AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania major

UniProt:

Q4Q470_LEIMA

TriTrypDb:

LmjF.33.1200 , LMJLV39_330019500 , LMJSD75_330019200

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q470

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q470

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016462	pyrophosphatase activity	5	17
GO:0016787	hydrolase activity	2	17
GO:0016817	hydrolase activity, acting on acid anhydrides	3	17
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	17
GO:0016887	ATP hydrolysis activity	7	17
GO:0017076	purine nucleotide binding	4	17
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.668
CLV_C14_Caspase3-7	380	384	PF00656	0.746
CLV_C14_Caspase3-7	409	413	PF00656	0.526
CLV_C14_Caspase3-7	454	458	PF00656	0.790
CLV_C14_Caspase3-7	470	474	PF00656	0.641
CLV_C14_Caspase3-7	58	62	PF00656	0.577
CLV_C14_Caspase3-7	612	616	PF00656	0.739
CLV_NRD_NRD_1	260	262	PF00675	0.478
CLV_NRD_NRD_1	438	440	PF00675	0.579
CLV_PCSK_FUR_1	436	440	PF00082	0.623
CLV_PCSK_KEX2_1	260	262	PF00082	0.504
CLV_PCSK_KEX2_1	350	352	PF00082	0.303
CLV_PCSK_KEX2_1	381	383	PF00082	0.404
CLV_PCSK_KEX2_1	438	440	PF00082	0.580
CLV_PCSK_KEX2_1	506	508	PF00082	0.541
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.337
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.402
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.450
CLV_PCSK_SKI1_1	243	247	PF00082	0.424
CLV_PCSK_SKI1_1	283	287	PF00082	0.372
CLV_PCSK_SKI1_1	325	329	PF00082	0.322
CLV_PCSK_SKI1_1	351	355	PF00082	0.308
CLV_PCSK_SKI1_1	369	373	PF00082	0.308
CLV_PCSK_SKI1_1	484	488	PF00082	0.601
CLV_PCSK_SKI1_1	512	516	PF00082	0.372
CLV_PCSK_SKI1_1	590	594	PF00082	0.413
CLV_PCSK_SKI1_1	83	87	PF00082	0.375
CLV_PCSK_SKI1_1	92	96	PF00082	0.399
CLV_Separin_Metazoa	644	648	PF03568	0.559
DEG_Nend_UBRbox_2	1	3	PF02207	0.427
DEG_SPOP_SBC_1	60	64	PF00917	0.549
DOC_CYCLIN_RxL_1	191	202	PF00134	0.639
DOC_CYCLIN_RxL_1	258	269	PF00134	0.608
DOC_CYCLIN_RxL_1	280	288	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	295	301	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.529
DOC_MAPK_gen_1	350	358	PF00069	0.491
DOC_PP1_RVXF_1	259	266	PF00149	0.759
DOC_PP2B_LxvP_1	106	109	PF13499	0.663
DOC_PP4_FxxP_1	67	70	PF00568	0.510
DOC_SPAK_OSR1_1	375	379	PF12202	0.576
DOC_SPAK_OSR1_1	97	101	PF12202	0.681
DOC_USP7_MATH_1	175	179	PF00917	0.675
DOC_USP7_MATH_1	199	203	PF00917	0.742
DOC_USP7_MATH_1	226	230	PF00917	0.670
DOC_USP7_MATH_1	32	36	PF00917	0.403
DOC_USP7_MATH_1	598	602	PF00917	0.594
DOC_USP7_MATH_1	613	617	PF00917	0.747
DOC_USP7_UBL2_3	312	316	PF12436	0.560
DOC_USP7_UBL2_3	377	381	PF12436	0.596
DOC_USP7_UBL2_3	502	506	PF12436	0.765
DOC_WW_Pin1_4	129	134	PF00397	0.677
DOC_WW_Pin1_4	622	627	PF00397	0.547
LIG_14-3-3_CanoR_1	140	147	PF00244	0.667
LIG_14-3-3_CanoR_1	148	152	PF00244	0.718
LIG_14-3-3_CanoR_1	186	190	PF00244	0.621
LIG_14-3-3_CanoR_1	272	279	PF00244	0.643
LIG_14-3-3_CanoR_1	360	368	PF00244	0.510
LIG_14-3-3_CanoR_1	52	57	PF00244	0.687
LIG_14-3-3_CanoR_1	573	583	PF00244	0.630
LIG_14-3-3_CanoR_1	83	93	PF00244	0.535
LIG_Actin_WH2_2	134	150	PF00022	0.671
LIG_Actin_WH2_2	3	19	PF00022	0.469
LIG_Actin_WH2_2	537	552	PF00022	0.644
LIG_BRCT_BRCA1_1	293	297	PF00533	0.529
LIG_BRCT_BRCA1_1	372	376	PF00533	0.553
LIG_BRCT_BRCA1_1	63	67	PF00533	0.659
LIG_CSL_BTD_1	44	47	PF09270	0.642
LIG_eIF4E_1	252	258	PF01652	0.619
LIG_eIF4E_1	348	354	PF01652	0.539
LIG_FHA_1	118	124	PF00498	0.674
LIG_FHA_1	140	146	PF00498	0.634
LIG_FHA_1	16	22	PF00498	0.374
LIG_FHA_1	3	9	PF00498	0.393
LIG_FHA_1	412	418	PF00498	0.630
LIG_FHA_1	485	491	PF00498	0.802
LIG_FHA_1	511	517	PF00498	0.567
LIG_FHA_1	536	542	PF00498	0.495
LIG_FHA_1	553	559	PF00498	0.594
LIG_FHA_1	577	583	PF00498	0.611
LIG_FHA_1	604	610	PF00498	0.635
LIG_FHA_1	79	85	PF00498	0.583
LIG_FHA_1	89	95	PF00498	0.594
LIG_FHA_2	150	156	PF00498	0.734
LIG_FHA_2	201	207	PF00498	0.768
LIG_FHA_2	257	263	PF00498	0.646
LIG_FHA_2	347	353	PF00498	0.544
LIG_FHA_2	426	432	PF00498	0.760
LIG_FHA_2	452	458	PF00498	0.827
LIG_FHA_2	465	471	PF00498	0.750
LIG_FHA_2	494	500	PF00498	0.738
LIG_FHA_2	636	642	PF00498	0.564
LIG_GBD_Chelix_1	519	527	PF00786	0.272
LIG_LIR_Apic_2	314	320	PF02991	0.582
LIG_LIR_Apic_2	64	70	PF02991	0.492
LIG_LIR_Gen_1	102	113	PF02991	0.614
LIG_LIR_Gen_1	125	134	PF02991	0.627
LIG_LIR_Gen_1	2	12	PF02991	0.405
LIG_LIR_Gen_1	291	299	PF02991	0.495
LIG_LIR_Nem_3	102	108	PF02991	0.583
LIG_LIR_Nem_3	125	129	PF02991	0.589
LIG_LIR_Nem_3	188	192	PF02991	0.647
LIG_LIR_Nem_3	2	7	PF02991	0.410
LIG_LIR_Nem_3	241	245	PF02991	0.671
LIG_LIR_Nem_3	291	295	PF02991	0.494
LIG_LIR_Nem_3	44	49	PF02991	0.565
LIG_LIR_Nem_3	74	80	PF02991	0.605
LIG_MLH1_MIPbox_1	293	297	PF16413	0.529
LIG_NRBOX	325	331	PF00104	0.463
LIG_NRBOX	588	594	PF00104	0.559
LIG_Pex14_2	292	296	PF04695	0.485
LIG_Pex14_2	372	376	PF04695	0.553
LIG_PTB_Apo_2	6	13	PF02174	0.401
LIG_SH2_CRK	126	130	PF00017	0.667
LIG_SH2_CRK	254	258	PF00017	0.574
LIG_SH2_CRK	317	321	PF00017	0.605
LIG_SH2_CRK	331	335	PF00017	0.415
LIG_SH2_NCK_1	317	321	PF00017	0.635
LIG_SH2_SRC	317	320	PF00017	0.628
LIG_SH2_STAP1	119	123	PF00017	0.660
LIG_SH2_STAP1	4	8	PF00017	0.381
LIG_SH2_STAP1	80	84	PF00017	0.600
LIG_SH2_STAT3	252	255	PF00017	0.527
LIG_SH2_STAT5	105	108	PF00017	0.594
LIG_SH2_STAT5	119	122	PF00017	0.610
LIG_SH2_STAT5	126	129	PF00017	0.648
LIG_SH2_STAT5	252	255	PF00017	0.539
LIG_SH2_STAT5	284	287	PF00017	0.617
LIG_SH2_STAT5	348	351	PF00017	0.423
LIG_SH2_STAT5	4	7	PF00017	0.425
LIG_SH2_STAT5	40	43	PF00017	0.514
LIG_SH2_STAT5	406	409	PF00017	0.519
LIG_SH2_STAT5	56	59	PF00017	0.662
LIG_SH2_STAT5	575	578	PF00017	0.612
LIG_SH2_STAT5	80	83	PF00017	0.550
LIG_SH2_STAT5	89	92	PF00017	0.544
LIG_SH3_1	317	323	PF00018	0.632
LIG_SH3_2	320	325	PF14604	0.568
LIG_SH3_3	295	301	PF00018	0.606
LIG_SH3_3	317	323	PF00018	0.556
LIG_SH3_3	90	96	PF00018	0.637
LIG_SUMO_SIM_anti_2	640	647	PF11976	0.559
LIG_SUMO_SIM_par_1	511	517	PF11976	0.657
LIG_TRAF2_1	174	177	PF00917	0.645
LIG_TRAF2_1	363	366	PF00917	0.470
LIG_TRAF2_1	460	463	PF00917	0.802
LIG_TRAF2_1	638	641	PF00917	0.617
LIG_TYR_ITIM	103	108	PF00017	0.644
LIG_TYR_ITIM	240	245	PF00017	0.553
LIG_UBA3_1	192	201	PF00899	0.560
LIG_UBA3_1	303	312	PF00899	0.577
MOD_CDC14_SPxK_1	132	135	PF00782	0.577
MOD_CDK_SPxK_1	129	135	PF00069	0.681
MOD_CK1_1	15	21	PF00069	0.423
MOD_CK1_1	169	175	PF00069	0.639
MOD_CK1_1	207	213	PF00069	0.646
MOD_CK1_1	288	294	PF00069	0.541
MOD_CK1_1	393	399	PF00069	0.609
MOD_CK1_1	450	456	PF00069	0.772
MOD_CK1_1	55	61	PF00069	0.610
MOD_CK1_1	577	583	PF00069	0.637
MOD_CK2_1	199	205	PF00069	0.730
MOD_CK2_1	226	232	PF00069	0.650
MOD_CK2_1	256	262	PF00069	0.527
MOD_CK2_1	360	366	PF00069	0.458
MOD_CK2_1	425	431	PF00069	0.756
MOD_CK2_1	453	459	PF00069	0.799
MOD_CK2_1	464	470	PF00069	0.740
MOD_CK2_1	493	499	PF00069	0.735
MOD_CK2_1	588	594	PF00069	0.653
MOD_CK2_1	622	628	PF00069	0.528
MOD_CK2_1	635	641	PF00069	0.518
MOD_GlcNHglycan	168	171	PF01048	0.548
MOD_GlcNHglycan	268	271	PF01048	0.437
MOD_GlcNHglycan	287	290	PF01048	0.341
MOD_GlcNHglycan	35	38	PF01048	0.356
MOD_GlcNHglycan	372	375	PF01048	0.309
MOD_GlcNHglycan	443	446	PF01048	0.567
MOD_GlcNHglycan	470	473	PF01048	0.590
MOD_GlcNHglycan	596	599	PF01048	0.459
MOD_GlcNHglycan	615	619	PF01048	0.518
MOD_GlcNHglycan	63	66	PF01048	0.435
MOD_GlcNHglycan	73	76	PF01048	0.443
MOD_GSK3_1	200	207	PF00069	0.746
MOD_GSK3_1	333	340	PF00069	0.463
MOD_GSK3_1	356	363	PF00069	0.484
MOD_GSK3_1	447	454	PF00069	0.772
MOD_GSK3_1	464	471	PF00069	0.776
MOD_GSK3_1	484	491	PF00069	0.754
MOD_GSK3_1	502	509	PF00069	0.573
MOD_GSK3_1	55	62	PF00069	0.689
MOD_GSK3_1	594	601	PF00069	0.621
MOD_GSK3_1	603	610	PF00069	0.756
MOD_GSK3_1	84	91	PF00069	0.580
MOD_N-GLC_1	117	122	PF02516	0.461
MOD_N-GLC_1	129	134	PF02516	0.505
MOD_N-GLC_1	468	473	PF02516	0.603
MOD_N-GLC_1	71	76	PF02516	0.531
MOD_NEK2_1	12	17	PF00069	0.459
MOD_NEK2_1	147	152	PF00069	0.642
MOD_NEK2_1	180	185	PF00069	0.636
MOD_NEK2_1	285	290	PF00069	0.601
MOD_NEK2_1	33	38	PF00069	0.386
MOD_NEK2_1	354	359	PF00069	0.484
MOD_NEK2_1	41	46	PF00069	0.487
MOD_NEK2_1	576	581	PF00069	0.639
MOD_NEK2_2	552	557	PF00069	0.540
MOD_NEK2_2	78	83	PF00069	0.642
MOD_PIKK_1	169	175	PF00454	0.778
MOD_PIKK_1	180	186	PF00454	0.616
MOD_PIKK_1	493	499	PF00454	0.790
MOD_PK_1	104	110	PF00069	0.607
MOD_PKA_1	506	512	PF00069	0.741
MOD_PKA_2	139	145	PF00069	0.635
MOD_PKA_2	147	153	PF00069	0.632
MOD_PKA_2	185	191	PF00069	0.677
MOD_PKA_2	506	512	PF00069	0.746
MOD_Plk_1	175	181	PF00069	0.634
MOD_Plk_1	231	237	PF00069	0.631
MOD_Plk_1	510	516	PF00069	0.638
MOD_Plk_1	614	620	PF00069	0.628
MOD_Plk_2-3	457	463	PF00069	0.793
MOD_Plk_2-3	588	594	PF00069	0.608
MOD_Plk_2-3	635	641	PF00069	0.632
MOD_Plk_4	226	232	PF00069	0.665
MOD_Plk_4	291	297	PF00069	0.507
MOD_Plk_4	52	58	PF00069	0.625
MOD_Plk_4	544	550	PF00069	0.642
MOD_Plk_4	577	583	PF00069	0.669
MOD_Plk_4	85	91	PF00069	0.610
MOD_ProDKin_1	129	135	PF00069	0.681
MOD_ProDKin_1	622	628	PF00069	0.545
MOD_SUMO_for_1	419	422	PF00179	0.638
MOD_SUMO_rev_2	236	245	PF00179	0.643
MOD_SUMO_rev_2	308	314	PF00179	0.552
TRG_DiLeu_BaEn_1	588	593	PF01217	0.633
TRG_DiLeu_BaEn_2	175	181	PF01217	0.700
TRG_DiLeu_BaEn_3	176	182	PF01217	0.490
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.619
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.606
TRG_ENDOCYTIC_2	105	108	PF00928	0.561
TRG_ENDOCYTIC_2	126	129	PF00928	0.638
TRG_ENDOCYTIC_2	242	245	PF00928	0.605
TRG_ENDOCYTIC_2	254	257	PF00928	0.526
TRG_ENDOCYTIC_2	4	7	PF00928	0.408
TRG_NES_CRM1_1	136	149	PF08389	0.599
TRG_NES_CRM1_1	366	380	PF08389	0.553
TRG_NES_CRM1_1	99	112	PF08389	0.558
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	590	594	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V2	Leptomonas seymouri	59%	97%
A0A0S4JAD3	Bodo saltans	32%	100%
A0A1X0NTT2	Trypanosomatidae	29%	97%
A0A1X0P2Y3	Trypanosomatidae	29%	100%
A0A1X0P9I4	Trypanosomatidae	29%	81%
A0A3S7X6K2	Leishmania donovani	93%	100%
A0A422NUH1	Trypanosoma rangeli	30%	97%
A0A422P3P3	Trypanosoma rangeli	30%	100%
A4HLH5	Leishmania braziliensis	71%	100%
A4I8Y5	Leishmania infantum	93%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	98%
D0A1W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	91%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
E9B3V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DQN5	Trypanosoma cruzi	32%	100%