LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q462_LEIMA
TriTrypDb:
LmjF.33.1270 , LMJLV39_330020300 , LMJSD75_330020000
Length:
330

Annotations

LeishMANIAdb annotations

A protein family restricted to kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 8
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1

Expansion

Sequence features

Q4Q462
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q462

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 169 173 PF00656 0.386
CLV_MEL_PAP_1 11 17 PF00089 0.625
CLV_NRD_NRD_1 187 189 PF00675 0.588
CLV_NRD_NRD_1 192 194 PF00675 0.577
CLV_NRD_NRD_1 196 198 PF00675 0.580
CLV_PCSK_FUR_1 262 266 PF00082 0.438
CLV_PCSK_KEX2_1 191 193 PF00082 0.580
CLV_PCSK_KEX2_1 196 198 PF00082 0.580
CLV_PCSK_KEX2_1 264 266 PF00082 0.438
CLV_PCSK_PC1ET2_1 264 266 PF00082 0.438
CLV_PCSK_PC7_1 188 194 PF00082 0.589
CLV_PCSK_SKI1_1 134 138 PF00082 0.617
CLV_PCSK_SKI1_1 196 200 PF00082 0.700
CLV_Separin_Metazoa 121 125 PF03568 0.368
DEG_Nend_UBRbox_3 1 3 PF02207 0.445
DOC_ANK_TNKS_1 123 130 PF00023 0.368
DOC_MAPK_gen_1 236 246 PF00069 0.547
DOC_MAPK_gen_1 254 263 PF00069 0.605
DOC_MAPK_MEF2A_6 19 26 PF00069 0.445
DOC_MAPK_MEF2A_6 254 263 PF00069 0.633
DOC_PP2B_PxIxI_1 21 27 PF00149 0.372
DOC_PP4_FxxP_1 302 305 PF00568 0.606
DOC_USP7_MATH_1 285 289 PF00917 0.602
DOC_USP7_MATH_1 5 9 PF00917 0.501
DOC_USP7_UBL2_3 185 189 PF12436 0.392
DOC_WW_Pin1_4 202 207 PF00397 0.392
DOC_WW_Pin1_4 281 286 PF00397 0.618
LIG_14-3-3_CanoR_1 265 271 PF00244 0.609
LIG_14-3-3_CanoR_1 27 33 PF00244 0.554
LIG_14-3-3_CanoR_1 289 297 PF00244 0.687
LIG_14-3-3_CanoR_1 34 42 PF00244 0.421
LIG_14-3-3_CanoR_1 6 10 PF00244 0.495
LIG_14-3-3_CanoR_1 77 86 PF00244 0.385
LIG_Actin_WH2_2 119 136 PF00022 0.403
LIG_AP2alpha_2 258 260 PF02296 0.604
LIG_Clathr_ClatBox_1 83 87 PF01394 0.368
LIG_deltaCOP1_diTrp_1 258 266 PF00928 0.607
LIG_eIF4E_1 217 223 PF01652 0.395
LIG_FHA_1 139 145 PF00498 0.409
LIG_FHA_1 218 224 PF00498 0.406
LIG_FHA_1 37 43 PF00498 0.561
LIG_FHA_1 79 85 PF00498 0.401
LIG_FHA_2 135 141 PF00498 0.416
LIG_FHA_2 176 182 PF00498 0.442
LIG_FHA_2 185 191 PF00498 0.392
LIG_FHA_2 248 254 PF00498 0.584
LIG_FHA_2 93 99 PF00498 0.391
LIG_LIR_Apic_2 299 305 PF02991 0.607
LIG_LIR_Gen_1 257 266 PF02991 0.622
LIG_LIR_Nem_3 137 142 PF02991 0.452
LIG_LIR_Nem_3 257 263 PF02991 0.620
LIG_LIR_Nem_3 309 315 PF02991 0.532
LIG_PCNA_yPIPBox_3 115 126 PF02747 0.368
LIG_SH2_GRB2like 209 212 PF00017 0.447
LIG_SH2_SRC 209 212 PF00017 0.447
LIG_SH2_SRC 85 88 PF00017 0.381
LIG_SH2_STAT5 112 115 PF00017 0.324
LIG_SH2_STAT5 132 135 PF00017 0.291
LIG_SH2_STAT5 176 179 PF00017 0.382
LIG_SH2_STAT5 209 212 PF00017 0.447
LIG_SH2_STAT5 85 88 PF00017 0.352
LIG_SH3_3 150 156 PF00018 0.369
LIG_SH3_3 70 76 PF00018 0.431
LIG_SH3_5 128 132 PF00018 0.377
LIG_SUMO_SIM_par_1 43 48 PF11976 0.444
LIG_TRAF2_1 250 253 PF00917 0.596
LIG_UBA3_1 174 179 PF00899 0.377
LIG_WW_3 74 78 PF00397 0.449
MOD_CDC14_SPxK_1 205 208 PF00782 0.385
MOD_CDK_SPxK_1 202 208 PF00069 0.392
MOD_CK1_1 184 190 PF00069 0.436
MOD_CK1_1 288 294 PF00069 0.603
MOD_CK1_1 300 306 PF00069 0.584
MOD_CK1_1 38 44 PF00069 0.514
MOD_CK1_1 48 54 PF00069 0.428
MOD_CK1_1 61 67 PF00069 0.483
MOD_CK2_1 134 140 PF00069 0.445
MOD_CK2_1 175 181 PF00069 0.466
MOD_CK2_1 247 253 PF00069 0.593
MOD_CK2_1 92 98 PF00069 0.418
MOD_GlcNHglycan 291 294 PF01048 0.444
MOD_GlcNHglycan 51 54 PF01048 0.642
MOD_GlcNHglycan 55 58 PF01048 0.635
MOD_GlcNHglycan 7 10 PF01048 0.711
MOD_GlcNHglycan 87 91 PF01048 0.585
MOD_GSK3_1 134 141 PF00069 0.413
MOD_GSK3_1 180 187 PF00069 0.407
MOD_GSK3_1 281 288 PF00069 0.609
MOD_GSK3_1 41 48 PF00069 0.476
MOD_GSK3_1 49 56 PF00069 0.440
MOD_GSK3_1 92 99 PF00069 0.390
MOD_N-GLC_1 134 139 PF02516 0.639
MOD_N-GLC_1 210 215 PF02516 0.624
MOD_NEK2_1 175 180 PF00069 0.427
MOD_NEK2_1 210 215 PF00069 0.424
MOD_NEK2_1 276 281 PF00069 0.674
MOD_NEK2_1 35 40 PF00069 0.458
MOD_NEK2_1 45 50 PF00069 0.471
MOD_NEK2_1 86 91 PF00069 0.453
MOD_NEK2_2 231 236 PF00069 0.521
MOD_PKA_1 264 270 PF00069 0.639
MOD_PKA_2 264 270 PF00069 0.626
MOD_PKA_2 288 294 PF00069 0.603
MOD_PKA_2 297 303 PF00069 0.599
MOD_PKA_2 5 11 PF00069 0.462
MOD_Plk_1 210 216 PF00069 0.320
MOD_Plk_1 276 282 PF00069 0.663
MOD_Plk_1 99 105 PF00069 0.336
MOD_Plk_2-3 166 172 PF00069 0.341
MOD_Plk_4 278 284 PF00069 0.667
MOD_Plk_4 28 34 PF00069 0.485
MOD_Plk_4 41 47 PF00069 0.535
MOD_Plk_4 79 85 PF00069 0.376
MOD_Plk_4 99 105 PF00069 0.319
MOD_ProDKin_1 202 208 PF00069 0.392
MOD_ProDKin_1 281 287 PF00069 0.615
MOD_SUMO_rev_2 102 111 PF00179 0.347
TRG_DiLeu_BaLyEn_6 19 24 PF01217 0.423
TRG_ER_diArg_1 104 107 PF00400 0.358
TRG_ER_diArg_1 191 193 PF00400 0.387
TRG_ER_diArg_1 196 198 PF00400 0.371

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4F7 Leptomonas seymouri 80% 100%
A0A0S4JAA8 Bodo saltans 57% 100%
A0A1X0P101 Trypanosomatidae 74% 99%
A0A3Q8IHR6 Leishmania donovani 96% 100%
A4HLI3 Leishmania braziliensis 89% 100%
A4I8Z3 Leishmania infantum 96% 100%
D0A4Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9B3W2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS