4	62	68	PF00069	0.638
MOD_Plk_4	731	737	PF00069	0.365
MOD_ProDKin_1	128	134	PF00069	0.661
MOD_ProDKin_1	190	196	PF00069	0.561
MOD_ProDKin_1	202	208	PF00069	0.573
MOD_ProDKin_1	430	436	PF00069	0.412
MOD_ProDKin_1	444	450	PF00069	0.294
MOD_ProDKin_1	467	473	PF00069	0.374
MOD_ProDKin_1	57	63	PF00069	0.681
MOD_ProDKin_1	645	651	PF00069	0.402
MOD_ProDKin_1	72	78	PF00069	0.638
MOD_SUMO_for_1	610	613	PF00179	0.333
MOD_SUMO_rev_2	161	169	PF00179	0.593
MOD_SUMO_rev_2	394	401	PF00179	0.503
MOD_SUMO_rev_2	612	616	PF00179	0.309
MOD_SUMO_rev_2	709	717	PF00179	0.630
TRG_DiLeu_BaEn_2	419	425	PF01217	0.309
TRG_DiLeu_BaEn_2	756	762	PF01217	0.374
TRG_ENDOCYTIC_2	302	305	PF00928	0.682
TRG_ENDOCYTIC_2	50	53	PF00928	0.642
TRG_ENDOCYTIC_2	620	623	PF00928	0.419
TRG_ENDOCYTIC_2	67	70	PF00928	0.615
TRG_ER_diArg_1	337	339	PF00400	0.689
TRG_ER_diArg_1	93	95	PF00400	0.481
TRG_NES_CRM1_1	478	490	PF08389	0.374
TRG_NES_CRM1_1	580	596	PF08389	0.374
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	782	786	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P2G5	Trypanosomatidae	48%	93%
A0A3Q8IET5	Leishmania donovani	97%	100%
A0A3R7N6T6	Trypanosoma rangeli	48%	100%
A4HLH0	Leishmania braziliensis	88%	100%
A4I8Y0	Leishmania infantum	97%	100%
D0A4X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B3U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BZN6	Trypanosoma cruzi	49%	100%