Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q466_LEIMA

TriTrypDb:

LmjF.33.1240 , LMJLV39_330019900 , LMJSD75_330019600

Length:

856

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0035869	ciliary transition zone	2	3
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4Q466

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q466

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.330
CLV_C14_Caspase3-7	39	43	PF00656	0.500
CLV_C14_Caspase3-7	427	431	PF00656	0.522
CLV_C14_Caspase3-7	551	555	PF00656	0.603
CLV_NRD_NRD_1	178	180	PF00675	0.541
CLV_NRD_NRD_1	456	458	PF00675	0.510
CLV_NRD_NRD_1	50	52	PF00675	0.648
CLV_NRD_NRD_1	57	59	PF00675	0.570
CLV_NRD_NRD_1	776	778	PF00675	0.791
CLV_NRD_NRD_1	796	798	PF00675	0.649
CLV_PCSK_FUR_1	48	52	PF00082	0.396
CLV_PCSK_FUR_1	793	797	PF00082	0.587
CLV_PCSK_KEX2_1	103	105	PF00082	0.641
CLV_PCSK_KEX2_1	456	458	PF00082	0.552
CLV_PCSK_KEX2_1	479	481	PF00082	0.504
CLV_PCSK_KEX2_1	50	52	PF00082	0.648
CLV_PCSK_KEX2_1	57	59	PF00082	0.570
CLV_PCSK_KEX2_1	6	8	PF00082	0.442
CLV_PCSK_KEX2_1	776	778	PF00082	0.791
CLV_PCSK_KEX2_1	792	794	PF00082	0.497
CLV_PCSK_KEX2_1	795	797	PF00082	0.636
CLV_PCSK_KEX2_1	834	836	PF00082	0.616
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.602
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.504
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.442
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.586
CLV_PCSK_PC1ET2_1	834	836	PF00082	0.616
CLV_PCSK_PC7_1	475	481	PF00082	0.469
CLV_PCSK_SKI1_1	123	127	PF00082	0.392
CLV_PCSK_SKI1_1	475	479	PF00082	0.526
CLV_PCSK_SKI1_1	834	838	PF00082	0.632
CLV_PCSK_SKI1_1	841	845	PF00082	0.575
CLV_Separin_Metazoa	54	58	PF03568	0.497
DEG_APCC_DBOX_1	500	508	PF00400	0.508
DEG_APCC_DBOX_1	796	804	PF00400	0.660
DEG_SPOP_SBC_1	594	598	PF00917	0.719
DEG_SPOP_SBC_1	836	840	PF00917	0.618
DEG_SPOP_SBC_1	847	851	PF00917	0.592
DOC_CYCLIN_RxL_1	117	130	PF00134	0.416
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	567	573	PF00134	0.759
DOC_CYCLIN_yCln2_LP_2	612	618	PF00134	0.586
DOC_MAPK_DCC_7	795	805	PF00069	0.661
DOC_MAPK_gen_1	795	805	PF00069	0.781
DOC_MAPK_MEF2A_6	501	508	PF00069	0.634
DOC_MAPK_MEF2A_6	796	805	PF00069	0.775
DOC_MAPK_NFAT4_5	501	509	PF00069	0.513
DOC_PP1_RVXF_1	360	367	PF00149	0.442
DOC_PP2B_LxvP_1	126	129	PF13499	0.498
DOC_PP2B_LxvP_1	20	23	PF13499	0.515
DOC_PP2B_LxvP_1	506	509	PF13499	0.583
DOC_PP2B_LxvP_1	571	574	PF13499	0.676
DOC_PP2B_LxvP_1	588	591	PF13499	0.608
DOC_PP2B_LxvP_1	610	613	PF13499	0.735
DOC_SPAK_OSR1_1	362	366	PF12202	0.493
DOC_USP7_MATH_1	155	159	PF00917	0.586
DOC_USP7_MATH_1	184	188	PF00917	0.526
DOC_USP7_MATH_1	237	241	PF00917	0.508
DOC_USP7_MATH_1	383	387	PF00917	0.533
DOC_USP7_MATH_1	563	567	PF00917	0.741
DOC_USP7_MATH_1	594	598	PF00917	0.690
DOC_USP7_MATH_1	647	651	PF00917	0.678
DOC_USP7_MATH_1	653	657	PF00917	0.591
DOC_USP7_MATH_1	669	673	PF00917	0.565
DOC_USP7_MATH_1	749	753	PF00917	0.735
DOC_USP7_MATH_1	781	785	PF00917	0.756
DOC_WW_Pin1_4	400	405	PF00397	0.574
DOC_WW_Pin1_4	528	533	PF00397	0.621
DOC_WW_Pin1_4	779	784	PF00397	0.638
DOC_WW_Pin1_4	815	820	PF00397	0.824
DOC_WW_Pin1_4	97	102	PF00397	0.524
LIG_14-3-3_CanoR_1	179	188	PF00244	0.410
LIG_14-3-3_CanoR_1	309	314	PF00244	0.437
LIG_14-3-3_CanoR_1	342	350	PF00244	0.444
LIG_14-3-3_CanoR_1	409	413	PF00244	0.576
LIG_14-3-3_CanoR_1	438	444	PF00244	0.650
LIG_14-3-3_CanoR_1	514	520	PF00244	0.560
LIG_14-3-3_CanoR_1	7	15	PF00244	0.443
LIG_14-3-3_CanoR_1	814	819	PF00244	0.562
LIG_14-3-3_CanoR_1	86	92	PF00244	0.572
LIG_BIR_III_4	284	288	PF00653	0.394
LIG_BRCT_BRCA1_1	172	176	PF00533	0.350
LIG_BRCT_BRCA1_1	440	444	PF00533	0.531
LIG_deltaCOP1_diTrp_1	34	40	PF00928	0.417
LIG_EVH1_1	588	592	PF00568	0.544
LIG_EVH1_1	610	614	PF00568	0.640
LIG_FHA_1	111	117	PF00498	0.614
LIG_FHA_1	169	175	PF00498	0.672
LIG_FHA_1	180	186	PF00498	0.339
LIG_FHA_1	244	250	PF00498	0.496
LIG_FHA_1	326	332	PF00498	0.404
LIG_FHA_1	414	420	PF00498	0.585
LIG_FHA_1	50	56	PF00498	0.672
LIG_FHA_1	522	528	PF00498	0.684
LIG_FHA_1	531	537	PF00498	0.611
LIG_FHA_1	573	579	PF00498	0.702
LIG_FHA_1	594	600	PF00498	0.726
LIG_FHA_1	653	659	PF00498	0.643
LIG_FHA_1	785	791	PF00498	0.696
LIG_FHA_1	842	848	PF00498	0.655
LIG_FHA_2	29	35	PF00498	0.445
LIG_FHA_2	350	356	PF00498	0.424
LIG_FHA_2	37	43	PF00498	0.343
LIG_FHA_2	498	504	PF00498	0.655
LIG_FHA_2	521	527	PF00498	0.682
LIG_FHA_2	549	555	PF00498	0.702
LIG_FHA_2	818	824	PF00498	0.663
LIG_LIR_Gen_1	34	45	PF02991	0.533
LIG_LIR_Gen_1	380	390	PF02991	0.503
LIG_LIR_LC3C_4	17	22	PF02991	0.534
LIG_LIR_Nem_3	135	141	PF02991	0.516
LIG_LIR_Nem_3	190	194	PF02991	0.444
LIG_LIR_Nem_3	34	40	PF02991	0.417
LIG_LIR_Nem_3	402	408	PF02991	0.577
LIG_LIR_Nem_3	553	559	PF02991	0.532
LIG_MAD2	18	26	PF02301	0.463
LIG_MYND_1	755	759	PF01753	0.515
LIG_MYND_3	619	623	PF01753	0.510
LIG_NRBOX	173	179	PF00104	0.447
LIG_REV1ctd_RIR_1	215	222	PF16727	0.331
LIG_SH2_SRC	194	197	PF00017	0.390
LIG_SH2_SRC	232	235	PF00017	0.514
LIG_SH2_STAP1	214	218	PF00017	0.481
LIG_SH2_STAT5	194	197	PF00017	0.442
LIG_SH2_STAT5	262	265	PF00017	0.524
LIG_SH2_STAT5	530	533	PF00017	0.686
LIG_SH2_STAT5	773	776	PF00017	0.641
LIG_SH3_3	19	25	PF00018	0.561
LIG_SH3_3	351	357	PF00018	0.445
LIG_SH3_3	556	562	PF00018	0.696
LIG_SH3_3	567	573	PF00018	0.662
LIG_SH3_3	586	592	PF00018	0.648
LIG_SH3_3	598	604	PF00018	0.689
LIG_SH3_3	605	611	PF00018	0.730
LIG_SH3_3	626	632	PF00018	0.717
LIG_SH3_3	639	645	PF00018	0.736
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.529
LIG_SUMO_SIM_par_1	112	119	PF11976	0.666
LIG_SUMO_SIM_par_1	124	130	PF11976	0.469
LIG_SUMO_SIM_par_1	25	31	PF11976	0.435
LIG_UBA3_1	174	180	PF00899	0.448
MOD_CDC14_SPxK_1	100	103	PF00782	0.526
MOD_CDK_SPxK_1	400	406	PF00069	0.598
MOD_CDK_SPxK_1	97	103	PF00069	0.526
MOD_CDK_SPxxK_3	779	786	PF00069	0.638
MOD_CDK_SPxxK_3	97	104	PF00069	0.528
MOD_CK1_1	158	164	PF00069	0.784
MOD_CK1_1	170	176	PF00069	0.401
MOD_CK1_1	28	34	PF00069	0.503
MOD_CK1_1	322	328	PF00069	0.567
MOD_CK1_1	400	406	PF00069	0.537
MOD_CK1_1	547	553	PF00069	0.800
MOD_CK1_1	565	571	PF00069	0.680
MOD_CK1_1	643	649	PF00069	0.668
MOD_CK1_1	69	75	PF00069	0.614
MOD_CK1_1	784	790	PF00069	0.653
MOD_CK1_1	8	14	PF00069	0.666
MOD_CK1_1	81	87	PF00069	0.515
MOD_CK1_1	815	821	PF00069	0.617
MOD_CK2_1	184	190	PF00069	0.391
MOD_CK2_1	194	200	PF00069	0.295
MOD_CK2_1	349	355	PF00069	0.402
MOD_CK2_1	38	44	PF00069	0.385
MOD_CK2_1	383	389	PF00069	0.559
MOD_CK2_1	444	450	PF00069	0.559
MOD_CK2_1	497	503	PF00069	0.441
MOD_CK2_1	817	823	PF00069	0.666
MOD_GlcNHglycan	157	160	PF01048	0.789
MOD_GlcNHglycan	196	199	PF01048	0.383
MOD_GlcNHglycan	239	242	PF01048	0.319
MOD_GlcNHglycan	281	284	PF01048	0.399
MOD_GlcNHglycan	285	288	PF01048	0.444
MOD_GlcNHglycan	306	309	PF01048	0.483
MOD_GlcNHglycan	321	324	PF01048	0.399
MOD_GlcNHglycan	335	338	PF01048	0.447
MOD_GlcNHglycan	368	371	PF01048	0.470
MOD_GlcNHglycan	385	388	PF01048	0.472
MOD_GlcNHglycan	399	402	PF01048	0.452
MOD_GlcNHglycan	580	583	PF01048	0.734
MOD_GlcNHglycan	585	588	PF01048	0.705
MOD_GlcNHglycan	605	608	PF01048	0.673
MOD_GlcNHglycan	63	66	PF01048	0.597
MOD_GlcNHglycan	633	636	PF01048	0.816
MOD_GlcNHglycan	655	658	PF01048	0.747
MOD_GlcNHglycan	736	739	PF01048	0.702
MOD_GlcNHglycan	750	754	PF01048	0.653
MOD_GlcNHglycan	827	830	PF01048	0.638
MOD_GlcNHglycan	87	90	PF01048	0.510
MOD_GSK3_1	103	110	PF00069	0.744
MOD_GSK3_1	112	119	PF00069	0.581
MOD_GSK3_1	163	170	PF00069	0.630
MOD_GSK3_1	179	186	PF00069	0.579
MOD_GSK3_1	239	246	PF00069	0.498
MOD_GSK3_1	279	286	PF00069	0.440
MOD_GSK3_1	321	328	PF00069	0.433
MOD_GSK3_1	393	400	PF00069	0.609
MOD_GSK3_1	544	551	PF00069	0.681
MOD_GSK3_1	574	581	PF00069	0.733
MOD_GSK3_1	643	650	PF00069	0.763
MOD_GSK3_1	730	737	PF00069	0.650
MOD_GSK3_1	749	756	PF00069	0.683
MOD_GSK3_1	781	788	PF00069	0.643
MOD_GSK3_1	81	88	PF00069	0.554
MOD_GSK3_1	810	817	PF00069	0.647
MOD_GSK3_1	823	830	PF00069	0.581
MOD_GSK3_1	835	842	PF00069	0.556
MOD_GSK3_1	93	100	PF00069	0.550
MOD_N-GLC_1	541	546	PF02516	0.538
MOD_N-GLC_2	143	145	PF02516	0.427
MOD_NEK2_1	139	144	PF00069	0.463
MOD_NEK2_1	217	222	PF00069	0.491
MOD_NEK2_1	257	262	PF00069	0.429
MOD_NEK2_1	408	413	PF00069	0.550
MOD_NEK2_1	444	449	PF00069	0.558
MOD_NEK2_1	497	502	PF00069	0.539
MOD_NEK2_1	538	543	PF00069	0.650
MOD_NEK2_1	763	768	PF00069	0.593
MOD_NEK2_1	79	84	PF00069	0.580
MOD_PIKK_1	413	419	PF00454	0.581
MOD_PKA_1	103	109	PF00069	0.596
MOD_PKA_1	179	185	PF00069	0.418
MOD_PKA_1	834	840	PF00069	0.614
MOD_PKA_2	103	109	PF00069	0.513
MOD_PKA_2	167	173	PF00069	0.527
MOD_PKA_2	257	263	PF00069	0.547
MOD_PKA_2	341	347	PF00069	0.538
MOD_PKA_2	408	414	PF00069	0.667
MOD_PKA_2	49	55	PF00069	0.641
MOD_PKA_2	763	769	PF00069	0.591
MOD_PKA_2	785	791	PF00069	0.640
MOD_PKA_2	834	840	PF00069	0.606
MOD_PKA_2	85	91	PF00069	0.567
MOD_PKB_1	810	818	PF00069	0.631
MOD_Plk_1	243	249	PF00069	0.508
MOD_Plk_2-3	393	399	PF00069	0.486
MOD_Plk_4	170	176	PF00069	0.460
MOD_Plk_4	393	399	PF00069	0.684
MOD_Plk_4	439	445	PF00069	0.618
MOD_Plk_4	753	759	PF00069	0.515
MOD_Plk_4	842	848	PF00069	0.614
MOD_ProDKin_1	400	406	PF00069	0.577
MOD_ProDKin_1	528	534	PF00069	0.620
MOD_ProDKin_1	779	785	PF00069	0.637
MOD_ProDKin_1	815	821	PF00069	0.824
MOD_ProDKin_1	97	103	PF00069	0.526
MOD_SUMO_for_1	791	794	PF00179	0.647
MOD_SUMO_for_1	803	806	PF00179	0.569
MOD_SUMO_rev_2	817	826	PF00179	0.647
TRG_DiLeu_BaEn_1	234	239	PF01217	0.572
TRG_DiLeu_BaEn_1	503	508	PF01217	0.514
TRG_ENDOCYTIC_2	214	217	PF00928	0.379
TRG_ENDOCYTIC_2	382	385	PF00928	0.472
TRG_ENDOCYTIC_2	405	408	PF00928	0.545
TRG_ER_diArg_1	456	458	PF00400	0.590
TRG_ER_diArg_1	468	471	PF00400	0.639
TRG_ER_diArg_1	47	50	PF00400	0.620
TRG_ER_diArg_1	56	58	PF00400	0.606
TRG_ER_diArg_1	776	778	PF00400	0.791
TRG_ER_diArg_1	795	797	PF00400	0.652
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.304
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I367	Leptomonas seymouri	30%	100%
A0A1X0P0X2	Trypanosomatidae	33%	100%
A0A3Q8IGU1	Leishmania donovani	29%	100%
A0A3S7X6R5	Leishmania donovani	92%	99%
A4HLH8	Leishmania braziliensis	28%	95%
A4HLH9	Leishmania braziliensis	74%	100%
A4I8Y8	Leishmania infantum	29%	100%
A4I8Y9	Leishmania infantum	94%	100%
D0A4Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B3V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4Q467	Leishmania major	30%	100%