Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q456_LEIMA

TriTrypDb:

LmjF.33.1320 , LMJLV39_330021100 , LMJSD75_330020800

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q456

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q456

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.677
CLV_NRD_NRD_1	181	183	PF00675	0.668
CLV_NRD_NRD_1	93	95	PF00675	0.627
CLV_PCSK_KEX2_1	181	183	PF00082	0.561
CLV_PCSK_KEX2_1	95	97	PF00082	0.592
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.546
CLV_PCSK_SKI1_1	113	117	PF00082	0.592
CLV_PCSK_SKI1_1	172	176	PF00082	0.566
CLV_PCSK_SKI1_1	211	215	PF00082	0.651
DOC_CKS1_1	82	87	PF01111	0.682
DOC_CYCLIN_RxL_1	208	216	PF00134	0.639
DOC_CYCLIN_yClb3_PxF_3	149	157	PF00134	0.716
DOC_PP1_RVXF_1	93	100	PF00149	0.604
DOC_PP2B_LxvP_1	261	264	PF13499	0.663
DOC_PP4_FxxP_1	118	121	PF00568	0.596
DOC_PP4_FxxP_1	246	249	PF00568	0.679
DOC_PP4_FxxP_1	257	260	PF00568	0.587
DOC_USP7_MATH_1	133	137	PF00917	0.715
DOC_USP7_MATH_1	6	10	PF00917	0.727
DOC_USP7_MATH_1	77	81	PF00917	0.671
DOC_USP7_MATH_2	88	94	PF00917	0.606
DOC_WW_Pin1_4	134	139	PF00397	0.662
DOC_WW_Pin1_4	147	152	PF00397	0.596
DOC_WW_Pin1_4	187	192	PF00397	0.672
DOC_WW_Pin1_4	7	12	PF00397	0.697
DOC_WW_Pin1_4	81	86	PF00397	0.623
LIG_BIR_II_1	1	5	PF00653	0.812
LIG_FHA_1	148	154	PF00498	0.714
LIG_FHA_1	208	214	PF00498	0.584
LIG_FHA_1	32	38	PF00498	0.631
LIG_FHA_1	57	63	PF00498	0.697
LIG_FHA_2	188	194	PF00498	0.674
LIG_FHA_2	254	260	PF00498	0.591
LIG_LIR_Apic_2	116	121	PF02991	0.568
LIG_LIR_Apic_2	243	249	PF02991	0.633
LIG_LIR_Apic_2	254	260	PF02991	0.477
LIG_LIR_Nem_3	212	217	PF02991	0.645
LIG_PDZ_Class_2	260	265	PF00595	0.570
LIG_Pex14_2	214	218	PF04695	0.691
LIG_Pex14_2	246	250	PF04695	0.627
LIG_SH2_NCK_1	130	134	PF00017	0.804
LIG_SH3_3	146	152	PF00018	0.735
LIG_SH3_3	5	11	PF00018	0.703
LIG_SH3_3	79	85	PF00018	0.654
LIG_SUMO_SIM_par_1	9	17	PF11976	0.778
LIG_TRAF2_1	2	5	PF00917	0.749
LIG_TRAF2_1	58	61	PF00917	0.638
LIG_TRFH_1	192	196	PF08558	0.641
MOD_CDC14_SPxK_1	137	140	PF00782	0.723
MOD_CDK_SPxK_1	134	140	PF00069	0.726
MOD_CDK_SPxK_1	81	87	PF00069	0.670
MOD_CK1_1	125	131	PF00069	0.728
MOD_CK1_1	136	142	PF00069	0.669
MOD_CK1_1	160	166	PF00069	0.623
MOD_CK1_1	204	210	PF00069	0.548
MOD_CK1_1	80	86	PF00069	0.614
MOD_CK2_1	187	193	PF00069	0.675
MOD_CK2_1	253	259	PF00069	0.592
MOD_GlcNHglycan	204	207	PF01048	0.623
MOD_GSK3_1	157	164	PF00069	0.498
MOD_GSK3_1	200	207	PF00069	0.561
MOD_GSK3_1	234	241	PF00069	0.664
MOD_GSK3_1	77	84	PF00069	0.590
MOD_N-GLC_1	142	147	PF02516	0.671
MOD_N-GLC_1	234	239	PF02516	0.669
MOD_NEK2_1	202	207	PF00069	0.638
MOD_NEK2_1	218	223	PF00069	0.709
MOD_NEK2_2	209	214	PF00069	0.648
MOD_PIKK_1	238	244	PF00454	0.713
MOD_PKA_2	125	131	PF00069	0.731
MOD_PKA_2	139	145	PF00069	0.711
MOD_PKB_1	232	240	PF00069	0.704
MOD_Plk_1	142	148	PF00069	0.680
MOD_Plk_1	160	166	PF00069	0.471
MOD_Plk_1	253	259	PF00069	0.592
MOD_Plk_4	77	83	PF00069	0.689
MOD_ProDKin_1	134	140	PF00069	0.665
MOD_ProDKin_1	147	153	PF00069	0.592
MOD_ProDKin_1	187	193	PF00069	0.675
MOD_ProDKin_1	7	13	PF00069	0.698
MOD_ProDKin_1	81	87	PF00069	0.620
TRG_DiLeu_BaEn_1	61	66	PF01217	0.621
TRG_ER_diArg_1	180	182	PF00400	0.678
TRG_ER_diArg_1	231	234	PF00400	0.694
TRG_ER_diArg_1	94	97	PF00400	0.594
TRG_NLS_MonoExtN_4	92	98	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	211	216	PF00026	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P385	Leptomonas seymouri	58%	95%
A0A1X0P111	Trypanosomatidae	33%	75%
A0A3S7X6L8	Leishmania donovani	94%	100%
A0A422NCP6	Trypanosoma rangeli	30%	89%
A4HLJ1	Leishmania braziliensis	68%	100%
A4HLJ3	Leishmania braziliensis	68%	100%
A4I8Z9	Leishmania infantum	94%	100%
E9B3W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%