LeishMANIAdb
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MFS_1_like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS_1_like domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q460_LEIMA
TriTrypDb:
LmjF.33.1290 , LMJLV39_330020500 * , LMJSD75_330020200 *
Length:
591

Annotations

LeishMANIAdb annotations

Appears to be a transporter, related to vertebrate MFSD6 proteins (whose function is likewise unexplored).. Only expanded in Leptomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14

Expansion

Sequence features

Q4Q460
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q460

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0022857 transmembrane transporter activity 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.697
CLV_C14_Caspase3-7 329 333 PF00656 0.421
CLV_C14_Caspase3-7 91 95 PF00656 0.636
CLV_NRD_NRD_1 10 12 PF00675 0.484
CLV_NRD_NRD_1 466 468 PF00675 0.540
CLV_NRD_NRD_1 526 528 PF00675 0.514
CLV_NRD_NRD_1 544 546 PF00675 0.542
CLV_PCSK_FUR_1 8 12 PF00082 0.484
CLV_PCSK_KEX2_1 10 12 PF00082 0.484
CLV_PCSK_KEX2_1 312 314 PF00082 0.254
CLV_PCSK_KEX2_1 544 546 PF00082 0.544
CLV_PCSK_PC1ET2_1 312 314 PF00082 0.311
CLV_PCSK_SKI1_1 201 205 PF00082 0.439
CLV_PCSK_SKI1_1 313 317 PF00082 0.322
CLV_PCSK_SKI1_1 467 471 PF00082 0.433
DEG_SIAH_1 32 40 PF03145 0.620
DOC_CDC14_PxL_1 161 169 PF14671 0.410
DOC_MAPK_gen_1 173 182 PF00069 0.507
DOC_MAPK_gen_1 293 301 PF00069 0.488
DOC_MAPK_gen_1 312 318 PF00069 0.447
DOC_MAPK_MEF2A_6 293 301 PF00069 0.521
DOC_MAPK_MEF2A_6 377 384 PF00069 0.453
DOC_MAPK_MEF2A_6 399 406 PF00069 0.335
DOC_MAPK_MEF2A_6 56 63 PF00069 0.563
DOC_MAPK_NFAT4_5 399 407 PF00069 0.239
DOC_USP7_MATH_1 531 535 PF00917 0.616
DOC_USP7_MATH_1 54 58 PF00917 0.733
DOC_USP7_MATH_1 548 552 PF00917 0.754
DOC_USP7_MATH_1 93 97 PF00917 0.699
DOC_WW_Pin1_4 99 104 PF00397 0.732
LIG_14-3-3_CanoR_1 175 181 PF00244 0.474
LIG_14-3-3_CanoR_1 232 242 PF00244 0.499
LIG_Actin_WH2_2 526 541 PF00022 0.564
LIG_AP2alpha_1 330 334 PF02296 0.421
LIG_BIR_III_4 94 98 PF00653 0.625
LIG_BRCT_BRCA1_1 123 127 PF00533 0.441
LIG_BRCT_BRCA1_1 135 139 PF00533 0.184
LIG_BRCT_BRCA1_1 257 261 PF00533 0.324
LIG_BRCT_BRCA1_1 27 31 PF00533 0.650
LIG_BRCT_BRCA1_1 425 429 PF00533 0.372
LIG_BRCT_BRCA1_1 64 68 PF00533 0.647
LIG_CaM_IQ_9 481 496 PF13499 0.468
LIG_CSL_BTD_1 417 420 PF09270 0.343
LIG_EH1_1 146 154 PF00400 0.324
LIG_eIF4E_1 147 153 PF01652 0.340
LIG_FHA_1 108 114 PF00498 0.689
LIG_FHA_1 177 183 PF00498 0.480
LIG_FHA_1 350 356 PF00498 0.347
LIG_FHA_1 411 417 PF00498 0.332
LIG_FHA_1 436 442 PF00498 0.505
LIG_FHA_1 443 449 PF00498 0.399
LIG_FHA_1 477 483 PF00498 0.440
LIG_FHA_1 533 539 PF00498 0.764
LIG_FHA_1 567 573 PF00498 0.786
LIG_FHA_2 14 20 PF00498 0.668
LIG_FHA_2 194 200 PF00498 0.458
LIG_FHA_2 38 44 PF00498 0.669
LIG_GBD_Chelix_1 268 276 PF00786 0.258
LIG_LIR_Gen_1 133 141 PF02991 0.337
LIG_LIR_Gen_1 236 247 PF02991 0.516
LIG_LIR_Gen_1 264 275 PF02991 0.340
LIG_LIR_Gen_1 326 336 PF02991 0.356
LIG_LIR_Gen_1 398 409 PF02991 0.271
LIG_LIR_Gen_1 413 422 PF02991 0.211
LIG_LIR_Gen_1 459 469 PF02991 0.278
LIG_LIR_Gen_1 65 74 PF02991 0.621
LIG_LIR_Nem_3 133 138 PF02991 0.217
LIG_LIR_Nem_3 204 210 PF02991 0.267
LIG_LIR_Nem_3 236 242 PF02991 0.450
LIG_LIR_Nem_3 244 248 PF02991 0.239
LIG_LIR_Nem_3 264 270 PF02991 0.285
LIG_LIR_Nem_3 28 34 PF02991 0.650
LIG_LIR_Nem_3 326 331 PF02991 0.357
LIG_LIR_Nem_3 332 337 PF02991 0.263
LIG_LIR_Nem_3 398 404 PF02991 0.264
LIG_LIR_Nem_3 459 464 PF02991 0.278
LIG_LIR_Nem_3 65 71 PF02991 0.612
LIG_MAD2 489 497 PF02301 0.481
LIG_NRBOX 334 340 PF00104 0.197
LIG_Pex14_2 123 127 PF04695 0.283
LIG_Pex14_2 330 334 PF04695 0.295
LIG_Pex14_2 414 418 PF04695 0.303
LIG_PTB_Apo_2 330 337 PF02174 0.376
LIG_PTB_Apo_2 67 74 PF02174 0.620
LIG_SH2_CRK 135 139 PF00017 0.247
LIG_SH2_CRK 283 287 PF00017 0.349
LIG_SH2_CRK 394 398 PF00017 0.259
LIG_SH2_CRK 461 465 PF00017 0.283
LIG_SH2_NCK_1 135 139 PF00017 0.271
LIG_SH2_NCK_1 291 295 PF00017 0.439
LIG_SH2_NCK_1 461 465 PF00017 0.340
LIG_SH2_SRC 147 150 PF00017 0.340
LIG_SH2_STAP1 135 139 PF00017 0.340
LIG_SH2_STAT5 169 172 PF00017 0.441
LIG_SH2_STAT5 195 198 PF00017 0.421
LIG_SH2_STAT5 263 266 PF00017 0.333
LIG_SH2_STAT5 274 277 PF00017 0.287
LIG_SH2_STAT5 283 286 PF00017 0.278
LIG_SH2_STAT5 394 397 PF00017 0.414
LIG_SH2_STAT5 461 464 PF00017 0.342
LIG_SH3_3 214 220 PF00018 0.239
LIG_SH3_3 284 290 PF00018 0.422
LIG_SH3_3 496 502 PF00018 0.691
LIG_SUMO_SIM_par_1 351 356 PF11976 0.309
LIG_SUMO_SIM_par_1 401 407 PF11976 0.286
LIG_SUMO_SIM_par_1 568 576 PF11976 0.661
LIG_SxIP_EBH_1 354 366 PF03271 0.272
LIG_TYR_ITIM 281 286 PF00017 0.376
LIG_TYR_ITSM 324 331 PF00017 0.405
LIG_TYR_ITSM 457 464 PF00017 0.421
LIG_WRC_WIRS_1 131 136 PF05994 0.203
LIG_WRC_WIRS_1 252 257 PF05994 0.376
LIG_WRC_WIRS_1 441 446 PF05994 0.395
MOD_CK1_1 133 139 PF00069 0.387
MOD_CK1_1 181 187 PF00069 0.323
MOD_CK1_1 188 194 PF00069 0.243
MOD_CK1_1 22 28 PF00069 0.764
MOD_CK1_1 237 243 PF00069 0.522
MOD_CK1_1 435 441 PF00069 0.464
MOD_CK1_1 532 538 PF00069 0.756
MOD_CK1_1 540 546 PF00069 0.658
MOD_CK1_1 580 586 PF00069 0.606
MOD_CK2_1 142 148 PF00069 0.271
MOD_CK2_1 193 199 PF00069 0.258
MOD_CK2_1 531 537 PF00069 0.757
MOD_CK2_1 54 60 PF00069 0.698
MOD_CK2_1 580 586 PF00069 0.728
MOD_Cter_Amidation 8 11 PF01082 0.483
MOD_GlcNHglycan 144 147 PF01048 0.530
MOD_GlcNHglycan 153 156 PF01048 0.270
MOD_GlcNHglycan 236 239 PF01048 0.314
MOD_GlcNHglycan 24 27 PF01048 0.524
MOD_GlcNHglycan 366 369 PF01048 0.255
MOD_GlcNHglycan 435 438 PF01048 0.270
MOD_GlcNHglycan 445 448 PF01048 0.278
MOD_GlcNHglycan 52 55 PF01048 0.507
MOD_GlcNHglycan 540 543 PF01048 0.576
MOD_GlcNHglycan 64 67 PF01048 0.548
MOD_GlcNHglycan 94 98 PF01048 0.445
MOD_GlcNHglycan 99 102 PF01048 0.428
MOD_GSK3_1 126 133 PF00069 0.334
MOD_GSK3_1 15 22 PF00069 0.738
MOD_GSK3_1 181 188 PF00069 0.286
MOD_GSK3_1 233 240 PF00069 0.511
MOD_GSK3_1 251 258 PF00069 0.211
MOD_GSK3_1 319 326 PF00069 0.368
MOD_GSK3_1 349 356 PF00069 0.261
MOD_GSK3_1 378 385 PF00069 0.504
MOD_GSK3_1 38 45 PF00069 0.738
MOD_GSK3_1 431 438 PF00069 0.446
MOD_GSK3_1 50 57 PF00069 0.717
MOD_GSK3_1 572 579 PF00069 0.797
MOD_GSK3_1 62 69 PF00069 0.670
MOD_GSK3_1 93 100 PF00069 0.696
MOD_N-GLC_1 19 24 PF02516 0.455
MOD_N-GLC_1 54 59 PF02516 0.562
MOD_NEK2_1 123 128 PF00069 0.330
MOD_NEK2_1 159 164 PF00069 0.367
MOD_NEK2_1 186 191 PF00069 0.302
MOD_NEK2_1 193 198 PF00069 0.265
MOD_NEK2_1 209 214 PF00069 0.325
MOD_NEK2_1 255 260 PF00069 0.338
MOD_NEK2_1 261 266 PF00069 0.312
MOD_NEK2_1 307 312 PF00069 0.423
MOD_NEK2_1 318 323 PF00069 0.274
MOD_NEK2_1 349 354 PF00069 0.317
MOD_NEK2_1 364 369 PF00069 0.442
MOD_NEK2_1 392 397 PF00069 0.311
MOD_NEK2_1 433 438 PF00069 0.455
MOD_NEK2_1 440 445 PF00069 0.259
MOD_NEK2_1 456 461 PF00069 0.232
MOD_NEK2_1 538 543 PF00069 0.584
MOD_NEK2_2 130 135 PF00069 0.395
MOD_PIKK_1 520 526 PF00454 0.626
MOD_PKA_2 234 240 PF00069 0.494
MOD_PKA_2 549 555 PF00069 0.734
MOD_PKA_2 87 93 PF00069 0.706
MOD_Plk_1 19 25 PF00069 0.637
MOD_Plk_1 42 48 PF00069 0.709
MOD_Plk_1 54 60 PF00069 0.716
MOD_Plk_4 130 136 PF00069 0.274
MOD_Plk_4 159 165 PF00069 0.311
MOD_Plk_4 178 184 PF00069 0.184
MOD_Plk_4 188 194 PF00069 0.312
MOD_Plk_4 201 207 PF00069 0.247
MOD_Plk_4 251 257 PF00069 0.365
MOD_Plk_4 27 33 PF00069 0.753
MOD_Plk_4 319 325 PF00069 0.331
MOD_Plk_4 326 332 PF00069 0.265
MOD_Plk_4 349 355 PF00069 0.382
MOD_Plk_4 382 388 PF00069 0.292
MOD_Plk_4 392 398 PF00069 0.223
MOD_Plk_4 456 462 PF00069 0.318
MOD_ProDKin_1 99 105 PF00069 0.731
MOD_SUMO_rev_2 532 541 PF00179 0.572
TRG_DiLeu_BaEn_1 148 153 PF01217 0.271
TRG_DiLeu_BaEn_1 303 308 PF01217 0.529
TRG_DiLeu_BaLyEn_6 154 159 PF01217 0.421
TRG_DiLeu_BaLyEn_6 217 222 PF01217 0.376
TRG_ENDOCYTIC_2 135 138 PF00928 0.264
TRG_ENDOCYTIC_2 283 286 PF00928 0.289
TRG_ENDOCYTIC_2 291 294 PF00928 0.424
TRG_ENDOCYTIC_2 328 331 PF00928 0.330
TRG_ENDOCYTIC_2 394 397 PF00928 0.259
TRG_ENDOCYTIC_2 461 464 PF00928 0.240
TRG_ER_diArg_1 7 10 PF00400 0.686
TRG_NES_CRM1_1 346 360 PF08389 0.376
TRG_NES_CRM1_1 488 501 PF08389 0.613

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4U9 Leptomonas seymouri 57% 100%
A0A0S4J6V2 Bodo saltans 37% 100%
A0A0S4JFI6 Bodo saltans 35% 100%
A0A1X0P0X3 Trypanosomatidae 44% 100%
A0A1X0P0Y1 Trypanosomatidae 36% 100%
A0A3R7NAF7 Trypanosoma rangeli 36% 100%
A0A3S7X6L2 Leishmania donovani 91% 100%
A4HLI5 Leishmania braziliensis 69% 100%
A4I8Z5 Leishmania infantum 91% 100%
D0A4Z3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9B3W4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
V5BHD1 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS