F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q468_LEIMA

TriTrypDb:

LmjF.33.1220 , LMJLV39_330019700 , LMJSD75_330019400

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q468

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q468

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	327	333	PF00089	0.574
CLV_NRD_NRD_1	124	126	PF00675	0.525
CLV_NRD_NRD_1	177	179	PF00675	0.759
CLV_NRD_NRD_1	196	198	PF00675	0.390
CLV_NRD_NRD_1	515	517	PF00675	0.572
CLV_NRD_NRD_1	777	779	PF00675	0.632
CLV_PCSK_FUR_1	775	779	PF00082	0.663
CLV_PCSK_KEX2_1	124	126	PF00082	0.525
CLV_PCSK_KEX2_1	196	198	PF00082	0.482
CLV_PCSK_KEX2_1	515	517	PF00082	0.572
CLV_PCSK_KEX2_1	775	777	PF00082	0.629
CLV_PCSK_SKI1_1	510	514	PF00082	0.482
CLV_PCSK_SKI1_1	699	703	PF00082	0.352
DEG_APCC_DBOX_1	338	346	PF00400	0.389
DEG_Kelch_Keap1_1	779	784	PF01344	0.554
DEG_ODPH_VHL_1	702	714	PF01847	0.380
DEG_SPOP_SBC_1	298	302	PF00917	0.687
DOC_CDC14_PxL_1	700	708	PF14671	0.362
DOC_CKS1_1	322	327	PF01111	0.667
DOC_CKS1_1	675	680	PF01111	0.607
DOC_CYCLIN_RxL_1	687	698	PF00134	0.489
DOC_MAPK_DCC_7	687	696	PF00069	0.519
DOC_MAPK_gen_1	377	384	PF00069	0.535
DOC_MAPK_gen_1	510	519	PF00069	0.530
DOC_MAPK_MEF2A_6	339	347	PF00069	0.378
DOC_PP2B_LxvP_1	271	274	PF13499	0.578
DOC_PP2B_LxvP_1	595	598	PF13499	0.520
DOC_PP2B_LxvP_1	83	86	PF13499	0.453
DOC_PP4_FxxP_1	149	152	PF00568	0.551
DOC_PP4_FxxP_1	701	704	PF00568	0.345
DOC_USP7_MATH_1	184	188	PF00917	0.473
DOC_USP7_MATH_1	262	266	PF00917	0.569
DOC_USP7_MATH_1	272	276	PF00917	0.657
DOC_USP7_MATH_1	320	324	PF00917	0.677
DOC_USP7_MATH_1	368	372	PF00917	0.655
DOC_USP7_MATH_1	439	443	PF00917	0.665
DOC_USP7_MATH_1	461	465	PF00917	0.641
DOC_USP7_MATH_1	537	541	PF00917	0.688
DOC_USP7_UBL2_3	114	118	PF12436	0.398
DOC_WW_Pin1_4	12	17	PF00397	0.592
DOC_WW_Pin1_4	237	242	PF00397	0.722
DOC_WW_Pin1_4	253	258	PF00397	0.498
DOC_WW_Pin1_4	273	278	PF00397	0.607
DOC_WW_Pin1_4	285	290	PF00397	0.619
DOC_WW_Pin1_4	291	296	PF00397	0.656
DOC_WW_Pin1_4	310	315	PF00397	0.718
DOC_WW_Pin1_4	321	326	PF00397	0.581
DOC_WW_Pin1_4	36	41	PF00397	0.600
DOC_WW_Pin1_4	417	422	PF00397	0.753
DOC_WW_Pin1_4	557	562	PF00397	0.720
DOC_WW_Pin1_4	631	636	PF00397	0.703
DOC_WW_Pin1_4	674	679	PF00397	0.663
DOC_WW_Pin1_4	685	690	PF00397	0.663
DOC_WW_Pin1_4	737	742	PF00397	0.507
LIG_14-3-3_CanoR_1	124	130	PF00244	0.570
LIG_14-3-3_CanoR_1	156	164	PF00244	0.604
LIG_14-3-3_CanoR_1	23	29	PF00244	0.589
LIG_14-3-3_CanoR_1	377	384	PF00244	0.616
LIG_14-3-3_CanoR_1	406	410	PF00244	0.567
LIG_14-3-3_CanoR_1	491	499	PF00244	0.499
LIG_14-3-3_CanoR_1	7	16	PF00244	0.590
LIG_AP2alpha_2	245	247	PF02296	0.611
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_BRCT_BRCA1_1	255	259	PF00533	0.544
LIG_Clathr_ClatBox_1	714	718	PF01394	0.349
LIG_Clathr_ClatBox_1	723	727	PF01394	0.390
LIG_deltaCOP1_diTrp_1	120	130	PF00928	0.480
LIG_deltaCOP1_diTrp_1	175	181	PF00928	0.584
LIG_deltaCOP1_diTrp_1	206	209	PF00928	0.500
LIG_EVH1_1	149	153	PF00568	0.493
LIG_FHA_1	143	149	PF00498	0.572
LIG_FHA_1	222	228	PF00498	0.600
LIG_FHA_1	322	328	PF00498	0.695
LIG_FHA_1	39	45	PF00498	0.646
LIG_FHA_1	435	441	PF00498	0.647
LIG_FHA_1	660	666	PF00498	0.542
LIG_FHA_1	686	692	PF00498	0.584
LIG_FHA_2	25	31	PF00498	0.530
LIG_FHA_2	492	498	PF00498	0.454
LIG_FHA_2	581	587	PF00498	0.408
LIG_FHA_2	622	628	PF00498	0.665
LIG_FHA_2	632	638	PF00498	0.586
LIG_FHA_2	760	766	PF00498	0.558
LIG_GBD_Chelix_1	384	392	PF00786	0.559
LIG_LIR_Apic_2	698	704	PF02991	0.350
LIG_LIR_Apic_2	737	741	PF02991	0.504
LIG_LIR_Gen_1	128	137	PF02991	0.618
LIG_LIR_Gen_1	187	193	PF02991	0.480
LIG_LIR_Gen_1	206	215	PF02991	0.513
LIG_LIR_Gen_1	30	38	PF02991	0.628
LIG_LIR_Gen_1	602	612	PF02991	0.463
LIG_LIR_Gen_1	669	680	PF02991	0.556
LIG_LIR_Gen_1	709	719	PF02991	0.347
LIG_LIR_Gen_1	764	773	PF02991	0.600
LIG_LIR_Gen_1	98	105	PF02991	0.495
LIG_LIR_Nem_3	187	192	PF02991	0.483
LIG_LIR_Nem_3	206	212	PF02991	0.508
LIG_LIR_Nem_3	30	34	PF02991	0.630
LIG_LIR_Nem_3	602	607	PF02991	0.438
LIG_LIR_Nem_3	66	71	PF02991	0.455
LIG_LIR_Nem_3	669	675	PF02991	0.560
LIG_LIR_Nem_3	709	714	PF02991	0.363
LIG_LIR_Nem_3	764	769	PF02991	0.592
LIG_LIR_Nem_3	93	99	PF02991	0.453
LIG_MYND_1	314	318	PF01753	0.595
LIG_MYND_1	325	329	PF01753	0.593
LIG_MYND_1	689	693	PF01753	0.642
LIG_Pex14_1	181	185	PF04695	0.556
LIG_Pex14_2	249	253	PF04695	0.563
LIG_Pex14_2	696	700	PF04695	0.402
LIG_PTAP_UEV_1	420	425	PF05743	0.584
LIG_REV1ctd_RIR_1	190	201	PF16727	0.479
LIG_REV1ctd_RIR_1	694	703	PF16727	0.402
LIG_SH2_CRK	616	620	PF00017	0.586
LIG_SH2_CRK	766	770	PF00017	0.599
LIG_SH2_PTP2	711	714	PF00017	0.333
LIG_SH2_PTP2	768	771	PF00017	0.609
LIG_SH2_SRC	610	613	PF00017	0.572
LIG_SH2_STAP1	189	193	PF00017	0.481
LIG_SH2_STAT3	75	78	PF00017	0.591
LIG_SH2_STAT3	756	759	PF00017	0.585
LIG_SH2_STAT5	129	132	PF00017	0.479
LIG_SH2_STAT5	199	202	PF00017	0.484
LIG_SH2_STAT5	348	351	PF00017	0.411
LIG_SH2_STAT5	403	406	PF00017	0.471
LIG_SH2_STAT5	711	714	PF00017	0.333
LIG_SH2_STAT5	761	764	PF00017	0.577
LIG_SH2_STAT5	768	771	PF00017	0.609
LIG_SH2_STAT5	96	99	PF00017	0.413
LIG_SH3_1	418	424	PF00018	0.605
LIG_SH3_1	687	693	PF00018	0.545
LIG_SH3_2	770	775	PF14604	0.616
LIG_SH3_3	144	150	PF00018	0.602
LIG_SH3_3	271	277	PF00018	0.618
LIG_SH3_3	283	289	PF00018	0.649
LIG_SH3_3	319	325	PF00018	0.611
LIG_SH3_3	328	334	PF00018	0.601
LIG_SH3_3	418	424	PF00018	0.659
LIG_SH3_3	559	565	PF00018	0.616
LIG_SH3_3	672	678	PF00018	0.783
LIG_SH3_3	687	693	PF00018	0.572
LIG_SH3_3	767	773	PF00018	0.610
LIG_SUMO_SIM_anti_2	468	475	PF11976	0.428
LIG_SUMO_SIM_par_1	223	229	PF11976	0.602
LIG_SUMO_SIM_par_1	468	475	PF11976	0.428
LIG_SUMO_SIM_par_1	578	584	PF11976	0.402
LIG_SUMO_SIM_par_1	713	718	PF11976	0.339
LIG_SUMO_SIM_par_1	722	727	PF11976	0.400
LIG_TRFH_1	700	704	PF08558	0.347
LIG_TYR_ITIM	485	490	PF00017	0.567
LIG_TYR_ITIM	614	619	PF00017	0.579
LIG_TYR_ITIM	97	102	PF00017	0.433
MOD_CDK_SPK_2	631	636	PF00069	0.703
MOD_CDK_SPxxK_3	685	692	PF00069	0.663
MOD_CK1_1	15	21	PF00069	0.587
MOD_CK1_1	155	161	PF00069	0.690
MOD_CK1_1	240	246	PF00069	0.588
MOD_CK1_1	276	282	PF00069	0.696
MOD_CK1_1	302	308	PF00069	0.739
MOD_CK1_1	309	315	PF00069	0.659
MOD_CK1_1	32	38	PF00069	0.479
MOD_CK1_1	380	386	PF00069	0.726
MOD_CK1_1	39	45	PF00069	0.572
MOD_CK1_1	393	399	PF00069	0.506
MOD_CK1_1	417	423	PF00069	0.647
MOD_CK1_1	6	12	PF00069	0.591
MOD_CK1_1	649	655	PF00069	0.585
MOD_CK1_1	656	662	PF00069	0.564
MOD_CK1_1	668	674	PF00069	0.701
MOD_CK2_1	184	190	PF00069	0.478
MOD_CK2_1	200	206	PF00069	0.485
MOD_CK2_1	262	268	PF00069	0.626
MOD_CK2_1	405	411	PF00069	0.562
MOD_CK2_1	491	497	PF00069	0.455
MOD_CK2_1	580	586	PF00069	0.408
MOD_CK2_1	631	637	PF00069	0.649
MOD_CK2_1	759	765	PF00069	0.558
MOD_GlcNHglycan	169	172	PF01048	0.672
MOD_GlcNHglycan	17	20	PF01048	0.630
MOD_GlcNHglycan	186	189	PF01048	0.516
MOD_GlcNHglycan	242	245	PF01048	0.577
MOD_GlcNHglycan	249	252	PF01048	0.606
MOD_GlcNHglycan	253	256	PF01048	0.637
MOD_GlcNHglycan	388	391	PF01048	0.711
MOD_GlcNHglycan	392	395	PF01048	0.631
MOD_GlcNHglycan	421	424	PF01048	0.632
MOD_GlcNHglycan	44	47	PF01048	0.588
MOD_GlcNHglycan	441	444	PF01048	0.656
MOD_GlcNHglycan	510	513	PF01048	0.467
MOD_GlcNHglycan	539	542	PF01048	0.699
MOD_GlcNHglycan	544	547	PF01048	0.637
MOD_GlcNHglycan	553	556	PF01048	0.569
MOD_GlcNHglycan	781	784	PF01048	0.667
MOD_GSK3_1	152	159	PF00069	0.577
MOD_GSK3_1	217	224	PF00069	0.592
MOD_GSK3_1	233	240	PF00069	0.712
MOD_GSK3_1	247	254	PF00069	0.665
MOD_GSK3_1	272	279	PF00069	0.697
MOD_GSK3_1	285	292	PF00069	0.591
MOD_GSK3_1	298	305	PF00069	0.616
MOD_GSK3_1	3	10	PF00069	0.585
MOD_GSK3_1	30	37	PF00069	0.752
MOD_GSK3_1	306	313	PF00069	0.653
MOD_GSK3_1	38	45	PF00069	0.581
MOD_GSK3_1	380	387	PF00069	0.651
MOD_GSK3_1	412	419	PF00069	0.597
MOD_GSK3_1	423	430	PF00069	0.640
MOD_GSK3_1	461	468	PF00069	0.478
MOD_GSK3_1	475	482	PF00069	0.445
MOD_GSK3_1	547	554	PF00069	0.671
MOD_GSK3_1	649	656	PF00069	0.751
MOD_GSK3_1	660	667	PF00069	0.572
MOD_LATS_1	297	303	PF00433	0.740
MOD_LATS_1	489	495	PF00433	0.498
MOD_N-GLC_1	305	310	PF02516	0.638
MOD_N-GLC_1	479	484	PF02516	0.506
MOD_N-GLC_1	491	496	PF02516	0.391
MOD_N-GLC_2	79	81	PF02516	0.455
MOD_NEK2_1	142	147	PF00069	0.584
MOD_NEK2_1	167	172	PF00069	0.514
MOD_NEK2_1	247	252	PF00069	0.641
MOD_NEK2_1	280	285	PF00069	0.650
MOD_NEK2_1	384	389	PF00069	0.577
MOD_NEK2_1	405	410	PF00069	0.466
MOD_NEK2_1	505	510	PF00069	0.439
MOD_NEK2_1	551	556	PF00069	0.705
MOD_NEK2_1	651	656	PF00069	0.516
MOD_NEK2_1	8	13	PF00069	0.584
MOD_NEK2_2	24	29	PF00069	0.532
MOD_PIKK_1	280	286	PF00454	0.662
MOD_PIKK_1	300	306	PF00454	0.659
MOD_PIKK_1	441	447	PF00454	0.813
MOD_PIKK_1	660	666	PF00454	0.649
MOD_PK_1	646	652	PF00069	0.597
MOD_PKA_1	777	783	PF00069	0.658
MOD_PKA_2	155	161	PF00069	0.626
MOD_PKA_2	298	304	PF00069	0.684
MOD_PKA_2	405	411	PF00069	0.573
MOD_PKA_2	503	509	PF00069	0.448
MOD_PKA_2	6	12	PF00069	0.591
MOD_PKA_2	659	665	PF00069	0.674
MOD_PKA_2	777	783	PF00069	0.711
MOD_PKB_1	344	352	PF00069	0.423
MOD_PKB_1	775	783	PF00069	0.660
MOD_Plk_1	29	35	PF00069	0.630
MOD_Plk_1	368	374	PF00069	0.551
MOD_Plk_1	646	652	PF00069	0.610
MOD_Plk_2-3	30	36	PF00069	0.521
MOD_Plk_4	118	124	PF00069	0.481
MOD_Plk_4	125	131	PF00069	0.479
MOD_Plk_4	39	45	PF00069	0.577
MOD_Plk_4	590	596	PF00069	0.517
MOD_Plk_4	646	652	PF00069	0.736
MOD_Plk_4	95	101	PF00069	0.535
MOD_ProDKin_1	12	18	PF00069	0.591
MOD_ProDKin_1	237	243	PF00069	0.720
MOD_ProDKin_1	253	259	PF00069	0.499
MOD_ProDKin_1	273	279	PF00069	0.611
MOD_ProDKin_1	285	291	PF00069	0.625
MOD_ProDKin_1	310	316	PF00069	0.686
MOD_ProDKin_1	321	327	PF00069	0.741
MOD_ProDKin_1	36	42	PF00069	0.599
MOD_ProDKin_1	417	423	PF00069	0.754
MOD_ProDKin_1	557	563	PF00069	0.718
MOD_ProDKin_1	631	637	PF00069	0.702
MOD_ProDKin_1	674	680	PF00069	0.664
MOD_ProDKin_1	685	691	PF00069	0.656
MOD_ProDKin_1	737	743	PF00069	0.511
MOD_SUMO_rev_2	211	220	PF00179	0.544
TRG_DiLeu_BaEn_2	496	502	PF01217	0.437
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.665
TRG_DiLeu_BaLyEn_6	738	743	PF01217	0.512
TRG_DiLeu_LyEn_5	338	343	PF01217	0.449
TRG_ENDOCYTIC_2	131	134	PF00928	0.565
TRG_ENDOCYTIC_2	189	192	PF00928	0.485
TRG_ENDOCYTIC_2	487	490	PF00928	0.569
TRG_ENDOCYTIC_2	616	619	PF00928	0.590
TRG_ENDOCYTIC_2	672	675	PF00928	0.725
TRG_ENDOCYTIC_2	711	714	PF00928	0.333
TRG_ENDOCYTIC_2	766	769	PF00928	0.599
TRG_ENDOCYTIC_2	99	102	PF00928	0.435
TRG_ER_diArg_1	123	125	PF00400	0.519
TRG_ER_diArg_1	196	198	PF00400	0.482
TRG_ER_diArg_1	343	346	PF00400	0.523
TRG_ER_diArg_1	451	454	PF00400	0.611
TRG_ER_diArg_1	515	517	PF00400	0.572
TRG_ER_diArg_1	775	778	PF00400	0.633
TRG_NES_CRM1_1	399	411	PF08389	0.465
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWH7	Leptomonas seymouri	51%	95%
A0A3Q8IK34	Leishmania donovani	91%	98%
A4HLH7	Leishmania braziliensis	76%	100%
A4I8Y7	Leishmania infantum	91%	98%
E9B3V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%