Mitochondrial RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q464_LEIMA

TriTrypDb:

LmjF.33.1250 , LMJLV39_330020100 , LMJSD75_330019800

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q464

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q464

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.593
CLV_C14_Caspase3-7	168	172	PF00656	0.787
CLV_PCSK_SKI1_1	154	158	PF00082	0.415
CLV_PCSK_SKI1_1	34	38	PF00082	0.346
DEG_Nend_UBRbox_1	1	4	PF02207	0.675
DOC_CYCLIN_RxL_1	150	161	PF00134	0.450
DOC_MAPK_DCC_7	295	303	PF00069	0.360
DOC_MAPK_MEF2A_6	295	303	PF00069	0.344
DOC_PP1_RVXF_1	32	39	PF00149	0.520
DOC_PP2B_LxvP_1	83	86	PF13499	0.388
DOC_USP7_MATH_1	3	7	PF00917	0.620
DOC_WW_Pin1_4	174	179	PF00397	0.714
DOC_WW_Pin1_4	253	258	PF00397	0.402
DOC_WW_Pin1_4	303	308	PF00397	0.469
LIG_14-3-3_CanoR_1	2	8	PF00244	0.579
LIG_14-3-3_CanoR_1	93	101	PF00244	0.367
LIG_BIR_III_2	194	198	PF00653	0.359
LIG_BRCT_BRCA1_1	93	97	PF00533	0.519
LIG_Clathr_ClatBox_1	219	223	PF01394	0.394
LIG_eIF4E_1	255	261	PF01652	0.360
LIG_FHA_1	2	8	PF00498	0.642
LIG_FHA_1	207	213	PF00498	0.438
LIG_FHA_1	254	260	PF00498	0.410
LIG_FHA_1	308	314	PF00498	0.649
LIG_FHA_2	50	56	PF00498	0.493
LIG_FHA_2	86	92	PF00498	0.459
LIG_LIR_Gen_1	182	189	PF02991	0.423
LIG_LIR_Nem_3	182	187	PF02991	0.437
LIG_LIR_Nem_3	200	204	PF02991	0.299
LIG_LIR_Nem_3	249	253	PF02991	0.447
LIG_LIR_Nem_3	35	41	PF02991	0.418
LIG_LIR_Nem_3	43	48	PF02991	0.320
LIG_PAM2_1	275	287	PF00658	0.328
LIG_SH2_CRK	45	49	PF00017	0.371
LIG_SH2_SRC	240	243	PF00017	0.354
LIG_SH2_STAT5	103	106	PF00017	0.376
LIG_SH2_STAT5	116	119	PF00017	0.424
LIG_SH2_STAT5	201	204	PF00017	0.347
LIG_SH2_STAT5	240	243	PF00017	0.381
LIG_SH2_STAT5	255	258	PF00017	0.479
LIG_SH3_3	11	17	PF00018	0.389
LIG_SH3_3	128	134	PF00018	0.362
LIG_SH3_3	172	178	PF00018	0.741
LIG_SH3_3	21	27	PF00018	0.444
LIG_SH3_5	197	201	PF00018	0.364
LIG_SUMO_SIM_par_1	185	190	PF11976	0.421
LIG_SUMO_SIM_par_1	218	223	PF11976	0.370
LIG_WRC_WIRS_1	247	252	PF05994	0.342
MOD_CK1_1	268	274	PF00069	0.420
MOD_CK1_1	293	299	PF00069	0.368
MOD_CK1_1	306	312	PF00069	0.550
MOD_CK2_1	179	185	PF00069	0.490
MOD_CK2_1	85	91	PF00069	0.448
MOD_GlcNHglycan	113	116	PF01048	0.462
MOD_GlcNHglycan	126	129	PF01048	0.343
MOD_GlcNHglycan	158	161	PF01048	0.548
MOD_GlcNHglycan	27	30	PF01048	0.493
MOD_GlcNHglycan	295	298	PF01048	0.364
MOD_GSK3_1	18	25	PF00069	0.516
MOD_GSK3_1	303	310	PF00069	0.573
MOD_GSK3_1	324	331	PF00069	0.648
MOD_GSK3_1	44	51	PF00069	0.349
MOD_N-GLC_1	206	211	PF02516	0.252
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	290	295	PF00069	0.308
MOD_NEK2_1	314	319	PF00069	0.647
MOD_NEK2_1	44	49	PF00069	0.368
MOD_NEK2_1	97	102	PF00069	0.384
MOD_NEK2_2	3	8	PF00069	0.635
MOD_NEK2_2	65	70	PF00069	0.490
MOD_PIKK_1	324	330	PF00454	0.669
MOD_PKA_2	1	7	PF00069	0.608
MOD_PKA_2	92	98	PF00069	0.372
MOD_Plk_1	206	212	PF00069	0.247
MOD_Plk_1	265	271	PF00069	0.406
MOD_Plk_2-3	185	191	PF00069	0.489
MOD_Plk_4	206	212	PF00069	0.448
MOD_Plk_4	49	55	PF00069	0.407
MOD_ProDKin_1	174	180	PF00069	0.716
MOD_ProDKin_1	253	259	PF00069	0.392
MOD_ProDKin_1	303	309	PF00069	0.476
TRG_ENDOCYTIC_2	201	204	PF00928	0.347
TRG_ENDOCYTIC_2	45	48	PF00928	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y0	Leptomonas seymouri	33%	78%
A0A0N1PDA3	Leptomonas seymouri	77%	100%
A0A0S4INL4	Bodo saltans	36%	77%
A0A0S4JAJ5	Bodo saltans	60%	100%
A0A1X0NQR5	Trypanosomatidae	35%	83%
A0A1X0P2H5	Trypanosomatidae	68%	100%
A0A3Q8IH71	Leishmania donovani	33%	77%
A0A3R7M1X1	Trypanosoma rangeli	33%	90%
A0A3R7MCA7	Trypanosoma rangeli	68%	100%
A0A3S7X6N8	Leishmania donovani	97%	100%
A4H647	Leishmania braziliensis	32%	77%
A4HLI1	Leishmania braziliensis	92%	100%
A4HUG7	Leishmania infantum	33%	77%
A4I8Z1	Leishmania infantum	97%	100%
D0A4Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AN65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	77%
E9B3W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QHG0	Leishmania major	33%	77%
V5B205	Trypanosoma cruzi	35%	79%
V5BLV5	Trypanosoma cruzi	67%	100%