SMAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q458_LEIMA

TriTrypDb:

LmjF.33.1305 , LMJLV39_330020900 , LMJSD75_330020600

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

Q4Q458

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q458

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.721
CLV_NRD_NRD_1	115	117	PF00675	0.525
CLV_NRD_NRD_1	19	21	PF00675	0.578
CLV_NRD_NRD_1	29	31	PF00675	0.677
CLV_PCSK_FUR_1	113	117	PF00082	0.558
CLV_PCSK_KEX2_1	115	117	PF00082	0.559
CLV_PCSK_KEX2_1	17	19	PF00082	0.553
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.551
CLV_PCSK_SKI1_1	105	109	PF00082	0.590
CLV_PCSK_SKI1_1	179	183	PF00082	0.538
CLV_PCSK_SKI1_1	209	213	PF00082	0.540
CLV_PCSK_SKI1_1	76	80	PF00082	0.697
DEG_SPOP_SBC_1	142	146	PF00917	0.733
DEG_SPOP_SBC_1	56	60	PF00917	0.720
DEG_SPOP_SBC_1	80	84	PF00917	0.732
DOC_USP7_MATH_1	11	15	PF00917	0.662
DOC_USP7_MATH_1	148	152	PF00917	0.619
DOC_USP7_MATH_1	177	181	PF00917	0.516
DOC_USP7_MATH_1	56	60	PF00917	0.698
DOC_USP7_MATH_1	66	70	PF00917	0.674
DOC_USP7_MATH_1	71	75	PF00917	0.711
DOC_USP7_MATH_1	80	84	PF00917	0.682
DOC_USP7_UBL2_3	186	190	PF12436	0.576
DOC_USP7_UBL2_3	209	213	PF12436	0.428
DOC_USP7_UBL2_3	72	76	PF12436	0.697
DOC_WW_Pin1_4	135	140	PF00397	0.719
DOC_WW_Pin1_4	144	149	PF00397	0.778
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BRCT_BRCA1_1	200	204	PF00533	0.497
LIG_eIF4E_1	163	169	PF01652	0.511
LIG_FHA_2	180	186	PF00498	0.583
LIG_LIR_Nem_3	201	207	PF02991	0.514
LIG_Pex14_2	207	211	PF04695	0.540
LIG_REV1ctd_RIR_1	209	213	PF16727	0.540
LIG_SH2_STAP1	163	167	PF00017	0.596
MOD_CK1_1	127	133	PF00069	0.668
MOD_CK1_1	135	141	PF00069	0.672
MOD_CK1_1	146	152	PF00069	0.710
MOD_CK1_1	82	88	PF00069	0.679
MOD_CK2_1	179	185	PF00069	0.666
MOD_CK2_1	87	93	PF00069	0.607
MOD_GlcNHglycan	1	4	PF01048	0.686
MOD_GlcNHglycan	121	124	PF01048	0.578
MOD_GlcNHglycan	127	130	PF01048	0.621
MOD_GlcNHglycan	134	137	PF01048	0.638
MOD_GlcNHglycan	148	151	PF01048	0.581
MOD_GlcNHglycan	179	182	PF01048	0.451
MOD_GlcNHglycan	63	66	PF01048	0.679
MOD_GlcNHglycan	68	71	PF01048	0.684
MOD_GlcNHglycan	85	88	PF01048	0.518
MOD_GSK3_1	124	131	PF00069	0.631
MOD_GSK3_1	142	149	PF00069	0.565
MOD_GSK3_1	175	182	PF00069	0.655
MOD_GSK3_1	20	27	PF00069	0.679
MOD_GSK3_1	57	64	PF00069	0.680
MOD_GSK3_1	66	73	PF00069	0.660
MOD_GSK3_1	79	86	PF00069	0.651
MOD_N-GLC_1	195	200	PF02516	0.536
MOD_NEK2_1	79	84	PF00069	0.690
MOD_NEK2_2	71	76	PF00069	0.510
MOD_PIKK_1	195	201	PF00454	0.578
MOD_PIKK_1	20	26	PF00454	0.703
MOD_PK_1	190	196	PF00069	0.630
MOD_PKA_1	30	36	PF00069	0.562
MOD_PKA_2	80	86	PF00069	0.719
MOD_PKB_1	18	26	PF00069	0.690
MOD_Plk_4	11	17	PF00069	0.638
MOD_Plk_4	190	196	PF00069	0.693
MOD_ProDKin_1	135	141	PF00069	0.720
MOD_ProDKin_1	144	150	PF00069	0.776
TRG_ER_diArg_1	113	116	PF00400	0.529
TRG_ER_diArg_1	169	172	PF00400	0.519
TRG_ER_diArg_1	18	20	PF00400	0.580
TRG_NLS_MonoCore_2	16	21	PF00514	0.576
TRG_NLS_MonoExtC_3	16	22	PF00514	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U6	Leptomonas seymouri	47%	100%
A0A3R7RIF0	Trypanosoma rangeli	31%	100%
A0A3S7X6R7	Leishmania donovani	89%	99%
A4HLI7	Leishmania braziliensis	75%	100%
A4I8Z7	Leishmania infantum	90%	100%
D0A4Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B3W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BLV0	Trypanosoma cruzi	31%	100%