Aa_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q474_LEIMA

TriTrypDb:

LmjF.33.1160 , LMJLV39_330019100 , LMJSD75_330018800

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q474

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q474

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	54	56	PF00082	0.599
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.623
CLV_PCSK_SKI1_1	18	22	PF00082	0.636
CLV_PCSK_SKI1_1	5	9	PF00082	0.633
DEG_Nend_Nbox_1	1	3	PF02207	0.418
DOC_CYCLIN_RxL_1	2	10	PF00134	0.489
DOC_USP7_MATH_1	3	7	PF00917	0.454
DOC_USP7_MATH_1	75	79	PF00917	0.413
DOC_WW_Pin1_4	82	87	PF00397	0.312
LIG_Clathr_ClatBox_1	137	141	PF01394	0.291
LIG_FHA_1	90	96	PF00498	0.270
LIG_FHA_2	112	118	PF00498	0.546
LIG_LIR_Gen_1	141	147	PF02991	0.291
LIG_LIR_Nem_3	141	147	PF02991	0.291
LIG_LIR_Nem_3	81	87	PF02991	0.256
LIG_PDZ_Class_2	142	147	PF00595	0.469
LIG_SH2_CRK	130	134	PF00017	0.325
LIG_SH2_CRK	84	88	PF00017	0.291
LIG_SH2_CRK	97	101	PF00017	0.291
LIG_SH2_NCK_1	84	88	PF00017	0.385
LIG_SH2_STAP1	109	113	PF00017	0.542
LIG_SH2_STAT5	118	121	PF00017	0.588
LIG_SH2_STAT5	57	60	PF00017	0.442
LIG_SUMO_SIM_par_1	98	104	PF11976	0.291
LIG_SxIP_EBH_1	55	69	PF03271	0.408
LIG_TYR_ITIM	82	87	PF00017	0.293
LIG_TYR_ITIM	95	100	PF00017	0.304
MOD_CK1_1	36	42	PF00069	0.499
MOD_CK1_1	78	84	PF00069	0.379
MOD_GlcNHglycan	35	38	PF01048	0.689
MOD_GlcNHglycan	46	49	PF01048	0.592
MOD_GSK3_1	107	114	PF00069	0.565
MOD_GSK3_1	29	36	PF00069	0.481
MOD_GSK3_1	3	10	PF00069	0.470
MOD_GSK3_1	44	51	PF00069	0.441
MOD_GSK3_1	78	85	PF00069	0.386
MOD_N-GLC_1	107	112	PF02516	0.403
MOD_NEK2_1	111	116	PF00069	0.588
MOD_NEK2_1	29	34	PF00069	0.510
MOD_NEK2_1	50	55	PF00069	0.435
MOD_NEK2_1	58	63	PF00069	0.404
MOD_NEK2_1	7	12	PF00069	0.471
MOD_PIKK_1	68	74	PF00454	0.411
MOD_PIKK_1	7	13	PF00454	0.478
MOD_PKA_2	29	35	PF00069	0.494
MOD_Plk_1	107	113	PF00069	0.603
MOD_Plk_4	123	129	PF00069	0.491
MOD_Plk_4	58	64	PF00069	0.445
MOD_Plk_4	78	84	PF00069	0.275
MOD_Plk_4	89	95	PF00069	0.291
MOD_ProDKin_1	82	88	PF00069	0.312
TRG_ENDOCYTIC_2	130	133	PF00928	0.291
TRG_ENDOCYTIC_2	84	87	PF00928	0.293
TRG_ENDOCYTIC_2	97	100	PF00928	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAG2	Leptomonas seymouri	73%	100%
A0A1X0P172	Trypanosomatidae	47%	100%
A0A3S5H7U3	Leishmania donovani	96%	100%
A0A422MW56	Trypanosoma rangeli	50%	100%
A4HLH1	Leishmania braziliensis	83%	100%
A4I8Y1	Leishmania infantum	96%	100%
E9B3V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%