Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q467_LEIMA

TriTrypDb:

LmjF.33.1230 , LMJLV39_330019800 , LMJSD75_330019500

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0035869	ciliary transition zone	2	3
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4Q467

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q467

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	212	218	PF00089	0.297
CLV_NRD_NRD_1	116	118	PF00675	0.517
CLV_NRD_NRD_1	253	255	PF00675	0.389
CLV_NRD_NRD_1	420	422	PF00675	0.553
CLV_NRD_NRD_1	430	432	PF00675	0.496
CLV_NRD_NRD_1	617	619	PF00675	0.715
CLV_NRD_NRD_1	77	79	PF00675	0.472
CLV_PCSK_FUR_1	75	79	PF00082	0.493
CLV_PCSK_KEX2_1	116	118	PF00082	0.377
CLV_PCSK_KEX2_1	403	405	PF00082	0.595
CLV_PCSK_KEX2_1	430	432	PF00082	0.626
CLV_PCSK_KEX2_1	617	619	PF00082	0.670
CLV_PCSK_KEX2_1	77	79	PF00082	0.497
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.579
CLV_PCSK_SKI1_1	158	162	PF00082	0.290
CLV_PCSK_SKI1_1	17	21	PF00082	0.561
CLV_Separin_Metazoa	427	431	PF03568	0.478
DEG_APCC_DBOX_1	429	437	PF00400	0.522
DEG_SPOP_SBC_1	497	501	PF00917	0.728
DOC_MAPK_gen_1	233	242	PF00069	0.460
DOC_MAPK_gen_1	77	87	PF00069	0.479
DOC_MAPK_MEF2A_6	42	50	PF00069	0.307
DOC_PP2B_LxvP_1	490	493	PF13499	0.720
DOC_PP2B_LxvP_1	537	540	PF13499	0.612
DOC_PP2B_LxvP_1	575	578	PF13499	0.721
DOC_USP7_MATH_1	139	143	PF00917	0.421
DOC_USP7_MATH_1	176	180	PF00917	0.563
DOC_USP7_MATH_1	439	443	PF00917	0.514
DOC_USP7_MATH_1	455	459	PF00917	0.513
DOC_USP7_MATH_1	493	497	PF00917	0.725
DOC_USP7_MATH_1	510	514	PF00917	0.598
DOC_USP7_MATH_1	553	557	PF00917	0.772
DOC_USP7_UBL2_3	399	403	PF12436	0.561
DOC_WW_Pin1_4	499	504	PF00397	0.719
DOC_WW_Pin1_4	520	525	PF00397	0.668
DOC_WW_Pin1_4	548	553	PF00397	0.603
DOC_WW_Pin1_4	8	13	PF00397	0.684
LIG_14-3-3_CanoR_1	249	254	PF00244	0.422
LIG_14-3-3_CanoR_1	336	346	PF00244	0.522
LIG_14-3-3_CanoR_1	42	47	PF00244	0.501
LIG_14-3-3_CanoR_1	421	427	PF00244	0.512
LIG_14-3-3_CanoR_1	511	516	PF00244	0.634
LIG_14-3-3_CterR_2	617	621	PF00244	0.727
LIG_Actin_WH2_2	239	256	PF00022	0.479
LIG_APCC_ABBA_1	106	111	PF00400	0.448
LIG_BRCT_BRCA1_1	140	144	PF00533	0.349
LIG_EVH1_1	537	541	PF00568	0.560
LIG_EVH1_1	575	579	PF00568	0.682
LIG_FHA_1	183	189	PF00498	0.492
LIG_FHA_1	338	344	PF00498	0.574
LIG_FHA_1	421	427	PF00498	0.507
LIG_FHA_1	43	49	PF00498	0.430
LIG_FHA_1	435	441	PF00498	0.481
LIG_FHA_1	595	601	PF00498	0.651
LIG_FHA_1	60	66	PF00498	0.616
LIG_FHA_2	405	411	PF00498	0.451
LIG_FHA_2	469	475	PF00498	0.701
LIG_FHA_2	600	606	PF00498	0.625
LIG_Integrin_RGD_1	133	135	PF01839	0.407
LIG_LIR_Gen_1	44	55	PF02991	0.524
LIG_LIR_Gen_1	86	95	PF02991	0.413
LIG_LIR_Nem_3	565	571	PF02991	0.700
LIG_LIR_Nem_3	86	91	PF02991	0.411
LIG_LYPXL_SIV_4	344	352	PF13949	0.562
LIG_NRBOX	358	364	PF00104	0.594
LIG_PCNA_yPIPBox_3	225	235	PF02747	0.353
LIG_SH2_CRK	88	92	PF00017	0.480
LIG_SH2_SRC	171	174	PF00017	0.510
LIG_SH2_SRC	568	571	PF00017	0.641
LIG_SH2_STAP1	109	113	PF00017	0.485
LIG_SH2_STAP1	339	343	PF00017	0.556
LIG_SH2_STAT3	339	342	PF00017	0.624
LIG_SH2_STAT5	109	112	PF00017	0.486
LIG_SH2_STAT5	127	130	PF00017	0.369
LIG_SH2_STAT5	166	169	PF00017	0.458
LIG_SH2_STAT5	270	273	PF00017	0.415
LIG_SH2_STAT5	303	306	PF00017	0.472
LIG_SH2_STAT5	339	342	PF00017	0.613
LIG_SH2_STAT5	345	348	PF00017	0.563
LIG_SH3_1	444	450	PF00018	0.619
LIG_SH3_2	538	543	PF14604	0.598
LIG_SH3_2	593	598	PF14604	0.576
LIG_SH3_3	444	450	PF00018	0.695
LIG_SH3_3	463	469	PF00018	0.728
LIG_SH3_3	486	492	PF00018	0.728
LIG_SH3_3	506	512	PF00018	0.723
LIG_SH3_3	521	527	PF00018	0.627
LIG_SH3_3	533	539	PF00018	0.615
LIG_SH3_3	541	547	PF00018	0.513
LIG_SH3_3	573	579	PF00018	0.629
LIG_SH3_3	580	586	PF00018	0.671
LIG_SH3_3	588	594	PF00018	0.753
LIG_SUMO_SIM_anti_2	238	243	PF11976	0.326
LIG_SUMO_SIM_anti_2	361	367	PF11976	0.576
LIG_SUMO_SIM_par_1	361	367	PF11976	0.462
LIG_SUMO_SIM_par_1	83	89	PF11976	0.481
LIG_TRAF2_1	407	410	PF00917	0.540
LIG_WRC_WIRS_1	66	71	PF05994	0.398
LIG_WW_3	508	512	PF00397	0.572
MOD_CDK_SPxxK_3	8	15	PF00069	0.568
MOD_CK1_1	13	19	PF00069	0.658
MOD_CK1_1	142	148	PF00069	0.343
MOD_CK1_1	181	187	PF00069	0.472
MOD_CK1_1	193	199	PF00069	0.368
MOD_CK1_1	289	295	PF00069	0.492
MOD_CK1_1	366	372	PF00069	0.540
MOD_CK1_1	41	47	PF00069	0.515
MOD_CK1_1	496	502	PF00069	0.773
MOD_CK2_1	364	370	PF00069	0.564
MOD_CK2_1	376	382	PF00069	0.488
MOD_CK2_1	404	410	PF00069	0.534
MOD_CK2_1	468	474	PF00069	0.744
MOD_CK2_1	553	559	PF00069	0.537
MOD_CK2_1	599	605	PF00069	0.705
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.574
MOD_GlcNHglycan	102	105	PF01048	0.478
MOD_GlcNHglycan	123	126	PF01048	0.422
MOD_GlcNHglycan	178	181	PF01048	0.300
MOD_GlcNHglycan	192	195	PF01048	0.494
MOD_GlcNHglycan	206	209	PF01048	0.544
MOD_GlcNHglycan	221	224	PF01048	0.336
MOD_GlcNHglycan	225	228	PF01048	0.356
MOD_GlcNHglycan	263	266	PF01048	0.392
MOD_GlcNHglycan	291	294	PF01048	0.460
MOD_GlcNHglycan	306	309	PF01048	0.446
MOD_GlcNHglycan	366	369	PF01048	0.572
MOD_GlcNHglycan	441	444	PF01048	0.705
MOD_GlcNHglycan	457	460	PF01048	0.495
MOD_GlcNHglycan	494	498	PF01048	0.792
MOD_GlcNHglycan	516	519	PF01048	0.716
MOD_GSK3_1	117	124	PF00069	0.550
MOD_GSK3_1	13	20	PF00069	0.599
MOD_GSK3_1	138	145	PF00069	0.410
MOD_GSK3_1	178	185	PF00069	0.564
MOD_GSK3_1	204	211	PF00069	0.504
MOD_GSK3_1	215	222	PF00069	0.526
MOD_GSK3_1	306	313	PF00069	0.410
MOD_GSK3_1	37	44	PF00069	0.494
MOD_GSK3_1	405	412	PF00069	0.564
MOD_GSK3_1	434	441	PF00069	0.566
MOD_GSK3_1	493	500	PF00069	0.660
MOD_GSK3_1	510	517	PF00069	0.736
MOD_GSK3_1	560	567	PF00069	0.672
MOD_GSK3_1	613	620	PF00069	0.808
MOD_N-GLC_1	42	47	PF02516	0.497
MOD_NEK2_1	144	149	PF00069	0.440
MOD_NEK2_1	304	309	PF00069	0.450
MOD_NEK2_1	363	368	PF00069	0.637
MOD_NEK2_1	376	381	PF00069	0.502
MOD_NEK2_1	38	43	PF00069	0.453
MOD_NEK2_1	498	503	PF00069	0.614
MOD_NEK2_1	528	533	PF00069	0.570
MOD_NEK2_1	99	104	PF00069	0.452
MOD_NEK2_2	83	88	PF00069	0.387
MOD_PIKK_1	127	133	PF00454	0.535
MOD_PIKK_1	144	150	PF00454	0.412
MOD_PIKK_1	338	344	PF00454	0.622
MOD_PKA_2	204	210	PF00069	0.511
MOD_PKA_2	383	389	PF00069	0.525
MOD_PKA_2	41	47	PF00069	0.554
MOD_PKA_2	420	426	PF00069	0.487
MOD_PKA_2	434	440	PF00069	0.433
MOD_PKA_2	510	516	PF00069	0.629
MOD_Plk_1	142	148	PF00069	0.440
MOD_Plk_1	17	23	PF00069	0.698
MOD_Plk_1	181	187	PF00069	0.493
MOD_Plk_1	275	281	PF00069	0.499
MOD_Plk_1	310	316	PF00069	0.459
MOD_Plk_1	42	48	PF00069	0.492
MOD_Plk_1	493	499	PF00069	0.638
MOD_Plk_4	208	214	PF00069	0.334
MOD_Plk_4	275	281	PF00069	0.499
MOD_Plk_4	42	48	PF00069	0.492
MOD_Plk_4	485	491	PF00069	0.625
MOD_Plk_4	511	517	PF00069	0.614
MOD_Plk_4	83	89	PF00069	0.416
MOD_ProDKin_1	499	505	PF00069	0.718
MOD_ProDKin_1	520	526	PF00069	0.668
MOD_ProDKin_1	548	554	PF00069	0.604
MOD_ProDKin_1	8	14	PF00069	0.681
MOD_SUMO_rev_2	24	29	PF00179	0.471
MOD_SUMO_rev_2	416	423	PF00179	0.480
TRG_DiLeu_BaEn_1	173	178	PF01217	0.568
TRG_DiLeu_BaEn_1	358	363	PF01217	0.507
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.315
TRG_ENDOCYTIC_2	200	203	PF00928	0.502
TRG_ENDOCYTIC_2	391	394	PF00928	0.521
TRG_ENDOCYTIC_2	568	571	PF00928	0.641
TRG_ENDOCYTIC_2	88	91	PF00928	0.476
TRG_ER_diArg_1	115	117	PF00400	0.378
TRG_ER_diArg_1	429	431	PF00400	0.483
TRG_ER_diArg_1	617	619	PF00400	0.726
TRG_ER_diArg_1	74	77	PF00400	0.639
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I367	Leptomonas seymouri	69%	91%
A0A1X0P0X2	Trypanosomatidae	39%	94%
A0A1X0P178	Trypanosomatidae	37%	100%
A0A3Q8IGU1	Leishmania donovani	92%	100%
A0A3S7X6R5	Leishmania donovani	31%	71%
A0A422N1N7	Trypanosoma rangeli	22%	72%
A4HLH8	Leishmania braziliensis	74%	98%
A4HLH9	Leishmania braziliensis	32%	80%
A4I8Y8	Leishmania infantum	92%	100%
A4I8Y9	Leishmania infantum	30%	73%
E9B3V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B3V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	71%
Q4Q466	Leishmania major	30%	73%