Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q469_LEIMA

TriTrypDb:

LmjF.33.1210 , LMJLV39_330019600 , LMJSD75_330019300

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q469

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q469

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	328	330	PF00675	0.463
CLV_PCSK_KEX2_1	327	329	PF00082	0.459
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.459
CLV_PCSK_SKI1_1	132	136	PF00082	0.496
CLV_PCSK_SKI1_1	179	183	PF00082	0.503
CLV_PCSK_SKI1_1	267	271	PF00082	0.541
CLV_PCSK_SKI1_1	276	280	PF00082	0.522
CLV_PCSK_SKI1_1	282	286	PF00082	0.532
CLV_PCSK_SKI1_1	298	302	PF00082	0.473
CLV_PCSK_SKI1_1	95	99	PF00082	0.349
DEG_APCC_DBOX_1	131	139	PF00400	0.279
DEG_APCC_DBOX_1	94	102	PF00400	0.342
DEG_SPOP_SBC_1	226	230	PF00917	0.449
DOC_PP2B_LxvP_1	261	264	PF13499	0.505
DOC_USP7_MATH_1	221	225	PF00917	0.611
DOC_USP7_MATH_1	226	230	PF00917	0.632
DOC_USP7_MATH_1	238	242	PF00917	0.565
DOC_USP7_MATH_1	322	326	PF00917	0.560
DOC_WW_Pin1_4	333	338	PF00397	0.458
LIG_14-3-3_CanoR_1	23	27	PF00244	0.412
LIG_14-3-3_CanoR_1	276	285	PF00244	0.564
LIG_14-3-3_CanoR_1	286	294	PF00244	0.564
LIG_14-3-3_CanoR_1	321	327	PF00244	0.494
LIG_BIR_II_1	1	5	PF00653	0.437
LIG_BIR_III_4	213	217	PF00653	0.367
LIG_FHA_1	120	126	PF00498	0.332
LIG_FHA_1	215	221	PF00498	0.487
LIG_FHA_1	287	293	PF00498	0.503
LIG_FHA_1	321	327	PF00498	0.400
LIG_FHA_2	184	190	PF00498	0.319
LIG_HCF-1_HBM_1	75	78	PF13415	0.446
LIG_Integrin_RGD_1	256	258	PF01839	0.469
LIG_LIR_Gen_1	27	34	PF02991	0.334
LIG_LIR_Nem_3	27	32	PF02991	0.336
LIG_LIR_Nem_3	63	68	PF02991	0.311
LIG_SH2_CRK	29	33	PF00017	0.304
LIG_SH2_STAP1	184	188	PF00017	0.417
LIG_SH2_STAP1	34	38	PF00017	0.351
LIG_SH2_STAP1	80	84	PF00017	0.378
LIG_SH2_STAT5	294	297	PF00017	0.442
LIG_SH2_STAT5	66	69	PF00017	0.307
LIG_SH3_3	297	303	PF00018	0.363
LIG_TRAF2_1	269	272	PF00917	0.597
LIG_TYR_ITSM	61	68	PF00017	0.334
MOD_CK1_1	111	117	PF00069	0.403
MOD_CK1_1	2	8	PF00069	0.368
MOD_CK1_1	228	234	PF00069	0.662
MOD_CK2_1	183	189	PF00069	0.388
MOD_CK2_1	202	208	PF00069	0.468
MOD_CMANNOS	310	313	PF00535	0.374
MOD_GlcNHglycan	223	226	PF01048	0.655
MOD_GlcNHglycan	240	243	PF01048	0.587
MOD_GlcNHglycan	244	247	PF01048	0.590
MOD_GlcNHglycan	267	270	PF01048	0.484
MOD_GSK3_1	111	118	PF00069	0.368
MOD_GSK3_1	183	190	PF00069	0.545
MOD_GSK3_1	221	228	PF00069	0.682
MOD_GSK3_1	238	245	PF00069	0.577
MOD_GSK3_1	28	35	PF00069	0.308
MOD_GSK3_1	292	299	PF00069	0.381
MOD_N-GLC_1	2	7	PF02516	0.504
MOD_NEK2_1	1	6	PF00069	0.408
MOD_NEK2_1	115	120	PF00069	0.333
MOD_NEK2_1	202	207	PF00069	0.566
MOD_NEK2_1	227	232	PF00069	0.658
MOD_NEK2_1	274	279	PF00069	0.559
MOD_NEK2_2	322	327	PF00069	0.500
MOD_PIKK_1	202	208	PF00454	0.453
MOD_PIKK_1	32	38	PF00454	0.300
MOD_PKA_2	22	28	PF00069	0.351
MOD_PKA_2	320	326	PF00069	0.386
MOD_PKB_1	165	173	PF00069	0.348
MOD_Plk_1	2	8	PF00069	0.526
MOD_Plk_1	257	263	PF00069	0.470
MOD_Plk_1	274	280	PF00069	0.310
MOD_Plk_4	115	121	PF00069	0.474
MOD_Plk_4	246	252	PF00069	0.488
MOD_Plk_4	28	34	PF00069	0.318
MOD_Plk_4	60	66	PF00069	0.330
MOD_ProDKin_1	333	339	PF00069	0.459
MOD_SUMO_rev_2	228	237	PF00179	0.615
TRG_DiLeu_BaEn_1	168	173	PF01217	0.331
TRG_ENDOCYTIC_2	29	32	PF00928	0.322
TRG_ENDOCYTIC_2	294	297	PF00928	0.488
TRG_ENDOCYTIC_2	64	67	PF00928	0.353
TRG_ER_diArg_1	164	167	PF00400	0.385
TRG_ER_diArg_1	301	304	PF00400	0.353
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F8	Leptomonas seymouri	80%	95%
A0A0S4J7D5	Bodo saltans	52%	97%
A0A1X0P104	Trypanosomatidae	64%	100%
A0A3Q8IGJ8	Leishmania donovani	97%	100%
A0A3R7N235	Trypanosoma rangeli	64%	100%
A4HLH6	Leishmania braziliensis	91%	100%
A4I8Y6	Leishmania infantum	97%	100%
D0A4Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B3V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BZN0	Trypanosoma cruzi	63%	100%