Putative expression-site associated gene (ESAG3)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression-site associated gene (ESAG3), putative

Species:

Leishmania major

UniProt:

Q4Q457_LEIMA

TriTrypDb:

LmjF.33.1310 , LMJLV39_330021000 , LMJSD75_330020700

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q457

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q457

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.478
CLV_NRD_NRD_1	133	135	PF00675	0.580
CLV_NRD_NRD_1	155	157	PF00675	0.546
CLV_NRD_NRD_1	199	201	PF00675	0.545
CLV_NRD_NRD_1	501	503	PF00675	0.569
CLV_NRD_NRD_1	629	631	PF00675	0.606
CLV_NRD_NRD_1	76	78	PF00675	0.664
CLV_PCSK_FUR_1	131	135	PF00082	0.557
CLV_PCSK_FUR_1	153	157	PF00082	0.557
CLV_PCSK_KEX2_1	12	14	PF00082	0.481
CLV_PCSK_KEX2_1	133	135	PF00082	0.581
CLV_PCSK_KEX2_1	155	157	PF00082	0.546
CLV_PCSK_KEX2_1	199	201	PF00082	0.545
CLV_PCSK_KEX2_1	24	26	PF00082	0.479
CLV_PCSK_KEX2_1	286	288	PF00082	0.612
CLV_PCSK_KEX2_1	386	388	PF00082	0.613
CLV_PCSK_KEX2_1	501	503	PF00082	0.569
CLV_PCSK_KEX2_1	610	612	PF00082	0.699
CLV_PCSK_KEX2_1	629	631	PF00082	0.571
CLV_PCSK_KEX2_1	76	78	PF00082	0.664
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.477
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.617
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.613
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.701
CLV_PCSK_SKI1_1	287	291	PF00082	0.648
CLV_PCSK_SKI1_1	357	361	PF00082	0.609
CLV_PCSK_SKI1_1	42	46	PF00082	0.494
CLV_PCSK_SKI1_1	574	578	PF00082	0.557
CLV_PCSK_SKI1_1	610	614	PF00082	0.585
DEG_APCC_DBOX_1	352	360	PF00400	0.292
DEG_APCC_DBOX_1	41	49	PF00400	0.707
DEG_APCC_DBOX_1	461	469	PF00400	0.354
DEG_COP1_1	434	441	PF00400	0.319
DOC_ANK_TNKS_1	489	496	PF00023	0.376
DOC_CKS1_1	480	485	PF01111	0.385
DOC_CKS1_1	566	571	PF01111	0.405
DOC_CYCLIN_RxL_1	197	211	PF00134	0.347
DOC_CYCLIN_RxL_1	351	361	PF00134	0.298
DOC_CYCLIN_RxL_1	36	49	PF00134	0.656
DOC_MAPK_gen_1	153	161	PF00069	0.354
DOC_MAPK_gen_1	199	207	PF00069	0.346
DOC_MAPK_gen_1	501	508	PF00069	0.362
DOC_MAPK_gen_1	80	89	PF00069	0.375
DOC_MAPK_MEF2A_6	402	409	PF00069	0.398
DOC_MAPK_MEF2A_6	52	61	PF00069	0.471
DOC_MAPK_MEF2A_6	641	648	PF00069	0.362
DOC_MAPK_RevD_3	61	77	PF00069	0.328
DOC_PP1_RVXF_1	156	162	PF00149	0.381
DOC_PP1_RVXF_1	201	208	PF00149	0.341
DOC_PP2B_LxvP_1	290	293	PF13499	0.349
DOC_PP2B_LxvP_1	667	670	PF13499	0.504
DOC_PP2B_LxvP_1	87	90	PF13499	0.469
DOC_PP4_FxxP_1	104	107	PF00568	0.369
DOC_PP4_FxxP_1	184	187	PF00568	0.341
DOC_USP7_MATH_1	109	113	PF00917	0.527
DOC_USP7_MATH_1	127	131	PF00917	0.318
DOC_USP7_MATH_1	385	389	PF00917	0.436
DOC_USP7_MATH_1	604	608	PF00917	0.436
DOC_USP7_MATH_1	631	635	PF00917	0.438
DOC_USP7_MATH_1	90	94	PF00917	0.456
DOC_WW_Pin1_4	241	246	PF00397	0.383
DOC_WW_Pin1_4	376	381	PF00397	0.383
DOC_WW_Pin1_4	433	438	PF00397	0.408
DOC_WW_Pin1_4	479	484	PF00397	0.442
DOC_WW_Pin1_4	565	570	PF00397	0.409
DOC_WW_Pin1_4	665	670	PF00397	0.490
LIG_14-3-3_CanoR_1	133	142	PF00244	0.325
LIG_14-3-3_CanoR_1	160	165	PF00244	0.279
LIG_14-3-3_CanoR_1	171	177	PF00244	0.260
LIG_14-3-3_CanoR_1	330	338	PF00244	0.435
LIG_14-3-3_CanoR_1	501	508	PF00244	0.365
LIG_14-3-3_CanoR_1	611	619	PF00244	0.383
LIG_14-3-3_CanoR_1	99	107	PF00244	0.368
LIG_Actin_WH2_2	406	424	PF00022	0.276
LIG_APCC_ABBA_1	233	238	PF00400	0.245
LIG_APCC_ABBAyCdc20_2	210	216	PF00400	0.335
LIG_BRCT_BRCA1_1	100	104	PF00533	0.344
LIG_BRCT_BRCA1_1	223	227	PF00533	0.308
LIG_BRCT_BRCA1_1	308	312	PF00533	0.369
LIG_BRCT_BRCA1_1	581	585	PF00533	0.429
LIG_Clathr_ClatBox_1	496	500	PF01394	0.393
LIG_CSL_BTD_1	32	35	PF09270	0.678
LIG_CtBP_PxDLS_1	477	481	PF00389	0.365
LIG_deltaCOP1_diTrp_1	225	233	PF00928	0.343
LIG_deltaCOP1_diTrp_1	645	654	PF00928	0.368
LIG_eIF4E_1	491	497	PF01652	0.370
LIG_FHA_1	121	127	PF00498	0.499
LIG_FHA_1	395	401	PF00498	0.416
LIG_FHA_1	404	410	PF00498	0.357
LIG_FHA_1	480	486	PF00498	0.536
LIG_FHA_1	539	545	PF00498	0.417
LIG_FHA_1	566	572	PF00498	0.401
LIG_FHA_1	60	66	PF00498	0.378
LIG_FHA_1	634	640	PF00498	0.392
LIG_FHA_1	68	74	PF00498	0.405
LIG_FHA_2	117	123	PF00498	0.479
LIG_FHA_2	134	140	PF00498	0.262
LIG_FHA_2	227	233	PF00498	0.380
LIG_FHA_2	575	581	PF00498	0.419
LIG_GBD_Chelix_1	57	65	PF00786	0.286
LIG_LIR_Apic_2	101	107	PF02991	0.340
LIG_LIR_Apic_2	488	494	PF02991	0.419
LIG_LIR_Gen_1	163	172	PF02991	0.311
LIG_LIR_Gen_1	193	201	PF02991	0.410
LIG_LIR_Gen_1	202	208	PF02991	0.387
LIG_LIR_Gen_1	238	245	PF02991	0.247
LIG_LIR_Gen_1	5	11	PF02991	0.669
LIG_LIR_Gen_1	651	660	PF02991	0.387
LIG_LIR_Nem_3	163	167	PF02991	0.311
LIG_LIR_Nem_3	193	198	PF02991	0.419
LIG_LIR_Nem_3	202	207	PF02991	0.391
LIG_LIR_Nem_3	225	231	PF02991	0.346
LIG_LIR_Nem_3	232	236	PF02991	0.347
LIG_LIR_Nem_3	238	243	PF02991	0.340
LIG_LIR_Nem_3	5	10	PF02991	0.669
LIG_LIR_Nem_3	651	657	PF02991	0.361
LIG_MYND_3	234	238	PF01753	0.247
LIG_PCNA_yPIPBox_3	453	464	PF02747	0.291
LIG_Pex14_1	74	78	PF04695	0.437
LIG_Pex14_2	236	240	PF04695	0.448
LIG_SH2_CRK	491	495	PF00017	0.373
LIG_SH2_CRK	603	607	PF00017	0.390
LIG_SH2_CRK	78	82	PF00017	0.454
LIG_SH2_NCK_1	603	607	PF00017	0.383
LIG_SH2_SRC	145	148	PF00017	0.330
LIG_SH2_STAP1	487	491	PF00017	0.406
LIG_SH2_STAP1	619	623	PF00017	0.360
LIG_SH2_STAT3	381	384	PF00017	0.415
LIG_SH2_STAT5	145	148	PF00017	0.409
LIG_SH2_STAT5	204	207	PF00017	0.384
LIG_SH2_STAT5	381	384	PF00017	0.389
LIG_SH2_STAT5	460	463	PF00017	0.344
LIG_SH2_STAT5	524	527	PF00017	0.371
LIG_SH3_3	310	316	PF00018	0.357
LIG_SH3_3	37	43	PF00018	0.607
LIG_SH3_3	504	510	PF00018	0.355
LIG_SH3_3	564	570	PF00018	0.380
LIG_SH3_3	593	599	PF00018	0.385
LIG_SH3_3	663	669	PF00018	0.392
LIG_SUMO_SIM_anti_2	62	71	PF11976	0.251
LIG_SUMO_SIM_par_1	122	130	PF11976	0.342
LIG_SUMO_SIM_par_1	215	225	PF11976	0.363
LIG_SUMO_SIM_par_1	62	71	PF11976	0.396
LIG_WRC_WIRS_1	161	166	PF05994	0.245
MOD_CDC14_SPxK_1	244	247	PF00782	0.275
MOD_CDK_SPxK_1	241	247	PF00069	0.271
MOD_CK1_1	403	409	PF00069	0.388
MOD_CK1_1	479	485	PF00069	0.437
MOD_CK1_1	6	12	PF00069	0.674
MOD_CK1_1	634	640	PF00069	0.343
MOD_CK2_1	116	122	PF00069	0.480
MOD_CK2_1	133	139	PF00069	0.266
MOD_CMANNOS	535	538	PF00535	0.605
MOD_Cter_Amidation	22	25	PF01082	0.485
MOD_Cter_Amidation	284	287	PF01082	0.536
MOD_GlcNHglycan	100	103	PF01048	0.553
MOD_GlcNHglycan	177	180	PF01048	0.538
MOD_GlcNHglycan	26	29	PF01048	0.448
MOD_GlcNHglycan	281	284	PF01048	0.609
MOD_GlcNHglycan	574	577	PF01048	0.559
MOD_GlcNHglycan	636	639	PF01048	0.520
MOD_GSK3_1	116	123	PF00069	0.478
MOD_GSK3_1	129	136	PF00069	0.309
MOD_GSK3_1	171	178	PF00069	0.388
MOD_GSK3_1	182	189	PF00069	0.308
MOD_GSK3_1	2	9	PF00069	0.657
MOD_GSK3_1	332	339	PF00069	0.345
MOD_GSK3_1	376	383	PF00069	0.381
MOD_GSK3_1	427	434	PF00069	0.441
MOD_LATS_1	22	28	PF00433	0.672
MOD_N-GLC_1	191	196	PF02516	0.575
MOD_N-GLC_1	279	284	PF02516	0.628
MOD_N-GLC_1	395	400	PF02516	0.596
MOD_N-GLC_1	538	543	PF02516	0.615
MOD_N-GLC_1	655	660	PF02516	0.652
MOD_N-GLC_1	85	90	PF02516	0.604
MOD_NEK2_1	17	22	PF00069	0.745
MOD_NEK2_1	172	177	PF00069	0.444
MOD_NEK2_1	191	196	PF00069	0.316
MOD_NEK2_1	336	341	PF00069	0.337
MOD_NEK2_1	394	399	PF00069	0.478
MOD_NEK2_1	413	418	PF00069	0.344
MOD_NEK2_1	558	563	PF00069	0.401
MOD_NEK2_1	572	577	PF00069	0.347
MOD_PIKK_1	340	346	PF00454	0.314
MOD_PIKK_1	380	386	PF00454	0.417
MOD_PIKK_1	444	450	PF00454	0.399
MOD_PIKK_1	500	506	PF00454	0.334
MOD_PK_1	85	91	PF00069	0.412
MOD_PKA_1	133	139	PF00069	0.286
MOD_PKA_1	24	30	PF00069	0.666
MOD_PKA_1	610	616	PF00069	0.358
MOD_PKA_2	109	115	PF00069	0.383
MOD_PKA_2	133	139	PF00069	0.314
MOD_PKA_2	154	160	PF00069	0.355
MOD_PKA_2	24	30	PF00069	0.704
MOD_PKA_2	444	450	PF00069	0.380
MOD_PKA_2	500	506	PF00069	0.368
MOD_PKA_2	610	616	PF00069	0.351
MOD_PKA_2	631	637	PF00069	0.422
MOD_PKA_2	98	104	PF00069	0.350
MOD_PKB_1	131	139	PF00069	0.289
MOD_PKB_1	158	166	PF00069	0.284
MOD_Plk_1	191	197	PF00069	0.407
MOD_Plk_1	395	401	PF00069	0.400
MOD_Plk_1	655	661	PF00069	0.403
MOD_Plk_1	85	91	PF00069	0.400
MOD_Plk_2-3	246	252	PF00069	0.386
MOD_Plk_4	395	401	PF00069	0.434
MOD_Plk_4	403	409	PF00069	0.373
MOD_Plk_4	427	433	PF00069	0.338
MOD_Plk_4	59	65	PF00069	0.487
MOD_Plk_4	6	12	PF00069	0.686
MOD_Plk_4	662	668	PF00069	0.439
MOD_ProDKin_1	241	247	PF00069	0.389
MOD_ProDKin_1	376	382	PF00069	0.387
MOD_ProDKin_1	433	439	PF00069	0.411
MOD_ProDKin_1	479	485	PF00069	0.437
MOD_ProDKin_1	565	571	PF00069	0.409
MOD_SUMO_rev_2	260	268	PF00179	0.360
TRG_DiLeu_BaEn_2	649	655	PF01217	0.373
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.415
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.639
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.377
TRG_ENDOCYTIC_2	195	198	PF00928	0.407
TRG_ENDOCYTIC_2	204	207	PF00928	0.384
TRG_ENDOCYTIC_2	619	622	PF00928	0.368
TRG_ENDOCYTIC_2	78	81	PF00928	0.512
TRG_ER_diArg_1	11	13	PF00400	0.695
TRG_ER_diArg_1	131	134	PF00400	0.362
TRG_ER_diArg_1	155	158	PF00400	0.358
TRG_ER_diArg_1	198	200	PF00400	0.351
TRG_ER_diArg_1	461	464	PF00400	0.329
TRG_ER_diArg_1	629	632	PF00400	0.360
TRG_ER_diArg_1	75	77	PF00400	0.558
TRG_NES_CRM1_1	337	350	PF08389	0.303
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	62%	100%
A0A3Q8ID98	Leishmania donovani	34%	100%
A0A3Q8IM92	Leishmania donovani	91%	100%
A4H7X2	Leishmania braziliensis	32%	100%
A4HLI8	Leishmania braziliensis	79%	100%
A4HLJ0	Leishmania braziliensis	76%	100%
A4HLJ2	Leishmania braziliensis	79%	100%
A4HW99	Leishmania infantum	34%	100%
A4I8Z8	Leishmania infantum	91%	100%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFI2	Leishmania major	33%	100%