Cysteine conjugate beta-lyase,aminotransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutamine aminotransferase, putative

Species:

Leishmania major

UniProt:

Q4Q455_LEIMA

TriTrypDb:

LmjF.33.1330 , LMJLV39_330021300 , LMJSD75_330021000

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q455

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q455

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0008483	transaminase activity	4	10
GO:0016212	kynurenine-oxoglutarate transaminase activity	6	2
GO:0016740	transferase activity	2	10
GO:0016769	transferase activity, transferring nitrogenous groups	3	10
GO:0016829	lyase activity	2	6
GO:0019842	vitamin binding	3	10
GO:0030170	pyridoxal phosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0036137	kynurenine aminotransferase activity	5	2
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0070279	vitamin B6 binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0047945	L-glutamine:pyruvate aminotransferase activity	6	1
GO:0070548	L-glutamine aminotransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	161	165	PF00082	0.429
CLV_PCSK_SKI1_1	173	177	PF00082	0.280
CLV_PCSK_SKI1_1	234	238	PF00082	0.355
CLV_PCSK_SKI1_1	45	49	PF00082	0.469
DEG_APCC_DBOX_1	160	168	PF00400	0.498
DEG_APCC_DBOX_1	44	52	PF00400	0.420
DOC_CKS1_1	177	182	PF01111	0.357
DOC_CYCLIN_RxL_1	42	52	PF00134	0.420
DOC_MAPK_gen_1	158	167	PF00069	0.498
DOC_PP1_RVXF_1	249	255	PF00149	0.357
DOC_PP2B_LxvP_1	261	264	PF13499	0.456
DOC_PP4_FxxP_1	41	44	PF00568	0.337
DOC_USP7_MATH_1	221	225	PF00917	0.442
DOC_USP7_MATH_1	309	313	PF00917	0.265
DOC_USP7_UBL2_3	337	341	PF12436	0.438
DOC_USP7_UBL2_3	349	353	PF12436	0.369
DOC_USP7_UBL2_3	82	86	PF12436	0.498
DOC_WW_Pin1_4	176	181	PF00397	0.382
DOC_WW_Pin1_4	20	25	PF00397	0.456
DOC_WW_Pin1_4	275	280	PF00397	0.357
LIG_14-3-3_CanoR_1	11	19	PF00244	0.586
LIG_14-3-3_CanoR_1	234	239	PF00244	0.357
LIG_APCC_ABBA_1	124	129	PF00400	0.357
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	276	280	PF00533	0.439
LIG_deltaCOP1_diTrp_1	354	360	PF00928	0.357
LIG_FHA_1	13	19	PF00498	0.593
LIG_FHA_1	136	142	PF00498	0.472
LIG_FHA_1	170	176	PF00498	0.357
LIG_FHA_1	233	239	PF00498	0.413
LIG_FHA_1	260	266	PF00498	0.423
LIG_FHA_1	360	366	PF00498	0.393
LIG_FHA_1	83	89	PF00498	0.457
LIG_FHA_1	98	104	PF00498	0.271
LIG_FHA_2	334	340	PF00498	0.442
LIG_LIR_Apic_2	217	221	PF02991	0.417
LIG_LIR_Apic_2	40	44	PF02991	0.334
LIG_LIR_Gen_1	129	137	PF02991	0.514
LIG_LIR_Gen_1	142	149	PF02991	0.283
LIG_LIR_Gen_1	16	26	PF02991	0.461
LIG_LIR_Gen_1	172	180	PF02991	0.456
LIG_LIR_Gen_1	210	221	PF02991	0.337
LIG_LIR_Gen_1	270	279	PF02991	0.456
LIG_LIR_Gen_1	385	391	PF02991	0.357
LIG_LIR_Gen_1	83	92	PF02991	0.498
LIG_LIR_Nem_3	125	131	PF02991	0.380
LIG_LIR_Nem_3	142	147	PF02991	0.391
LIG_LIR_Nem_3	172	177	PF02991	0.456
LIG_LIR_Nem_3	210	216	PF02991	0.337
LIG_LIR_Nem_3	270	274	PF02991	0.456
LIG_LIR_Nem_3	293	299	PF02991	0.387
LIG_LIR_Nem_3	385	390	PF02991	0.357
LIG_LIR_Nem_3	83	87	PF02991	0.498
LIG_PDZ_Class_2	409	414	PF00595	0.526
LIG_SH2_CRK	213	217	PF00017	0.340
LIG_SH2_CRK	218	222	PF00017	0.335
LIG_SH2_CRK	297	301	PF00017	0.498
LIG_SH2_CRK	67	71	PF00017	0.456
LIG_SH2_CRK	84	88	PF00017	0.456
LIG_SH2_GRB2like	384	387	PF00017	0.442
LIG_SH2_PTP2	144	147	PF00017	0.413
LIG_SH2_SRC	132	135	PF00017	0.498
LIG_SH2_STAP1	128	132	PF00017	0.386
LIG_SH2_STAP1	304	308	PF00017	0.427
LIG_SH2_STAP1	384	388	PF00017	0.382
LIG_SH2_STAP1	84	88	PF00017	0.382
LIG_SH2_STAT5	144	147	PF00017	0.452
LIG_SH2_STAT5	215	218	PF00017	0.450
LIG_SH2_STAT5	387	390	PF00017	0.389
LIG_SH2_STAT5	67	70	PF00017	0.408
LIG_SH2_STAT5	84	87	PF00017	0.291
LIG_SH3_3	319	325	PF00018	0.357
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.456
LIG_SUMO_SIM_par_1	119	125	PF11976	0.456
LIG_SUMO_SIM_par_1	162	169	PF11976	0.425
LIG_SUMO_SIM_par_1	233	240	PF11976	0.413
LIG_TYR_ITAM	129	147	PF00017	0.456
LIG_UBA3_1	47	53	PF00899	0.442
LIG_WRC_WIRS_1	271	276	PF05994	0.382
LIG_WRC_WIRS_1	38	43	PF05994	0.393
LIG_WW_3	42	46	PF00397	0.498
LIG_WW_3	68	72	PF00397	0.420
MOD_CK1_1	14	20	PF00069	0.534
MOD_CK1_1	150	156	PF00069	0.456
MOD_CK1_1	169	175	PF00069	0.168
MOD_CK1_1	224	230	PF00069	0.363
MOD_CK1_1	270	276	PF00069	0.467
MOD_CK1_1	347	353	PF00069	0.498
MOD_CK2_1	14	20	PF00069	0.601
MOD_CK2_1	392	398	PF00069	0.475
MOD_GlcNHglycan	152	155	PF01048	0.503
MOD_GlcNHglycan	168	171	PF01048	0.233
MOD_GlcNHglycan	239	242	PF01048	0.384
MOD_GlcNHglycan	317	320	PF01048	0.444
MOD_GSK3_1	135	142	PF00069	0.449
MOD_GSK3_1	143	150	PF00069	0.359
MOD_GSK3_1	237	244	PF00069	0.393
MOD_GSK3_1	270	277	PF00069	0.421
MOD_GSK3_1	82	89	PF00069	0.429
MOD_GSK3_1	97	104	PF00069	0.247
MOD_N-GLC_1	347	352	PF02516	0.444
MOD_NEK2_1	13	18	PF00069	0.617
MOD_NEK2_1	214	219	PF00069	0.456
MOD_NEK2_1	245	250	PF00069	0.384
MOD_NEK2_1	274	279	PF00069	0.421
MOD_NEK2_1	315	320	PF00069	0.469
MOD_NEK2_1	80	85	PF00069	0.452
MOD_PIKK_1	101	107	PF00454	0.258
MOD_PIKK_1	347	353	PF00454	0.498
MOD_PIKK_1	392	398	PF00454	0.420
MOD_PIKK_1	86	92	PF00454	0.450
MOD_PKB_1	9	17	PF00069	0.564
MOD_Plk_1	232	238	PF00069	0.382
MOD_Plk_4	14	20	PF00069	0.502
MOD_ProDKin_1	176	182	PF00069	0.382
MOD_ProDKin_1	20	26	PF00069	0.448
MOD_ProDKin_1	275	281	PF00069	0.357
MOD_SUMO_rev_2	378	383	PF00179	0.434
TRG_DiLeu_BaEn_4	20	26	PF01217	0.548
TRG_DiLeu_BaEn_4	378	384	PF01217	0.382
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.420
TRG_ENDOCYTIC_2	132	135	PF00928	0.408
TRG_ENDOCYTIC_2	144	147	PF00928	0.360
TRG_ENDOCYTIC_2	213	216	PF00928	0.337
TRG_ENDOCYTIC_2	271	274	PF00928	0.382
TRG_ENDOCYTIC_2	297	300	PF00928	0.384
TRG_ENDOCYTIC_2	387	390	PF00928	0.386
TRG_ENDOCYTIC_2	84	87	PF00928	0.507
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I393	Leptomonas seymouri	22%	96%
A0A0N1II57	Leptomonas seymouri	23%	93%
A0A0N1PA03	Leptomonas seymouri	24%	100%
A0A0N1PB68	Leptomonas seymouri	76%	100%
A0A0P0VI36	Oryza sativa subsp. japonica	22%	84%
A0A0S4IKK8	Bodo saltans	24%	85%
A0A0S4J4K7	Bodo saltans	25%	95%
A0A0S4KNT6	Bodo saltans	49%	98%
A0A1X0NDS5	Trypanosomatidae	22%	98%
A0A1X0P1M2	Trypanosomatidae	56%	98%
A0A1X0P7X4	Trypanosomatidae	24%	100%
A0A3Q8IGK8	Leishmania donovani	96%	100%
A0A3Q8INT3	Leishmania donovani	24%	92%
A0LEA5	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	26%	100%
A0PP15	Mycobacterium ulcerans (strain Agy99)	25%	100%
A1VDD3	Desulfovibrio vulgaris subsp. vulgaris (strain DP4)	24%	100%
A2AIG8	Mus musculus	27%	82%
A3PMF8	Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)	27%	100%
A4HLJ4	Leishmania braziliensis	85%	100%
A4HPA3	Leishmania braziliensis	24%	92%
A4I904	Leishmania infantum	96%	100%
A4IDL0	Leishmania infantum	24%	92%
A5FRC5	Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)	23%	100%
B1I544	Desulforudis audaxviator (strain MP104C)	25%	100%
B2A250	Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)	22%	100%
B2HQA3	Mycobacterium marinum (strain ATCC BAA-535 / M)	25%	100%
B8CX89	Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)	22%	100%
B8DJJ6	Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F)	24%	100%
C6BUK3	Maridesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIMB 8403 / VKM B-1763)	24%	100%
C6C2Z3	Musicola paradisiaca (strain Ech703)	27%	100%
D0A500	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9AT13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	92%
E9B3W9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9L7A5	Petunia hybrida	25%	86%
H3ZPL1	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	25%	99%
H3ZPU1	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	28%	100%
O07587	Bacillus subtilis (strain 168)	24%	100%
O14209	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	98%
O31665	Bacillus subtilis (strain 168)	23%	100%
O33822	Thermus aquaticus	29%	100%
O58489	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	26%	100%
O66630	Aquifex aeolicus (strain VF5)	25%	100%
O67781	Aquifex aeolicus (strain VF5)	28%	100%
O86459	Rhizobium leguminosarum bv. phaseoli	27%	100%
O87320	Rhizobium meliloti (strain 1021)	25%	100%
P04694	Rattus norvegicus	22%	91%
P09053	Escherichia coli (strain K12)	23%	99%
P0A959	Escherichia coli (strain K12)	24%	100%
P0A960	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	24%	100%
P0A961	Shigella flexneri	24%	100%
P14909	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	22%	100%
P16524	Bacillus subtilis (strain 168)	27%	100%
P17735	Homo sapiens	22%	91%
P18485	Solanum lycopersicum	24%	85%
P23034	Bacillus sp. (strain YM-2)	27%	100%
P23279	Cucurbita pepo	21%	84%
P23599	Cucurbita maxima	21%	84%
P27486	Dianthus caryophyllus	23%	80%
P31531	Glycine max	21%	86%
P39643	Bacillus subtilis (strain 168)	24%	100%
P47039	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	93%
P53001	Bacillus subtilis (strain 168)	29%	100%
P58350	Rhizobium meliloti (strain 1021)	26%	100%
P63499	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	23%	97%
P71348	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	100%
P77434	Escherichia coli (strain K12)	24%	100%
P77730	Escherichia coli (strain K12)	26%	88%
P77806	Escherichia coli (strain K12)	33%	100%
P96847	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
P9WPZ4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	35%	100%
P9WPZ5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	35%	100%
P9WQ90	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	23%	97%
P9WQ91	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	23%	97%
Q00379	Cucurbita pepo	22%	84%
Q02635	Rhizobium meliloti (strain 1021)	28%	100%
Q06191	Rhizobium meliloti	25%	100%
Q08415	Rattus norvegicus	33%	98%
Q0P5G4	Bos taurus	36%	91%
Q16773	Homo sapiens	36%	98%
Q17CS8	Aedes aegypti	37%	87%
Q1RGV0	Rickettsia bellii (strain RML369-C)	28%	100%
Q2RK33	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	24%	100%
Q30ZX9	Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20)	24%	100%
Q3AC10	Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)	27%	100%
Q3S8P9	Streptomyces rimosus	24%	100%
Q3Z8H5	Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)	23%	100%
Q3ZXC8	Dehalococcoides mccartyi (strain CBDB1)	23%	100%
Q42881	Solanum lycopersicum	22%	88%
Q46E46	Methanosarcina barkeri (strain Fusaro / DSM 804)	21%	100%
Q4J8X2	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	25%	100%
Q4Q1I5	Leishmania major	23%	93%
Q4QLD1	Haemophilus influenzae (strain 86-028NP)	23%	100%
Q4UND3	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	28%	100%
Q54KM6	Dictyostelium discoideum	36%	95%
Q55128	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
Q56232	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	28%	100%
Q57004	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
Q58097	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q58786	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	99%
Q58CZ9	Bos taurus	22%	93%
Q58FK9	Rattus norvegicus	37%	91%
Q59228	Geobacillus stearothermophilus	28%	100%
Q5E9H2	Bos taurus	26%	82%
Q5F4K8	Pinus pinaster	26%	84%
Q60013	Streptomyces virginiae	25%	100%
Q60317	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	100%
Q63A05	Bacillus cereus (strain ZK / E33L)	23%	100%
Q67Y55	Arabidopsis thaliana	23%	92%
Q68XV9	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	27%	100%
Q6HHF6	Bacillus thuringiensis subsp. konkukian (strain 97-27)	23%	100%
Q6YP21	Homo sapiens	38%	91%
Q71RI9	Mus musculus	37%	91%
Q72BI1	Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough)	24%	100%
Q795M6	Bacillus subtilis (strain 168)	30%	100%
Q7T3E5	Danio rerio	35%	92%
Q81C43	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	23%	100%
Q81P62	Bacillus anthracis	23%	100%
Q82DR2	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	25%	100%
Q82WA8	Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)	26%	100%
Q84CG1	Streptomyces vinaceus	24%	100%
Q8BTY1	Mus musculus	34%	98%
Q8DTM1	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	26%	100%
Q8KD01	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	23%	100%
Q8KDS8	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	26%	100%
Q8N5Z0	Homo sapiens	26%	97%
Q8QZR1	Mus musculus	21%	91%
Q92JE7	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	28%	100%
Q93703	Caenorhabditis elegans	24%	89%
Q96QU6	Homo sapiens	27%	83%
Q972A2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	26%	100%
Q9C969	Arabidopsis thaliana	26%	100%
Q9HUI9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	32%	100%
Q9LVY1	Arabidopsis thaliana	25%	99%
Q9SIE1	Arabidopsis thaliana	24%	87%
Q9SIV0	Arabidopsis thaliana	23%	90%
Q9SK47	Arabidopsis thaliana	21%	93%
Q9SNN8	Oryza sativa subsp. japonica	26%	76%
Q9ST02	Hordeum vulgare	23%	90%
Q9SUR6	Arabidopsis thaliana	23%	98%
Q9V0L2	Pyrococcus abyssi (strain GE5 / Orsay)	28%	100%
Q9X0Y2	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	29%	100%
Q9ZE56	Rickettsia prowazekii (strain Madrid E)	27%	100%
V5BGG8	Trypanosoma cruzi	22%	100%