Putative ABC transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter, putative

Species:

Leishmania major

UniProt:

Q4Q459_LEIMA

TriTrypDb:

LmjF.33.1300 , LMJLV39_330020800 , LMJSD75_330020500

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	7
GO:0016020	membrane	2	4
GO:0005576	extracellular region	2	2

Expansion

Sequence features

Q4Q459

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q459

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	495	499	PF00656	0.418
CLV_NRD_NRD_1	125	127	PF00675	0.511
CLV_NRD_NRD_1	14	16	PF00675	0.252
CLV_NRD_NRD_1	180	182	PF00675	0.508
CLV_NRD_NRD_1	214	216	PF00675	0.506
CLV_NRD_NRD_1	239	241	PF00675	0.483
CLV_NRD_NRD_1	389	391	PF00675	0.500
CLV_NRD_NRD_1	447	449	PF00675	0.634
CLV_NRD_NRD_1	621	623	PF00675	0.449
CLV_NRD_NRD_1	9	11	PF00675	0.331
CLV_PCSK_FUR_1	237	241	PF00082	0.513
CLV_PCSK_KEX2_1	14	16	PF00082	0.223
CLV_PCSK_KEX2_1	236	238	PF00082	0.502
CLV_PCSK_KEX2_1	239	241	PF00082	0.512
CLV_PCSK_KEX2_1	286	288	PF00082	0.554
CLV_PCSK_KEX2_1	389	391	PF00082	0.499
CLV_PCSK_KEX2_1	447	449	PF00082	0.594
CLV_PCSK_KEX2_1	502	504	PF00082	0.578
CLV_PCSK_KEX2_1	621	623	PF00082	0.438
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.510
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.554
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.605
CLV_PCSK_PC7_1	10	16	PF00082	0.323
CLV_PCSK_SKI1_1	111	115	PF00082	0.461
CLV_PCSK_SKI1_1	204	208	PF00082	0.491
CLV_PCSK_SKI1_1	239	243	PF00082	0.517
CLV_PCSK_SKI1_1	260	264	PF00082	0.504
CLV_PCSK_SKI1_1	286	290	PF00082	0.483
CLV_PCSK_SKI1_1	43	47	PF00082	0.510
CLV_PCSK_SKI1_1	440	444	PF00082	0.623
CLV_PCSK_SKI1_1	576	580	PF00082	0.595
CLV_PCSK_SKI1_1	75	79	PF00082	0.617
CLV_Separin_Metazoa	441	445	PF03568	0.453
DEG_APCC_DBOX_1	510	518	PF00400	0.458
DEG_SPOP_SBC_1	336	340	PF00917	0.353
DOC_CKS1_1	361	366	PF01111	0.340
DOC_CKS1_1	57	62	PF01111	0.412
DOC_CYCLIN_RxL_1	108	115	PF00134	0.346
DOC_CYCLIN_RxL_1	201	211	PF00134	0.340
DOC_CYCLIN_RxL_1	254	266	PF00134	0.280
DOC_CYCLIN_RxL_1	573	582	PF00134	0.428
DOC_MAPK_gen_1	239	250	PF00069	0.322
DOC_MAPK_gen_1	368	377	PF00069	0.250
DOC_MAPK_gen_1	40	48	PF00069	0.358
DOC_MAPK_gen_1	447	456	PF00069	0.394
DOC_MAPK_MEF2A_6	135	144	PF00069	0.309
DOC_MAPK_MEF2A_6	243	250	PF00069	0.341
DOC_MAPK_MEF2A_6	83	91	PF00069	0.331
DOC_PP1_RVXF_1	202	208	PF00149	0.286
DOC_PP1_RVXF_1	364	370	PF00149	0.335
DOC_PP2B_LxvP_1	162	165	PF13499	0.335
DOC_PP2B_LxvP_1	248	251	PF13499	0.354
DOC_PP4_FxxP_1	207	210	PF00568	0.249
DOC_USP7_MATH_1	148	152	PF00917	0.249
DOC_USP7_MATH_1	256	260	PF00917	0.354
DOC_USP7_MATH_1	346	350	PF00917	0.299
DOC_USP7_MATH_2	63	69	PF00917	0.399
DOC_USP7_UBL2_3	502	506	PF12436	0.403
DOC_USP7_UBL2_3	7	11	PF12436	0.589
DOC_WW_Pin1_4	144	149	PF00397	0.366
DOC_WW_Pin1_4	360	365	PF00397	0.359
DOC_WW_Pin1_4	469	474	PF00397	0.389
DOC_WW_Pin1_4	56	61	PF00397	0.357
LIG_14-3-3_CanoR_1	215	219	PF00244	0.327
LIG_14-3-3_CanoR_1	287	293	PF00244	0.354
LIG_14-3-3_CanoR_1	40	46	PF00244	0.327
LIG_14-3-3_CanoR_1	511	519	PF00244	0.316
LIG_14-3-3_CanoR_1	614	619	PF00244	0.717
LIG_Actin_WH2_2	373	391	PF00022	0.335
LIG_Actin_WH2_2	449	466	PF00022	0.352
LIG_Actin_WH2_2	598	616	PF00022	0.605
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BIR_III_4	294	298	PF00653	0.290
LIG_BRCT_BRCA1_1	581	585	PF00533	0.344
LIG_CaM_NSCaTE_8	191	198	PF13499	0.271
LIG_Clathr_ClatBox_1	262	266	PF01394	0.255
LIG_CSL_BTD_1	160	163	PF09270	0.335
LIG_CtBP_PxDLS_1	63	67	PF00389	0.445
LIG_eIF4E_1	257	263	PF01652	0.310
LIG_eIF4E_1	371	377	PF01652	0.335
LIG_eIF4E_1	595	601	PF01652	0.429
LIG_FHA_1	105	111	PF00498	0.339
LIG_FHA_1	18	24	PF00498	0.313
LIG_FHA_1	185	191	PF00498	0.334
LIG_FHA_1	37	43	PF00498	0.320
LIG_FHA_1	444	450	PF00498	0.404
LIG_FHA_1	52	58	PF00498	0.306
LIG_FHA_2	131	137	PF00498	0.301
LIG_FHA_2	215	221	PF00498	0.274
LIG_FHA_2	289	295	PF00498	0.284
LIG_FHA_2	422	428	PF00498	0.367
LIG_FHA_2	533	539	PF00498	0.429
LIG_FHA_2	59	65	PF00498	0.363
LIG_LIR_Gen_1	105	114	PF02991	0.177
LIG_LIR_Gen_1	138	149	PF02991	0.262
LIG_LIR_Gen_1	290	301	PF02991	0.283
LIG_LIR_Gen_1	349	359	PF02991	0.338
LIG_LIR_Gen_1	401	411	PF02991	0.320
LIG_LIR_Gen_1	419	428	PF02991	0.357
LIG_LIR_Gen_1	524	533	PF02991	0.438
LIG_LIR_Gen_1	565	575	PF02991	0.436
LIG_LIR_Gen_1	594	605	PF02991	0.364
LIG_LIR_Gen_1	85	95	PF02991	0.293
LIG_LIR_Nem_3	105	109	PF02991	0.170
LIG_LIR_Nem_3	138	144	PF02991	0.262
LIG_LIR_Nem_3	290	296	PF02991	0.283
LIG_LIR_Nem_3	349	355	PF02991	0.338
LIG_LIR_Nem_3	358	362	PF02991	0.278
LIG_LIR_Nem_3	401	406	PF02991	0.326
LIG_LIR_Nem_3	419	423	PF02991	0.347
LIG_LIR_Nem_3	520	525	PF02991	0.421
LIG_LIR_Nem_3	565	571	PF02991	0.396
LIG_LIR_Nem_3	572	578	PF02991	0.314
LIG_LIR_Nem_3	594	600	PF02991	0.364
LIG_LIR_Nem_3	85	91	PF02991	0.317
LIG_MAD2	111	119	PF02301	0.335
LIG_NRBOX	109	115	PF00104	0.320
LIG_NRBOX	201	207	PF00104	0.335
LIG_NRBOX	41	47	PF00104	0.347
LIG_NRBOX	579	585	PF00104	0.328
LIG_PCNA_yPIPBox_3	260	268	PF02747	0.352
LIG_PCNA_yPIPBox_3	598	612	PF02747	0.587
LIG_Pex14_2	238	242	PF04695	0.335
LIG_Pex14_2	301	305	PF04695	0.261
LIG_Pex14_2	377	381	PF04695	0.310
LIG_Rb_pABgroove_1	201	209	PF01858	0.335
LIG_Rb_pABgroove_1	287	295	PF01858	0.310
LIG_SH2_CRK	196	200	PF00017	0.261
LIG_SH2_CRK	352	356	PF00017	0.335
LIG_SH2_CRK	373	377	PF00017	0.249
LIG_SH2_CRK	470	474	PF00017	0.297
LIG_SH2_CRK	575	579	PF00017	0.359
LIG_SH2_CRK	597	601	PF00017	0.333
LIG_SH2_NCK_1	420	424	PF00017	0.449
LIG_SH2_NCK_1	494	498	PF00017	0.307
LIG_SH2_NCK_1	525	529	PF00017	0.432
LIG_SH2_PTP2	88	91	PF00017	0.313
LIG_SH2_SRC	371	374	PF00017	0.335
LIG_SH2_SRC	420	423	PF00017	0.446
LIG_SH2_STAP1	106	110	PF00017	0.384
LIG_SH2_STAP1	196	200	PF00017	0.323
LIG_SH2_STAP1	373	377	PF00017	0.249
LIG_SH2_STAP1	525	529	PF00017	0.432
LIG_SH2_STAP1	53	57	PF00017	0.255
LIG_SH2_STAT5	106	109	PF00017	0.302
LIG_SH2_STAT5	249	252	PF00017	0.261
LIG_SH2_STAT5	257	260	PF00017	0.261
LIG_SH2_STAT5	27	30	PF00017	0.334
LIG_SH2_STAT5	32	35	PF00017	0.368
LIG_SH2_STAT5	500	503	PF00017	0.314
LIG_SH2_STAT5	53	56	PF00017	0.281
LIG_SH2_STAT5	595	598	PF00017	0.422
LIG_SH2_STAT5	88	91	PF00017	0.288
LIG_SH3_3	115	121	PF00018	0.261
LIG_SH3_3	177	183	PF00018	0.283
LIG_SH3_3	57	63	PF00018	0.413
LIG_SUMO_SIM_anti_2	459	465	PF11976	0.302
LIG_SUMO_SIM_par_1	261	266	PF11976	0.263
LIG_SUMO_SIM_par_1	353	358	PF11976	0.249
LIG_TRAF2_1	62	65	PF00917	0.367
LIG_UBA3_1	199	204	PF00899	0.354
LIG_UBA3_1	376	385	PF00899	0.343
LIG_UBA3_1	402	410	PF00899	0.355
LIG_WRC_WIRS_1	601	606	PF05994	0.215
MOD_CDK_SPxK_1	360	366	PF00069	0.340
MOD_CDK_SPxxK_3	469	476	PF00069	0.387
MOD_CK1_1	186	192	PF00069	0.335
MOD_CK1_1	214	220	PF00069	0.335
MOD_CK1_1	379	385	PF00069	0.310
MOD_CK1_1	41	47	PF00069	0.339
MOD_CK1_1	532	538	PF00069	0.456
MOD_CK1_1	68	74	PF00069	0.356
MOD_CK2_1	130	136	PF00069	0.277
MOD_CK2_1	416	422	PF00069	0.369
MOD_CK2_1	480	486	PF00069	0.370
MOD_CK2_1	532	538	PF00069	0.421
MOD_CK2_1	58	64	PF00069	0.360
MOD_Cter_Amidation	12	15	PF01082	0.287
MOD_GlcNHglycan	150	153	PF01048	0.449
MOD_GlcNHglycan	169	172	PF01048	0.449
MOD_GlcNHglycan	482	485	PF01048	0.547
MOD_GlcNHglycan	530	534	PF01048	0.634
MOD_GlcNHglycan	605	608	PF01048	0.360
MOD_GSK3_1	144	151	PF00069	0.357
MOD_GSK3_1	194	201	PF00069	0.332
MOD_GSK3_1	226	233	PF00069	0.354
MOD_GSK3_1	335	342	PF00069	0.329
MOD_GSK3_1	34	41	PF00069	0.333
MOD_GSK3_1	51	58	PF00069	0.277
MOD_GSK3_1	596	603	PF00069	0.459
MOD_GSK3_1	64	71	PF00069	0.340
MOD_NEK2_1	17	22	PF00069	0.344
MOD_NEK2_1	230	235	PF00069	0.359
MOD_NEK2_1	3	8	PF00069	0.630
MOD_NEK2_1	376	381	PF00069	0.277
MOD_NEK2_1	38	43	PF00069	0.345
MOD_NEK2_1	402	407	PF00069	0.339
MOD_NEK2_1	443	448	PF00069	0.441
MOD_NEK2_1	480	485	PF00069	0.373
MOD_NEK2_1	579	584	PF00069	0.380
MOD_NEK2_1	600	605	PF00069	0.323
MOD_PIKK_1	184	190	PF00454	0.354
MOD_PKA_2	214	220	PF00069	0.288
MOD_PKA_2	346	352	PF00069	0.335
MOD_PKA_2	443	449	PF00069	0.433
MOD_Plk_1	226	232	PF00069	0.290
MOD_Plk_1	34	40	PF00069	0.414
MOD_Plk_1	64	70	PF00069	0.426
MOD_Plk_2-3	524	530	PF00069	0.445
MOD_Plk_4	186	192	PF00069	0.318
MOD_Plk_4	195	201	PF00069	0.274
MOD_Plk_4	288	294	PF00069	0.256
MOD_Plk_4	376	382	PF00069	0.264
MOD_Plk_4	524	530	PF00069	0.351
MOD_Plk_4	579	585	PF00069	0.281
MOD_Plk_4	596	602	PF00069	0.265
MOD_ProDKin_1	144	150	PF00069	0.366
MOD_ProDKin_1	360	366	PF00069	0.359
MOD_ProDKin_1	469	475	PF00069	0.387
MOD_ProDKin_1	56	62	PF00069	0.358
MOD_SUMO_for_1	82	85	PF00179	0.336
MOD_SUMO_rev_2	631	637	PF00179	0.655
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.556
TRG_ENDOCYTIC_2	106	109	PF00928	0.302
TRG_ENDOCYTIC_2	196	199	PF00928	0.265
TRG_ENDOCYTIC_2	352	355	PF00928	0.335
TRG_ENDOCYTIC_2	373	376	PF00928	0.249
TRG_ENDOCYTIC_2	420	423	PF00928	0.382
TRG_ENDOCYTIC_2	494	497	PF00928	0.338
TRG_ENDOCYTIC_2	525	528	PF00928	0.416
TRG_ENDOCYTIC_2	568	571	PF00928	0.398
TRG_ENDOCYTIC_2	575	578	PF00928	0.317
TRG_ENDOCYTIC_2	597	600	PF00928	0.327
TRG_ENDOCYTIC_2	88	91	PF00928	0.288
TRG_ER_diArg_1	238	240	PF00400	0.290
TRG_ER_diArg_1	366	369	PF00400	0.335
TRG_ER_diArg_1	388	390	PF00400	0.299
TRG_ER_diArg_1	447	449	PF00400	0.406
TRG_NLS_MonoExtC_3	235	240	PF00514	0.277
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML7	Leptomonas seymouri	28%	100%
A0A0N1PA82	Leptomonas seymouri	67%	100%
A0A0S4KEI7	Bodo saltans	27%	100%
A0A0S4KLC8	Bodo saltans	41%	100%
A0A179HKZ8	Purpureocillium lilacinum	29%	100%
A0A1X0P192	Trypanosomatidae	46%	100%
A0A3R7KBH2	Trypanosoma rangeli	43%	100%
A0A3R7KJM1	Trypanosoma rangeli	32%	100%
A0A3S5H636	Leishmania donovani	30%	100%
A0A3S5H7U4	Leishmania donovani	93%	99%
A4H590	Leishmania braziliensis	29%	100%
A4HLI6	Leishmania braziliensis	84%	99%
A4HTH4	Leishmania infantum	30%	100%
A4I8Z6	Leishmania infantum	92%	99%
C9ZPL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A4Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
E9AMA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B3W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O42653	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O60111	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q06567	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q3MIX3	Homo sapiens	31%	100%
Q4QIE6	Leishmania major	30%	100%
Q54P00	Dictyostelium discoideum	31%	93%
Q54TR5	Dictyostelium discoideum	28%	97%
Q5M7P6	Xenopus tropicalis	31%	100%
Q5ZMT7	Gallus gallus	29%	100%
Q80V03	Mus musculus	29%	100%
Q86TW2	Homo sapiens	29%	100%
Q9D0L4	Mus musculus	29%	100%
Q9W133	Drosophila melanogaster	27%	100%
V5AX60	Trypanosoma cruzi	30%	100%
V5BCS0	Trypanosoma cruzi	46%	100%