Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q465_LEIMA

TriTrypDb:

LmjF.33.1245 , LMJLV39_330020000 , LMJSD75_330019700

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q465

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q465

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.670
CLV_NRD_NRD_1	313	315	PF00675	0.628
CLV_NRD_NRD_1	361	363	PF00675	0.640
CLV_NRD_NRD_1	395	397	PF00675	0.555
CLV_NRD_NRD_1	74	76	PF00675	0.618
CLV_PCSK_KEX2_1	313	315	PF00082	0.628
CLV_PCSK_KEX2_1	361	363	PF00082	0.640
CLV_PCSK_KEX2_1	395	397	PF00082	0.555
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.628
CLV_PCSK_PC7_1	391	397	PF00082	0.541
CLV_PCSK_SKI1_1	315	319	PF00082	0.538
DEG_COP1_1	219	227	PF00400	0.577
DEG_SCF_FBW7_1	350	357	PF00400	0.574
DEG_SPOP_SBC_1	181	185	PF00917	0.568
DEG_SPOP_SBC_1	355	359	PF00917	0.629
DOC_CKS1_1	351	356	PF01111	0.577
DOC_CKS1_1	78	83	PF01111	0.645
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.674
DOC_MAPK_MEF2A_6	104	113	PF00069	0.568
DOC_MAPK_MEF2A_6	47	55	PF00069	0.646
DOC_PP2B_LxvP_1	214	217	PF13499	0.672
DOC_PP2B_LxvP_1	227	230	PF13499	0.548
DOC_PP2B_LxvP_1	276	279	PF13499	0.517
DOC_PP4_FxxP_1	398	401	PF00568	0.559
DOC_PP4_FxxP_1	5	8	PF00568	0.602
DOC_PP4_FxxP_1	59	62	PF00568	0.551
DOC_USP7_MATH_1	100	104	PF00917	0.591
DOC_USP7_MATH_1	142	146	PF00917	0.722
DOC_USP7_MATH_1	149	153	PF00917	0.636
DOC_USP7_MATH_1	181	185	PF00917	0.582
DOC_USP7_MATH_1	194	198	PF00917	0.558
DOC_USP7_MATH_1	308	312	PF00917	0.559
DOC_USP7_MATH_1	321	325	PF00917	0.572
DOC_USP7_MATH_1	33	37	PF00917	0.601
DOC_USP7_MATH_1	336	340	PF00917	0.523
DOC_USP7_MATH_1	355	359	PF00917	0.507
DOC_USP7_MATH_1	66	70	PF00917	0.677
DOC_USP7_MATH_1	89	93	PF00917	0.682
DOC_USP7_UBL2_3	63	67	PF12436	0.794
DOC_WW_Pin1_4	104	109	PF00397	0.555
DOC_WW_Pin1_4	134	139	PF00397	0.633
DOC_WW_Pin1_4	140	145	PF00397	0.589
DOC_WW_Pin1_4	159	164	PF00397	0.629
DOC_WW_Pin1_4	188	193	PF00397	0.604
DOC_WW_Pin1_4	204	209	PF00397	0.632
DOC_WW_Pin1_4	228	233	PF00397	0.649
DOC_WW_Pin1_4	255	260	PF00397	0.629
DOC_WW_Pin1_4	279	284	PF00397	0.616
DOC_WW_Pin1_4	334	339	PF00397	0.630
DOC_WW_Pin1_4	350	355	PF00397	0.540
DOC_WW_Pin1_4	77	82	PF00397	0.656
DOC_WW_Pin1_4	83	88	PF00397	0.647
DOC_WW_Pin1_4	90	95	PF00397	0.677
LIG_14-3-3_CanoR_1	126	134	PF00244	0.646
LIG_14-3-3_CanoR_1	361	370	PF00244	0.639
LIG_14-3-3_CanoR_1	75	81	PF00244	0.560
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BRCT_BRCA1_1	1	5	PF00533	0.555
LIG_BRCT_BRCA1_1	336	340	PF00533	0.639
LIG_BRCT_BRCA1_1	55	59	PF00533	0.634
LIG_FHA_1	129	135	PF00498	0.659
LIG_FHA_1	219	225	PF00498	0.645
LIG_FHA_1	263	269	PF00498	0.584
LIG_LIR_Apic_2	2	8	PF02991	0.618
LIG_LIR_Apic_2	298	304	PF02991	0.625
LIG_LIR_Apic_2	56	62	PF02991	0.545
LIG_LIR_Nem_3	381	387	PF02991	0.560
LIG_MYND_1	279	283	PF01753	0.524
LIG_MYND_1	304	308	PF01753	0.621
LIG_Pex14_1	328	332	PF04695	0.607
LIG_Pex14_1	379	383	PF04695	0.572
LIG_SH2_STAT5	392	395	PF00017	0.528
LIG_SH2_STAT5	397	400	PF00017	0.524
LIG_SH3_3	102	108	PF00018	0.587
LIG_SH3_3	11	17	PF00018	0.552
LIG_SH3_3	157	163	PF00018	0.784
LIG_SH3_3	166	172	PF00018	0.668
LIG_SH3_3	200	206	PF00018	0.654
LIG_SH3_3	22	28	PF00018	0.472
LIG_SH3_3	222	228	PF00018	0.572
LIG_SH3_3	249	255	PF00018	0.569
LIG_SH3_3	284	290	PF00018	0.619
LIG_SH3_3	29	35	PF00018	0.513
LIG_SH3_3	299	305	PF00018	0.511
LIG_SH3_3	4	10	PF00018	0.603
LIG_SH3_3	42	48	PF00018	0.662
LIG_SH3_3	92	98	PF00018	0.674
LIG_TRFH_1	332	336	PF08558	0.615
LIG_WW_3	202	206	PF00397	0.646
MOD_CDK_SPK_2	83	88	PF00069	0.686
MOD_CK1_1	128	134	PF00069	0.657
MOD_CK1_1	145	151	PF00069	0.600
MOD_CK1_1	152	158	PF00069	0.616
MOD_CK1_1	185	191	PF00069	0.642
MOD_CK1_1	324	330	PF00069	0.579
MOD_CK1_1	36	42	PF00069	0.585
MOD_CK1_1	83	89	PF00069	0.816
MOD_CK2_1	36	42	PF00069	0.650
MOD_GlcNHglycan	147	150	PF01048	0.653
MOD_GlcNHglycan	151	154	PF01048	0.564
MOD_GlcNHglycan	184	187	PF01048	0.650
MOD_GlcNHglycan	198	201	PF01048	0.569
MOD_GlcNHglycan	218	221	PF01048	0.549
MOD_GlcNHglycan	318	321	PF01048	0.628
MOD_GlcNHglycan	323	326	PF01048	0.569
MOD_GlcNHglycan	371	374	PF01048	0.545
MOD_GlcNHglycan	38	41	PF01048	0.717
MOD_GlcNHglycan	82	85	PF01048	0.684
MOD_GSK3_1	100	107	PF00069	0.696
MOD_GSK3_1	128	135	PF00069	0.708
MOD_GSK3_1	140	147	PF00069	0.653
MOD_GSK3_1	148	155	PF00069	0.718
MOD_GSK3_1	181	188	PF00069	0.783
MOD_GSK3_1	246	253	PF00069	0.584
MOD_GSK3_1	279	286	PF00069	0.616
MOD_GSK3_1	324	331	PF00069	0.515
MOD_GSK3_1	350	357	PF00069	0.664
MOD_GSK3_1	76	83	PF00069	0.600
MOD_N-GLC_1	90	95	PF02516	0.677
MOD_NEK2_1	1	6	PF00069	0.566
MOD_NEK2_1	195	200	PF00069	0.650
MOD_NEK2_1	53	58	PF00069	0.634
MOD_NEK2_1	82	87	PF00069	0.621
MOD_OFUCOSY	141	146	PF10250	0.567
MOD_PKA_1	76	82	PF00069	0.596
MOD_PKA_2	125	131	PF00069	0.811
MOD_PKA_2	379	385	PF00069	0.574
MOD_Plk_4	283	289	PF00069	0.601
MOD_Plk_4	379	385	PF00069	0.555
MOD_ProDKin_1	104	110	PF00069	0.554
MOD_ProDKin_1	134	140	PF00069	0.631
MOD_ProDKin_1	159	165	PF00069	0.630
MOD_ProDKin_1	188	194	PF00069	0.576
MOD_ProDKin_1	204	210	PF00069	0.631
MOD_ProDKin_1	228	234	PF00069	0.647
MOD_ProDKin_1	255	261	PF00069	0.625
MOD_ProDKin_1	279	285	PF00069	0.616
MOD_ProDKin_1	334	340	PF00069	0.633
MOD_ProDKin_1	350	356	PF00069	0.540
MOD_ProDKin_1	77	83	PF00069	0.659
MOD_ProDKin_1	90	96	PF00069	0.677
MOD_SUMO_rev_2	327	337	PF00179	0.521
MOD_SUMO_rev_2	69	78	PF00179	0.621
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.519
TRG_ER_diArg_1	395	397	PF00400	0.554
TRG_NLS_MonoCore_2	312	317	PF00514	0.627
TRG_NLS_MonoExtN_4	310	317	PF00514	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ITZ0	Leishmania donovani	89%	71%
A4I8Z0	Leishmania infantum	89%	100%
E9B3V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%