Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q471_LEIMA

TriTrypDb:

LmjF.33.1190 , LMJLV39_330019400 , LMJSD75_330019100

Length:

884

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q471

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q471

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	499	503	PF00656	0.650
CLV_C14_Caspase3-7	839	843	PF00656	0.641
CLV_NRD_NRD_1	287	289	PF00675	0.466
CLV_NRD_NRD_1	326	328	PF00675	0.612
CLV_NRD_NRD_1	39	41	PF00675	0.589
CLV_NRD_NRD_1	410	412	PF00675	0.547
CLV_NRD_NRD_1	441	443	PF00675	0.544
CLV_NRD_NRD_1	469	471	PF00675	0.523
CLV_NRD_NRD_1	488	490	PF00675	0.636
CLV_NRD_NRD_1	494	496	PF00675	0.612
CLV_NRD_NRD_1	590	592	PF00675	0.563
CLV_NRD_NRD_1	63	65	PF00675	0.576
CLV_NRD_NRD_1	657	659	PF00675	0.644
CLV_NRD_NRD_1	779	781	PF00675	0.537
CLV_NRD_NRD_1	807	809	PF00675	0.522
CLV_PCSK_FUR_1	285	289	PF00082	0.462
CLV_PCSK_KEX2_1	287	289	PF00082	0.466
CLV_PCSK_KEX2_1	326	328	PF00082	0.602
CLV_PCSK_KEX2_1	377	379	PF00082	0.410
CLV_PCSK_KEX2_1	39	41	PF00082	0.589
CLV_PCSK_KEX2_1	441	443	PF00082	0.544
CLV_PCSK_KEX2_1	469	471	PF00082	0.523
CLV_PCSK_KEX2_1	488	490	PF00082	0.636
CLV_PCSK_KEX2_1	494	496	PF00082	0.612
CLV_PCSK_KEX2_1	590	592	PF00082	0.642
CLV_PCSK_KEX2_1	63	65	PF00082	0.576
CLV_PCSK_KEX2_1	657	659	PF00082	0.671
CLV_PCSK_KEX2_1	779	781	PF00082	0.537
CLV_PCSK_KEX2_1	807	809	PF00082	0.522
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.397
CLV_PCSK_SKI1_1	109	113	PF00082	0.540
CLV_PCSK_SKI1_1	137	141	PF00082	0.529
CLV_PCSK_SKI1_1	160	164	PF00082	0.536
CLV_PCSK_SKI1_1	220	224	PF00082	0.472
CLV_PCSK_SKI1_1	39	43	PF00082	0.585
CLV_PCSK_SKI1_1	488	492	PF00082	0.650
CLV_PCSK_SKI1_1	63	67	PF00082	0.506
CLV_PCSK_SKI1_1	780	784	PF00082	0.500
DEG_APCC_DBOX_1	136	144	PF00400	0.522
DEG_APCC_DBOX_1	38	46	PF00400	0.578
DEG_APCC_DBOX_1	62	70	PF00400	0.560
DEG_APCC_DBOX_1	8	16	PF00400	0.523
DEG_SCF_FBW7_1	703	710	PF00400	0.465
DEG_SCF_FBW7_1	859	864	PF00400	0.534
DEG_SIAH_1	403	411	PF03145	0.624
DEG_SPOP_SBC_1	563	567	PF00917	0.539
DOC_CKS1_1	527	532	PF01111	0.614
DOC_CYCLIN_RxL_1	482	492	PF00134	0.573
DOC_CYCLIN_RxL_1	61	71	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	737	743	PF00134	0.428
DOC_MAPK_gen_1	112	121	PF00069	0.468
DOC_MAPK_gen_1	14	23	PF00069	0.588
DOC_MAPK_gen_1	193	201	PF00069	0.519
DOC_MAPK_gen_1	39	47	PF00069	0.581
DOC_MAPK_gen_1	52	62	PF00069	0.441
DOC_MAPK_gen_1	554	562	PF00069	0.538
DOC_MAPK_gen_1	63	69	PF00069	0.421
DOC_MAPK_MEF2A_6	195	203	PF00069	0.492
DOC_MAPK_MEF2A_6	39	47	PF00069	0.533
DOC_MAPK_RevD_3	25	40	PF00069	0.583
DOC_PP1_RVXF_1	591	597	PF00149	0.528
DOC_PP1_RVXF_1	753	759	PF00149	0.508
DOC_PP2B_LxvP_1	156	159	PF13499	0.593
DOC_PP2B_LxvP_1	207	210	PF13499	0.374
DOC_PP2B_LxvP_1	30	33	PF13499	0.591
DOC_PP2B_LxvP_1	309	312	PF13499	0.416
DOC_PP2B_LxvP_1	43	46	PF13499	0.445
DOC_PP2B_LxvP_1	576	579	PF13499	0.662
DOC_PP2B_LxvP_1	737	740	PF13499	0.536
DOC_PP4_FxxP_1	401	404	PF00568	0.547
DOC_PP4_FxxP_1	537	540	PF00568	0.527
DOC_USP7_MATH_1	194	198	PF00917	0.547
DOC_USP7_MATH_1	261	265	PF00917	0.601
DOC_USP7_MATH_1	268	272	PF00917	0.567
DOC_USP7_MATH_1	339	343	PF00917	0.526
DOC_USP7_MATH_1	532	536	PF00917	0.694
DOC_USP7_MATH_1	699	703	PF00917	0.479
DOC_USP7_MATH_1	768	772	PF00917	0.641
DOC_USP7_MATH_1	816	820	PF00917	0.725
DOC_USP7_MATH_1	855	859	PF00917	0.644
DOC_USP7_MATH_1	868	872	PF00917	0.595
DOC_USP7_MATH_1	879	883	PF00917	0.534
DOC_WW_Pin1_4	176	181	PF00397	0.421
DOC_WW_Pin1_4	271	276	PF00397	0.499
DOC_WW_Pin1_4	406	411	PF00397	0.598
DOC_WW_Pin1_4	473	478	PF00397	0.625
DOC_WW_Pin1_4	489	494	PF00397	0.537
DOC_WW_Pin1_4	515	520	PF00397	0.657
DOC_WW_Pin1_4	526	531	PF00397	0.530
DOC_WW_Pin1_4	543	548	PF00397	0.649
DOC_WW_Pin1_4	564	569	PF00397	0.616
DOC_WW_Pin1_4	673	678	PF00397	0.471
DOC_WW_Pin1_4	703	708	PF00397	0.497
DOC_WW_Pin1_4	739	744	PF00397	0.565
DOC_WW_Pin1_4	812	817	PF00397	0.552
DOC_WW_Pin1_4	857	862	PF00397	0.702
LIG_14-3-3_CanoR_1	115	120	PF00244	0.479
LIG_14-3-3_CanoR_1	160	170	PF00244	0.656
LIG_14-3-3_CanoR_1	193	203	PF00244	0.545
LIG_14-3-3_CanoR_1	258	266	PF00244	0.607
LIG_14-3-3_CanoR_1	338	344	PF00244	0.518
LIG_14-3-3_CanoR_1	512	520	PF00244	0.577
LIG_14-3-3_CanoR_1	523	527	PF00244	0.619
LIG_14-3-3_CanoR_1	593	603	PF00244	0.566
LIG_14-3-3_CanoR_1	612	621	PF00244	0.602
LIG_14-3-3_CanoR_1	657	666	PF00244	0.596
LIG_14-3-3_CanoR_1	731	739	PF00244	0.480
LIG_14-3-3_CanoR_1	773	777	PF00244	0.503
LIG_Actin_WH2_2	23	41	PF00022	0.524
LIG_ActinCP_TwfCPI_2	401	411	PF01115	0.550
LIG_APCC_ABBA_1	534	539	PF00400	0.523
LIG_BIR_III_2	72	76	PF00653	0.526
LIG_BRCT_BRCA1_1	117	121	PF00533	0.595
LIG_BRCT_BRCA1_1	171	175	PF00533	0.553
LIG_BRCT_BRCA1_1	601	605	PF00533	0.571
LIG_CaM_NSCaTE_8	439	446	PF13499	0.535
LIG_DLG_GKlike_1	595	603	PF00625	0.553
LIG_FHA_1	105	111	PF00498	0.529
LIG_FHA_1	124	130	PF00498	0.424
LIG_FHA_1	176	182	PF00498	0.588
LIG_FHA_1	198	204	PF00498	0.392
LIG_FHA_1	210	216	PF00498	0.433
LIG_FHA_1	226	232	PF00498	0.388
LIG_FHA_1	311	317	PF00498	0.503
LIG_FHA_1	338	344	PF00498	0.619
LIG_FHA_1	522	528	PF00498	0.575
LIG_FHA_1	666	672	PF00498	0.454
LIG_FHA_1	781	787	PF00498	0.636
LIG_FHA_1	858	864	PF00498	0.605
LIG_FHA_2	348	354	PF00498	0.451
LIG_FHA_2	458	464	PF00498	0.544
LIG_FHA_2	499	505	PF00498	0.693
LIG_FHA_2	516	522	PF00498	0.502
LIG_FHA_2	708	714	PF00498	0.634
LIG_Integrin_RGD_1	554	556	PF01839	0.539
LIG_LIR_Apic_2	535	540	PF02991	0.524
LIG_LIR_Gen_1	624	635	PF02991	0.473
LIG_LIR_Nem_3	274	279	PF02991	0.413
LIG_LIR_Nem_3	624	630	PF02991	0.481
LIG_LIR_Nem_3	71	77	PF02991	0.602
LIG_LIR_Nem_3	735	741	PF02991	0.406
LIG_LYPXL_yS_3	10	13	PF13949	0.566
LIG_MLH1_MIPbox_1	171	175	PF16413	0.504
LIG_NRBOX	135	141	PF00104	0.522
LIG_NRBOX	486	492	PF00104	0.599
LIG_PCNA_yPIPBox_3	478	491	PF02747	0.649
LIG_PDZ_Class_1	879	884	PF00595	0.550
LIG_SH2_STAP1	233	237	PF00017	0.383
LIG_SH2_STAP1	242	246	PF00017	0.402
LIG_SH2_STAT5	186	189	PF00017	0.434
LIG_SH2_STAT5	526	529	PF00017	0.665
LIG_SH2_STAT5	627	630	PF00017	0.452
LIG_SH2_STAT5	738	741	PF00017	0.414
LIG_SH3_2	477	482	PF14604	0.618
LIG_SH3_3	146	152	PF00018	0.503
LIG_SH3_3	309	315	PF00018	0.464
LIG_SH3_3	382	388	PF00018	0.507
LIG_SH3_3	432	438	PF00018	0.591
LIG_SH3_3	474	480	PF00018	0.655
LIG_SH3_3	62	68	PF00018	0.510
LIG_SH3_3	671	677	PF00018	0.395
LIG_SH3_3	718	724	PF00018	0.405
LIG_SH3_3	737	743	PF00018	0.343
LIG_SUMO_SIM_par_1	277	283	PF11976	0.363
LIG_SUMO_SIM_par_1	361	369	PF11976	0.429
LIG_SUMO_SIM_par_1	546	553	PF11976	0.557
LIG_SUMO_SIM_par_1	640	645	PF11976	0.534
LIG_SxIP_EBH_1	870	883	PF03271	0.543
LIG_TRAF2_1	460	463	PF00917	0.563
LIG_TRAF2_1	578	581	PF00917	0.650
LIG_TRAF2_1	710	713	PF00917	0.654
LIG_TYR_ITIM	736	741	PF00017	0.404
LIG_UBA3_1	372	377	PF00899	0.499
LIG_UBA3_1	753	760	PF00899	0.391
LIG_WRC_WIRS_1	630	635	PF05994	0.442
LIG_WW_3	479	483	PF00397	0.506
MOD_CDC14_SPxK_1	492	495	PF00782	0.610
MOD_CDC14_SPxK_1	567	570	PF00782	0.571
MOD_CDK_SPK_2	406	411	PF00069	0.598
MOD_CDK_SPK_2	473	478	PF00069	0.517
MOD_CDK_SPK_2	489	494	PF00069	0.537
MOD_CDK_SPK_2	673	678	PF00069	0.460
MOD_CDK_SPxK_1	406	412	PF00069	0.551
MOD_CDK_SPxK_1	489	495	PF00069	0.597
MOD_CDK_SPxK_1	564	570	PF00069	0.591
MOD_CK1_1	150	156	PF00069	0.616
MOD_CK1_1	176	182	PF00069	0.577
MOD_CK1_1	197	203	PF00069	0.423
MOD_CK1_1	271	277	PF00069	0.522
MOD_CK1_1	416	422	PF00069	0.752
MOD_CK1_1	426	432	PF00069	0.595
MOD_CK1_1	515	521	PF00069	0.665
MOD_CK1_1	629	635	PF00069	0.441
MOD_CK1_1	702	708	PF00069	0.552
MOD_CK1_1	771	777	PF00069	0.653
MOD_CK1_1	833	839	PF00069	0.565
MOD_CK1_1	857	863	PF00069	0.587
MOD_CK1_1	89	95	PF00069	0.585
MOD_CK2_1	102	108	PF00069	0.443
MOD_CK2_1	256	262	PF00069	0.512
MOD_CK2_1	457	463	PF00069	0.546
MOD_CK2_1	515	521	PF00069	0.660
MOD_CK2_1	706	712	PF00069	0.681
MOD_CK2_1	772	778	PF00069	0.605
MOD_CMANNOS	436	439	PF00535	0.510
MOD_Cter_Amidation	285	288	PF01082	0.469
MOD_DYRK1A_RPxSP_1	673	677	PF00069	0.391
MOD_GlcNHglycan	152	155	PF01048	0.615
MOD_GlcNHglycan	156	159	PF01048	0.646
MOD_GlcNHglycan	171	174	PF01048	0.376
MOD_GlcNHglycan	262	266	PF01048	0.668
MOD_GlcNHglycan	270	273	PF01048	0.555
MOD_GlcNHglycan	3	6	PF01048	0.639
MOD_GlcNHglycan	331	334	PF01048	0.502
MOD_GlcNHglycan	415	418	PF01048	0.693
MOD_GlcNHglycan	425	428	PF01048	0.531
MOD_GlcNHglycan	504	507	PF01048	0.747
MOD_GlcNHglycan	514	517	PF01048	0.622
MOD_GlcNHglycan	623	626	PF01048	0.667
MOD_GlcNHglycan	644	647	PF01048	0.508
MOD_GlcNHglycan	747	750	PF01048	0.401
MOD_GlcNHglycan	768	771	PF01048	0.597
MOD_GlcNHglycan	786	789	PF01048	0.495
MOD_GlcNHglycan	818	821	PF01048	0.769
MOD_GlcNHglycan	832	835	PF01048	0.558
MOD_GlcNHglycan	838	841	PF01048	0.505
MOD_GlcNHglycan	863	866	PF01048	0.703
MOD_GlcNHglycan	89	92	PF01048	0.657
MOD_GSK3_1	115	122	PF00069	0.543
MOD_GSK3_1	150	157	PF00069	0.578
MOD_GSK3_1	169	176	PF00069	0.563
MOD_GSK3_1	205	212	PF00069	0.475
MOD_GSK3_1	256	263	PF00069	0.575
MOD_GSK3_1	267	274	PF00069	0.570
MOD_GSK3_1	412	419	PF00069	0.769
MOD_GSK3_1	426	433	PF00069	0.520
MOD_GSK3_1	498	505	PF00069	0.625
MOD_GSK3_1	508	515	PF00069	0.671
MOD_GSK3_1	522	529	PF00069	0.490
MOD_GSK3_1	558	565	PF00069	0.744
MOD_GSK3_1	595	602	PF00069	0.591
MOD_GSK3_1	699	706	PF00069	0.496
MOD_GSK3_1	768	775	PF00069	0.554
MOD_GSK3_1	780	787	PF00069	0.557
MOD_GSK3_1	812	819	PF00069	0.773
MOD_GSK3_1	85	92	PF00069	0.623
MOD_GSK3_1	855	862	PF00069	0.652
MOD_GSK3_1	868	875	PF00069	0.734
MOD_GSK3_1	95	102	PF00069	0.639
MOD_N-GLC_1	502	507	PF02516	0.571
MOD_N-GLC_1	707	712	PF02516	0.508
MOD_N-GLC_1	86	91	PF02516	0.634
MOD_NEK2_1	119	124	PF00069	0.593
MOD_NEK2_1	174	179	PF00069	0.434
MOD_NEK2_1	26	31	PF00069	0.515
MOD_NEK2_1	594	599	PF00069	0.556
MOD_NEK2_1	601	606	PF00069	0.548
MOD_NEK2_1	86	91	PF00069	0.586
MOD_NEK2_1	872	877	PF00069	0.562
MOD_NEK2_2	339	344	PF00069	0.541
MOD_NEK2_2	532	537	PF00069	0.534
MOD_NEK2_2	768	773	PF00069	0.696
MOD_PKA_1	657	663	PF00069	0.605
MOD_PKA_1	780	786	PF00069	0.500
MOD_PKA_2	194	200	PF00069	0.533
MOD_PKA_2	257	263	PF00069	0.605
MOD_PKA_2	337	343	PF00069	0.583
MOD_PKA_2	347	353	PF00069	0.416
MOD_PKA_2	522	528	PF00069	0.578
MOD_PKA_2	594	600	PF00069	0.527
MOD_PKA_2	656	662	PF00069	0.620
MOD_PKA_2	730	736	PF00069	0.486
MOD_PKA_2	772	778	PF00069	0.502
MOD_PKB_1	593	601	PF00069	0.554
MOD_Plk_1	261	267	PF00069	0.605
MOD_Plk_1	449	455	PF00069	0.475
MOD_Plk_1	707	713	PF00069	0.480
MOD_Plk_2-3	364	370	PF00069	0.410
MOD_Plk_2-3	713	719	PF00069	0.489
MOD_Plk_4	197	203	PF00069	0.505
MOD_Plk_4	449	455	PF00069	0.475
MOD_Plk_4	522	528	PF00069	0.593
MOD_Plk_4	532	538	PF00069	0.603
MOD_Plk_4	595	601	PF00069	0.553
MOD_Plk_4	626	632	PF00069	0.457
MOD_Plk_4	772	778	PF00069	0.726
MOD_Plk_4	793	799	PF00069	0.676
MOD_Plk_4	833	839	PF00069	0.564
MOD_Plk_4	872	878	PF00069	0.596
MOD_Plk_4	89	95	PF00069	0.570
MOD_ProDKin_1	176	182	PF00069	0.413
MOD_ProDKin_1	271	277	PF00069	0.479
MOD_ProDKin_1	406	412	PF00069	0.599
MOD_ProDKin_1	473	479	PF00069	0.620
MOD_ProDKin_1	489	495	PF00069	0.543
MOD_ProDKin_1	515	521	PF00069	0.660
MOD_ProDKin_1	526	532	PF00069	0.529
MOD_ProDKin_1	543	549	PF00069	0.652
MOD_ProDKin_1	564	570	PF00069	0.615
MOD_ProDKin_1	673	679	PF00069	0.472
MOD_ProDKin_1	703	709	PF00069	0.501
MOD_ProDKin_1	739	745	PF00069	0.561
MOD_ProDKin_1	812	818	PF00069	0.551
MOD_ProDKin_1	857	863	PF00069	0.706
TRG_DiLeu_BaEn_1	134	139	PF01217	0.427
TRG_DiLeu_BaEn_4	734	740	PF01217	0.485
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.402
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.551
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.495
TRG_DiLeu_LyEn_5	134	139	PF01217	0.427
TRG_ENDOCYTIC_2	10	13	PF00928	0.650
TRG_ENDOCYTIC_2	627	630	PF00928	0.452
TRG_ENDOCYTIC_2	738	741	PF00928	0.414
TRG_ER_diArg_1	13	16	PF00400	0.570
TRG_ER_diArg_1	284	287	PF00400	0.428
TRG_ER_diArg_1	326	328	PF00400	0.630
TRG_ER_diArg_1	38	40	PF00400	0.586
TRG_ER_diArg_1	441	443	PF00400	0.544
TRG_ER_diArg_1	468	470	PF00400	0.523
TRG_ER_diArg_1	487	489	PF00400	0.564
TRG_ER_diArg_1	493	495	PF00400	0.612
TRG_ER_diArg_1	590	593	PF00400	0.531
TRG_ER_diArg_1	62	64	PF00400	0.559
TRG_ER_diArg_1	695	698	PF00400	0.481
TRG_ER_diArg_1	807	809	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	755	759	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS9	Leptomonas seymouri	35%	94%
A0A3S7X6J9	Leishmania donovani	88%	100%
A4HLH4	Leishmania braziliensis	68%	100%
A4I8Y4	Leishmania infantum	88%	100%
E9B3V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%