Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MICOS complex subunit MIC20, putative

Species:

Leishmania major

UniProt:

Q4Q461_LEIMA

TriTrypDb:

LmjF.33.1280 , LMJLV39_330020400 , LMJSD75_330020100

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q461

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q461

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.491
CLV_NRD_NRD_1	9	11	PF00675	0.431
CLV_PCSK_KEX2_1	160	162	PF00082	0.550
CLV_PCSK_KEX2_1	9	11	PF00082	0.431
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.486
CLV_PCSK_SKI1_1	36	40	PF00082	0.443
CLV_PCSK_SKI1_1	9	13	PF00082	0.398
DOC_MAPK_DCC_7	79	88	PF00069	0.277
DOC_MAPK_MEF2A_6	79	88	PF00069	0.306
DOC_PP1_RVXF_1	102	109	PF00149	0.277
DOC_USP7_MATH_1	54	58	PF00917	0.378
DOC_USP7_UBL2_3	101	105	PF12436	0.349
DOC_USP7_UBL2_3	160	164	PF12436	0.500
DOC_WW_Pin1_4	127	132	PF00397	0.277
DOC_WW_Pin1_4	162	167	PF00397	0.495
LIG_14-3-3_CanoR_1	147	155	PF00244	0.243
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_CaM_IQ_9	1	17	PF13499	0.553
LIG_CtBP_PxDLS_1	18	22	PF00389	0.431
LIG_FHA_1	111	117	PF00498	0.314
LIG_FHA_1	128	134	PF00498	0.302
LIG_FHA_1	149	155	PF00498	0.388
LIG_FHA_1	2	8	PF00498	0.548
LIG_FHA_2	154	160	PF00498	0.243
LIG_FHA_2	85	91	PF00498	0.355
LIG_LIR_Gen_1	123	131	PF02991	0.281
LIG_LIR_Gen_1	87	96	PF02991	0.337
LIG_LIR_Nem_3	123	127	PF02991	0.281
LIG_LIR_Nem_3	24	29	PF02991	0.450
LIG_Pex14_1	37	41	PF04695	0.355
LIG_PTB_Apo_2	20	27	PF02174	0.522
LIG_PTB_Phospho_1	20	26	PF10480	0.522
LIG_SH2_CRK	124	128	PF00017	0.298
LIG_SH2_STAP1	26	30	PF00017	0.388
LIG_SH3_1	160	166	PF00018	0.545
LIG_SH3_3	160	166	PF00018	0.545
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.278
LIG_TRAF2_1	22	25	PF00917	0.548
LIG_TRAF2_1	57	60	PF00917	0.349
LIG_TYR_ITIM	122	127	PF00017	0.295
LIG_UBA3_1	154	160	PF00899	0.314
LIG_UBA3_1	72	79	PF00899	0.360
LIG_WRC_WIRS_1	133	138	PF05994	0.277
MOD_CK1_1	110	116	PF00069	0.286
MOD_CK2_1	19	25	PF00069	0.445
MOD_CK2_1	54	60	PF00069	0.320
MOD_CK2_1	84	90	PF00069	0.277
MOD_GlcNHglycan	127	130	PF01048	0.363
MOD_GSK3_1	110	117	PF00069	0.372
MOD_GSK3_1	125	132	PF00069	0.369
MOD_NEK2_1	1	6	PF00069	0.528
MOD_NEK2_1	47	52	PF00069	0.460
MOD_PIKK_1	1	7	PF00454	0.563
MOD_PKA_2	97	103	PF00069	0.349
MOD_Plk_2-3	153	159	PF00069	0.199
MOD_ProDKin_1	127	133	PF00069	0.277
MOD_SUMO_for_1	55	58	PF00179	0.372
MOD_SUMO_rev_2	110	116	PF00179	0.256
MOD_SUMO_rev_2	97	106	PF00179	0.338
TRG_DiLeu_BaEn_2	41	47	PF01217	0.377
TRG_ENDOCYTIC_2	124	127	PF00928	0.298
TRG_ER_diArg_1	8	10	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUS4	Leptomonas seymouri	87%	100%
A0A0S4JAW9	Bodo saltans	60%	100%
A0A1X0P1L7	Trypanosomatidae	69%	100%
A0A3Q8IHG4	Leishmania donovani	96%	100%
A0A3R7KXB5	Trypanosoma rangeli	72%	100%
A4HLI4	Leishmania braziliensis	95%	100%
A4I8Z4	Leishmania infantum	97%	100%
D0A4Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9B3W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%